Coexpression cluster:C138

Full id: C138_diffuse_Burkitt_lymphangiectasia_lymphoma_acute_CD19_pineal

Phase1 CAGE Peaks

Hg19::chr10:560037..560049,-	p@chr10:560037..560049 -
Hg19::chr11:111224906..111224920,-	p@chr11:111224906..111224920 -
Hg19::chr11:111229505..111229516,-	p@chr11:111229505..111229516 -
Hg19::chr11:2407318..2407325,+	p24@CD81
Hg19::chr11:2407761..2407778,+	p26@CD81
Hg19::chr11:26122006..26122011,-	p@chr11:26122006..26122011 -
Hg19::chr11:26124040..26124064,-	p@chr11:26124040..26124064 -
Hg19::chr12:113494494..113494505,+	p4@DTX1
Hg19::chr12:113494516..113494577,+	p1@DTX1
Hg19::chr12:113495162..113495172,+	p11@DTX1
Hg19::chr12:113495245..113495253,+	p5@DTX1
Hg19::chr12:113495715..113495725,+	p8@DTX1
Hg19::chr12:113496099..113496108,+	p3@AB384763
Hg19::chr12:113496125..113496146,+	p1@AB384763
Hg19::chr12:113533128..113533138,+	p@chr12:113533128..113533138 +
Hg19::chr12:117256221..117256231,+	p@chr12:117256221..117256231 +
Hg19::chr12:117256250..117256271,+	p@chr12:117256250..117256271 +
Hg19::chr12:117256273..117256285,+	p@chr12:117256273..117256285 +
Hg19::chr12:11905315..11905321,+	p30@ETV6
Hg19::chr12:11905335..11905342,+	p28@ETV6
Hg19::chr12:122435304..122435308,-	p@chr12:122435304..122435308 -
Hg19::chr12:122458855..122458857,+	p16@BCL7A
Hg19::chr12:122459183..122459198,+	p10@BCL7A
Hg19::chr12:122459199..122459208,+	p13@BCL7A
Hg19::chr12:122462311..122462330,-	p@chr12:122462311..122462330 -
Hg19::chr12:122462770..122462775,+	p@chr12:122462770..122462775 +
Hg19::chr12:2296602..2296621,+	p@chr12:2296602..2296621 +
Hg19::chr12:4313305..4313315,+	p@chr12:4313305..4313315 +
Hg19::chr12:4313331..4313334,+	p@chr12:4313331..4313334 +
Hg19::chr12:8808206..8808209,-	p@chr12:8808206..8808209 -
Hg19::chr12:94551874..94551884,+	p16@PLXNC1
Hg19::chr13:103821459..103821470,+	p@chr13:103821459..103821470 +
Hg19::chr13:61236926..61236943,+	p@chr13:61236926..61236943 +
Hg19::chr14:106332392..106332397,-	p@chr14:106332392..106332397 -
Hg19::chr14:106332402..106332439,-	p@chr14:106332402..106332439 -
Hg19::chr14:106332443..106332451,-	p@chr14:106332443..106332451 -
Hg19::chr14:106332453..106332464,-	p@chr14:106332453..106332464 -
Hg19::chr14:106332480..106332490,-	p@chr14:106332480..106332490 -
Hg19::chr14:106332501..106332515,-	p@chr14:106332501..106332515 -
Hg19::chr14:106332518..106332527,-	p@chr14:106332518..106332527 -
Hg19::chr14:106332629..106332637,-	p@chr14:106332629..106332637 -
Hg19::chr14:33433362..33433367,-	p@chr14:33433362..33433367 -
Hg19::chr14:33449602..33449615,-	p@chr14:33449602..33449615 -
Hg19::chr14:53594794..53594799,+	p@chr14:53594794..53594799 +
Hg19::chr14:75906948..75906962,+	p@chr14:75906948..75906962 +
Hg19::chr14:91750002..91750014,-	p21@CCDC88C
Hg19::chr14:96152757..96152769,+	p1@TCL1B
Hg19::chr14:96181789..96181822,+	p1@ENST00000556386 p1@uc001yfd.1
Hg19::chr14:96181832..96181839,+	p2@uc001yfd.1
Hg19::chr14:96184093..96184099,+	p@chr14:96184093..96184099 +
Hg19::chr15:66446160..66446166,-	p@chr15:66446160..66446166 -
Hg19::chr15:66446174..66446184,-	p@chr15:66446174..66446184 -
Hg19::chr15:66446191..66446202,-	p@chr15:66446191..66446202 -
Hg19::chr15:66464730..66464736,-	p@chr15:66464730..66464736 -
Hg19::chr15:67841330..67841348,+	p4@MAP2K5
Hg19::chr15:84653070..84653073,+	p@chr15:84653070..84653073 +
Hg19::chr16:86604624..86604648,+	p@chr16:86604624..86604648 +
Hg19::chr16:87098907..87098937,-	p@chr16:87098907..87098937 -
Hg19::chr17:3123719..3123724,-	p@chr17:3123719..3123724 -
