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{{Coexpression_clusters
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|full_id=C1759_neuroectodermal_neuroblastoma_peripheral_occipital_postcentral_paracentral_parietal
|gostat_on_coexpression_clusters=GO:0016167!glial cell line-derived neurotrophic factor receptor activity!0.00612259915710724!2675$GO:0008467!heparin-glucosamine 3-O-sulfotransferase activity!0.00765291100983854!9951$GO:0030201!heparan sulfate proteoglycan metabolic process!0.0122433959859717!9951$GO:0006029!proteoglycan metabolic process!0.0221856018006757!9951$GO:0008146!sulfotransferase activity!0.0301459095476488!9951$GO:0016782!transferase activity, transferring sulfur-containing groups!0.0301459095476488!9951$GO:0004896!hematopoietin/interferon-class (D200-domain) cytokine receptor activity!0.0301459095476488!2675$GO:0006790!sulfur metabolic process!0.0328682829093709!9951$GO:0019898!extrinsic to membrane!0.0363392028844498!2675$GO:0048503!GPI anchor binding!0.038501975748613!2675
|id=C1759
|ontology_enrichment_celltype=
|ontology_enrichment_disease=DOID:171!1.73e-07!10
|ontology_enrichment_uberon=UBERON:0007023!8.73e-58!115;UBERON:0001049!1.84e-38!57;UBERON:0005068!1.84e-38!57;UBERON:0006241!1.84e-38!57;UBERON:0007135!1.84e-38!57;UBERON:0000073!1.32e-37!94;UBERON:0001016!1.32e-37!94;UBERON:0001017!2.24e-37!82;UBERON:0005743!7.80e-37!86;UBERON:0002346!3.98e-35!90;UBERON:0002616!1.55e-33!59;UBERON:0000955!1.31e-31!69;UBERON:0006238!1.31e-31!69;UBERON:0003075!1.34e-31!86;UBERON:0007284!1.34e-31!86;UBERON:0003080!2.88e-28!42;UBERON:0002780!7.92e-28!41;UBERON:0001890!7.92e-28!41;UBERON:0006240!7.92e-28!41;UBERON:0001893!2.39e-26!34;UBERON:0002020!2.67e-26!34;UBERON:0003528!2.67e-26!34;UBERON:0002791!2.14e-25!33;UBERON:0001869!5.90e-25!32;UBERON:0003056!1.54e-22!61;UBERON:0000924!7.21e-22!173;UBERON:0006601!7.21e-22!173;UBERON:0002619!1.59e-21!22;UBERON:0000153!2.01e-21!129;UBERON:0007811!2.01e-21!129;UBERON:0000956!2.31e-20!25;UBERON:0000203!2.31e-20!25;UBERON:0000033!3.39e-20!123;UBERON:0001950!6.72e-20!20;UBERON:0004121!2.15e-19!169;UBERON:0000922!3.19e-15!612;UBERON:0000468!9.60e-14!659;UBERON:0000062!6.87e-13!511;UBERON:0002050!2.20e-12!605;UBERON:0005423!2.20e-12!605;UBERON:0000923!5.48e-12!604;UBERON:0005291!5.48e-12!604;UBERON:0006598!5.48e-12!604;UBERON:0002532!5.48e-12!604;UBERON:0003076!3.96e-11!15;UBERON:0003057!3.96e-11!15;UBERON:0000467!1.86e-09!625;UBERON:0004732!2.05e-09!13;UBERON:0000480!2.43e-09!626;UBERON:0004733!5.21e-09!12;UBERON:0002028!5.21e-09!12;UBERON:0007277!5.21e-09!12;UBERON:0001871!3.47e-08!7;UBERON:0002420!2.11e-07!9;UBERON:0007245!2.11e-07!9;UBERON:0010009!2.11e-07!9;UBERON:0010011!2.11e-07!9;UBERON:0000454!2.11e-07!9;UBERON:0002308!2.25e-07!9;UBERON:0000125!2.25e-07!9;UBERON:0002298!3.07e-07!8;UBERON:0000025!4.88e-07!194;UBERON:0000200!5.19e-07!6;UBERON:0002680!8.21e-07!9;UBERON:0001895!8.21e-07!9;UBERON:0010092!8.21e-07!9
}}

Latest revision as of 11:51, 17 September 2013


Full id: C1759_neuroectodermal_neuroblastoma_peripheral_occipital_postcentral_paracentral_parietal



Phase1 CAGE Peaks

Hg19::chr16:25703274..25703350,+p1@HS3ST4
Hg19::chr8:21645804..21645850,-p3@GFRA2
Hg19::chr8:21646290..21646308,-p4@GFRA2
Hg19::chr8:21646311..21646351,-p1@GFRA2
Hg19::chr8:21646364..21646402,-p2@GFRA2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0016167glial cell line-derived neurotrophic factor receptor activity0.00612259915710724
GO:0008467heparin-glucosamine 3-O-sulfotransferase activity0.00765291100983854
GO:0030201heparan sulfate proteoglycan metabolic process0.0122433959859717
GO:0006029proteoglycan metabolic process0.0221856018006757
GO:0008146sulfotransferase activity0.0301459095476488
GO:0016782transferase activity, transferring sulfur-containing groups0.0301459095476488
GO:0004896hematopoietin/interferon-class (D200-domain) cytokine receptor activity0.0301459095476488
GO:0006790sulfur metabolic process0.0328682829093709
GO:0019898extrinsic to membrane0.0363392028844498
GO:0048503GPI anchor binding0.038501975748613



