Novel motif:27

name:	motif27_CCTGCA

Association to promoter expression in human samples<b>Summary:</b>Significance of the correlation with CAGE expression, human <br><b>Analyst:</b> Michiel de Hoon<br><br>link to source dataset <br>data

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Association to promoter expression in mouse samples <b>Summary:</b>Significance of the correlation with CAGE expression, mouse <br><b>Analyst:</b> Michiel de Hoon<br><br>link to source dataset <br>data

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GREAT analysis results for human <b>Summary:</b>Genomic Enrichment of Annotations Tool (GREAT, Nat Biotechnol. 2010 May;28(5):495-501) is used to identify, both in human and in mouse, the gene ontology terms of biological processes enriched given the predicted TFBSs, and evaluated the overlap in the top-500 gene ontology terms between human and mouse. For each novel motif, the P value for the overlap was then evaluated by calculating its relative rank with respect to this background distribution.<br>Analyst: Michiel de Hoon<br><br>link to source dataset <br>data

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GO ID	GO Term	p-value
GO:0043462	regulation of ATPase activity	2.348151e-14
GO:0045321	leukocyte activation	5.380176e-12
GO:0042110	T cell activation	3.696196e-11
GO:0002149	hypochlorous acid biosynthetic process	1.554332e-10
GO:0072376	protein activation cascade	2.592249e-10
GO:0007522	visceral muscle development	1.718101e-9
GO:0050728	negative regulation of inflammatory response	3.011636e-9
GO:0046655	folic acid metabolic process	5.082912e-9
GO:0045104	intermediate filament cytoskeleton organization	5.464915e-9
GO:0046649	lymphocyte activation	6.234167e-9
GO:0002679	respiratory burst involved in defense response	7.546112e-9
GO:0034762	regulation of transmembrane transport	8.432219e-9
GO:0006956	complement activation	8.626217e-9
GO:0006545	glycine biosynthetic process	1.010643e-8
GO:0051917	regulation of fibrinolysis	1.213215e-8
GO:0045103	intermediate filament-based process	1.289789e-8
GO:0042790	transcription of nuclear large rRNA transcript from RNA polymerase I promoter	1.319782e-8
GO:0050832	defense response to fungus	1.565295e-8
GO:0006544	glycine metabolic process	1.848921e-8
GO:0003009	skeletal muscle contraction	2.331589e-8
GO:0061041	regulation of wound healing	2.368799e-8
GO:0002604	regulation of dendritic cell antigen processing and presentation	2.422962e-8
GO:0046724	oxalic acid secretion	3.086503e-8
GO:0019265	glycine biosynthetic process, by transamination of glyoxylate	3.086503e-8
GO:0044258	intestinal lipid catabolic process	3.355298e-8
GO:0018350	protein esterification	3.355298e-8
GO:0002577	regulation of antigen processing and presentation	3.609898e-8
GO:0032796	uropod organization	4.145491e-8
GO:0060037	pharyngeal system development	4.234614e-8
GO:0002455	humoral immune response mediated by circulating immunoglobulin	4.322717e-8
GO:0006692	prostanoid metabolic process	4.384617e-8
GO:0009620	response to fungus	4.862952e-8
GO:0032715	negative regulation of interleukin-6 production	4.936645e-8
GO:0035691	macrophage migration inhibitory factor signaling pathway	6.392083e-8
GO:0090130	tissue migration	6.401878e-8
GO:0050821	protein stabilization	6.680658e-8
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	7.101046e-8
GO:0006958	complement activation, classical pathway	7.148450e-8
GO:0055009	atrial cardiac muscle tissue morphogenesis	8.124191e-8
GO:0051918	negative regulation of fibrinolysis	9.505968e-8
GO:0044130	negative regulation of growth of symbiont in host	9.869380e-8
GO:0001775	cell activation	9.973316e-8
GO:0016601	Rac protein signal transduction	1.103026e-7
GO:0019724	B cell mediated immunity	1.242077e-7
GO:0006979	response to oxidative stress	1.270688e-7
GO:0050678	regulation of epithelial cell proliferation	1.404229e-7
GO:0032101	regulation of response to external stimulus	1.623842e-7
GO:0043249	erythrocyte maturation	1.627562e-7
GO:0042415	norepinephrine metabolic process	1.727854e-7
GO:0043901	negative regulation of multi-organism process	1.997708e-7
GO:0051234	establishment of localization	2.091928e-7
GO:0006760	folic acid-containing compound metabolic process	2.131472e-7
GO:0006952	defense response	2.484845e-7
GO:0002902	regulation of B cell apoptosis	2.491094e-7
GO:0060300	regulation of cytokine activity	2.671416e-7
GO:0031348	negative regulation of defense response	3.104723e-7
GO:0003229	ventricular cardiac muscle tissue development	3.649890e-7
GO:0070301	cellular response to hydrogen peroxide	3.806347e-7
GO:0008016	regulation of heart contraction	3.923026e-7
GO:0051764	actin crosslink formation	4.513450e-7
GO:0030193	regulation of blood coagulation	4.539607e-7
GO:0043368	positive T cell selection	4.864470e-7
GO:0006811	ion transport	5.124739e-7
GO:0006909	phagocytosis	5.499731e-7
GO:0008203	cholesterol metabolic process	5.651054e-7
GO:0006548	histidine catabolic process	5.671186e-7
GO:0000212	meiotic spindle organization	5.760825e-7
GO:0002443	leukocyte mediated immunity	5.766906e-7
GO:0006810	transport	5.874189e-7
GO:0022406	membrane docking	6.003020e-7
GO:0030100	regulation of endocytosis	6.702512e-7
GO:0046456	icosanoid biosynthetic process	7.472407e-7
GO:0001836	release of cytochrome c from mitochondria	7.992603e-7
GO:0016125	sterol metabolic process	8.269985e-7
GO:0090344	negative regulation of cell aging	8.830393e-7
GO:0006707	cholesterol catabolic process	9.082481e-7
GO:0034765	regulation of ion transmembrane transport	9.625839e-7
GO:0006959	humoral immune response	1.014608e-6
GO:0035814	negative regulation of renal sodium excretion	1.039104e-6
GO:0002449	lymphocyte mediated immunity	1.132037e-6
GO:0051693	actin filament capping	1.143434e-6
GO:0002478	antigen processing and presentation of exogenous peptide antigen	1.202169e-6
GO:0010310	regulation of hydrogen peroxide metabolic process	1.271461e-6
GO:0016064	immunoglobulin mediated immune response	1.282778e-6
GO:0002026	regulation of the force of heart contraction	1.338066e-6
GO:0006821	chloride transport	1.349103e-6
GO:0060301	positive regulation of cytokine activity	1.368107e-6
GO:0055010	ventricular cardiac muscle tissue morphogenesis	1.389013e-6
GO:0090263	positive regulation of canonical Wnt receptor signaling pathway	1.488755e-6
GO:0008078	mesodermal cell migration	1.500420e-6
GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production	1.537155e-6
GO:0000302	response to reactive oxygen species	1.589957e-6
GO:0043903	regulation of symbiosis, encompassing mutualism through parasitism	1.616321e-6
GO:0002252	immune effector process	1.828074e-6
GO:0006636	unsaturated fatty acid biosynthetic process	1.830421e-6
GO:0003180	aortic valve morphogenesis	1.984101e-6
