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{{CL
{{CL
|id=CL:0000553
|alt_id=
|name=megakaryocyte progenitor cell
|namespace=cell;;efo
|def="The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative)." [GOC:dsd, GOC:tfm, ISBN:0721601464]
|xref=BTO:0001164;;FMA:84235
|is_a=CL:0000839
|synonym="CFU-Meg" EXACT [PMID:11722431, PMID:12482498];;"colony-forming unit-megakaryocyte" EXACT [];;"Meg-CFC" EXACT [PMCID:PMC1794060];;"megacaryoblast" EXACT [];;"megacaryocyte progenitor cell" EXACT [];;"megakaryoblast" EXACT [];;"megakaryocytic progenitor cell" EXACT [PMID:12482498];;"promegacaryocyte" RELATED [];;"promegakaryocyte" RELATED []
|comment=Lineage negative is described here as CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD14-negative, CD19-negative, CD20-negative, CD56-negative, Ly6g-negative, and Ter119-negative.
|comment=Lineage negative is described here as CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD14-negative, CD19-negative, CD20-negative, CD56-negative, Ly6g-negative, and Ter119-negative.
|alt_id=
|disjoint_from=
|union_of=
|created_by=
|created_by=
|obo_creation_date=
|def="The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative)." [GOC:dsd, GOC:tfm, ISBN:0721601464]
|subset=
|derives_from=
|derives_from=
|develops_from=CL:0000050
|develops_from=CL:0000050
|disjoint_from=
|has_quality=
|has_quality=
|id=CL:0000553
|is_a=CL:0000763 ;;CL:0000839
|is_obsolete=
|located_in=
|located_in=
|name=megakaryocyte progenitor cell
|namespace=cell;;efo
|obo_creation_date=
|part_of=
|part_of=
|preceded_by=
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl.owl;;IAO:0000412 http://purl.obolibrary.org/obo/efo.owl
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl.owl;;IAO:0000412 http://purl.obolibrary.org/obo/efo.owl
|is_obsolete=
|subset=
|preceded_by=
|synonym="CFU-Meg" EXACT [PMID:11722431, PMID:12482498];;"colony-forming unit-megakaryocyte" EXACT [];;"Meg-CFC" EXACT [PMCID:PMC1794060];;"megacaryoblast" EXACT [];;"megacaryocyte progenitor cell" EXACT [];;"megakaryoblast" EXACT [];;"megakaryocytic progenitor cell" EXACT [PMID:12482498];;"promegacaryocyte" RELATED [];;"promegakaryocyte" RELATED []
|union_of=
|xref=BTO:0001164;;FMA:84235
}}
}}

Revision as of 10:18, 12 September 2014

Name:megakaryocyte progenitor cell
Namespace:cell;;efo
Definition:"The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative)." [GOC:dsd, GOC:tfm, ISBN:0721601464]
Xrefs:
links:

BTO:0001164

FMA:84235
Synonyms: "CFU-Meg" EXACT [PMID:11722431, PMID:12482498]
"colony-forming unit-megakaryocyte" EXACT []
"Meg-CFC" EXACT [PMCID:PMC1794060]
"megacaryoblast" EXACT []
"megacaryocyte progenitor cell" EXACT []
"megakaryoblast" EXACT []
"megakaryocytic progenitor cell" EXACT [PMID:12482498]
"promegacaryocyte" RELATED []
"promegakaryocyte" RELATED []
Comments:Lineage negative is described here as CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD14-negative, CD19-negative, CD20-negative, CD56-negative, Ly6g-negative, and Ter119-negative.


Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:CL:0000763(myeloid cell),CL:0000839(myeloid lineage restricted progenitor cell)
develops_from:CL:0000050(megakaryocyte-erythroid progenitor cell)



Children


is a:CL:0002024 (Kit-positive megakaryocyte progenitor cell)
develops from:CL:0000556 (megakaryocyte)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)


FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.



Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000553 (megakaryocyte progenitor cell), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
1.0e-60FFCP PHASE2:Mm9::chr3:40893940..40893948,+#_870ee79bf8670f6927cb44737baf3c01p@chr3:40893940..40893948, +
1.0e-60FFCP PHASE1:Mm9::chr3:40893940..40893948,+#_870ee79bf8670f6927cb44737baf3c01p@chr3:40893940..40893948, +
2.34e-60FFCP PHASE1:Mm9::chr6:68860437..68860451,-#_c55795c925c1953aeb4a336479cb1955p@chr6:68860437..68860451, -
2.34e-60FFCP PHASE2:Mm9::chr6:68860437..68860451,-#_c55795c925c1953aeb4a336479cb1955p@chr6:68860437..68860451, -
3.38e-58FFCP PHASE1:Mm9::chr3:41343162..41343165,+#_51d8887eb0b704903aea91d87734d301p@chr3:41343162..41343165, +
3.38e-58FFCP PHASE2:Mm9::chr3:41343162..41343165,+#_51d8887eb0b704903aea91d87734d301p@chr3:41343162..41343165, +
3.91e-58FFCP PHASE1:Mm9::chr9:108276696..108276698,+#_00c68f64d87039bc7379f9a4958b8ad1p@chr9:108276696..108276698, +
3.91e-58FFCP PHASE2:Mm9::chr9:108276696..108276698,+#_00c68f64d87039bc7379f9a4958b8ad1p@chr9:108276696..108276698, +
4.23e-58FFCP PHASE2:Mm9::chr2:98503916..98503926,+#_89245964831126fb37531ce19e9a05dap@chr2:98503916..98503926, +
4.23e-58FFCP PHASE1:Mm9::chr2:98503916..98503926,+#_89245964831126fb37531ce19e9a05dap@chr2:98503916..98503926, +
1.25e-52FFCP PHASE1:Mm9::chr4:105391511..105391533,+#_89ce68a7f9653f003f4ff92cd82fb1b7p@chr4:105391511..105391533, +
1.25e-52FFCP PHASE2:Mm9::chr4:105391511..105391533,+#_89ce68a7f9653f003f4ff92cd82fb1b7p@chr4:105391511..105391533, +
5.18e-52FFCP PHASE2:Mm9::chr6:69851116..69851126,-#_b9fba6f781bb072b3e1f9233b1e1a8e6p2@ENSMUST00000103370
5.18e-52FFCP PHASE1:Mm9::chr6:69851116..69851126,-#_b9fba6f781bb072b3e1f9233b1e1a8e6p2@ENSMUST00000103370
5.23e-52FFCP PHASE2:Mm9::chr17:34376620..34376634,-#_775900836efd06a8b686861be508b003p@chr17:34376620..34376634, -
5.23e-52FFCP PHASE2:Mm9::chr10:41613773..41613784,+#_775900836efd06a8b686861be508b003p@chr10:41613773..41613784, +
5.23e-52FFCP PHASE1:Mm9::chr10:41613773..41613784,+#_775900836efd06a8b686861be508b003p@chr10:41613773..41613784, +
5.23e-52FFCP PHASE1:Mm9::chr17:34376620..34376634,-#_775900836efd06a8b686861be508b003p@chr17:34376620..34376634, -
1.08e-51FFCP PHASE1:Mm9::chr9:32425275..32425296,+#_0a97d838c42178f12ed85e584a6b51ddp@chr9:32425275..32425296, +
1.08e-51FFCP PHASE2:Mm9::chr9:32425275..32425296,+#_0a97d838c42178f12ed85e584a6b51ddp@chr9:32425275..32425296, +
1.74e-51FFCP PHASE1:Mm9::chr6:70676952..70676959,-#_bb1d6a7b14546f704f7c161df98c1d3cp@chr6:70676952..70676959, -
1.74e-51FFCP PHASE2:Mm9::chr6:70676952..70676959,-#_bb1d6a7b14546f704f7c161df98c1d3cp@chr6:70676952..70676959, -
6.51e-48FFCP PHASE1:Mm9::chr17:88981299..88981314,+#_29758e29c728b1d3062cf77b12cfa578p@chr17:88981299..88981314, +
6.51e-48FFCP PHASE2:Mm9::chr17:88981299..88981314,+#_29758e29c728b1d3062cf77b12cfa578p@chr17:88981299..88981314, +
