CL:0000235: Difference between revisions
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|id=CL:0000235 | |id=CL:0000235 | ||
|name=macrophage | |name=macrophage | ||
|namespace=efo | |namespace=cell;;efo | ||
|def="A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [GO_REF:0000031, GOC:add, GOC:tfm, http://www.clt.astate.edu/wwilliam/, PMID:16213494, PMID:1919437] | |def="A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [GO_REF:0000031, GOC:add, GOC:tfm, http://www.clt.astate.edu/wwilliam/, PMID:16213494, PMID:1919437] | ||
|xref=BTO:0000801;;FMA:63261;;FMA:83585 | |xref=BTO:0000801;;FMA:63261;;FMA:83585 | ||
|is_a=CL:0000766 | |is_a=CL:0000234;;CL:0000766 | ||
|synonym="histiocyte" EXACT [] | |synonym="histiocyte" EXACT [] | ||
|comment=Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid. | |comment=Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid. | ||
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|obo_creation_date= | |obo_creation_date= | ||
|subset= | |subset= | ||
|derives_from= | |derives_from= | ||
|develops_from= | |develops_from= | ||
|has_quality= | |has_quality= | ||
|located_in= | |located_in= | ||
|part_of= | |part_of= | ||
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl.owl;;IAO:0000412 http://purl.obolibrary.org/obo/efo | |property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl.owl;;IAO:0000412 http://purl.obolibrary.org/obo/efo.owl | ||
|is_obsolete= | |is_obsolete= | ||
|preceded_by= | |preceded_by= | ||
}} | }} | ||
Revision as of 17:25, 26 June 2012
| Name: | macrophage | |
|---|---|---|
| Namespace: | cell;;efo | |
| Definition: | "A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [GO_REF:0000031, GOC:add, GOC:tfm, http://www.clt.astate.edu/wwilliam/, PMID:16213494, PMID:1919437] | |
| Xrefs: |
| |
| Synonyms: | "histiocyte" EXACT [] | |
| Comments: | Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid. |
Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data
Parents
| is_a: | CL:0000234(phagocyte),CL:0000766(myeloid leukocyte) |
|---|
Children
| is a: | CL:0000864 (tissue-resident macrophage) |
|---|---|
| derives from: | FF:0000086 (human macrophage sample),FF:0200001 (macrophage, TB infection sample) |
Ontology Tree: Loaded from BioPortal
Ontorolgy tree(Small window open)
FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.
Human (Homo sapiens)
- 11232-116C8 (Macrophage - monocyte derived, donor1)
- 11313-117C8 (Macrophage - monocyte derived, donor2)
- 11389-118C3 (Macrophage - monocyte derived, donor3)
- 11501-119F7
- 11641-122D3 (Mouse Microglia, donor3)
- 11662-122F6
- 11718-123C8 (Mouse Microglia, donor1)
- 11736-123E8 (Mouse Microglia, donor2)
- 12698-135D7 (Monocyte-derived macrophages response to LPS)
- 12699-135D8 (Monocyte-derived macrophages response to LPS, 00hr15min, donor1 (t2 Subject1))
... further results Mouse (Mus musculus)
- 11232-116C8 (Macrophage - monocyte derived, donor1)
- 11313-117C8 (Macrophage - monocyte derived, donor2)
- 11389-118C3 (Macrophage - monocyte derived, donor3)
- 11501-119F7
- 11641-122D3 (Mouse Microglia, donor3)
- 11662-122F6
- 11718-123C8 (Mouse Microglia, donor1)
- 11736-123E8 (Mouse Microglia, donor2)
- 12698-135D7 (Monocyte-derived macrophages response to LPS)
- 12699-135D8 (Monocyte-derived macrophages response to LPS, 00hr15min, donor1 (t2 Subject1))
Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000235 (macrophage), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data
