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{{Coexpression_clusters
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|coexpression_dpi_cluster_scores_median=0,

Latest revision as of 12:03, 17 September 2013


Full id: C2316_mycosis_occipital_frontal_parietal_paracentral_postcentral_medial



Phase1 CAGE Peaks

Hg19::chr14:78870030..78870098,+p5@NRXN3
Hg19::chr6:128134199..128134253,-p3@THEMIS
Hg19::chrX:21977968..21977978,+p@chrX:21977968..21977978
+
Hg19::chrX:21977990..21978030,+p@chrX:21977990..21978030
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
neural tube3.00e-7456
neural rod3.00e-7456
future spinal cord3.00e-7456
neural keel3.00e-7456
regional part of nervous system7.36e-7153
regional part of brain7.36e-7153
central nervous system1.30e-5981
brain4.87e-5968
future brain4.87e-5968
telencephalon5.22e-5634
brain grey matter1.51e-5534
gray matter1.51e-5534
adult organism1.28e-53114
regional part of forebrain1.10e-5241
forebrain1.10e-5241
anterior neural tube1.10e-5241
future forebrain1.10e-5241
nervous system1.11e-5289
cerebral hemisphere4.53e-5132
regional part of telencephalon1.51e-5032
neural plate2.70e-5082
presumptive neural plate2.70e-5082
regional part of cerebral cortex8.91e-4822
neurectoderm1.71e-4786
neocortex3.10e-4220
cerebral cortex1.23e-4125
pallium1.23e-4125
ecto-epithelium1.55e-37104
pre-chordal neural plate1.34e-3561
structure with developmental contribution from neural crest2.08e-34132
ectoderm-derived structure3.20e-25171
ectoderm3.20e-25171
presumptive ectoderm3.20e-25171
organ system subdivision2.48e-22223
posterior neural tube9.64e-2215
chordal neural plate9.64e-2215
gyrus3.53e-206
segmental subdivision of hindbrain1.02e-1812
hindbrain1.02e-1812
presumptive hindbrain1.02e-1812
brainstem2.01e-176
segmental subdivision of nervous system3.84e-1713
tube8.84e-17192
limbic system7.71e-165
basal ganglion1.91e-159
nuclear complex of neuraxis1.91e-159
aggregate regional part of brain1.91e-159
collection of basal ganglia1.91e-159
cerebral subcortex1.91e-159
neural nucleus4.71e-159
nucleus of brain4.71e-159
organ part1.16e-12218
anatomical conduit3.18e-12240
temporal lobe1.38e-116
regional part of metencephalon1.46e-119
metencephalon1.46e-119
future metencephalon1.46e-119
anatomical cluster2.43e-11373
parietal lobe3.66e-115
occipital lobe4.48e-115
frontal cortex5.64e-113
telencephalic nucleus2.64e-107
pons1.45e-093
medulla oblongata1.45e-093
myelencephalon1.45e-093
future myelencephalon1.45e-093
epithelium2.15e-09306
cell layer3.35e-09309
multi-tissue structure4.25e-09342
middle frontal gyrus8.14e-082
middle temporal gyrus8.69e-082
corpus striatum2.43e-074
striatum2.43e-074
ventral part of telencephalon2.43e-074
future corpus striatum2.43e-074
amygdala2.58e-072
Ammon's horn2.83e-072
lobe parts of cerebral cortex2.83e-072
hippocampal formation2.83e-072
limbic lobe2.83e-072
meninx3.63e-072
membrane organ3.63e-072
meningeal cluster3.63e-072
thymus4.13e-074
hemolymphoid system gland4.13e-074
thymic region4.13e-074
pharyngeal gland4.13e-074
thymus primordium4.13e-074
locus ceruleus8.78e-072
brainstem nucleus8.78e-072
hindbrain nucleus8.78e-072


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0214529
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.0695829
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.12.70453
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.10.248209
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.0343867
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.10.232357
MA0106.10.869173
MA0107.11.1497
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.10.195821
MA0146.10.061409
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.20.0247757
MA0138.20.928035
MA0002.20.379056
MA0137.21.37305
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.11.21162
MA0155.10.180766
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.309472
MA0163.10.0725493
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.20.000248021
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.