MCL coexpression mm9:1557: Difference between revisions
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{{MCL_coexpression_mm9 | 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guanyl-nucleotide exchange factor activity;0.00854560379022112;57257!GO:0006906;vesicle fusion;0.00854560379022112;57257!GO:0043552;positive regulation of phosphoinositide 3-kinase activity;0.00854560379022112;57257!GO:0043550;regulation of lipid kinase activity;0.00854560379022112;57257!GO:0043551;regulation of phosphoinositide 3-kinase activity;0.00854560379022112;57257!GO:0005154;epidermal growth factor receptor binding;0.00996932479428507;57257!GO:0045785;positive regulation of cell adhesion;0.014646796983947;57257!GO:0030032;lamellipodium biogenesis;0.0160186172417038;57257!GO:0006944;membrane fusion;0.0208795244679757;57257!GO:0007242;intracellular signaling cascade;0.0226924411442025;57257,56193!GO:0019992;diacylglycerol binding;0.0314652936105574;57257!GO:0030155;regulation of cell adhesion;0.0314652936105574;57257!GO:0030031;cell projection biogenesis;0.0314652936105574;57257!GO:0005089;Rho guanyl-nucleotide exchange factor activity;0.0314652936105574;57257!GO:0035023;regulation of Rho protein signal transduction;0.0314652936105574;57257!GO:0005088;Ras guanyl-nucleotide exchange factor activity;0.0314652936105574;57257!GO:0043087;regulation of GTPase activity;0.0321196813119172;57257!GO:0007266;Rho protein signal transduction;0.0369436987527164;57257!GO:0033674;positive regulation of kinase activity;0.0369436987527164;57257!GO:0051347;positive regulation of transferase activity;0.0369436987527164;57257!GO:0007229;integrin-mediated signaling pathway;0.0369436987527164;57257!GO:0046578;regulation of Ras protein signal transduction;0.0387425536716064;57257!GO:0051336;regulation of hydrolase activity;0.0403833373613207;57257!GO:0005085;guanyl-nucleotide exchange factor activity;0.0410552713598788;57257!GO:0051056;regulation of small GTPase mediated signal transduction;0.0410552713598788;57257!GO:0043549;regulation of kinase activity;0.0410552713598788;57257!GO:0043085;positive regulation of catalytic 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| |||
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Latest revision as of 17:07, 17 September 2013
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0030676 | Rac guanyl-nucleotide exchange factor activity | 0.00854560379022112 |
| GO:0006906 | vesicle fusion | 0.00854560379022112 |
| GO:0043552 | positive regulation of phosphoinositide 3-kinase activity | 0.00854560379022112 |
| GO:0043550 | regulation of lipid kinase activity | 0.00854560379022112 |
| GO:0043551 | regulation of phosphoinositide 3-kinase activity | 0.00854560379022112 |
| GO:0005154 | epidermal growth factor receptor binding | 0.00996932479428507 |
| GO:0045785 | positive regulation of cell adhesion | 0.014646796983947 |
| GO:0030032 | lamellipodium biogenesis | 0.0160186172417038 |
| GO:0006944 | membrane fusion | 0.0208795244679757 |
| GO:0007242 | intracellular signaling cascade | 0.0226924411442025 |
| GO:0019992 | diacylglycerol binding | 0.0314652936105574 |
| GO:0030155 | regulation of cell adhesion | 0.0314652936105574 |
| GO:0030031 | cell projection biogenesis | 0.0314652936105574 |
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | 0.0314652936105574 |
| GO:0035023 | regulation of Rho protein signal transduction | 0.0314652936105574 |
| GO:0005088 | Ras guanyl-nucleotide exchange factor activity | 0.0314652936105574 |
| GO:0043087 | regulation of GTPase activity | 0.0321196813119172 |
| GO:0007266 | Rho protein signal transduction | 0.0369436987527164 |
| GO:0033674 | positive regulation of kinase activity | 0.0369436987527164 |