GO:0050727	regulation of inflammatory response	2.056830e-6
GO:0003208	cardiac ventricle morphogenesis	2.211181e-6
GO:0035089	establishment of apical/basal cell polarity	2.315840e-6
GO:0031295	T cell costimulation	2.384773e-6
GO:0033326	cerebrospinal fluid secretion	2.514954e-6
GO:0043269	regulation of ion transport	2.653537e-6
GO:0015874	norepinephrine transport	2.692711e-6
GO:0072268	pattern specification involved in metanephros development	3.018391e-6
GO:0032680	regulation of tumor necrosis factor production	3.196382e-6
GO:0034220	ion transmembrane transport	3.204755e-6
GO:0001546	preantral ovarian follicle growth	3.478487e-6
GO:0051932	synaptic transmission, GABAergic	3.478487e-6
GO:0002460	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	3.556583e-6
GO:0048144	fibroblast proliferation	3.790125e-6
GO:0001880	Mullerian duct regression	3.790125e-6
GO:0045575	basophil activation	3.996195e-6
GO:0021570	rhombomere 4 development	3.996195e-6
GO:0001694	histamine biosynthetic process	3.996195e-6
GO:0006955	immune response	4.410768e-6
GO:0030195	negative regulation of blood coagulation	4.466518e-6
GO:0032695	negative regulation of interleukin-12 production	4.496802e-6
GO:0051298	centrosome duplication	5.041468e-6
GO:0032914	positive regulation of transforming growth factor beta1 production	5.239612e-6
GO:0001937	negative regulation of endothelial cell proliferation	5.325197e-6
GO:0051346	negative regulation of hydrolase activity	5.562885e-6
GO:0030835	negative regulation of actin filament depolymerization	5.817582e-6
GO:0051179	localization	6.214374e-6
GO:0002093	auditory receptor cell morphogenesis	6.812802e-6
GO:0021526	medial motor column neuron differentiation	7.373481e-6
GO:0051488	activation of anaphase-promoting complex activity	7.642860e-6
GO:0071392	cellular response to estradiol stimulus	8.261592e-6
GO:0032720	negative regulation of tumor necrosis factor production	9.817000e-6
GO:0006633	fatty acid biosynthetic process	9.942355e-6
GO:0030157	pancreatic juice secretion	1.039862e-5
GO:0051220	cytoplasmic sequestering of protein	1.045504e-5
GO:0007155	cell adhesion	1.055189e-5
GO:0048243	norepinephrine secretion	1.081050e-5
GO:0006690	icosanoid metabolic process	1.106853e-5
GO:0034551	mitochondrial respiratory chain complex III assembly	1.107043e-5
GO:0010535	positive regulation of activation of JAK2 kinase activity	1.138110e-5
GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase	1.149971e-5
GO:0071805	potassium ion transmembrane transport	1.157863e-5
GO:0002903	negative regulation of B cell apoptosis	1.182564e-5
GO:0072593	reactive oxygen species metabolic process	1.192226e-5
GO:0050881	musculoskeletal movement	1.221583e-5
GO:0048278	vesicle docking	1.234087e-5
GO:0051293	establishment of spindle localization	1.251794e-5
GO:0000060	protein import into nucleus, translocation	1.253556e-5
GO:0051533	positive regulation of NFAT protein import into nucleus	1.354286e-5
GO:0009144	purine nucleoside triphosphate metabolic process	1.376787e-5
GO:0002367	cytokine production involved in immune response	1.419145e-5
GO:0045414	regulation of interleukin-8 biosynthetic process	1.461640e-5
GO:0045058	T cell selection	1.462262e-5
GO:0045668	negative regulation of osteoblast differentiation	1.513870e-5
GO:0042363	fat-soluble vitamin catabolic process	1.616253e-5
GO:0042744	hydrogen peroxide catabolic process	1.618413e-5
GO:0055085	transmembrane transport	1.637212e-5
GO:0002250	adaptive immune response	1.738820e-5
GO:0007586	digestion	1.763606e-5
GO:0019226	transmission of nerve impulse	1.801895e-5
GO:0071636	positive regulation of transforming growth factor beta production	1.901329e-5
GO:0009205	purine ribonucleoside triphosphate metabolic process	1.901798e-5
GO:0016056	rhodopsin mediated signaling pathway	1.905930e-5
GO:0070727	cellular macromolecule localization	1.946829e-5
GO:0044057	regulation of system process	1.969223e-5
GO:0033559	unsaturated fatty acid metabolic process	2.083302e-5
GO:0032102	negative regulation of response to external stimulus	2.091959e-5
GO:0021548	pons development	2.101655e-5
GO:0009070	serine family amino acid biosynthetic process	2.105341e-5
GO:0007386	compartment pattern specification	2.122464e-5
GO:0002019	regulation of renal output by angiotensin	2.172671e-5
GO:0010754	negative regulation of cGMP-mediated signaling	2.174169e-5
GO:0043652	engulfment of apoptotic cell	2.174169e-5
GO:0010751	negative regulation of nitric oxide mediated signal transduction	2.174169e-5
GO:0002605	negative regulation of dendritic cell antigen processing and presentation	2.174169e-5
GO:0002581	negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	2.174169e-5
GO:0045059	positive thymic T cell selection	2.207231e-5
GO:0051323	metaphase	2.318454e-5
GO:0032972	regulation of muscle filament sliding speed	2.321737e-5
GO:0042534	regulation of tumor necrosis factor biosynthetic process	2.350614e-5
GO:0042491	auditory receptor cell differentiation	2.460248e-5
GO:0060337	type I interferon-mediated signaling pathway	2.547120e-5
GO:0009720	detection of hormone stimulus	2.548596e-5
GO:0034436	glycoprotein transport	2.548596e-5
GO:0031333	negative regulation of protein complex assembly	2.636210e-5
GO:0009199	ribonucleoside triphosphate metabolic process	2.639797e-5
GO:0043206	fibril organization	2.747916e-5
GO:0043587	tongue morphogenesis	2.821062e-5
GO:0006434	seryl-tRNA aminoacylation	2.917567e-5
GO:0050818	regulation of coagulation	2.954754e-5
GO:0034613	cellular protein localization	2.987281e-5
GO:0048562	embryonic organ morphogenesis	3.047563e-5
GO:0032206	positive regulation of telomere maintenance	3.080126e-5
GO:0019884	antigen processing and presentation of exogenous antigen	3.170363e-5
GO:0060956	endocardial cell differentiation	3.191138e-5
GO:0045061	thymic T cell selection	3.204940e-5
GO:0002495	antigen processing and presentation of peptide antigen via MHC class II	3.211161e-5
GO:0034340	response to type I interferon	3.259187e-5
GO:0009150	purine ribonucleotide metabolic process	3.332703e-5
GO:0051895	negative regulation of focal adhesion assembly	3.336399e-5
GO:0002906	negative regulation of mature B cell apoptosis	3.388155e-5
GO:0031647	regulation of protein stability	3.417303e-5
GO:0006886	intracellular protein transport	3.511948e-5
GO:0009141	nucleoside triphosphate metabolic process	3.708616e-5
GO:0050680	negative regulation of epithelial cell proliferation	3.745618e-5
GO:0001798	positive regulation of type IIa hypersensitivity	3.763506e-5
GO:0035264	multicellular organism growth	3.767037e-5
GO:0051295	establishment of meiotic spindle localization	3.789281e-5
GO:0072081	specification of nephron tubule identity	3.873390e-5
GO:0072500	negative regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	3.884140e-5
