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{{UBERON
{{UBERON
|id=UBERON:0001434
|alt_id=UBERON:FMA_23875-FMA_23881-MA_0000018-MIAA_0000032-XAO_0003060-ZFA_0000434
|name=skeletal system
|anatomical_img_id=FMA:23875
|namespace=
|def="Organ system subdivision which consists of the skeleton and the articular system.[FMA]" [AAO:0000566, FMA:FMA, Wikipedia:Skeleton]
|xref=AAO:0000566;;BTO:0001486;;EFO:0000806;;EHDAA2:0003168;;EV:0100139;;FMA:23881;;MA:0000018;;MESH:A.02;;ncithesaurus:Skeletal_System;;OpenCyc:Mx4rvVi1rpwpEbGdrcN5Y29ycA;;TAO:0000434;;VAO:0000027;;VHOG:0001254;;XAO:0003060;;ZFA:0000434
|is_a=UBERON:0000467;;UBERON:0004120
|synonym="set of all bones and joints" NARROW SENSU [];;"skeleton system" EXACT [];;"Skelettsystem" RELATED [BTO:0001486]
|comment=Note that GO defines skeletal system very generically: The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton) GO:0001501; however, all annotations are to vertebrates
|comment=Note that GO defines skeletal system very generically: The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton) GO:0001501; however, all annotations are to vertebrates
|alt_id=UBERON:FMA_23875-FMA_23881-MA_0000018-MIAA_0000032-XAO_0003060-ZFA_0000434
|disjoint_from=UBERON:0001474;;UBERON:0002204;;UBERON:0002294;;UBERON:0002330;;UBERON:0002390;;UBERON:0002405;;UBERON:0002416;;UBERON:0002423;;UBERON:0004456
|union_of=
|created_by=
|created_by=
|obo_creation_date=
|def="Organ system subdivision which consists of the skeleton and the articular system.[FMA]" [AAO:0000566, FMA:FMA]
|subset=uberon_slim;;vertebrate_core
|adjacent_to=
|derives_from=
|derives_from=
|develops_from=
|develops_from=
|disjoint_from=UBERON:0001474;;UBERON:0002204;;UBERON:0002294;;UBERON:0002330;;UBERON:0002390;;UBERON:0002405;;UBERON:0002416;;UBERON:0002423;;UBERON:0004456
|has_quality=
|has_quality=
|id=UBERON:0001434
|is_a=UBERON:0000467
|is_obsolete=
|located_in=
|located_in=
|name=skeletal system
|namespace=FANTOM
|obo_creation_date=
|part_of=UBERON:0002204
|part_of=UBERON:0002204
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl
|preceded_by=
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl;;"spatially_disjoint_from" UBERON:0001016;;UBPROP:0000001 "Anatomical system consisting of multiple elements and tissues that provides physical support.[TAO]" xsd:string;;UBPROP:0000001 "Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system.[VSAO]" xsd:string;;UBPROP:0000001 "System that provides physical support to the organism.[AAO]" xsd:string
|subset=uberon_slim;;vertebrate_core
|synonym="set of all bones and joints" NARROW SENSU [];;"skeleton system" EXACT [];;"Skelettsystem" RELATED [BTO:0001486]
|union_of=
|xref=AAO:0000566;;BTO:0001486;;EFO:0000806;;EHDAA2:0003168;;FMA:23881;;MA:0000018;;ncithesaurus:Skeletal_System;;OpenCyc:Mx4rvVi1rpwpEbGdrcN5Y29ycA;;TAO:0000434;;VHOG:0001254;;VSAO:0000027;;XAO:0003060;;ZFA:0000434
}}
}}

Latest revision as of 17:18, 12 September 2014

Name:skeletal system
Namespace:FANTOM
Definition:"Organ system subdivision which consists of the skeleton and the articular system.[FMA]" [AAO:0000566, FMA:FMA]
Xrefs:
links:

