MSC to adipocyte (mouse): Difference between revisions
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<html><img src='https://fantom5-collaboration.gsc.riken.jp/resource_browser/images/TC_qc/500px-Figure1.png'></html><br> | <html><img src='https://fantom5-collaboration.gsc.riken.jp/resource_browser/images/TC_qc/500px-Figure1.png'></html><br> | ||
Figure 3. Sampling points for ST2 time-course CAGE data<br> | Figure 3. Sampling points for ST2 time-course CAGE data<br> | ||
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References:<br> | |||
3. Tokuzawa Y, Yagi K, Yamashita Y, Nakachi Y, Nikaido I, et al. Id4, a new candidate gene for senile osteoporosis, acts as a molecular switch promoting osteoblast differentiation. PLoS Genet (2010) 6(7):e1001019. PMID:20628571<br> | |||
4. Mizuno Y, Yagi K, Tokuzawa Y, Kanesaki-Yatsuka Y, Suda T, et al. miR-125b inhibits osteoblastic differentiation by down-regulation of cell proliferation. Biochem Biophys Res Commun (2008) 368(2):267-272. PMID:18230348.<br> | |||
|TCQuality_control='''Marker gene expression:'''<br> | |TCQuality_control='''Marker gene expression:'''<br> | ||
Adipocyte differentation, hCAGE:<br> | Adipocyte differentation, hCAGE:<br> | ||
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<img src='https://fantom5-collaboration.gsc.riken.jp/resource_browser/images/TC_qc/Osteo5.jpg'><img src='https://fantom5-collaboration.gsc.riken.jp/resource_browser/images/TC_qc/Osteo6.jpg'><img src='https://fantom5-collaboration.gsc.riken.jp/resource_browser/images/TC_qc/Legend.jpg'><br> | <img src='https://fantom5-collaboration.gsc.riken.jp/resource_browser/images/TC_qc/Osteo5.jpg'><img src='https://fantom5-collaboration.gsc.riken.jp/resource_browser/images/TC_qc/Osteo6.jpg'><img src='https://fantom5-collaboration.gsc.riken.jp/resource_browser/images/TC_qc/Legend.jpg'><br> | ||
</html><br> | </html><br> | ||
Figurea 4. Gene expression (TPM) of key regulators (Hes1, Id1, Id2,Sp7) and differentiation markers (Alpl, Bglap).<br> | |||
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Revision as of 16:13, 11 December 2014
Series: | IN_VITRO DIFFERENTIATION SERIES |
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Species: | Mouse (Mus musculus) |
Genomic View: | Zenbu |
Expression table: | [{{{tet_config}}} FILE] |
Link to TET: | [{{{tet_file}}} TET] |
Sample providers : | Yasushi Okazaki |
Germ layer: | {{{germ_layer}}} |
Primary cells or cell line: | {{{primary_cells}}} |
Time span: | {{{time_span}}} |
Number of time points: | {{{number_time_points}}} |
Overview |
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Senile osteoporosis is the most common metabolic bone disease. This disease is often accompanied by increasing adipocytes in bone marrow tissues [1]. The ectopic adipocytes differentiation following bone loss seems to be caused by unbalanced differentiation of mesenchymal stem cells (MSCs) [2]. Although several differentiation regulators of MSCs have already been reported, little is known about the regulatory dynamics of bi-directional adipocytes/osteoblasts differentiation. |
Sample description |
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Cell line: |
Quality control |
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Marker gene expression: |
Profiled time course samples
Only samples that passed quality controls (Arner et al. 2015) are shown here. The entire set of samples are downloadable from FANTOM5 human / mouse samples