Coexpression cluster:C506

Full id: C506_Smooth_Renal_Endothelial_hepatic_Adipocyte_Fibroblast_Preadipocyte

Phase1 CAGE Peaks

Hg19::chr6:132269835..132269894,-	p7@CTGF
Hg19::chr6:132269939..132269966,-	p12@CTGF
Hg19::chr6:132270118..132270130,-	p13@CTGF
Hg19::chr6:132270276..132270290,-	p10@CTGF
Hg19::chr6:132270471..132270530,-	p5@CTGF
Hg19::chr6:132270532..132270550,-	p9@CTGF
Hg19::chr6:132270563..132270604,-	p3@CTGF
Hg19::chr6:132270672..132270706,-	p8@CTGF
Hg19::chr6:132271115..132271160,-	p@chr6:132271115..132271160 -
Hg19::chr6:132271128..132271174,+	p@chr6:132271128..132271174 +
Hg19::chr6:132271161..132271207,-	p@chr6:132271161..132271207 -
Hg19::chr6:132271279..132271304,-	p@chr6:132271279..132271304 -
Hg19::chr6:132271546..132271561,-	p@chr6:132271546..132271561 -
Hg19::chr6:132271569..132271590,-	p@chr6:132271569..132271590 -
Hg19::chr6:132271627..132271658,-	p@chr6:132271627..132271658 -
Hg19::chr6:132271932..132271967,-	p6@CTGF
Hg19::chr6:132271980..132271991,-	p16@CTGF
Hg19::chr6:132271998..132272086,-	p2@CTGF
Hg19::chr6:132272504..132272519,-	p1@CTGF

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

---

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

---

Cell Type

Ontology term	p-value	n
mesodermal cell	3.21e-29	121
muscle precursor cell	1.77e-16	58
myoblast	1.77e-16	58
multi-potent skeletal muscle stem cell	1.77e-16	58
muscle cell	7.97e-16	55
smooth muscle cell	1.09e-15	43
smooth muscle myoblast	1.09e-15	43
contractile cell	3.24e-15	59
embryonic cell	5.37e-15	250
vascular associated smooth muscle cell	9.18e-15	32
non-terminally differentiated cell	1.22e-14	106
electrically responsive cell	2.69e-14	61
electrically active cell	2.69e-14	61
lining cell	5.32e-13	58
barrier cell	5.32e-13	58
endothelial cell	9.16e-13	36
fibroblast	1.01e-12	76
meso-epithelial cell	2.04e-12	45
endothelial cell of vascular tree	2.30e-12	24
blood vessel endothelial cell	3.01e-09	18
embryonic blood vessel endothelial progenitor cell	3.01e-09	18
cardiocyte	5.15e-08	16
somatic cell	8.51e-08	588
preadipocyte	1.46e-07	12

Uber Anatomy

Ontology term	p-value	n
vasculature	1.21e-32	78
vascular system	1.21e-32	78
vessel	5.01e-28	68
splanchnic layer of lateral plate mesoderm	1.99e-27	83
epithelial tube	1.48e-26	117
cardiovascular system	3.07e-26	109
circulatory system	7.70e-26	112
epithelial tube open at both ends	5.57e-25	59
blood vessel	5.57e-25	59
blood vasculature	5.57e-25	59
vascular cord	5.57e-25	59
artery	3.52e-22	42
arterial blood vessel	3.52e-22	42
arterial system	3.52e-22	42
unilaminar epithelium	6.40e-20	148
systemic artery	4.66e-17	33
systemic arterial system	4.66e-17	33
trunk mesenchyme	1.01e-16	122
epithelial vesicle	8.39e-16	78
muscle tissue	1.04e-15	64
musculature	1.04e-15	64
musculature of body	1.04e-15	64
skeletal muscle tissue	1.70e-15	62
striated muscle tissue	1.70e-15	62
myotome	1.70e-15	62
mesenchyme	3.13e-14	160
entire embryonic mesenchyme	3.13e-14	160
dense mesenchyme tissue	1.07e-13	73
somite	1.26e-13	71
presomitic mesoderm	1.26e-13	71
presumptive segmental plate	1.26e-13	71
dermomyotome	1.26e-13	71
trunk paraxial mesoderm	1.26e-13	71
paraxial mesoderm	3.77e-13	72
presumptive paraxial mesoderm	3.77e-13	72
trunk	6.37e-13	199
aorta	5.44e-12	21
aortic system	5.44e-12	21
organism subdivision	1.32e-11	264
squamous epithelium	9.88e-11	25
multilaminar epithelium	1.01e-10	83
simple squamous epithelium	1.69e-10	22
mesoderm	3.27e-10	315
mesoderm-derived structure	3.27e-10	315
presumptive mesoderm	3.27e-10	315
anatomical cluster	3.50e-10	373
cell layer	6.17e-10	309
anatomical conduit	7.30e-10	240
epithelium	1.51e-09	306
blood vessel endothelium	3.01e-09	18
endothelium	3.01e-09	18
cardiovascular system endothelium	3.01e-09	18
tube	1.74e-08	192
multi-cellular organism	1.77e-07	656
heart	3.17e-07	24
primitive heart tube	3.17e-07	24
primary heart field	3.17e-07	24
anterior lateral plate mesoderm	3.17e-07	24
heart tube	3.17e-07	24
heart primordium	3.17e-07	24
cardiac mesoderm	3.17e-07	24
cardiogenic plate	3.17e-07	24
heart rudiment	3.17e-07	24
smooth muscle tissue	6.23e-07	15
primary circulatory organ	9.14e-07	27

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

---

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
CTCF#10664	12	3.3854250777316	2.39602138640007e-05	0.000522308657011557
GATA3#2625	6	8.60100516543348	4.38557728836884e-05	0.000777764147427328
HEY1#23462	19	4.04011104310571	3.00127317794054e-12	3.98791309708564e-10
JUN#3725	7	4.6099897024397	0.000441885070713004	0.00411612869248978
JUND#3727	16	5.89024331947034	1.90674971775736e-11	2.29422849968734e-09
NR3C1#2908	7	5.51637701674796	0.00014542250124313	0.00187967581773901
POLR2A#5430	19	2.14745317655807	4.9316078952508e-07	2.31380142395372e-05
POU5F1#5460	3	52.9640844397746	2.46415883246597e-05	0.00053404084727934
RAD21#5885	10	5.45001783971386	2.85321341547804e-06	9.81511053686135e-05
STAT3#6774	6	3.32193631489081	0.00671975157504051	0.0285622943610621
TAF7#6879	18	10.8313289099279	1.55076047024434e-18	3.52853753272002e-16
USF2#7392	7	4.78659903660459	0.000350930992195822	0.00353261512230742

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

---

This analysis result is provided for C0 - C305 clusters.