AAO:0000566
BTO:0001486
EFO:0000806
EHDAA2:0003168
FMA:23881
MA:0000018
ncithesaurus:Skeletal_System
OpenCyc:Mx4rvVi1rpwpEbGdrcN5Y29ycA
TAO:0000434
VHOG:0001254
VSAO:0000027
XAO:0003060

ZFA:0000434
Synonyms: "set of all bones and joints" NARROW SENSU []
"skeleton system" EXACT []
"Skelettsystem" RELATED [BTO:0001486]
Comments:Note that GO defines skeletal system very generically: The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton) GO:0001501; however, all annotations are to vertebrates
Alt_id: UBERON:FMA_23875-FMA_23881-MA_0000018-MIAA_0000032-XAO_0003060-ZFA_0000434
Subset: uberon_slim
vertebrate_core

Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:UBERON:0000467(anatomical system)
disjoint_from:UBERON:0001474(bone element),UBERON:0002204(musculoskeletal system),UBERON:0002294(biliary system),UBERON:0002330(exocrine system),UBERON:0002390(hematopoietic system),UBERON:0002405(immune system),UBERON:0002416(integumental system),UBERON:0002423(hepatobiliary system),UBERON:0004456(entire sense organ system)
part_of:UBERON:0002204(musculoskeletal system)



Children

disjoint from:UBERON:0000949 (endocrine system),UBERON:0000990 (reproductive system),UBERON:0001004 (respiratory system),UBERON:0001007 (digestive system),UBERON:0001008 (renal system),UBERON:0001009 (circulatory system),UBERON:0001016 (nervous system),UBERON:0001033 (gustatory system)
part of:UBERON:0000075 (subdivision of skeletal system),UBERON:0001474 (bone element),UBERON:0004288 (skeleton),UBERON:0004765 (skeletal element),UBERON:0004770 (articular system),UBERON:0008846 (skeletal ligament)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)

FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology

Human (Homo sapiens)

... further results Mouse (Mus musculus)