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>

Uber Anatomy
Ontology termp-valuen
adult organism6.58e-63114
neural tube4.91e-4156
neural rod4.91e-4156
future spinal cord4.91e-4156
neural keel4.91e-4156
nervous system4.25e-3989
neurectoderm3.07e-3886
regional part of nervous system1.39e-3753
regional part of brain1.39e-3753
central nervous system1.46e-3781
neural plate3.48e-3382
presumptive neural plate3.48e-3382
brain grey matter5.77e-3234
gray matter5.77e-3234
telencephalon5.99e-3234
regional part of cerebral cortex1.56e-3122
brain4.81e-3168
future brain4.81e-3168
regional part of forebrain2.34e-3041
forebrain2.34e-3041
anterior neural tube2.34e-3041
future forebrain2.34e-3041
cerebral hemisphere6.15e-3032
regional part of telencephalon1.77e-2932
neocortex5.66e-2920
cerebral cortex6.03e-2725
pallium6.03e-2725
ectoderm-derived structure5.12e-25171
ectoderm5.12e-25171
presumptive ectoderm5.12e-25171
ecto-epithelium5.60e-24104
pre-chordal neural plate9.30e-2461
structure with developmental contribution from neural crest1.93e-23132
organ system subdivision9.74e-23223
anatomical cluster3.73e-16373
embryo1.93e-15592
developing anatomical structure8.13e-13581
multi-cellular organism3.58e-12656
embryonic structure4.14e-12564
germ layer7.33e-12560
germ layer / neural crest7.33e-12560
embryonic tissue7.33e-12560
presumptive structure7.33e-12560
germ layer / neural crest derived structure7.33e-12560
epiblast (generic)7.33e-12560
posterior neural tube1.42e-1115
chordal neural plate1.42e-1115
gyrus1.29e-106
organ3.22e-10503
multi-tissue structure1.57e-09342
organ part1.63e-09218
occipital lobe3.36e-095
parietal lobe4.62e-095
brainstem6.20e-096
tube7.97e-09192
segmental subdivision of hindbrain2.28e-0812
hindbrain2.28e-0812
presumptive hindbrain2.28e-0812
temporal lobe2.50e-086
limbic system3.67e-085
anatomical system7.84e-08624
anatomical group9.07e-08625
segmental subdivision of nervous system1.44e-0713
anatomical conduit4.24e-07240
basal ganglion7.89e-079
nuclear complex of neuraxis7.89e-079
aggregate regional part of brain7.89e-079
collection of basal ganglia7.89e-079
cerebral subcortex7.89e-079
neural nucleus9.63e-079
nucleus of brain9.63e-079
Disease
Ontology termp-valuen
neuroectodermal tumor2.97e-1010


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.12.24383
MA0004.10.626788
MA0006.12.00428
MA0007.11.47524
MA0009.11.11255
MA0014.12.48957
MA0017.10.496101
MA0019.10.784036
MA0024.11.00439
MA0025.11.24931
MA0027.12.73598
MA0028.10.470679
MA0029.11.02437
MA0030.11.01252
MA0031.10.945567
MA0038.10.736268
MA0040.11.03042
MA0041.10.64667
MA0042.10.612397
MA0043.11.11288
MA0046.11.10134
MA0048.10.195817
MA0050.10.613347
MA0051.10.731787
MA0052.11.03442
MA0055.10.0853006
MA0056.10
MA0057.11.66737
MA0058.10.523638
MA0059.10.522232
MA0060.10.321781
MA0061.10.291022
MA0063.10
MA0066.10.736721
MA0067.11.43651
MA0068.10.247962
MA0069.11.09737
MA0070.11.08584
MA0071.10.695094
MA0072.11.0812
MA0073.10.551452
MA0074.10.730989
MA0076.10.540943
MA0077.11.07324
MA0078.10.836493
MA0081.10.522409
MA0083.11.12028
MA0084.11.62584
MA0087.11.07867
MA0088.10.132006
MA0089.10
MA0090.10.556637
MA0091.10.629594
MA0092.10.588959
MA0093.10.456342
MA0095.10
MA0098.10
MA0100.10.750974
MA0101.10.459973
MA0103.10.442769
MA0105.10.520776
MA0106.10.779931
MA0107.10.378225
MA0108.20.94238
MA0109.10
MA0111.10.5713
MA0113.10.797251
MA0114.10.372523
MA0115.11.35895
MA0116.10.382106
MA0117.11.1512
MA0119.10.504689
MA0122.11.17777
MA0124.11.31673
MA0125.11.23103
MA0130.10
MA0131.10.855546
MA0132.10
MA0133.10
MA0135.11.14377
MA0136.10.743749
MA0139.10.277033
MA0140.10.692258
MA0141.10.520334
MA0142.10.912455
MA0143.10.797437
MA0144.10.356507
MA0145.10.143698
MA0146.10.0359558
MA0147.10.386018
MA0148.10.653474
MA0149.10.681935
MA0062.20.284987
MA0035.20.691506
MA0039.20.311551
MA0138.20.837782
MA0002.20.30855
MA0137.20.47779
MA0104.20.320919
MA0047.20.767096
MA0112.20.136971
MA0065.21.41695
MA0150.10.550239
MA0151.10
MA0152.10.69926
MA0153.11.21379
MA0154.10.98952
MA0155.10.409315
MA0156.10.480289
MA0157.10.883854
MA0158.10
MA0159.10.386729
MA0160.10.669748
MA0161.10
MA0162.11.23503
MA0163.11.05321
MA0164.10.810347
MA0080.20.456437
MA0018.20.781393
MA0099.20.699641
MA0079.214.351
MA0102.21.66336
MA0258.10.345771
MA0259.10.395396
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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