GO:0043585	nose morphogenesis	3.895256e-5
GO:0007440	foregut morphogenesis	4.444854e-5
GO:0032707	negative regulation of interleukin-23 production	4.561685e-5
GO:0046632	alpha-beta T cell differentiation	4.781555e-5
GO:0048259	regulation of receptor-mediated endocytosis	4.819440e-5
GO:0009259	ribonucleotide metabolic process	4.832910e-5
GO:0002376	immune system process	4.857273e-5
GO:0007632	visual behavior	4.981084e-5
GO:0007321	sperm displacement	5.115382e-5
GO:0051343	positive regulation of cyclic-nucleotide phosphodiesterase activity	5.282613e-5
GO:0015698	inorganic anion transport	5.473595e-5
GO:0010757	negative regulation of plasminogen activation	5.499756e-5
GO:0007423	sensory organ development	5.544563e-5
GO:0001768	establishment of T cell polarity	5.652989e-5
GO:0050819	negative regulation of coagulation	5.684404e-5
GO:0001692	histamine metabolic process	5.847895e-5
GO:0070585	protein localization in mitochondrion	6.073308e-5
GO:0017187	peptidyl-glutamic acid carboxylation	6.129012e-5
GO:0097118	neuroligin clustering	6.236890e-5
GO:0001970	positive regulation of activation of membrane attack complex	6.236890e-5
GO:0031639	plasminogen activation	6.326237e-5
GO:0010872	regulation of cholesterol esterification	6.516922e-5
GO:0030194	positive regulation of blood coagulation	6.598991e-5
GO:0090231	regulation of spindle checkpoint	6.648404e-5
GO:0072659	protein localization in plasma membrane	6.673101e-5
GO:0009145	purine nucleoside triphosphate biosynthetic process	6.840379e-5
GO:0010984	regulation of lipoprotein particle clearance	6.870198e-5
GO:0051291	protein heterooligomerization	7.014501e-5
GO:0043535	regulation of blood vessel endothelial cell migration	7.102654e-5
GO:0006547	histidine metabolic process	7.185183e-5
GO:0060311	negative regulation of elastin catabolic process	7.218906e-5
GO:0060313	negative regulation of blood vessel remodeling	7.218906e-5
GO:0010711	negative regulation of collagen catabolic process	7.218906e-5
GO:0010703	negative regulation of histolysis	7.218906e-5
GO:0043537	negative regulation of blood vessel endothelial cell migration	7.339625e-5
GO:0010755	regulation of plasminogen activation	7.558398e-5
GO:0010758	regulation of macrophage chemotaxis	7.643111e-5
GO:0030198	extracellular matrix organization	7.670278e-5
GO:0090136	epithelial cell-cell adhesion	7.876015e-5
GO:0007509	mesoderm migration involved in gastrulation	8.144397e-5
GO:0070228	regulation of lymphocyte apoptosis	8.237191e-5
GO:0046034	ATP metabolic process	8.459288e-5
GO:0010812	negative regulation of cell-substrate adhesion	8.673684e-5
GO:0009206	purine ribonucleoside triphosphate biosynthetic process	8.699551e-5
GO:0071622	regulation of granulocyte chemotaxis	8.734361e-5
GO:0010641	positive regulation of platelet-derived growth factor receptor signaling pathway	8.783343e-5
GO:0010759	positive regulation of macrophage chemotaxis	8.786490e-5
GO:0032908	regulation of transforming growth factor beta1 production	8.800523e-5
GO:0072657	protein localization in membrane	8.910968e-5
GO:0050866	negative regulation of cell activation	9.048809e-5
GO:0042421	norepinephrine biosynthetic process	9.181280e-5
GO:0006706	steroid catabolic process	9.216354e-5
GO:0060088	auditory receptor cell stereocilium organization	9.297154e-5
GO:0070613	regulation of protein processing	9.826573e-5
GO:0034465	response to carbon monoxide	9.975502e-5
GO:0008625	induction of apoptosis via death domain receptors	1.005194e-4
GO:0045198	establishment of epithelial cell apical/basal polarity	1.014288e-4
GO:0006939	smooth muscle contraction	1.036975e-4
GO:0003084	positive regulation of systemic arterial blood pressure	1.040916e-4
GO:0030217	T cell differentiation	1.068646e-4
GO:0001867	complement activation, lectin pathway	1.071990e-4
GO:0085029	extracellular matrix assembly	1.085195e-4
GO:0048168	regulation of neuronal synaptic plasticity	1.089896e-4
GO:0031960	response to corticosteroid stimulus	1.107469e-4
GO:0072143	mesangial cell development	1.126271e-4
GO:0045777	positive regulation of blood pressure	1.146110e-4
GO:0030834	regulation of actin filament depolymerization	1.150645e-4
GO:0010748	negative regulation of plasma membrane long-chain fatty acid transport	1.162597e-4
GO:0000185	activation of MAPKKK activity	1.179282e-4
GO:2000377	regulation of reactive oxygen species metabolic process	1.181932e-4
GO:0003206	cardiac chamber morphogenesis	1.185084e-4
GO:0050779	RNA destabilization	1.192131e-4
GO:0048771	tissue remodeling	1.194804e-4
GO:0010594	regulation of endothelial cell migration	1.242872e-4
GO:0006766	vitamin metabolic process	1.254183e-4
GO:0045112	integrin biosynthetic process	1.255559e-4
GO:0007051	spindle organization	1.262662e-4
GO:0051937	catecholamine transport	1.313124e-4
GO:0030029	actin filament-based process	1.326035e-4
GO:0060119	inner ear receptor cell development	1.338950e-4
GO:0002115	store-operated calcium entry	1.362524e-4
GO:0006801	superoxide metabolic process	1.382352e-4
GO:0008633	activation of pro-apoptotic gene products	1.416077e-4
GO:0045416	positive regulation of interleukin-8 biosynthetic process	1.418649e-4
GO:0009142	nucleoside triphosphate biosynthetic process	1.422202e-4
GO:0009303	rRNA transcription	1.464443e-4
GO:0006904	vesicle docking involved in exocytosis	1.471544e-4
GO:0042098	T cell proliferation	1.479205e-4
GO:0071356	cellular response to tumor necrosis factor	1.497189e-4
GO:0048261	negative regulation of receptor-mediated endocytosis	1.517587e-4
GO:0009207	purine ribonucleoside triphosphate catabolic process	1.562174e-4
GO:0021984	adenohypophysis development	1.624168e-4
GO:0009146	purine nucleoside triphosphate catabolic process	1.629733e-4
GO:0048659	smooth muscle cell proliferation	1.646353e-4
GO:0007506	gonadal mesoderm development	1.646353e-4
GO:0048251	elastic fiber assembly	1.680560e-4
GO:0042743	hydrogen peroxide metabolic process	1.685156e-4
GO:0019532	oxalate transport	1.733252e-4
GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	1.769197e-4
GO:0050710	negative regulation of cytokine secretion	1.769272e-4
GO:0061143	alveolar primary septum development	1.810942e-4
GO:0035845	photoreceptor cell outer segment organization	1.811525e-4
GO:0050951	sensory perception of temperature stimulus	1.836405e-4
GO:0010466	negative regulation of peptidase activity	1.848748e-4
GO:0002606	positive regulation of dendritic cell antigen processing and presentation	1.869945e-4
GO:0007132	meiotic metaphase I	1.895347e-4
GO:0009201	ribonucleoside triphosphate biosynthetic process	1.897663e-4
GO:0072655	establishment of protein localization in mitochondrion	1.900032e-4
GO:0010609	posttranscriptional regulation of gene expression by mRNA localization	1.916300e-4
GO:0061157	mRNA destabilization	1.916300e-4