... further results


Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0001434 (skeletal system), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
5.22e-88FFCP PHASE2:Hg19::chr1:161187824..161187847,+#_b8fb1dc3c69368b3650732dc0aecdc7ap@chr1:161187824..161187847, +
5.22e-88FFCP PHASE1:Hg19::chr1:161187824..161187847,+#_b8fb1dc3c69368b3650732dc0aecdc7ap@chr1:161187824..161187847, +
1.6e-84FFCP PHASE1:Hg19::chr1:161188661..161188679,+#_40f568ef6a98d4da4b4cb418dc3115dfp@chr1:161188661..161188679, +
1.6e-84FFCP PHASE2:Hg19::chr1:161188661..161188679,+#_40f568ef6a98d4da4b4cb418dc3115dfp@chr1:161188661..161188679, +
3.06e-84FFCP PHASE2:Hg19::chr16:50313426..50313459,+#_bda333b0b7fb872c9ebbb0a7b48c6d1cp@chr16:50313426..50313459, +
3.06e-84FFCP PHASE1:Hg19::chr16:50313426..50313459,+#_bda333b0b7fb872c9ebbb0a7b48c6d1cp@chr16:50313426..50313459, +
2.31e-83FFCP PHASE2:Hg19::chr7:77050554..77050601,+#_259f6bfe43b31a3e2a2f77a5e9bc22b6p@chr7:77050554..77050601, +
2.31e-83FFCP PHASE1:Hg19::chr7:77050554..77050601,+#_259f6bfe43b31a3e2a2f77a5e9bc22b6p@chr7:77050554..77050601, +
7.38e-83FFCP PHASE1:Hg19::chr18:2847062..2847071,+#_5d215e08e77c728ac215157ea88017edp7@EMILIN2
7.38e-83FFCP PHASE2:Hg19::chr18:2847062..2847071,+#_5d215e08e77c728ac215157ea88017edp7@EMILIN2
3.86e-82FFCP PHASE2:Hg19::chr1:161188746..161188758,+#_a93cfd5d4cd17804ed28c681a231aebap@chr1:161188746..161188758, +
3.86e-82FFCP PHASE1:Hg19::chr1:161188746..161188758,+#_a93cfd5d4cd17804ed28c681a231aebap@chr1:161188746..161188758, +
3.87e-82FFCP PHASE2:Hg19::chr17:7482481..7482508,-#_aca3cc4a8525ee70a1fe49da68df0dfep@chr17:7482481..7482508, -
3.87e-82FFCP PHASE1:Hg19::chr17:7482481..7482508,-#_aca3cc4a8525ee70a1fe49da68df0dfep@chr17:7482481..7482508, -
3.14e-81FFCP PHASE2:Hg19::chr19:18288651..18288682,+#_34939878aaf05426d639c7f432e4f00fp5@IFI30
3.14e-81FFCP PHASE1:Hg19::chr19:18288651..18288682,+#_34939878aaf05426d639c7f432e4f00fp5@IFI30
1.7e-79FFCP PHASE1:Hg19::chr4:3387239..3387324,-#_0bc340a150597692010c3da40d81e99ap@chr4:3387239..3387324, -
1.7e-79FFCP PHASE2:Hg19::chr4:3387239..3387324,-#_0bc340a150597692010c3da40d81e99ap@chr4:3387239..3387324, -
2.9e-79FFCP PHASE2:Hg19::chr7:2832730..2832791,+#_617300c784aeedbec9f776477c70e711p@chr7:2832730..2832791, +
2.9e-79FFCP PHASE1:Hg19::chr7:2832730..2832791,+#_617300c784aeedbec9f776477c70e711p@chr7:2832730..2832791, +
5.36e-79FFCP PHASE2:Hg19::chr5:180242646..180242657,-#_bc3e474ce90ba89ac46a2c41981af839p15@MGAT1
5.36e-79FFCP PHASE1:Hg19::chr5:180242646..180242657,-#_bc3e474ce90ba89ac46a2c41981af839p15@MGAT1
3.48e-78FFCP PHASE1:Hg19::chr1:111743000..111743011,+#_d598be908f9f657841ad83ca22a72db3p8@CHI3L2
3.48e-78FFCP PHASE2:Hg19::chr1:111743000..111743011,+#_d598be908f9f657841ad83ca22a72db3p8@CHI3L2
3.72e-78FFCP PHASE2:Hg19::chr19:18288828..18288861,+#_ae71ebd8cc905eb042b783f55eb2cc74p7@IFI30
3.72e-78FFCP PHASE1:Hg19::chr19:18288828..18288861,+#_ae71ebd8cc905eb042b783f55eb2cc74p7@IFI30