1.98e-47FFCP PHASE1:Mm9::chr12:48935035..48935049,+#_041c49995a7ddb259be095831b148eacp@chr12:48935035..48935049, +
1.98e-47FFCP PHASE2:Mm9::chr12:48935035..48935049,+#_041c49995a7ddb259be095831b148eacp@chr12:48935035..48935049, +
8.31e-47FFCP PHASE1:Mm9::chr13:30095274..30095283,+#_0b1d2c035d00c5193b7bdb6ea522879dp@chr13:30095274..30095283, +
8.31e-47FFCP PHASE2:Mm9::chr13:30095274..30095283,+#_0b1d2c035d00c5193b7bdb6ea522879dp@chr13:30095274..30095283, +
8.31e-47FFCP PHASE1:Mm9::chr11:96193855..96193860,+#_0b1d2c035d00c5193b7bdb6ea522879dp@chr11:96193855..96193860, +
8.31e-47FFCP PHASE2:Mm9::chr11:96193855..96193860,+#_0b1d2c035d00c5193b7bdb6ea522879dp@chr11:96193855..96193860, +
1.42e-46FFCP PHASE2:Mm9::chr19:11463663..11463671,+#_2439f36cb52c02793615004637aac939p@chr19:11463663..11463671, +
1.42e-46FFCP PHASE1:Mm9::chr19:11463663..11463671,+#_2439f36cb52c02793615004637aac939p@chr19:11463663..11463671, +
1.86e-46FFCP PHASE1:Mm9::chr3:58321410..58321423,+#_b9c0a7bd86d8ad72ad02afe6b153ee77p@chr3:58321410..58321423, +
1.86e-46FFCP PHASE1:Mm9::chr13:112658212..112658227,+#_b9c0a7bd86d8ad72ad02afe6b153ee77p3@ENSMUST00000128198, p3@uc007rwb.1
1.86e-46FFCP PHASE2:Mm9::chr13:112658212..112658227,+#_b9c0a7bd86d8ad72ad02afe6b153ee77p3@ENSMUST00000128198, p3@uc007rwb.1
1.86e-46FFCP PHASE2:Mm9::chr3:58321410..58321423,+#_b9c0a7bd86d8ad72ad02afe6b153ee77p@chr3:58321410..58321423, +
1.86e-46FFCP PHASE1:Mm9::chr17:34400036..34400056,-#_b9c0a7bd86d8ad72ad02afe6b153ee77p@chr17:34400036..34400056, -
1.86e-46FFCP PHASE2:Mm9::chr17:34400036..34400056,-#_b9c0a7bd86d8ad72ad02afe6b153ee77p@chr17:34400036..34400056, -
9.65e-46FFCP PHASE2:Mm9::chr2:99640370..99640374,+#_3a27bc10ac07afdaa2bb8989ca15e31cp@chr2:99640370..99640374, +
9.65e-46FFCP PHASE1:Mm9::chr4:135451095..135451110,+#_3a27bc10ac07afdaa2bb8989ca15e31cp4@Cnr2
9.65e-46FFCP PHASE2:Mm9::chr12:114659326..114659343,-#_3a27bc10ac07afdaa2bb8989ca15e31cp5@uc007pgs.1
9.65e-46FFCP PHASE1:Mm9::chr2:99640370..99640374,+#_3a27bc10ac07afdaa2bb8989ca15e31cp@chr2:99640370..99640374, +
9.65e-46FFCP PHASE2:Mm9::chr4:135451095..135451110,+#_3a27bc10ac07afdaa2bb8989ca15e31cp4@Cnr2
9.65e-46FFCP PHASE1:Mm9::chr12:114659326..114659343,-#_3a27bc10ac07afdaa2bb8989ca15e31cp5@uc007pgs.1
9.65e-46FFCP PHASE1:Mm9::chr16:19200368..19200390,-#_3a27bc10ac07afdaa2bb8989ca15e31cp2@ENSMUST00000103749
9.65e-46FFCP PHASE2:Mm9::chr16:19200368..19200390,-#_3a27bc10ac07afdaa2bb8989ca15e31cp2@ENSMUST00000103749
1.19e-45FFCP PHASE2:Mm9::chr12:100880892..100880902,-#_8feeb532524861d0650bd1e358f730bbp@chr12:100880892..100880902, -
1.19e-45FFCP PHASE1:Mm9::chr12:100880892..100880902,-#_8feeb532524861d0650bd1e358f730bbp@chr12:100880892..100880902, -
1.82e-45FFCP PHASE2:Mm9::chr9:32460050..32460070,+#_5e34e52e62fac4ca9288b197ce34fa27p@chr9:32460050..32460070, +
1.82e-45FFCP PHASE1:Mm9::chr9:32460050..32460070,+#_5e34e52e62fac4ca9288b197ce34fa27p@chr9:32460050..32460070, +
