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{{Coexpression_clusters
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amidase activity!0.00976204444926934!57115$GO:0016019!peptidoglycan receptor activity!0.00976204444926934!57115$GO:0009253!peptidoglycan catabolic process!0.00976204444926934!57115$GO:0000270!peptidoglycan metabolic process!0.00976204444926934!57115$GO:0050830!defense response to Gram-positive bacterium!0.00976204444926934!57115$GO:0016045!detection of bacterium!0.00976204444926934!57115$GO:0042834!peptidoglycan binding!0.00976204444926934!57115$GO:0008329!pattern recognition receptor activity!0.0113880460240682!57115$GO:0009595!detection of biotic stimulus!0.0118091301495636!57115$GO:0009581!detection of external 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,MA0156.1;1.07131,MA0157.1;0.810597,MA0158.1;0,MA0159.1;0.328286,MA0160.1;0.600559,MA0161.1;0,MA0162.1;0.0383129,MA0163.1;0.813808,MA0164.1;0.738243,MA0080.2;0.394469,MA0018.2;0.709805,MA0099.2;0.629739,MA0079.2;0.248693,MA0102.2;1.58513,MA0258.1;0.788656,MA0259.1;0.336472,MA0442.1;0}}
|full_id=C1451_immature_Sebocyte_squamous_Keratinocyte_Corneal_Small_Urothelial
|gostat_on_coexpression_clusters=GO:0008745!N-acetylmuramoyl-L-alanine amidase activity!0.00976204444926934!57115$GO:0016019!peptidoglycan receptor activity!0.00976204444926934!57115$GO:0009253!peptidoglycan catabolic process!0.00976204444926934!57115$GO:0000270!peptidoglycan metabolic process!0.00976204444926934!57115$GO:0050830!defense response to Gram-positive bacterium!0.00976204444926934!57115$GO:0016045!detection of bacterium!0.00976204444926934!57115$GO:0042834!peptidoglycan binding!0.00976204444926934!57115$GO:0008329!pattern recognition receptor activity!0.0113880460240682!57115$GO:0009595!detection of biotic stimulus!0.0118091301495636!57115$GO:0009581!detection of external stimulus!0.0379177019804636!57115
|id=C1451
|ontology_enrichment_celltype=CL:0000066!1.14e-18!254;CL:0002076!2.14e-13!43;CL:0000220!1.43e-10!246;CL:0002321!1.52e-10!248;CL:0002368!1.95e-08!13;CL:0000223!2.71e-08!59;CL:0000076!1.61e-07!62
|ontology_enrichment_disease=DOID:1749!6.39e-07!14
|ontology_enrichment_uberon=UBERON:0000464!1.14e-10!104;UBERON:0001637!5.42e-09!42;UBERON:0003509!5.42e-09!42;UBERON:0004572!5.42e-09!42;UBERON:0000475!1.35e-08!365;UBERON:0001004!5.58e-08!72;UBERON:0004573!1.58e-07!33;UBERON:0004571!1.58e-07!33;UBERON:0000483!1.72e-07!309;UBERON:0000119!2.46e-07!312;UBERON:0001981!2.64e-07!60;UBERON:0007500!2.64e-07!60;UBERON:0004537!2.64e-07!60;UBERON:0006965!2.64e-07!60;UBERON:0002100!7.66e-07!216;UBERON:0000161!9.75e-07!35;UBERON:0002049!9.84e-07!79;UBERON:0007798!9.84e-07!79
}}

Latest revision as of 11:45, 17 September 2013


Full id: C1451_immature_Sebocyte_squamous_Keratinocyte_Corneal_Small_Urothelial



Phase1 CAGE Peaks

Hg19::chr19:3136918..3136931,-p@chr19:3136918..3136931
-
Hg19::chr1:153321301..153321325,-p1@PGLYRP4
Hg19::chr1:24646263..24646277,+p4@GRHL3
Hg19::chr1:27188807..27188826,+p@chr1:27188807..27188826
+
Hg19::chr1:6550625..6550646,-p3@PLEKHG5
Hg19::chr20:33880219..33880234,-p1@FAM83C


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0008745N-acetylmuramoyl-L-alanine amidase activity0.00976204444926934
GO:0016019peptidoglycan receptor activity0.00976204444926934
GO:0009253peptidoglycan catabolic process0.00976204444926934
GO:0000270peptidoglycan metabolic process0.00976204444926934
GO:0050830defense response to Gram-positive bacterium0.00976204444926934
GO:0016045detection of bacterium0.00976204444926934
GO:0042834peptidoglycan binding0.00976204444926934
GO:0008329pattern recognition receptor activity0.0113880460240682
GO:0009595detection of biotic stimulus0.0118091301495636
GO:0009581detection of external stimulus0.0379177019804636