Hg19::chr17:74846230..74846245,+	p1@uc002jtf.2
Hg19::chr17:74965032..74965049,-	p@chr17:74965032..74965049 -
Hg19::chr17:74965255..74965298,-	p1@AK123869
Hg19::chr18:3174522..3174533,-	p@chr18:3174522..3174533 -
Hg19::chr18:71693057..71693059,-	p@chr18:71693057..71693059 -
Hg19::chr18:71733441..71733451,-	p@chr18:71733441..71733451 -
Hg19::chr19:29097532..29097550,+	p@chr19:29097532..29097550 +
Hg19::chr19:29098223..29098234,+	p@chr19:29098223..29098234 +
Hg19::chr1:160414041..160414045,-	p@chr1:160414041..160414045 -
Hg19::chr1:167666666..167666680,+	p4@RCSD1
Hg19::chr1:171125500..171125502,-	p@chr1:171125500..171125502 -
Hg19::chr1:178636283..178636287,+	p@chr1:178636283..178636287 +
Hg19::chr22:23234780..23234786,+	p@chr22:23234780..23234786 +
Hg19::chr22:23235755..23235760,+	p@chr22:23235755..23235760 +
Hg19::chr22:23235843..23235863,+	p1@IGLJ1
Hg19::chr22:23235880..23235915,+	p2@AK097035
Hg19::chr22:23235933..23235972,+	p1@AK097035
Hg19::chr2:198220285..198220289,-	p@chr2:198220285..198220289 -
Hg19::chr2:198220897..198220904,-	p@chr2:198220897..198220904 -
Hg19::chr2:89162159..89162169,-	p@chr2:89162159..89162169 -
Hg19::chr2:98534317..98534328,-	p@chr2:98534317..98534328 -
Hg19::chr3:153480361..153480373,-	p1@ENST00000493214
Hg19::chr3:19436672..19436686,+	p@chr3:19436672..19436686 +
Hg19::chr3:62809350..62809370,+	p@chr3:62809350..62809370 +
Hg19::chr3:77626663..77626683,+	p@chr3:77626663..77626683 +
Hg19::chr4:176346295..176346296,-	p@chr4:176346295..176346296 -
Hg19::chr4:176353908..176353917,-	p@chr4:176353908..176353917 -
Hg19::chr4:176358284..176358287,-	p@chr4:176358284..176358287 -
Hg19::chr4:71532616..71532662,-	p5@IGJ
Hg19::chr4:8046897..8046900,+	p@chr4:8046897..8046900 +
Hg19::chr4:8046990..8046993,-	p@chr4:8046990..8046993 -
Hg19::chr4:86525299..86525314,+	p27@ARHGAP24
Hg19::chr4:86525321..86525343,+	p19@ARHGAP24
Hg19::chr4:86525345..86525360,+	p17@ARHGAP24
Hg19::chr5:118755330..118755335,+	p@chr5:118755330..118755335 +
Hg19::chr6:184352..184384,-	p@chr6:184352..184384 -
Hg19::chr6:26220614..26220622,-	p@chr6:26220614..26220622 -
Hg19::chr6:39962285..39962290,+	p@chr6:39962285..39962290 +
Hg19::chr6:39962295..39962305,+	p@chr6:39962295..39962305 +
Hg19::chr6:39962337..39962342,+	p@chr6:39962337..39962342 +
Hg19::chr6:89324309..89324332,-	p@chr6:89324309..89324332 -
Hg19::chr6:89324350..89324357,-	p@chr6:89324350..89324357 -
Hg19::chr7:44140835..44140864,+	p@chr7:44140835..44140864 +
Hg19::chr7:47131937..47131939,-	p@chr7:47131937..47131939 -
Hg19::chr7:47143537..47143540,-	p@chr7:47143537..47143540 -
Hg19::chr7:47143563..47143572,-	p@chr7:47143563..47143572 -
Hg19::chr7:47225953..47225964,-	p@chr7:47225953..47225964 -
Hg19::chr7:47225965..47225970,-	p@chr7:47225965..47225970 -
Hg19::chr7:47226019..47226026,-	p@chr7:47226019..47226026 -
Hg19::chr7:47226094..47226108,-	p@chr7:47226094..47226108 -
Hg19::chr8:103211732..103211741,-	p@chr8:103211732..103211741 -
Hg19::chr8:54811712..54811719,+	p1@ENST00000508149
Hg19::chr8:9577966..9577972,+	p26@TNKS
Hg19::chr8:9577986..9578004,+	p12@TNKS
Hg19::chr8:9578005..9578014,+	p22@TNKS
Hg19::chr9:120707790..120707797,-	p@chr9:120707790..120707797 -
Hg19::chr9:120707817..120707824,-	p@chr9:120707817..120707824 -
Hg19::chr9:138904824..138904829,+	p@chr9:138904824..138904829 +
Hg19::chr9:71805723..71805737,+	p@chr9:71805723..71805737 +
Hg19::chr9:96029287..96029296,+	p15@WNK2
Hg19::chr9:96029313..96029322,+	p9@WNK2