GO:0008628	induction of apoptosis by hormones	1.973944e-4
GO:0003161	cardiac conduction system development	1.976427e-4
GO:0006626	protein targeting to mitochondrion	2.023646e-4
GO:0009143	nucleoside triphosphate catabolic process	2.068446e-4
GO:0010810	regulation of cell-substrate adhesion	2.069340e-4
GO:0097116	gephyrin clustering	2.078747e-4
GO:0016337	cell-cell adhesion	2.210613e-4
GO:0002690	positive regulation of leukocyte chemotaxis	2.214109e-4
GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development	2.243123e-4
GO:0060356	leucine import	2.263700e-4
GO:0002883	regulation of hypersensitivity	2.268779e-4
GO:0031640	killing of cells of other organism	2.288781e-4
GO:0060070	canonical Wnt receptor signaling pathway	2.312047e-4
GO:0010763	positive regulation of fibroblast migration	2.345698e-4
GO:0044062	regulation of excretion	2.347492e-4
GO:0048241	epinephrine transport	2.380757e-4
GO:2000060	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process	2.425761e-4
GO:0009119	ribonucleoside metabolic process	2.461642e-4
GO:0006754	ATP biosynthetic process	2.540382e-4
GO:0048752	semicircular canal morphogenesis	2.560573e-4
GO:0015696	ammonium transport	2.578002e-4
GO:0007253	cytoplasmic sequestering of NF-kappaB	2.578002e-4
GO:0032462	regulation of protein homooligomerization	2.588139e-4
GO:0007268	synaptic transmission	2.589519e-4
GO:0009154	purine ribonucleotide catabolic process	2.611503e-4
GO:0042797	tRNA transcription from RNA polymerase III promoter	2.614160e-4
GO:0060973	cell migration involved in heart development	2.614160e-4
GO:0042791	5S class rRNA transcription from RNA polymerase III type 1 promoter	2.614160e-4
GO:0060117	auditory receptor cell development	2.676119e-4
GO:0003231	cardiac ventricle development	2.698435e-4
GO:0032925	regulation of activin receptor signaling pathway	2.702425e-4
GO:0010934	macrophage cytokine production	2.773325e-4
GO:0045040	protein import into mitochondrial outer membrane	2.788949e-4
GO:0019370	leukotriene biosynthetic process	2.793352e-4
GO:0042535	positive regulation of tumor necrosis factor biosynthetic process	2.801454e-4
GO:0009261	ribonucleotide catabolic process	2.885323e-4
GO:0010916	negative regulation of very-low-density lipoprotein particle clearance	2.900999e-4
GO:0034369	plasma lipoprotein particle remodeling	2.957156e-4
GO:0045806	negative regulation of endocytosis	2.968153e-4
GO:0002579	positive regulation of antigen processing and presentation	2.968942e-4
GO:0021636	trigeminal nerve morphogenesis	2.990891e-4
GO:0003308	negative regulation of Wnt receptor signaling pathway involved in heart development	3.042886e-4
GO:0065008	regulation of biological quality	3.067473e-4
GO:0018200	peptidyl-glutamic acid modification	3.080538e-4
GO:0097104	postsynaptic membrane assembly	3.150104e-4
GO:0097119	postsynaptic density protein 95 clustering	3.150104e-4
GO:0006691	leukotriene metabolic process	3.172592e-4
GO:0003205	cardiac chamber development	3.218524e-4
GO:0006693	prostaglandin metabolic process	3.232397e-4
GO:0051128	regulation of cellular component organization	3.237909e-4
GO:0001878	response to yeast	3.369943e-4
GO:0042542	response to hydrogen peroxide	3.384211e-4
GO:0042221	response to chemical stimulus	3.409344e-4
GO:0033077	T cell differentiation in thymus	3.414644e-4
GO:0002864	regulation of acute inflammatory response to antigenic stimulus	3.444221e-4
GO:0046333	octopamine metabolic process	3.513488e-4
GO:0042309	homoiothermy	3.513488e-4
GO:0034612	response to tumor necrosis factor	3.530896e-4
GO:0032926	negative regulation of activin receptor signaling pathway	3.532821e-4
GO:0021773	striatal medium spiny neuron differentiation	3.568160e-4
GO:0043586	tongue development	3.599001e-4
GO:0019228	regulation of action potential in neuron	3.619612e-4
GO:0043583	ear development	3.642560e-4
GO:0070213	protein auto-ADP-ribosylation	3.672686e-4
GO:0006911	phagocytosis, engulfment	3.801196e-4
GO:0015669	gas transport	3.815442e-4
GO:0006936	muscle contraction	4.019634e-4
GO:0048708	astrocyte differentiation	4.020408e-4
GO:0048711	positive regulation of astrocyte differentiation	4.090180e-4
GO:0034614	cellular response to reactive oxygen species	4.101497e-4
GO:0043534	blood vessel endothelial cell migration	4.121401e-4
GO:0008542	visual learning	4.121401e-4
GO:0032212	positive regulation of telomere maintenance via telomerase	4.155106e-4
GO:0032497	detection of lipopolysaccharide	4.194813e-4
GO:0050921	positive regulation of chemotaxis	4.330416e-4
GO:0060446	branching involved in open tracheal system development	4.363873e-4
GO:0048613	embryonic ectodermal digestive tract morphogenesis	4.363873e-4
GO:0060461	right lung morphogenesis	4.363873e-4
GO:0090131	mesenchyme migration	4.363873e-4
GO:0048371	lateral mesodermal cell differentiation	4.363873e-4
GO:0010107	potassium ion import	4.363873e-4
GO:0014822	detection of wounding	4.363873e-4
GO:0009416	response to light stimulus	4.455169e-4
GO:0002077	acrosome matrix dispersal	4.465073e-4
GO:0021523	somatic motor neuron differentiation	4.481468e-4
GO:0046128	purine ribonucleoside metabolic process	4.552221e-4
GO:0035082	axoneme assembly	4.627239e-4
GO:0072208	metanephric smooth muscle tissue development	4.782883e-4
GO:0072184	renal vesicle progenitor cell differentiation	4.782883e-4
GO:0072259	metanephric interstitial cell development	4.782883e-4
GO:0090094	metanephric cap mesenchymal cell proliferation involved in metanephros development	4.782883e-4
GO:0072169	specification of posterior mesonephric tubule identity	4.782883e-4
GO:0008065	establishment of blood-nerve barrier	4.782883e-4
GO:0072168	specification of anterior mesonephric tubule identity	4.782883e-4
GO:0010746	regulation of plasma membrane long-chain fatty acid transport	4.794245e-4
GO:0010596	negative regulation of endothelial cell migration	4.808742e-4
GO:0045019	negative regulation of nitric oxide biosynthetic process	4.914128e-4
GO:0034063	stress granule assembly	4.991437e-4
GO:0015671	oxygen transport	4.991437e-4
GO:0014873	response to muscle activity involved in regulation of muscle adaptation	4.996905e-4
GO:0061049	cell growth involved in cardiac muscle cell development	4.996905e-4
GO:0001998	angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure	4.996905e-4
GO:0003331	positive regulation of extracellular matrix constituent secretion	4.996905e-4
GO:0008637	apoptotic mitochondrial changes	5.114397e-4
GO:0048368	lateral mesoderm development	5.126177e-4
GO:0032891	negative regulation of organic acid transport	5.195069e-4
GO:0051893	regulation of focal adhesion assembly	5.214285e-4
GO:0015884	folic acid transport	5.269902e-4
GO:0010595	positive regulation of endothelial cell migration	5.283774e-4
GO:0007010	cytoskeleton organization	5.289675e-4