5.03e-78FFCP PHASE1:Hg19::chr17:40168698..40168726,-#_19d12ebc48d08b6207caced3eb3e5d4fp1@AK126179
5.03e-78FFCP PHASE2:Hg19::chr17:40168698..40168726,-#_19d12ebc48d08b6207caced3eb3e5d4fp1@AK126179
2.92e-77FFCP PHASE1:Hg19::chr2:145429606..145429658,+#_0a67019169a7a7f4345806ccc5dbc935p@chr2:145429606..145429658, +
2.92e-77FFCP PHASE2:Hg19::chr2:145429606..145429658,+#_0a67019169a7a7f4345806ccc5dbc935p@chr2:145429606..145429658, +
1.44e-76FFCP PHASE1:Hg19::chr17:72542163..72542182,-#_f574d8e021e7f7acf47c71a399fb841cp2@CD300C
1.44e-76FFCP PHASE2:Hg19::chr17:72542163..72542182,-#_f574d8e021e7f7acf47c71a399fb841cp2@CD300C
1.96e-76FFCP PHASE1:Hg19::chr19:18286116..18286156,+#_1b952f09e9ff88ac58fa7f5f6daa9f73p@chr19:18286116..18286156, +
1.96e-76FFCP PHASE2:Hg19::chr19:18286116..18286156,+#_1b952f09e9ff88ac58fa7f5f6daa9f73p@chr19:18286116..18286156, +
5.23e-76FFCP PHASE2:Hg19::chr2:38358217..38358244,+#_e26bc96e31cb890924e2d7bca655f033p1@CYP1B1-AS1
5.23e-76FFCP PHASE1:Hg19::chr2:38358217..38358244,+#_e26bc96e31cb890924e2d7bca655f033p1@CYP1B1-AS1
1.18e-75FFCP PHASE2:Hg19::chr15:65174546..65174583,-#_b259dcc4857287c72e20e465059a896dp@chr15:65174546..65174583, -
1.18e-75FFCP PHASE1:Hg19::chr15:65174546..65174583,-#_b259dcc4857287c72e20e465059a896dp@chr15:65174546..65174583, -
1.51e-75FFCP PHASE2:Hg19::chr4:159727272..159727307,+#_6f48ac63d86c6a3f1cb35d319a538d30p7@FNIP2
1.51e-75FFCP PHASE1:Hg19::chr4:159727272..159727307,+#_6f48ac63d86c6a3f1cb35d319a538d30p7@FNIP2
2.32e-75FFCP PHASE2:Hg19::chr3:149531627..149531651,+#_ff7528f93dbb9d38ac3844f4439947cbp7@RNF13
2.32e-75FFCP PHASE1:Hg19::chr3:149531627..149531651,+#_ff7528f93dbb9d38ac3844f4439947cbp7@RNF13
3.02e-75FFCP PHASE1:Hg19::chr19:52299474..52299504,-#_73245971218a4642facdf635e67460a5p@chr19:52299474..52299504, -
3.02e-75FFCP PHASE2:Hg19::chr19:52299474..52299504,-#_73245971218a4642facdf635e67460a5p@chr19:52299474..52299504, -
3.37e-75FFCP PHASE1:Hg19::chr4:185314125..185314143,-#_dc9a8f2e7f44fe01bbe3943ff3e2c35ap@chr4:185314125..185314143, -
3.37e-75FFCP PHASE2:Hg19::chr4:185314125..185314143,-#_dc9a8f2e7f44fe01bbe3943ff3e2c35ap@chr4:185314125..185314143, -
3.49e-75FFCP PHASE2:Hg19::chr5:131280548..131280574,-#_a4ee29bf08abc170f72213d0cd871f42p1@ENST00000425320
3.49e-75FFCP PHASE1:Hg19::chr5:131280548..131280574,-#_a4ee29bf08abc170f72213d0cd871f42p1@ENST00000425320
6.13e-75FFCP PHASE2:Hg19::chr19:18288064..18288080,+#_07f01debd643cdfdf967c8595772b9a1p@chr19:18288064..18288080, +
6.13e-75FFCP PHASE1:Hg19::chr19:18288064..18288080,+#_07f01debd643cdfdf967c8595772b9a1p@chr19:18288064..18288080, +
2.26e-74FFCP PHASE2:Hg19::chr10:73648356..73648408,-#_4f1e54e6f8eed162d093a975e4dd2a31p@chr10:73648356..73648408, -
2.26e-74FFCP PHASE1:Hg19::chr10:73648356..73648408,-#_4f1e54e6f8eed162d093a975e4dd2a31p@chr10:73648356..73648408, -
2.87e-74FFCP PHASE2:Hg19::chr1:161188686..161188721,+#_470933509c1b77a3af91fa270dc2ff67p@chr1:161188686..161188721, +
