MCL coexpression mm9:2905

Phase1 CAGE Peaks

	Short description
Mm9::chr14:35315849..35315901,-	p2@Bmpr1a
Mm9::chr8:131209774..131209811,+	p3@Itgb1
Mm9::chr8:131209812..131209823,+	p4@Itgb1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0007507	heart development	0.00314103617670155
GO:0008284	positive regulation of cell proliferation	0.00314103617670155
GO:0042684	cardioblast cell fate commitment	0.00314103617670155
GO:0042685	cardioblast cell fate specification	0.00314103617670155
GO:0048382	mesendoderm development	0.00314103617670155
GO:0001880	Mullerian duct regression	0.00314103617670155
GO:0042127	regulation of cell proliferation	0.00628172816797938
GO:0010002	cardioblast differentiation	0.00628172816797938
GO:0060033	anatomical structure regression	0.00628172816797938
GO:0009950	dorsal/ventral axis specification	0.00753786729032103
GO:0008283	cell proliferation	0.00999617726056794
GO:0045214	sarcomere organization	0.0134564208330796
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	0.0134564208330796
GO:0005024	transforming growth factor beta receptor activity	0.0134564208330796
GO:0031594	neuromuscular junction	0.0134564208330796
GO:0030239	myofibril assembly	0.0134564208330796
GO:0055002	striated muscle cell development	0.0134564208330796
GO:0048522	positive regulation of cellular process	0.0134564208330796
GO:0050679	positive regulation of epithelial cell proliferation	0.0134564208330796
GO:0055001	muscle cell development	0.0134564208330796
GO:0035051	cardiac cell differentiation	0.0134564208330796
GO:0009798	axis specification	0.0139237070595951
GO:0007492	endoderm development	0.0139237070595951
GO:0048518	positive regulation of biological process	0.0141257569973187
GO:0031032	actomyosin structure organization and biogenesis	0.0141257569973187
GO:0048628	myoblast maturation	0.0141257569973187
GO:0048627	myoblast development	0.0141257569973187
GO:0005178	integrin binding	0.0141257569973187
GO:0035137	hindlimb morphogenesis	0.0141257569973187
GO:0001708	cell fate specification	0.0141257569973187
GO:0050678	regulation of epithelial cell proliferation	0.0141257569973187
GO:0000082	G1/S transition of mitotic cell cycle	0.0141257569973187
GO:0046661	male sex differentiation	0.0154086494961967
GO:0042383	sarcolemma	0.0155089344533936
GO:0051146	striated muscle cell differentiation	0.01560345934
GO:0050673	epithelial cell proliferation	0.0162153497277896
GO:0008305	integrin complex	0.0173024896210547
GO:0045445	myoblast differentiation	0.0178371922030721
GO:0051325	interphase	0.0192962050831568
GO:0051329	interphase of mitotic cell cycle	0.0192962050831568
GO:0009953	dorsal/ventral pattern formation	0.0197428032994193
GO:0004702	receptor signaling protein serine/threonine kinase activity	0.020048920647292
GO:0048513	organ development	0.020048920647292
GO:0051216	cartilage development	0.020048920647292
GO:0007498	mesoderm development	0.020048920647292
GO:0032403	protein complex binding	0.020048920647292
GO:0019717	synaptosome	0.0208220025003276
GO:0042692	muscle cell differentiation	0.0225101491194736
GO:0007160	cell-matrix adhesion	0.0225101491194736
GO:0048741	skeletal muscle fiber development	0.0225101491194736
GO:0030324	lung development	0.0225101491194736
GO:0048747	muscle fiber development	0.0225101491194736
GO:0030323	respiratory tube development	0.0225101491194736
GO:0031589	cell-substrate adhesion	0.0225101491194736
GO:0043235	receptor complex	0.0225101491194736
GO:0019199	transmembrane receptor protein kinase activity	0.0225101491194736
GO:0007548	sex differentiation	0.0225101491194736
GO:0048731	system development	0.0225101491194736
GO:0048469	cell maturation	0.0225101491194736
GO:0035107	appendage morphogenesis	0.0225101491194736
GO:0035108	limb morphogenesis	0.0225101491194736
GO:0048869	cellular developmental process	0.0225101491194736
GO:0030154	cell differentiation	0.0225101491194736
GO:0060173	limb development	0.0225101491194736
GO:0048736	appendage development	0.0225101491194736
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	0.0225101491194736
GO:0045596	negative regulation of cell differentiation	0.0234347923769146
GO:0005057	receptor signaling protein activity	0.0234347923769146
GO:0003006	reproductive developmental process	0.0234347923769146
GO:0007229	integrin-mediated signaling pathway	0.0240954568246319
GO:0021700	developmental maturation	0.0240954568246319
GO:0009952	anterior/posterior pattern formation	0.0244627432461561
GO:0007519	skeletal muscle development	0.0244627432461561
GO:0048856	anatomical structure development	0.0249770199198955
GO:0045165	cell fate commitment	0.0249770199198955
GO:0007398	ectoderm development	0.0249770199198955
GO:0051093	negative regulation of developmental process	0.0253828078295289
GO:0001701	in utero embryonic development	0.0286596186228907
GO:0014706	striated muscle development	0.0290078124494747
GO:0007275	multicellular organismal development	0.029292524320212
GO:0030145	manganese ion binding	0.0299091014344784
GO:0003002	regionalization	0.033650165201287
GO:0045595	regulation of cell differentiation	0.0344065819266945
GO:0030036	actin cytoskeleton organization and biogenesis	0.0344065819266945
GO:0030029	actin filament-based process	0.0358386395598984
GO:0007517	muscle development	0.0358386395598984
GO:0007166	cell surface receptor linked signal transduction	0.0358386395598984
GO:0001501	skeletal development	0.0383600521512519
GO:0035295	tube development	0.0423296095286837
GO:0022414	reproductive process	0.0428946476526525
GO:0004872	receptor activity	0.0435784814301501
GO:0032502	developmental process	0.0441059329296329
GO:0043009	chordate embryonic development	0.044165931537471
GO:0009792	embryonic development ending in birth or egg hatching	0.044165931537471
GO:0000278	mitotic cell cycle	0.044165931537471
GO:0007389	pattern specification process	0.0456444403706497
GO:0004871	signal transducer activity	0.0467989271816792
GO:0060089	molecular transducer activity	0.0467989271816792
GO:0050793	regulation of developmental process	0.0483932215224717
GO:0007167	enzyme linked receptor protein signaling pathway	0.0497670129224057
GO:0022403	cell cycle phase	0.0498889685485099
GO:0050794	regulation of cellular process	0.0498889685485099

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
multi-cellular organism	8.90e-07	333

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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