Hg19::chr9:96030923..96030932,-	p@chr9:96030923..96030932 -
Hg19::chr9:96030936..96030946,-	p@chr9:96030936..96030946 -
Hg19::chr9:96059957..96059996,+	p@chr9:96059957..96059996 +
Hg19::chrX:42727011..42727017,-	p@chrX:42727011..42727017 -
Hg19::chrX:42727038..42727047,-	p@chrX:42727038..42727047 -
Hg19::chrX:42727059..42727068,-	p@chrX:42727059..42727068 -
Hg19::chrX:47051618..47051644,+	p@chrX:47051618..47051644 +
Hg19::chrX:47051652..47051664,+	p@chrX:47051652..47051664 +
Hg19::chrX:89012355..89012363,+	p@chrX:89012355..89012363 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0006468	protein amino acid phosphorylation	0.00792695412488815
GO:0016310	phosphorylation	0.00792695412488815
GO:0001932	regulation of protein amino acid phosphorylation	0.00792695412488815
GO:0033238	regulation of amine metabolic process	0.00792695412488815
GO:0006521	regulation of amino acid metabolic process	0.00792695412488815
GO:0042325	regulation of phosphorylation	0.00841869775108913
GO:0006793	phosphorus metabolic process	0.00841869775108913
GO:0006796	phosphate metabolic process	0.00841869775108913
GO:0051174	regulation of phosphorus metabolic process	0.00841869775108913
GO:0019220	regulation of phosphate metabolic process	0.00841869775108913
GO:0043126	regulation of 1-phosphatidylinositol 4-kinase activity	0.00841869775108913
GO:0043128	positive regulation of 1-phosphatidylinositol 4-kinase activity	0.00841869775108913
GO:0046813	virion attachment, binding of host cell surface receptor	0.00841869775108913
GO:0031648	protein destabilization	0.0156319629705365
GO:0018193	peptidyl-amino acid modification	0.0172743813151962
GO:0043687	post-translational protein modification	0.0172743813151962
GO:0018210	peptidyl-threonine modification	0.0172743813151962
GO:0018107	peptidyl-threonine phosphorylation	0.0172743813151962
GO:0019062	virion attachment to host cell surface receptor	0.0172743813151962
GO:0007165	signal transduction	0.0191047159318527
GO:0008593	regulation of Notch signaling pathway	0.0202675609349334
GO:0005515	protein binding	0.0202675609349334
GO:0007154	cell communication	0.0266769412154499
GO:0006661	phosphatidylinositol biosynthetic process	0.0272081182847486
GO:0006464	protein modification process	0.0272081182847486
GO:0043550	regulation of lipid kinase activity	0.0294342336391061
GO:0043412	biopolymer modification	0.0300437386506703
GO:0005112	Notch binding	0.0300437386506703
GO:0043621	protein self-association	0.0300437386506703
GO:0018209	peptidyl-serine modification	0.0300437386506703
GO:0018105	peptidyl-serine phosphorylation	0.0300437386506703
GO:0044409	entry into host	0.0300437386506703
GO:0045665	negative regulation of neuron differentiation	0.0300437386506703
GO:0052192	movement in environment of other organism during symbiotic interaction	0.0300437386506703
GO:0046718	entry of virus into host cell	0.0300437386506703
GO:0030260	entry into host cell	0.0300437386506703
GO:0019059	initiation of viral infection	0.0300437386506703
GO:0052126	movement in host environment	0.0300437386506703
GO:0051828	entry into other organism during symbiotic interaction	0.0300437386506703
GO:0051806	entry into cell of other organism during symbiotic interaction	0.0300437386506703
GO:0007004	telomere maintenance via telomerase	0.0441734036898593
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	0.0441734036898593
GO:0030165	PDZ domain binding	0.0495802336358574
GO:0005626	insoluble fraction	0.0495802336358574

