Coexpression cluster:C3509

Full id: C3509_Fibroblast_Keratocytes_Myoblast_tridermal_Smooth_optic_embryonic

Phase1 CAGE Peaks

Hg19::chr15:71146436..71146447,-	p3@LARP6
Hg19::chr15:71146461..71146475,-	p2@LARP6
Hg19::chr15:71146480..71146531,-	p1@LARP6

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
non-terminally differentiated cell	2.19e-30	180
contractile cell	2.91e-17	59
muscle precursor cell	4.50e-17	57
myoblast	4.50e-17	57
multi-potent skeletal muscle stem cell	4.50e-17	57
muscle cell	2.60e-16	54
smooth muscle cell	2.76e-16	42
smooth muscle myoblast	2.76e-16	42
vascular associated smooth muscle cell	1.36e-14	32
fibroblast	5.36e-14	75
electrically responsive cell	9.68e-14	60
electrically active cell	9.68e-14	60
mesodermal cell	3.30e-13	119
embryonic cell	8.22e-11	248

Uber Anatomy

Ontology term	p-value	n
organism subdivision	5.11e-25	365
cell layer	3.93e-19	312
epithelium	1.39e-18	309
somite	2.90e-17	83
paraxial mesoderm	2.90e-17	83
presomitic mesoderm	2.90e-17	83
presumptive segmental plate	2.90e-17	83
trunk paraxial mesoderm	2.90e-17	83
presumptive paraxial mesoderm	2.90e-17	83
multi-tissue structure	2.93e-17	347
dermomyotome	2.08e-15	70
skeletal muscle tissue	4.13e-15	61
striated muscle tissue	4.13e-15	61
myotome	4.13e-15	61
anatomical conduit	5.88e-15	241
tube	6.62e-15	194
anatomical cluster	7.60e-15	286
trunk	3.84e-14	216
multilaminar epithelium	4.28e-14	82
muscle tissue	4.48e-14	63
musculature	4.48e-14	63
musculature of body	4.48e-14	63
multi-cellular organism	5.38e-13	659
trunk mesenchyme	6.04e-13	143
artery	1.08e-12	42
arterial blood vessel	1.08e-12	42
arterial system	1.08e-12	42
splanchnic layer of lateral plate mesoderm	4.71e-12	84
vasculature	8.73e-12	79
vascular system	8.73e-12	79
systemic artery	1.78e-11	33
systemic arterial system	1.78e-11	33
anatomical system	3.63e-11	625
blood vessel	4.12e-11	60
epithelial tube open at both ends	4.12e-11	60
blood vasculature	4.12e-11	60
vascular cord	4.12e-11	60
anatomical group	7.00e-11	626
vessel	3.82e-10	69
epithelial tube	1.05e-09	118
germ layer	2.18e-09	604
embryonic tissue	2.18e-09	604
presumptive structure	2.18e-09	604
epiblast (generic)	2.18e-09	604
circulatory system	2.25e-09	113
embryonic structure	2.82e-09	605
developing anatomical structure	2.82e-09	605
cardiovascular system	5.78e-09	110
embryo	7.00e-09	612
unilaminar epithelium	1.04e-08	138
mesenchyme	1.84e-08	238
entire embryonic mesenchyme	1.84e-08	238
head	1.94e-08	123
regional part of nervous system	1.95e-07	94
nervous system	1.95e-07	94
neural plate	2.65e-07	86
presumptive neural plate	2.65e-07	86
ectoderm	2.80e-07	173
presumptive ectoderm	2.80e-07	173
ectoderm-derived structure	2.83e-07	169
neurectoderm	3.26e-07	90
brain	4.60e-07	69
future brain	4.60e-07	69
anterior region of body	6.80e-07	129
craniocervical region	6.80e-07	129
regional part of brain	8.26e-07	59

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.