2.38e-44FFCP PHASE1:Mm9::chr9:32487351..32487367,+#_28ef2acc39e7a9a95aac78364a0b1c32p@chr9:32487351..32487367, +
2.38e-44FFCP PHASE2:Mm9::chr12:114659633..114659652,-#_28ef2acc39e7a9a95aac78364a0b1c32p4@uc007pgs.1
2.38e-44FFCP PHASE2:Mm9::chr9:32487351..32487367,+#_28ef2acc39e7a9a95aac78364a0b1c32p@chr9:32487351..32487367, +
2.38e-44FFCP PHASE1:Mm9::chr12:114659633..114659652,-#_28ef2acc39e7a9a95aac78364a0b1c32p4@uc007pgs.1
3.35e-44FFCP PHASE2:Mm9::chr5:122674421..122674426,+#_85a8c6c1a9b1d26521167ce3af376be6p@chr5:122674421..122674426, +
3.35e-44FFCP PHASE1:Mm9::chr5:122674421..122674426,+#_85a8c6c1a9b1d26521167ce3af376be6p@chr5:122674421..122674426, +
5.38e-44FFCP PHASE2:Mm9::chr19:43721970..43721975,+#_7076bffd597815ecd2325fc938467866p@chr19:43721970..43721975, +
5.38e-44FFCP PHASE1:Mm9::chr6:135966781..135966785,+#_7076bffd597815ecd2325fc938467866p@chr6:135966781..135966785, +
5.38e-44FFCP PHASE1:Mm9::chr17:84975629..84975633,+#_7076bffd597815ecd2325fc938467866p@chr17:84975629..84975633, +
5.38e-44FFCP PHASE2:Mm9::chr4:44980637..44980644,+#_7076bffd597815ecd2325fc938467866p4@ENSMUST00000150111
5.38e-44FFCP PHASE2:Mm9::chr18:55201820..55201826,+#_7076bffd597815ecd2325fc938467866p@chr18:55201820..55201826, +
5.38e-44FFCP PHASE1:Mm9::chr19:43721970..43721975,+#_7076bffd597815ecd2325fc938467866p@chr19:43721970..43721975, +
5.38e-44FFCP PHASE1:Mm9::chr18:55201820..55201826,+#_7076bffd597815ecd2325fc938467866p@chr18:55201820..55201826, +
5.38e-44FFCP PHASE1:Mm9::chr1:156964198..156964201,+#_7076bffd597815ecd2325fc938467866p@chr1:156964198..156964201, +
5.38e-44FFCP PHASE1:Mm9::chr4:44980637..44980644,+#_7076bffd597815ecd2325fc938467866p4@ENSMUST00000150111
5.38e-44FFCP PHASE1:Mm9::chr4:59740918..59740923,+#_7076bffd597815ecd2325fc938467866p@chr4:59740918..59740923, +
5.38e-44FFCP PHASE2:Mm9::chr11:102210718..102210728,-#_7076bffd597815ecd2325fc938467866p@chr11:102210718..102210728, -
5.38e-44FFCP PHASE2:Mm9::chr6:135966781..135966785,+#_7076bffd597815ecd2325fc938467866p@chr6:135966781..135966785, +
5.38e-44FFCP PHASE2:Mm9::chr17:84975629..84975633,+#_7076bffd597815ecd2325fc938467866p@chr17:84975629..84975633, +
5.38e-44FFCP PHASE2:Mm9::chr4:59740918..59740923,+#_7076bffd597815ecd2325fc938467866p@chr4:59740918..59740923, +
5.38e-44FFCP PHASE1:Mm9::chr11:102210718..102210728,-#_7076bffd597815ecd2325fc938467866p@chr11:102210718..102210728, -
5.38e-44FFCP PHASE2:Mm9::chr1:156964198..156964201,+#_7076bffd597815ecd2325fc938467866p@chr1:156964198..156964201, +
5.38e-44FFCP PHASE1:Mm9::chr18:35809146..35809153,-#_7076bffd597815ecd2325fc938467866p4@2010001M09Rik
5.38e-44FFCP PHASE2:Mm9::chr18:35809146..35809153,-#_7076bffd597815ecd2325fc938467866p4@2010001M09Rik
6.62e-44FFCP PHASE2:Mm9::chr17:34282256..34282276,+#_61b855da092991876771f8c21006a357p4@H2-DMb2