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
lymphocyte	3.79e-17	53
common lymphoid progenitor	3.79e-17	53
lymphoid lineage restricted progenitor cell	1.58e-16	52
lymphocyte of B lineage	1.74e-16	24
pro-B cell	1.74e-16	24
hematopoietic cell	1.11e-12	182
hematopoietic stem cell	1.11e-12	172
angioblastic mesenchymal cell	1.11e-12	172
B cell	1.01e-10	14
hematopoietic oligopotent progenitor cell	1.88e-10	165
hematopoietic multipotent progenitor cell	1.88e-10	165
leukocyte	9.08e-10	140
nongranular leukocyte	3.08e-08	119
hematopoietic lineage restricted progenitor cell	2.60e-07	124

Uber Anatomy

Ontology term	p-value	n
adult organism	1.93e-35	115
central nervous system	4.35e-18	82
neural tube	3.30e-17	57
neural rod	3.30e-17	57
future spinal cord	3.30e-17	57
neural keel	3.30e-17	57
regional part of nervous system	5.22e-16	94
nervous system	5.22e-16	94
anterior neural tube	2.02e-14	42
regional part of brain	5.32e-14	59
regional part of forebrain	6.00e-14	41
forebrain	6.00e-14	41
future forebrain	6.00e-14	41
brain	7.06e-14	69
future brain	7.06e-14	69
gray matter	1.09e-11	34
brain grey matter	1.09e-11	34
telencephalon	1.31e-11	34
cerebral hemisphere	2.89e-11	32
regional part of telencephalon	3.84e-11	33
regional part of cerebral cortex	1.02e-09	22
cerebral cortex	2.90e-09	25
pallium	2.90e-09	25
neocortex	3.32e-09	20
neurectoderm	2.73e-08	90
neural plate	9.20e-08	86
presumptive neural plate	9.20e-08	86

Disease

Ontology term	p-value	n
hematologic cancer	5.33e-09	51
immune system cancer	5.33e-09	51

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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