| GO:0051347 | positive regulation of transferase activity | 0.0369436987527164 |
| GO:0007229 | integrin-mediated signaling pathway | 0.0369436987527164 |
| GO:0046578 | regulation of Ras protein signal transduction | 0.0387425536716064 |
| GO:0051336 | regulation of hydrolase activity | 0.0403833373613207 |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 0.0410552713598788 |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 0.0410552713598788 |
| GO:0043549 | regulation of kinase activity | 0.0410552713598788 |
| GO:0043085 | positive regulation of catalytic activity | 0.0410552713598788 |
| GO:0051338 | regulation of transferase activity | 0.0410552713598788 |
| GO:0007265 | Ras protein signal transduction | 0.0428408209211364 |
| GO:0005083 | small GTPase regulator activity | 0.0428408209211364 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br><br><br>
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 5.19399 |
| MA0004.1 | 0.603793 |
| MA0006.1 | 0.419915 |
| MA0007.1 | 0.587678 |
| MA0009.1 | 1.06266 |
| MA0014.1 | 2.11217 |
| MA0017.1 | 0.449113 |
| MA0019.1 | 0.874061 |
| MA0024.1 | 1.01759 |
| MA0025.1 | 1.30092 |
| MA0027.1 | 2.72141 |
| MA0028.1 | 0.43138 |
| MA0029.1 | 0.995171 |
| MA0030.1 | 1.00195 |
| MA0031.1 | 0.965177 |
| MA0038.1 | 0.757669 |
| MA0040.1 | 1.07552 |
| MA0041.1 | 0.522007 |
| MA0042.1 | 0.507715 |
| MA0043.1 | 1.1618 |
| MA0046.1 | 1.09955 |
| MA0048.1 | 0.205696 |
| MA0050.1 | 0.645342 |
| MA0051.1 | 0.767098 |
| MA0052.1 | 1.08379 |
| MA0055.1 | 0.0851423 |
| MA0056.1 | 0 |
| MA0057.1 | 0.192781 |
| MA0058.1 | 0.50032 |
| MA0059.1 | 0.513699 |
| MA0060.1 | 0.330907 |
| MA0061.1 | 0.955135 |
| MA0063.1 | 0 |
| MA0066.1 | 0.746072 |
| MA0067.1 | 1.41352 |
| MA0068.1 | 0.197245 |
| MA0069.1 | 1.08414 |
| MA0070.1 | 1.07418 |
| MA0071.1 | 0.644448 |
| MA0072.1 | 1.06547 |
| MA0073.1 | 1.13827 |
| MA0074.1 | 1.68683 |
| MA0076.1 | 0.470037 |
| MA0077.1 | 1.04318 |
| MA0078.1 | 0.801834 |
| MA0081.1 | 0.53877 |
| MA0083.1 | 1.16099 |
| MA0084.1 | 1.74401 |
| MA0087.1 | 1.11687 |
| MA0088.1 | 1.42769 |
| MA0089.1 | 0 |
| MA0090.1 | 0.566938 |
| MA0091.1 | 0.617887 |
| MA0092.1 | 0.567278 |
| MA0093.1 | 0.440484 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.695835 |
| MA0101.1 | 0.523409 |
| MA0103.1 | 0.460936 |
| MA0105.1 | 1.28296 |
| MA0106.1 | 0.809991 |
| MA0107.1 | 0.454197 |
| MA0108.2 | 0.897859 |
| MA0109.1 | 0 |
| MA0111.1 | 0.582193 |
| MA0113.1 | 0.780358 |
| MA0114.1 | 0.361633 |
| MA0115.1 | 1.16466 |
| MA0116.1 | 0.419688 |
| MA0117.1 | 1.13165 |
| MA0119.1 | 0.524046 |
| MA0122.1 | 1.15196 |
| MA0124.1 | 1.35963 |
| MA0125.1 | 1.28445 |
| MA0130.1 | 0 |
| MA0131.1 | 0.869325 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 1.19898 |
| MA0136.1 | 0.729175 |
| MA0139.1 | 0.8026 |
| MA0140.1 | 0.695713 |
| MA0141.1 | 0.482463 |
| MA0142.1 | 0.950155 |
| MA0143.1 | 0.797553 |
| MA0144.1 | 0.365053 |
| MA0145.1 | 0.157686 |
| MA0146.1 | 0.822925 |
| MA0147.1 | 0.378658 |
| MA0148.1 | 0.621195 |
| MA0149.1 | 0.529387 |
| MA0062.2 | 0.254018 |
| MA0035.2 | 0.700704 |
| MA0039.2 | 0.749235 |
| MA0138.2 | 0.861035 |
| MA0002.2 | 0.809945 |
| MA0137.2 | 1.20517 |
| MA0104.2 | 1.52809 |
| MA0047.2 | 0.75686 |
| MA0112.2 | 0.157681 |
| MA0065.2 | 0.158101 |
| MA0150.1 | 0.587557 |
| MA0151.1 | 0 |
| MA0152.1 | 0.756973 |
| MA0153.1 | 1.21594 |
| MA0154.1 | 3.26157 |
| MA0155.1 | 0.515751 |
| MA0156.1 | 0.469089 |
| MA0157.1 | 0.91689 |
| MA0158.1 | 0 |
| MA0159.1 | 1.01146 |
| MA0160.1 | 0.624415 |
| MA0161.1 | 0 |
| MA0162.1 | 0.245828 |
| MA0163.1 | 2.36557 |
| MA0164.1 | 0.729558 |
| MA0080.2 | 1.15331 |
| MA0018.2 | 0.739807 |
| MA0099.2 | 0.854449 |
| MA0079.2 | 1.7149 |
| MA0102.2 | 1.79669 |
| MA0258.1 | 0.346619 |
| MA0259.1 | 0.366802 |
| MA0442.1 | 0 |
