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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0.353783282099689,

Latest revision as of 11:39, 17 September 2013


Full id: C1192_extraskeletal_Cardiac_Lens_cholangiocellular_pineal_Fibroblast_rectum



Phase1 CAGE Peaks

Hg19::chr13:93879041..93879078,+p1@GPC6
Hg19::chr13:93879085..93879136,+p2@GPC6
Hg19::chr13:93879137..93879148,+p10@GPC6
Hg19::chr13:93879165..93879189,+p3@GPC6
Hg19::chr13:93879196..93879223,+p4@GPC6
Hg19::chr13:93879225..93879248,+p9@GPC6
Hg19::chr13:93879313..93879326,+p7@GPC6


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
non-terminally differentiated cell4.44e-14106
fibroblast9.62e-1476
electrically responsive cell1.87e-1061
electrically active cell1.87e-1061
muscle precursor cell1.57e-0958
myoblast1.57e-0958
multi-potent skeletal muscle stem cell1.57e-0958
contractile cell2.75e-0959
muscle cell3.43e-0955
neural cell4.49e-0725
Uber Anatomy
Ontology termp-valuen
multi-tissue structure2.81e-21342
anatomical cluster1.47e-17373
cell layer3.81e-15309
epithelium8.38e-15306
mesenchyme1.34e-14160
entire embryonic mesenchyme1.34e-14160
organ system subdivision8.36e-13223
organism subdivision1.20e-12264
multi-cellular organism7.88e-12656
trunk mesenchyme2.46e-11122
trunk2.56e-11199
nervous system1.01e-1089
structure with developmental contribution from neural crest1.56e-10132
central nervous system1.07e-0981
muscle tissue1.44e-0964
musculature1.44e-0964
musculature of body1.44e-0964
tube1.82e-09192
neurectoderm1.92e-0986
tissue1.95e-09773
skeletal muscle tissue2.03e-0962
striated muscle tissue2.03e-0962
myotome2.03e-0962
ectoderm-derived structure4.01e-09171
ectoderm4.01e-09171
presumptive ectoderm4.01e-09171
dense mesenchyme tissue5.87e-0973
embryo1.06e-08592
anatomical conduit1.26e-08240
paraxial mesoderm1.33e-0872
presumptive paraxial mesoderm1.33e-0872
somite1.43e-0871
presomitic mesoderm1.43e-0871
presumptive segmental plate1.43e-0871
dermomyotome1.43e-0871
trunk paraxial mesoderm1.43e-0871
neural plate1.63e-0882
presumptive neural plate1.63e-0882
epithelial vesicle4.20e-0878
developing anatomical structure5.22e-08581
anatomical system1.30e-07624
anatomical group1.31e-07625
brain2.05e-0768
future brain2.05e-0768
germ layer3.72e-07560
germ layer / neural crest3.72e-07560
embryonic tissue3.72e-07560
presumptive structure3.72e-07560
germ layer / neural crest derived structure3.72e-07560
epiblast (generic)3.72e-07560
embryonic structure7.16e-07564
pre-chordal neural plate9.19e-0761
primordium9.47e-07160


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.00215847
MA0004.10.502801
MA0006.12.45306
MA0007.10.483857
MA0009.10.973289
MA0014.10.0156227
MA0017.10.380797
MA0019.10.652951
MA0024.12.01466
MA0025.11.10816
MA0027.12.59001
MA0028.10.35747
MA0029.12.05477
MA0030.12.03099
MA0031.10.809638
MA0038.10.60704
MA0040.14.88057
MA0041.10.521615
MA0042.11.22641
MA0043.10.973609
MA0046.10.962263
MA0048.10.120314
MA0050.10.490116
MA0051.10.602745
MA0052.10.896548
MA0055.10.0407081
MA0056.10
MA0057.13.85869
MA0058.10.406232
MA0059.10.404929
MA0060.10.224688
MA0061.10.198335
MA0063.10
MA0066.11.47685
MA0067.11.29359
MA0068.10.162298
MA0069.10.958358
MA0070.10.947018
MA0071.10.567661
MA0072.10.942461
MA0073.10.336328
MA0074.10.60198
MA0076.10.422297
MA0077.10.934645
MA0078.10.703614
MA0081.10.405093
MA0083.10.980893
MA0084.11.48179
MA0087.12.1637
MA0088.10.0723293
MA0089.10
MA0090.11.95014
MA0091.10.505453
MA0092.10.467172
MA0093.10.344385
MA0095.10
MA0098.10
MA0100.10.621149
MA0101.10.347695
MA0103.10.332048
MA0105.10.104569
MA0106.10.648997
MA0107.10.274127
MA0108.20.806528
MA0109.10
MA0111.10.45062
MA0113.10.665691
MA0114.10.269076
MA0115.11.21667
MA0116.10.277571
MA0117.11.01134
MA0119.10.388712
MA0122.11.03753
MA0124.11.17486
MA0125.11.0901
MA0130.10
MA0131.10.722072
MA0132.10
MA0133.10
MA0135.11.00402
MA0136.10.614215
MA0139.10.547495
MA0140.10.564957
MA0141.10.403171
MA0142.10.777365
MA0143.10.66587
MA0144.10.254954
MA0145.10.0807715
MA0146.10.0127148
MA0147.10.281049
MA0148.10.528066
MA0149.10.555119
MA0062.20.193221
MA0035.20.564239
MA0039.20.00276064
MA0138.20.704862
MA0002.20.213296
MA0137.20.36398
MA0104.20.223944
MA0047.20.636643
MA0112.20.0758925
MA0065.20.0828768
MA0150.10.430951
MA0151.10
MA0152.10.571637
MA0153.11.07307
MA0154.10.335384
MA0155.10.071478
MA0156.10.36627
MA0157.10.749547
MA0158.10
MA0159.10.281681
MA0160.10.543522
MA0161.10
MA0162.10.0249953
MA0163.10.0167306
MA0164.10.678332
MA0080.20.344472
MA0018.20.650405
MA0099.20.572
MA0079.20.0015479
MA0102.21.51913
MA0258.10.245543
MA0259.10.289405
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BHLHE40#8553744.87181354697742.71655591272133e-123.64671443404503e-10
EP300#203376.77394172622321.52695018318475e-065.85867561284469e-05
HEY1#2346274.040111043105715.68979821988558e-050.000950018922920273
JUND#372776.994663941871031.21993360047445e-064.92495729802671e-05
MAX#414976.452555509007122.14589603858566e-067.76829242197047e-05
POLR2A#543072.147453176558070.004747636447610280.0223370755451829
RAD21#5885710.35503389545637.82487927673307e-084.69668141829152e-06
REST#597879.650028716128021.28195528172884e-077.31618183980753e-06
RFX5#5993712.04791082719512.7106444306642e-081.86003281007975e-06
SETDB1#9869740.32002617801055.74662948954468e-127.45555574234232e-10
SP1#666775.69838137814095.12280185510121e-060.000157220188934739
TAF1#687273.343046285745290.0002142336319622450.00246576441354474
TBP#690873.706770687096390.0001039672097505110.00145085935584362
TRIM28#10155718.59052504526251.300439693691e-091.17386880872424e-07
YY1#752874.911170749853861.45048003565243e-050.000345386877436169
ZNF263#1012778.221841637010683.93423095812578e-071.90844006983603e-05



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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