GO:0030177	positive regulation of Wnt receptor signaling pathway	5.320344e-4
GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	5.371192e-4
GO:0070327	thyroid hormone transport	5.405263e-4
GO:0001779	natural killer cell differentiation	5.458511e-4
GO:0050829	defense response to Gram-negative bacterium	5.477077e-4
GO:0044240	multicellular organismal lipid catabolic process	5.511714e-4
GO:0032571	response to vitamin K	5.543433e-4
GO:0071593	lymphocyte aggregation	5.547449e-4
GO:0035457	cellular response to interferon-alpha	5.652045e-4
GO:0008366	axon ensheathment	5.698034e-4
GO:0048210	Golgi vesicle fusion to target membrane	5.815933e-4
GO:0045355	negative regulation of interferon-alpha biosynthetic process	5.815933e-4
GO:0001516	prostaglandin biosynthetic process	5.818348e-4
GO:0070212	protein poly-ADP-ribosylation	5.972727e-4
GO:0050877	neurological system process	6.025205e-4
GO:0003199	endocardial cushion to mesenchymal transition involved in heart valve formation	6.049131e-4
GO:0072337	modified amino acid transport	6.129722e-4
GO:0009152	purine ribonucleotide biosynthetic process	6.131935e-4
GO:0051181	cofactor transport	6.157349e-4
GO:0045608	negative regulation of auditory receptor cell differentiation	6.191952e-4
GO:0090232	positive regulation of spindle checkpoint	6.308825e-4
GO:0003307	regulation of Wnt receptor signaling pathway involved in heart development	6.378597e-4
GO:0003179	heart valve morphogenesis	6.394867e-4
GO:0006725	cellular aromatic compound metabolic process	6.406534e-4
GO:0071529	cementum mineralization	6.532774e-4
GO:0006816	calcium ion transport	6.539807e-4
GO:0030048	actin filament-based movement	6.683629e-4
GO:0008285	negative regulation of cell proliferation	6.690498e-4
GO:0008360	regulation of cell shape	6.756682e-4
GO:0019049	evasion of host defenses by virus	6.861604e-4
GO:0051496	positive regulation of stress fiber assembly	6.887498e-4
GO:0010888	negative regulation of lipid storage	6.909821e-4
GO:0071675	regulation of mononuclear cell migration	6.961793e-4
GO:0010985	negative regulation of lipoprotein particle clearance	6.983648e-4
GO:0006200	ATP catabolic process	7.107512e-4
GO:0006884	cell volume homeostasis	7.271238e-4
GO:0014002	astrocyte development	7.278896e-4
GO:0050920	regulation of chemotaxis	7.293175e-4
GO:0001933	negative regulation of protein phosphorylation	7.385642e-4
GO:0048872	homeostasis of number of cells	7.463473e-4
GO:0003334	keratinocyte development	7.485889e-4
GO:0006695	cholesterol biosynthetic process	7.568365e-4
GO:0050896	response to stimulus	7.594221e-4
GO:0045930	negative regulation of mitotic cell cycle	7.628144e-4
GO:0051896	regulation of protein kinase B signaling cascade	7.753080e-4
GO:0060251	regulation of glial cell proliferation	7.763651e-4
GO:0042116	macrophage activation	7.769187e-4
GO:0050965	detection of temperature stimulus involved in sensory perception of pain	7.990308e-4
GO:0032383	regulation of intracellular cholesterol transport	7.990308e-4
GO:0006836	neurotransmitter transport	8.030851e-4
GO:0060426	lung vasculature development	8.034414e-4
GO:0035813	regulation of renal sodium excretion	8.127483e-4
GO:0043313	regulation of neutrophil degranulation	8.190317e-4
GO:0048857	neural nucleus development	8.194800e-4
GO:0045217	cell-cell junction maintenance	8.197242e-4
GO:0030299	intestinal cholesterol absorption	8.495546e-4
GO:0042558	pteridine-containing compound metabolic process	8.521822e-4
GO:0043900	regulation of multi-organism process	8.568749e-4
GO:0003157	endocardium development	8.822788e-4
GO:0071482	cellular response to light stimulus	8.847941e-4
GO:0007512	adult heart development	9.054029e-4
GO:0045620	negative regulation of lymphocyte differentiation	9.074549e-4
GO:0055099	response to high density lipoprotein particle stimulus	9.461526e-4
GO:0010543	regulation of platelet activation	9.648830e-4
GO:0048545	response to steroid hormone stimulus	9.682112e-4
GO:0032459	regulation of protein oligomerization	9.759398e-4
GO:0030432	peristalsis	9.787932e-4
GO:2000667	positive regulation of interleukin-13 secretion	1.030955e-3
GO:2000703	negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation	1.030955e-3
GO:2000734	negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation	1.030955e-3
GO:2000665	regulation of interleukin-13 secretion	1.030955e-3
GO:0040040	thermosensory behavior	1.030955e-3
GO:2000664	positive regulation of interleukin-5 secretion	1.030955e-3
GO:2000607	negative regulation of cell proliferation involved in mesonephros development	1.030955e-3

GREAT analysis results for mouseGenomic Enrichment of Annotations Tool (GREAT, Nat Biotechnol. 2010 May;28(5):495-501) is used to identify, both in human and in mouse, the gene ontology terms of biological processes enriched given the predicted TFBSs, and evaluated the overlap in the top-500 gene ontology terms between human and mouse. For each novel motif, the P value for the overlap was then evaluated by calculating its relative rank with respect to this background distribution.<br>Analyst: Michiel de Hoon <br><br>link to source dataset <br>data

---

GO ID	GO Term	p-value
GO:0045940	positive regulation of steroid metabolic process	1.288429e-15
GO:0019218	regulation of steroid metabolic process	1.540320e-15
GO:0033700	phospholipid efflux	8.335341e-13
GO:0034369	plasma lipoprotein particle remodeling	1.107385e-11
GO:0060192	negative regulation of lipase activity	2.150423e-11
GO:0030301	cholesterol transport	3.786042e-11
GO:0046890	regulation of lipid biosynthetic process	4.264106e-11
GO:0034382	chylomicron remnant clearance	1.291169e-10
GO:0010872	regulation of cholesterol esterification	1.564439e-10
GO:0010916	negative regulation of very-low-density lipoprotein particle clearance	1.642276e-10
GO:0033344	cholesterol efflux	6.939116e-10
GO:0010873	positive regulation of cholesterol esterification	7.215566e-10
GO:0042304	regulation of fatty acid biosynthetic process	8.042770e-10
GO:0010984	regulation of lipoprotein particle clearance	1.559570e-9
GO:0051005	negative regulation of lipoprotein lipase activity	1.653868e-9
GO:0032374	regulation of cholesterol transport	1.800046e-9
GO:0010985	negative regulation of lipoprotein particle clearance	1.994234e-9
GO:0032352	positive regulation of hormone metabolic process	3.990110e-9
GO:0010900	negative regulation of phosphatidylcholine catabolic process	4.296273e-9
GO:0002924	negative regulation of humoral immune response mediated by circulating immunoglobulin	4.383551e-9
GO:0050810	regulation of steroid biosynthetic process	1.049043e-8
GO:0045717	negative regulation of fatty acid biosynthetic process	1.321098e-8
GO:0010901	regulation of very-low-density lipoprotein particle remodeling	1.657300e-8
GO:0071827	plasma lipoprotein particle organization	3.790273e-8