2.87e-74FFCP PHASE1:Hg19::chr1:161188686..161188721,+#_470933509c1b77a3af91fa270dc2ff67p@chr1:161188686..161188721, +
3.62e-74FFCP PHASE2:Hg19::chr4:185314151..185314178,-#_5a623635a44db9539ee3adb3b61af175p@chr4:185314151..185314178, -
3.62e-74FFCP PHASE1:Hg19::chr4:185314151..185314178,-#_5a623635a44db9539ee3adb3b61af175p@chr4:185314151..185314178, -
4.15e-74FFCP PHASE1:Hg19::chr2:119726719..119726744,+#_b9ec632bd2dc2ccdf28bac896c05f791p@chr2:119726719..119726744, +
4.15e-74FFCP PHASE2:Hg19::chr2:119726719..119726744,+#_b9ec632bd2dc2ccdf28bac896c05f791p@chr2:119726719..119726744, +
5.35e-74FFCP PHASE1:Hg19::chr4:185314188..185314207,-#_eac542b7495c58d738e0aa4d5b1a2417p@chr4:185314188..185314207, -
5.35e-74FFCP PHASE2:Hg19::chr4:185314188..185314207,-#_eac542b7495c58d738e0aa4d5b1a2417p@chr4:185314188..185314207, -
1.29e-73FFCP PHASE2:Hg19::chr2:145276939..145276960,+#_54b98a33d474fb722ea5285782f2f5ffp2@ZEB2-AS1
1.29e-73FFCP PHASE1:Hg19::chr2:145276939..145276960,+#_54b98a33d474fb722ea5285782f2f5ffp2@ZEB2-AS1
1.68e-73FFCP PHASE1:Hg19::chrX:37664331..37664352,+#_7be6b321255c45fe5a68aef13c4847a1p@chrX:37664331..37664352, +
1.68e-73FFCP PHASE2:Hg19::chrX:37664331..37664352,+#_7be6b321255c45fe5a68aef13c4847a1p@chrX:37664331..37664352, +
1.8e-73FFCP PHASE1:Hg19::chr1:145610717..145610730,+#_ff341745ca5cbd8f3dc7e46ae43e56d8p4@RNF115
1.8e-73FFCP PHASE2:Hg19::chr1:145610717..145610730,+#_ff341745ca5cbd8f3dc7e46ae43e56d8p4@RNF115
1.87e-73FFCP PHASE2:Hg19::chr8:116588888..116588904,+#_855c0a9bb3b9531709fc4c525a102bbdp@chr8:116588888..116588904, +
1.87e-73FFCP PHASE1:Hg19::chr8:116588888..116588904,+#_855c0a9bb3b9531709fc4c525a102bbdp@chr8:116588888..116588904, +
2.59e-73FFCP PHASE2:Hg19::chr2:129283966..129283970,+#_d2560a29ff0e02991537e3913be85da5p@chr2:129283966..129283970, +
2.59e-73FFCP PHASE1:Hg19::chr2:129283966..129283970,+#_d2560a29ff0e02991537e3913be85da5p@chr2:129283966..129283970, +
3.0e-73FFCP PHASE1:Hg19::chrX:153286067..153286101,-#_0bc4faf23774ad57b40b4c4fa21ff151p@chrX:153286067..153286101, -
3.0e-73FFCP PHASE2:Hg19::chrX:153286067..153286101,-#_0bc4faf23774ad57b40b4c4fa21ff151p@chrX:153286067..153286101, -
3.74e-73FFCP PHASE1:Hg19::chr19:18288914..18288931,-#_a38e472aa970ce0248f70f4ab1db493bp5@CU676849, p5@CU689079
3.74e-73FFCP PHASE2:Hg19::chr19:18288914..18288931,-#_a38e472aa970ce0248f70f4ab1db493bp5@CU676849, p5@CU689079
3.98e-73FFCP PHASE1:Hg19::chr1:26602990..26603008,+#_83a92db549413285f9778b1f281745ebp@chr1:26602990..26603008, +
3.98e-73FFCP PHASE2:Hg19::chr1:26602990..26603008,+#_83a92db549413285f9778b1f281745ebp@chr1:26602990..26603008, +
4.47e-73FFCP PHASE1:Hg19::chr1:108593061..108593077,+#_c60e3753c2ec894c19888f14c33256f3p@chr1:108593061..108593077, +
4.47e-73FFCP PHASE2:Hg19::chr1:108593061..108593077,+#_c60e3753c2ec894c19888f14c33256f3p@chr1:108593061..108593077, +
5.41e-73FFCP PHASE2:Hg19::chr1:150724282..150724308,-#_4cc517d04d553c14feea0420f52cb2a8p8@CTSS