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Uber Anatomy
Ontology termp-valuen
respiratory system5.30e-1874
endoderm-derived structure1.56e-15160
endoderm1.56e-15160
presumptive endoderm1.56e-15160
oral opening6.05e-1422
orifice6.01e-1336
surface structure6.86e-1399
respiratory tract4.96e-1254
mouth1.54e-1129
stomodeum1.54e-1129
urothelium2.40e-115
anterior region of body4.87e-1162
craniocervical region4.87e-1162
mucosa7.32e-1120
tracheobronchial tree1.34e-1015
lower respiratory tract1.34e-1015
mouth mucosa9.22e-1013
transitional epithelium2.28e-096
head2.48e-0956
digestive system4.51e-09145
digestive tract4.51e-09145
primitive gut4.51e-09145
neck7.07e-0910
segment of respiratory tract8.27e-0947
mucosa of oral region1.51e-084
respiratory system mucosa1.51e-084
pharynx2.54e-0811
gingival epithelium4.18e-083
lower respiratory tract epithelium5.13e-083
epithelium of bronchus5.13e-083
thoracic cavity element5.27e-0834
thoracic cavity5.27e-0834
trachea7.80e-087
respiratory airway7.80e-087
thoracic segment organ1.09e-0735
subdivision of head1.23e-0749
tongue3.32e-073
gustatory system3.32e-073
future tongue3.32e-073
respiratory system epithelium5.26e-0728
organism subdivision7.16e-07264
chordate pharynx7.17e-0710
pharyngeal region of foregut7.17e-0710
Disease
Ontology termp-valuen
squamous cell carcinoma6.55e-1914


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.321379
MA0004.10.558729
MA0006.10.391183
MA0007.10.539222
MA0009.11.03681
MA0014.10.262822
MA0017.10.432438
MA0019.10.7124
MA0024.10.929647
MA0025.11.17262
MA0027.12.65688
MA0028.10.408079
MA0029.10.949428
MA0030.10.937696
MA0031.10.871496
MA0038.10.665566
MA0040.10.955415
MA0041.10.578072
MA0042.10.544748
MA0043.11.03713
MA0046.11.02569
MA0048.10.152639
MA0050.10.545671
MA0051.10.661179
MA0052.10.959373
MA0055.10.0586456
MA0056.10
MA0057.10.450439
MA0058.10.458909
MA0059.10.457555
MA0060.10.267412
MA0061.10.23892
MA0063.10
MA0066.10.66601
MA0067.11.35893
MA0068.10.199491
MA0069.11.02175
MA0070.11.01032
MA0071.10.625297
MA0072.11.00572
MA0073.10.216116
MA0074.10.660398
MA0076.10.475586
MA0077.10.997832
MA0078.10.763954
MA0081.10.457725
MA0083.11.04447
MA0084.11.5477
MA0087.11.00322
MA0088.10.32124
MA0089.10
MA0090.10.490736
MA0091.10.561458
MA0092.10.522012
MA0093.10.394379
MA0095.10
MA0098.10
MA0100.10.679972
MA0101.10.397846
MA0103.10.993014
MA0105.10.134725
MA0106.10.70837
MA0107.10.857383
MA0108.20.868347
MA0109.10
MA0111.10.504913
MA0113.10.725375
MA0114.10.845337
MA0115.11.28169
MA0116.11.55935
MA0117.11.07516
MA0119.11.12205
MA0122.11.10154
MA0124.11.23968
MA0125.11.15445
MA0130.10
MA0131.10.782708
MA0132.10
MA0133.10
MA0135.11.06778
MA0136.10.672893
MA0139.10.226048
MA0140.10.622527
MA0141.10.455728
MA0142.10.838805
MA0143.10.725558
MA0144.11.47313
MA0145.10.707171
MA0146.10.718193
MA0147.10.327615
MA0148.10.584698
MA0149.10.612449
MA0062.20.23336
MA0035.20.621793
MA0039.20.35955
MA0138.20.765223
MA0002.20.255126
MA0137.21.06611
MA0104.20.26661
MA0047.20.695777
MA0112.20.680553
MA0065.20.718489
MA0150.10.484557
MA0151.10
MA0152.10.629368
MA0153.11.13732
MA0154.11.92418
MA0155.10.0961854
MA0156.11.07131
MA0157.10.810597
MA0158.10
MA0159.10.328286
MA0160.10.600559
MA0161.10
MA0162.10.0383129
MA0163.10.813808
MA0164.10.738243
MA0080.20.394469
MA0018.20.709805
MA0099.20.629739
MA0079.20.248693
MA0102.21.58513
MA0258.10.788656
MA0259.10.336472
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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