GO:0048739	cardiac muscle fiber development	5.595884e-8
GO:0016074	snoRNA metabolic process	5.890449e-8
GO:0032350	regulation of hormone metabolic process	6.763974e-8
GO:0010893	positive regulation of steroid biosynthetic process	7.482825e-8
GO:0032375	negative regulation of cholesterol transport	9.407317e-8
GO:0006641	triglyceride metabolic process	1.002624e-7
GO:0033490	cholesterol biosynthetic process via lathosterol	1.630442e-7
GO:0046885	regulation of hormone biosynthetic process	2.308109e-7
GO:0060191	regulation of lipase activity	2.667164e-7
GO:0090031	positive regulation of steroid hormone biosynthetic process	2.848020e-7
GO:0002227	innate immune response in mucosa	3.317290e-7
GO:0051004	regulation of lipoprotein lipase activity	3.867892e-7
GO:0046464	acylglycerol catabolic process	3.935455e-7
GO:0090030	regulation of steroid hormone biosynthetic process	3.938864e-7
GO:0019433	triglyceride catabolic process	3.986751e-7
GO:0046886	positive regulation of hormone biosynthetic process	4.473443e-7
GO:0060696	regulation of phospholipid catabolic process	4.838520e-7
GO:0002642	positive regulation of immunoglobulin biosynthetic process	5.084655e-7
GO:0002456	T cell mediated immunity	6.270316e-7
GO:0034447	very-low-density lipoprotein particle clearance	6.816690e-7
GO:0046889	positive regulation of lipid biosynthetic process	1.118041e-6
GO:0010902	positive regulation of very-low-density lipoprotein particle remodeling	1.245582e-6
GO:0050995	negative regulation of lipid catabolic process	1.497797e-6
GO:0050927	positive regulation of positive chemotaxis	1.606276e-6
GO:0006982	response to lipid hydroperoxide	1.692026e-6
GO:0046503	glycerolipid catabolic process	1.780222e-6
GO:0070328	triglyceride homeostasis	1.917737e-6
GO:0030300	regulation of intestinal cholesterol absorption	2.060157e-6
GO:0048261	negative regulation of receptor-mediated endocytosis	2.066787e-6
GO:0043503	skeletal muscle fiber adaptation	2.361643e-6
GO:0008203	cholesterol metabolic process	2.463319e-6
GO:0002449	lymphocyte mediated immunity	2.602813e-6
GO:0019216	regulation of lipid metabolic process	2.644318e-6
GO:0060037	pharyngeal system development	2.840516e-6
GO:0055090	acylglycerol homeostasis	3.005374e-6
GO:0090181	regulation of cholesterol metabolic process	3.180198e-6
GO:0045922	negative regulation of fatty acid metabolic process	3.321554e-6
GO:0045834	positive regulation of lipid metabolic process	3.553457e-6
GO:0050921	positive regulation of chemotaxis	3.641427e-6
GO:0006639	acylglycerol metabolic process	3.970595e-6
GO:0033238	regulation of cellular amine metabolic process	4.842982e-6
GO:0050930	induction of positive chemotaxis	5.386434e-6
GO:0006638	neutral lipid metabolic process	6.380989e-6
GO:0050926	regulation of positive chemotaxis	6.900758e-6
GO:0044058	regulation of digestive system process	7.072659e-6
GO:0030241	skeletal muscle myosin thick filament assembly	7.073418e-6
GO:0006869	lipid transport	8.026591e-6
GO:0008207	C21-steroid hormone metabolic process	8.910233e-6
GO:0010876	lipid localization	1.052097e-5
GO:0048520	positive regulation of behavior	1.217779e-5
GO:0051129	negative regulation of cellular component organization	1.434747e-5
GO:0043691	reverse cholesterol transport	1.525745e-5
GO:0060415	muscle tissue morphogenesis	1.622071e-5
GO:0033239	negative regulation of cellular amine metabolic process	1.626971e-5
GO:0072376	protein activation cascade	1.637822e-5
GO:0016079	synaptic vesicle exocytosis	1.642391e-5
GO:0016125	sterol metabolic process	1.925989e-5
GO:0060290	transdifferentiation	2.057703e-5
GO:0002443	leukocyte mediated immunity	2.242044e-5
GO:0002921	negative regulation of humoral immune response	2.282112e-5
GO:0000305	response to oxygen radical	2.439285e-5
GO:0045065	cytotoxic T cell differentiation	2.454185e-5
GO:0006956	complement activation	2.624819e-5
GO:0048747	muscle fiber development	2.691908e-5
GO:0045540	regulation of cholesterol biosynthetic process	2.786667e-5
GO:0032369	negative regulation of lipid transport	3.109990e-5
GO:0007218	neuropeptide signaling pathway	3.206214e-5
GO:0050994	regulation of lipid catabolic process	3.208114e-5
GO:0003012	muscle system process	3.680187e-5
GO:0060620	regulation of cholesterol import	3.696092e-5
GO:0032693	negative regulation of interleukin-10 production	4.069308e-5
GO:0010896	regulation of triglyceride catabolic process	4.253069e-5
GO:0001867	complement activation, lectin pathway	4.337247e-5
GO:0045577	regulation of B cell differentiation	4.930709e-5
GO:0002358	B cell homeostatic proliferation	5.035404e-5
GO:0001845	phagolysosome assembly	5.035404e-5
GO:0055010	ventricular cardiac muscle tissue morphogenesis	5.085895e-5
GO:0006936	muscle contraction	5.182466e-5
GO:0010625	positive regulation of Schwann cell proliferation	5.429870e-5
GO:0060621	negative regulation of cholesterol import	5.554487e-5
GO:0000303	response to superoxide	5.557016e-5
GO:0019240	citrulline biosynthetic process	5.870005e-5
GO:0044342	type B pancreatic cell proliferation	5.936938e-5
GO:0018101	peptidyl-citrulline biosynthetic process from peptidyl-arginine	5.936938e-5
GO:0002635	negative regulation of germinal center formation	5.936938e-5
GO:0031034	myosin filament assembly	5.979638e-5
GO:0051615	histamine uptake	6.047047e-5
GO:0006642	triglyceride mobilization	6.369591e-5
GO:0097006	regulation of plasma lipoprotein particle levels	6.414908e-5
GO:0060537	muscle tissue development	7.311725e-5
GO:0002830	positive regulation of type 2 immune response	7.545503e-5
GO:0035640	exploration behavior	8.374319e-5
GO:0006662	glycerol ether metabolic process	8.674701e-5
GO:0003229	ventricular cardiac muscle tissue development	9.108193e-5
GO:0042492	gamma-delta T cell differentiation	9.487274e-5
GO:0003208	cardiac ventricle morphogenesis	9.527296e-5
GO:0044062	regulation of excretion	9.603164e-5
GO:0051342	regulation of cyclic-nucleotide phosphodiesterase activity	1.065995e-4
GO:0042632	cholesterol homeostasis	1.077384e-4
GO:0051494	negative regulation of cytoskeleton organization	1.087162e-4
GO:0007016	cytoskeletal anchoring at plasma membrane	1.089685e-4
GO:0006700	C21-steroid hormone biosynthetic process	1.090232e-4
GO:0050819	negative regulation of coagulation	1.171417e-4
GO:0032368	regulation of lipid transport	1.187404e-4
GO:0090102	cochlea development	1.191375e-4
GO:0010454	negative regulation of cell fate commitment	1.231141e-4
GO:0009582	detection of abiotic stimulus	1.233714e-4
GO:0017004	cytochrome complex assembly	1.260128e-4
GO:0007517	muscle organ development	1.261116e-4
GO:0032094	response to food	1.345103e-4
GO:0060754	positive regulation of mast cell chemotaxis	1.348549e-4
GO:0046600	negative regulation of centriole replication	1.355099e-4
GO:0007269	neurotransmitter secretion	1.411391e-4
