Coexpression cluster:C3172

Full id: C3172_Mesenchymal_Small_Renal_mature_Fibroblast_Urothelial_Endothelial

Phase1 CAGE Peaks

Hg19::chr11:61658913..61658932,-	p2@FADS3
Hg19::chr11:61658952..61658974,-	p3@FADS3
Hg19::chr11:61659006..61659046,-	p1@FADS3

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
embryonic cell	2.33e-21	248
mesodermal cell	2.55e-20	119
non-terminally differentiated cell	3.55e-20	180
fibroblast	2.59e-14	75
animal cell	7.45e-13	679
eukaryotic cell	7.45e-13	679
somatic cell	5.59e-12	591
lining cell	2.99e-11	57
barrier cell	2.99e-11	57
meso-epithelial cell	1.64e-10	44
endothelial cell of vascular tree	1.81e-10	24
epithelial cell	3.96e-10	254
endothelial cell	7.66e-10	35
contractile cell	9.15e-09	59
muscle precursor cell	1.28e-08	57
myoblast	1.28e-08	57
multi-potent skeletal muscle stem cell	1.28e-08	57
squamous epithelial cell	1.34e-07	62
blood vessel endothelial cell	1.55e-07	18
embryonic blood vessel endothelial progenitor cell	1.55e-07	18
fat cell	1.56e-07	15
muscle cell	2.13e-07	54

Uber Anatomy

Ontology term	p-value	n
vasculature	2.46e-17	79
vascular system	2.46e-17	79
vessel	8.34e-17	69
organism subdivision	2.02e-15	365
epithelium	4.53e-14	309
cell layer	7.27e-14	312
blood vessel	1.16e-13	60
epithelial tube open at both ends	1.16e-13	60
blood vasculature	1.16e-13	60
vascular cord	1.16e-13	60
splanchnic layer of lateral plate mesoderm	1.99e-12	84
epithelial tube	2.44e-12	118
anatomical conduit	1.62e-11	241
multilaminar epithelium	2.31e-11	82
circulatory system	3.11e-11	113
cardiovascular system	4.24e-11	110
anatomical cluster	5.02e-11	286
multi-cellular organism	1.17e-10	659
trunk mesenchyme	2.18e-10	143
somite	2.52e-10	83
paraxial mesoderm	2.52e-10	83
presomitic mesoderm	2.52e-10	83
presumptive segmental plate	2.52e-10	83
trunk paraxial mesoderm	2.52e-10	83
presumptive paraxial mesoderm	2.52e-10	83
trunk	4.75e-10	216
artery	1.67e-09	42
arterial blood vessel	1.67e-09	42
arterial system	1.67e-09	42
dermomyotome	5.50e-09	70
unilaminar epithelium	1.25e-08	138
anatomical system	1.49e-08	625
anatomical group	2.43e-08	626
surface structure	2.84e-08	95
tube	4.12e-08	194
skeletal muscle tissue	4.29e-08	61
striated muscle tissue	4.29e-08	61
myotome	4.29e-08	61
multi-tissue structure	8.01e-08	347
systemic artery	9.02e-08	33
systemic arterial system	9.02e-08	33
endothelium	1.55e-07	18
blood vessel endothelium	1.55e-07	18
cardiovascular system endothelium	1.55e-07	18
muscle tissue	2.29e-07	63
musculature	2.29e-07	63
musculature of body	2.29e-07	63
integument	3.57e-07	45
integumental system	3.57e-07	45
aorta	9.56e-07	21
aortic system	9.56e-07	21

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
E2F1#1869	3	4.90738921487932	0.00846098534723939	0.0323766844495048
ELF1#1997	3	4.25809795880754	0.0129517987505461	0.0460202398431015
IRF1#3659	3	7.6371637535639	0.00224469274729724	0.0127652309194107
NFYB#4801	3	16.7597932535365	0.000212364992329618	0.00245019746287152
SIN3A#25942	3	5.40888472681514	0.00631896197799152	0.0275517083463222
SP1#6667	3	5.6983813781409	0.00540396270171217	0.0245523322140391
ZBTB7A#51341	3	7.3519093078759	0.00251625586028227	0.0139650996807323

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.