5.41e-73FFCP PHASE1:Hg19::chr1:150724282..150724308,-#_4cc517d04d553c14feea0420f52cb2a8p8@CTSS
1.14e-72FFCP PHASE2:Hg19::chr1:161188826..161188842,+#_554457fb0bef3cc72eeab9b429f35834p@chr1:161188826..161188842, +
1.14e-72FFCP PHASE1:Hg19::chr1:161188826..161188842,+#_554457fb0bef3cc72eeab9b429f35834p@chr1:161188826..161188842, +
3.78e-72FFCP PHASE2:Hg19::chr20:1517991..1518011,-#_dbfed40f66267c3a7a2e065b22572e4dp@chr20:1517991..1518011, -
3.78e-72FFCP PHASE1:Hg19::chr20:1517991..1518011,-#_dbfed40f66267c3a7a2e065b22572e4dp@chr20:1517991..1518011, -
5.08e-72FFCP PHASE2:Hg19::chr19:18285955..18285972,+#_34906eca045f8a5e168bf54e036318d3p@chr19:18285955..18285972, +
5.08e-72FFCP PHASE1:Hg19::chr19:18285955..18285972,+#_34906eca045f8a5e168bf54e036318d3p@chr19:18285955..18285972, +
1.2e-71FFCP PHASE1:Hg19::chr7:6066589..6066602,-#_59987aebe1e389a47fdd1c7a910aa25ap4@EIF2AK1
1.2e-71FFCP PHASE2:Hg19::chr7:6066589..6066602,-#_59987aebe1e389a47fdd1c7a910aa25ap4@EIF2AK1
1.4e-71FFCP PHASE1:Hg19::chr19:18288514..18288554,+#_46cadc8e285ae63e16eaba28d5bd8e46p6@IFI30
1.4e-71FFCP PHASE2:Hg19::chr19:18288514..18288554,+#_46cadc8e285ae63e16eaba28d5bd8e46p6@IFI30
1.48e-71FFCP PHASE1:Hg19::chr8:53373491..53373506,-#_95aabc22399274364cbfb86146a7b49fp4@ST18
1.48e-71FFCP PHASE2:Hg19::chr8:53373491..53373506,-#_95aabc22399274364cbfb86146a7b49fp4@ST18
1.68e-71FFCP PHASE1:Hg19::chr5:180242576..180242585,-#_52a1f993252bbd517847039839c49b86p12@MGAT1
1.68e-71FFCP PHASE2:Hg19::chr5:180242576..180242585,-#_52a1f993252bbd517847039839c49b86p12@MGAT1
1.69e-71FFCP PHASE2:Hg19::chr19:51625924..51625942,+#_bc93acf21881b6837078a2c25c74a48fp@chr19:51625924..51625942, +
1.69e-71FFCP PHASE1:Hg19::chr19:51625924..51625942,+#_bc93acf21881b6837078a2c25c74a48fp@chr19:51625924..51625942, +
2.0e-71FFCP PHASE2:Hg19::chr17:7483714..7483726,+#_efa5568338d71098ccddca5916a2292cp@chr17:7483714..7483726, +
2.0e-71FFCP PHASE1:Hg19::chr17:7483714..7483726,+#_efa5568338d71098ccddca5916a2292cp@chr17:7483714..7483726, +
2.47e-71FFCP PHASE2:Hg19::chr4:185266972..185267007,+#_a4e85fb73ca77f3485efa4eb871d275ep@chr4:185266972..185267007, +
2.47e-71FFCP PHASE1:Hg19::chr4:185266972..185267007,+#_a4e85fb73ca77f3485efa4eb871d275ep@chr4:185266972..185267007, +










Property "Property value" (as page type) with input value "UBPROP:0000001 "Anatomical system consisting of multiple elements and tissues that provides physical support.[TAO]" xsd:string" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process., Property "Property value" (as page type) with input value "UBPROP:0000001 "Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system.[VSAO]" xsd:string" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process., Property "Property value" (as page type) with input value "UBPROP:0000001 "System that provides physical support to the organism.[AAO]" xsd:string" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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