6.62e-44FFCP PHASE1:Mm9::chr17:34282256..34282276,+#_61b855da092991876771f8c21006a357p4@H2-DMb2
2.83e-41FFCP PHASE1:Mm9::chr12:114660740..114660753,+#_2fe0ae9b0e77d1d5d3eca9954c522a16p@chr12:114660740..114660753, +
2.83e-41FFCP PHASE2:Mm9::chr12:114660740..114660753,+#_2fe0ae9b0e77d1d5d3eca9954c522a16p@chr12:114660740..114660753, +
4.64e-41FFCP PHASE2:Mm9::chr19:21705252..21705273,-#_a503ecf78ca33556a6ff64359b08305ap@chr19:21705252..21705273, -
4.64e-41FFCP PHASE1:Mm9::chr19:21705252..21705273,-#_a503ecf78ca33556a6ff64359b08305ap@chr19:21705252..21705273, -
7.27e-41FFCP PHASE1:Mm9::chr12:114652607..114652619,-#_0ede2ca0d677d36344fd98a823ac3305p@chr12:114652607..114652619, -
7.27e-41FFCP PHASE2:Mm9::chr12:114652607..114652619,-#_0ede2ca0d677d36344fd98a823ac3305p@chr12:114652607..114652619, -
8.77e-41FFCP PHASE2:Mm9::chr18:36069982..36069991,+#_05dca6394f1dff04c4e76d92247963a6p@chr18:36069982..36069991, +
8.77e-41FFCP PHASE1:Mm9::chr18:36069982..36069991,+#_05dca6394f1dff04c4e76d92247963a6p@chr18:36069982..36069991, +
8.77e-41FFCP PHASE1:Mm9::chr13:30095241..30095252,+#_05dca6394f1dff04c4e76d92247963a6p@chr13:30095241..30095252, +
8.77e-41FFCP PHASE2:Mm9::chr13:30095241..30095252,+#_05dca6394f1dff04c4e76d92247963a6p@chr13:30095241..30095252, +
1.02e-40FFCP PHASE1:Mm9::chr12:114659852..114659872,+#_5e23c1ad39181c1ddd1e5497f6952b75p@chr12:114659852..114659872, +
1.02e-40FFCP PHASE1:Mm9::chr12:53180087..53180104,+#_5e23c1ad39181c1ddd1e5497f6952b75p@chr12:53180087..53180104, +
1.02e-40FFCP PHASE2:Mm9::chr12:114659852..114659872,+#_5e23c1ad39181c1ddd1e5497f6952b75p@chr12:114659852..114659872, +
1.02e-40FFCP PHASE2:Mm9::chr12:53180087..53180104,+#_5e23c1ad39181c1ddd1e5497f6952b75p@chr12:53180087..53180104, +
1.06e-40FFCP PHASE1:Mm9::chr10:50076400..50076404,+#_d2ac5d2b8188a524708b108e73286cfbp@chr10:50076400..50076404, +
1.06e-40FFCP PHASE2:Mm9::chr10:50076400..50076404,+#_d2ac5d2b8188a524708b108e73286cfbp@chr10:50076400..50076404, +
1.91e-40FFCP PHASE1:Mm9::chr8:70480444..70480457,+#_67061e9276cd7d62ef3c45864cf3680cp2@ENSMUST00000127631
1.91e-40FFCP PHASE2:Mm9::chr8:70480444..70480457,+#_67061e9276cd7d62ef3c45864cf3680cp2@ENSMUST00000127631
4.18e-40FFCP PHASE2:Mm9::chr6:70676615..70676621,+#_614e7e8306842c5d5dbb57af624fa4b9p@chr6:70676615..70676621, +
4.18e-40FFCP PHASE1:Mm9::chr6:70676615..70676621,+#_614e7e8306842c5d5dbb57af624fa4b9p@chr6:70676615..70676621, +
2.4e-39FFCP PHASE2:Mm9::chr1:134238914..134238921,+#_bc04fdf92a2c4ebe1baae3e3c517f793p@chr1:134238914..134238921, +
2.4e-39FFCP PHASE2:Mm9::chr12:100880924..100880933,-#_bc04fdf92a2c4ebe1baae3e3c517f793p@chr12:100880924..100880933, -
2.4e-39FFCP PHASE1:Mm9::chr1:134238914..134238921,+#_bc04fdf92a2c4ebe1baae3e3c517f793p@chr1:134238914..134238921, +
2.4e-39FFCP PHASE1:Mm9::chr12:100880924..100880933,-#_bc04fdf92a2c4ebe1baae3e3c517f793p@chr12:100880924..100880933, -

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