GO:0002707	negative regulation of lymphocyte mediated immunity	1.468427e-4
GO:0050760	negative regulation of thymidylate synthase biosynthetic process	1.531335e-4
GO:0018364	peptidyl-glutamine methylation	1.531335e-4
GO:0008633	activation of pro-apoptotic gene products	1.542384e-4
GO:0071169	establishment of protein localization to chromatin	1.562717e-4
GO:0034370	triglyceride-rich lipoprotein particle remodeling	1.565050e-4
GO:0005997	xylulose metabolic process	1.602607e-4
GO:0019430	removal of superoxide radicals	1.721713e-4
GO:0001844	protein insertion into mitochondrial membrane involved in induction of apoptosis	1.787774e-4
GO:0002823	negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	1.813187e-4
GO:0034381	plasma lipoprotein particle clearance	1.895260e-4
GO:0032231	regulation of actin filament bundle assembly	2.033986e-4
GO:0042732	D-xylose metabolic process	2.110323e-4
GO:0002460	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	2.125011e-4
GO:0000387	spliceosomal snRNP assembly	2.238300e-4
GO:0060193	positive regulation of lipase activity	2.269853e-4
GO:0050746	regulation of lipoprotein metabolic process	2.326522e-4
GO:0032103	positive regulation of response to external stimulus	2.515230e-4
GO:0010982	regulation of high-density lipoprotein particle clearance	2.537528e-4
GO:0045906	negative regulation of vasoconstriction	2.695829e-4
GO:0045806	negative regulation of endocytosis	2.728934e-4
GO:0061061	muscle structure development	2.745088e-4
GO:0003205	cardiac chamber development	2.762933e-4
GO:0055009	atrial cardiac muscle tissue morphogenesis	2.763890e-4
GO:0003231	cardiac ventricle development	2.800590e-4
GO:0014706	striated muscle tissue development	2.813899e-4
GO:0031100	organ regeneration	2.855593e-4
GO:0033979	box H/ACA snoRNA metabolic process	2.999249e-4
GO:0046086	adenosine biosynthetic process	2.999249e-4
GO:0010918	positive regulation of mitochondrial membrane potential	2.999249e-4
GO:0006196	AMP catabolic process	2.999249e-4
GO:0002690	positive regulation of leukocyte chemotaxis	3.022061e-4
GO:0007522	visceral muscle development	3.056240e-4
GO:0061041	regulation of wound healing	3.179545e-4
GO:0030878	thyroid gland development	3.234349e-4
GO:0030029	actin filament-based process	3.239792e-4
GO:0045823	positive regulation of heart contraction	3.448744e-4
GO:0034374	low-density lipoprotein particle remodeling	3.610703e-4
GO:0042790	transcription of nuclear large rRNA transcript from RNA polymerase I promoter	3.821671e-4
GO:0035691	macrophage migration inhibitory factor signaling pathway	3.821671e-4
GO:0018904	organic ether metabolic process	3.994927e-4
GO:0007010	cytoskeleton organization	4.073149e-4
GO:0008211	glucocorticoid metabolic process	4.134689e-4
GO:0034551	mitochondrial respiratory chain complex III assembly	4.247503e-4
GO:0002897	positive regulation of central B cell tolerance induction	4.247503e-4
GO:0002508	central tolerance induction	4.247503e-4
GO:0000238	zygotene	4.247503e-4
GO:0090183	regulation of kidney development	4.349980e-4
GO:0019884	antigen processing and presentation of exogenous antigen	4.417671e-4
GO:0034372	very-low-density lipoprotein particle remodeling	4.428985e-4
GO:0002902	regulation of B cell apoptosis	4.438161e-4
GO:0007183	SMAD protein complex assembly	4.459320e-4
GO:0006887	exocytosis	4.509764e-4
GO:0043279	response to alkaloid	4.576840e-4
GO:0007202	activation of phospholipase C activity	4.708384e-4
GO:0045343	regulation of MHC class I biosynthetic process	4.719019e-4
GO:0065008	regulation of biological quality	4.761751e-4
GO:0042454	ribonucleoside catabolic process	4.835093e-4
GO:0045579	positive regulation of B cell differentiation	4.848018e-4
GO:0002250	adaptive immune response	4.864232e-4
GO:0008202	steroid metabolic process	5.104239e-4
GO:0061290	canonical Wnt receptor signaling pathway involved in metanephric kidney development	5.235191e-4
GO:0046599	regulation of centriole replication	5.235191e-4
GO:0030195	negative regulation of blood coagulation	5.387468e-4
GO:0045217	cell-cell junction maintenance	5.390648e-4
GO:0043583	ear development	5.432377e-4
GO:0042730	fibrinolysis	5.464910e-4
GO:0046604	positive regulation of mitotic centrosome separation	5.465623e-4
GO:0002923	regulation of humoral immune response mediated by circulating immunoglobulin	5.530068e-4
GO:0048644	muscle organ morphogenesis	5.638317e-4
GO:0048878	chemical homeostasis	5.678282e-4
GO:0055008	cardiac muscle tissue morphogenesis	5.802887e-4
GO:0009133	nucleoside diphosphate biosynthetic process	5.972229e-4
GO:0002478	antigen processing and presentation of exogenous peptide antigen	6.099404e-4
GO:0051346	negative regulation of hydrolase activity	6.174792e-4
GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity	6.438527e-4
GO:2000611	positive regulation of thyroid hormone generation	6.501459e-4
GO:0006066	alcohol metabolic process	6.558890e-4
GO:0046434	organophosphate catabolic process	6.596036e-4
GO:0070869	heterochromatin formation involved in chromatin silencing	6.631349e-4
GO:0070327	thyroid hormone transport	6.705445e-4
GO:0030049	muscle filament sliding	6.925847e-4
GO:0030035	microspike assembly	6.988235e-4
GO:0001935	endothelial cell proliferation	7.102562e-4
GO:0046874	quinolinate metabolic process	7.377651e-4
GO:0002088	lens development in camera-type eye	7.438040e-4
GO:0071956	cellular component maintenance at cellular level	7.478199e-4
GO:0003350	pulmonary myocardium development	7.607359e-4
GO:0051204	protein insertion into mitochondrial membrane	7.776997e-4
GO:0060070	canonical Wnt receptor signaling pathway	7.779741e-4
GO:0072513	positive regulation of secondary heart field cardioblast proliferation	8.016397e-4
GO:0060026	convergent extension	8.034978e-4
GO:0009887	organ morphogenesis	8.184559e-4
GO:0006958	complement activation, classical pathway	8.205664e-4
GO:0045647	negative regulation of erythrocyte differentiation	8.409688e-4
GO:0033085	negative regulation of T cell differentiation in thymus	8.409688e-4
GO:0003206	cardiac chamber morphogenesis	8.457571e-4
GO:0009115	xanthine catabolic process	8.513485e-4
GO:0034445	negative regulation of plasma lipoprotein particle oxidation	8.521191e-4
GO:0015671	oxygen transport	8.521191e-4
GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling	8.521191e-4
GO:0045345	positive regulation of MHC class I biosynthetic process	8.923209e-4
GO:0060307	regulation of ventricular cardiomyocyte membrane repolarization	9.374145e-4
GO:0060299	negative regulation of sarcomere organization	9.374145e-4
GO:0006258	UDP-glucose catabolic process	9.374145e-4
GO:0010455	positive regulation of cell fate commitment	9.374145e-4
GO:0034442	regulation of lipoprotein oxidation	9.439339e-4
GO:0045608	negative regulation of auditory receptor cell differentiation	9.603089e-4
GO:0010897	negative regulation of triglyceride catabolic process	9.603089e-4
GO:0010987	negative regulation of high-density lipoprotein particle clearance	9.603089e-4
GO:0045576	mast cell activation	9.638155e-4
GO:0032101	regulation of response to external stimulus	9.727403e-4
GO:0070627	ferrous iron import	1.007200e-3
GO:0090177	establishment of planar polarity involved in neural tube closure	1.007200e-3
GO:0008057	eye pigment granule organization	1.007200e-3
GO:0046853	inositol or phosphatidylinositol phosphorylation	1.007200e-3
GO:0015692	lead ion transport	1.007200e-3
GO:0015676	vanadium ion transport	1.007200e-3
GO:0032233	positive regulation of actin filament bundle assembly	1.025023e-3
GO:0009581	detection of external stimulus	1.031980e-3
GO:0070306	lens fiber cell differentiation	1.036066e-3
GO:0002889	regulation of immunoglobulin mediated immune response	1.055596e-3
GO:0060020	Bergmann glial cell differentiation	1.058161e-3
GO:0045723	positive regulation of fatty acid biosynthetic process	1.059278e-3
GO:0035304	regulation of protein dephosphorylation	1.093259e-3
GO:0002086	diaphragm contraction	1.103792e-3
GO:0045226	extracellular polysaccharide biosynthetic process	1.103792e-3
GO:0019359	nicotinamide nucleotide biosynthetic process	1.126249e-3
GO:0009996	negative regulation of cell fate specification	1.126249e-3
GO:0042267	natural killer cell mediated cytotoxicity	1.129952e-3
GO:0048731	system development	1.136536e-3
GO:0002495	antigen processing and presentation of peptide antigen via MHC class II	1.151317e-3
GO:0051344	negative regulation of cyclic-nucleotide phosphodiesterase activity	1.155529e-3
GO:0022417	protein maturation by protein folding	1.155529e-3
GO:0051239	regulation of multicellular organismal process	1.188391e-3
GO:0002740	negative regulation of cytokine secretion involved in immune response	1.199695e-3
GO:0006959	humoral immune response	1.210036e-3
GO:0050748	negative regulation of lipoprotein metabolic process	1.215650e-3
GO:0007423	sensory organ development	1.217656e-3
GO:0033025	regulation of mast cell apoptosis	1.244822e-3
GO:0006917	induction of apoptosis	1.245005e-3
GO:0046110	xanthine metabolic process	1.247395e-3
GO:0032717	negative regulation of interleukin-8 production	1.247395e-3
GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	1.249242e-3
GO:0006438	valyl-tRNA aminoacylation	1.249242e-3
GO:0010863	positive regulation of phospholipase C activity	1.262675e-3
GO:0043502	regulation of muscle adaptation	1.277657e-3
GO:0051492	regulation of stress fiber assembly	1.278170e-3
GO:0070670	response to interleukin-4	1.287026e-3
GO:0051905	establishment of pigment granule localization	1.303277e-3
GO:0060251	regulation of glial cell proliferation	1.307971e-3
GO:0048729	tissue morphogenesis	1.323426e-3
GO:0002820	negative regulation of adaptive immune response	1.325699e-3
GO:0060749	mammary gland alveolus development	1.347637e-3
GO:0071702	organic substance transport	1.379783e-3
GO:0012502	induction of programmed cell death	1.405109e-3
GO:0048563	post-embryonic organ morphogenesis	1.425945e-3
GO:0002385	mucosal immune response	1.425945e-3
GO:0008105	asymmetric protein localization	1.430786e-3
GO:0009164	nucleoside catabolic process	1.457437e-3
GO:0007621	negative regulation of female receptivity	1.496409e-3
GO:0045607	regulation of auditory receptor cell differentiation	1.496409e-3
GO:0000052	citrulline metabolic process	1.496409e-3
GO:0055088	lipid homeostasis	1.499252e-3
GO:0032736	positive regulation of interleukin-13 production	1.499526e-3
GO:0030263	apoptotic chromosome condensation	1.501800e-3
GO:0002352	B cell negative selection	1.501800e-3
GO:0009169	purine ribonucleoside monophosphate catabolic process	1.501800e-3
GO:0003016	respiratory system process	1.515882e-3
GO:0045930	negative regulation of mitotic cell cycle	1.535246e-3
GO:0051919	positive regulation of fibrinolysis	1.550858e-3
GO:0070366	regulation of hepatocyte differentiation	1.550858e-3
GO:0006705	mineralocorticoid biosynthetic process	1.552665e-3
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	1.566993e-3
GO:0002739	regulation of cytokine secretion involved in immune response	1.572278e-3
GO:0032026	response to magnesium ion	1.575749e-3
GO:0051006	positive regulation of lipoprotein lipase activity	1.625024e-3
GO:0061009	common bile duct development	1.633689e-3
GO:0045542	positive regulation of cholesterol biosynthetic process	1.633689e-3
GO:0030036	actin cytoskeleton organization	1.634364e-3
GO:0042537	benzene-containing compound metabolic process	1.668293e-3
GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase cascade	1.685893e-3
GO:0008637	apoptotic mitochondrial changes	1.748000e-3
GO:0016998	cell wall macromolecule catabolic process	1.751062e-3
GO:0090086	negative regulation of protein deubiquitination	1.791948e-3
GO:0071674	mononuclear cell migration	1.791948e-3
GO:0003094	glomerular filtration	1.791948e-3
GO:0042946	glucoside transport	1.791948e-3
GO:0032571	response to vitamin K	1.799153e-3
GO:0034375	high-density lipoprotein particle remodeling	1.800520e-3
GO:0019852	L-ascorbic acid metabolic process	1.843301e-3
GO:0006584	catecholamine metabolic process	1.862864e-3
GO:0016576	histone dephosphorylation	1.869232e-3
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	1.908289e-3
GO:0048239	negative regulation of DNA recombination at telomere	1.911568e-3
GO:0042450	arginine biosynthetic process via ornithine	1.911568e-3
GO:0006430	lysyl-tRNA aminoacylation	1.911568e-3
GO:0019676	ammonia assimilation cycle	1.911568e-3
GO:0033617	mitochondrial respiratory chain complex IV assembly	1.911568e-3
GO:0048690	regulation of axon extension involved in regeneration	1.928595e-3
GO:0035552	oxidative single-stranded DNA demethylation	1.928595e-3
GO:0051297	centrosome organization	2.007888e-3
GO:0042220	response to cocaine	2.007888e-3
GO:0050982	detection of mechanical stimulus	2.019642e-3
GO:0048839	inner ear development	2.081364e-3
GO:0015734	taurine transport	2.116001e-3
GO:0002904	positive regulation of B cell apoptosis	2.126174e-3
GO:0006811	ion transport	2.128574e-3
GO:0050847	progesterone receptor signaling pathway	2.133728e-3
GO:0035235	ionotropic glutamate receptor signaling pathway	2.150502e-3
GO:0003007	heart morphogenesis	2.172291e-3
GO:0070383	DNA cytosine deamination	2.211896e-3
GO:0043985	histone H4-R3 methylation	2.211896e-3
GO:0010529	negative regulation of transposition	2.211896e-3
GO:0010977	negative regulation of neuron projection development	2.232189e-3
GO:0003062	regulation of heart rate by chemical signal	2.235533e-3
GO:0003008	system process	2.236130e-3
GO:0060029	convergent extension involved in organogenesis	2.240399e-3
GO:0016575	histone deacetylation	2.264588e-3
GO:2000172	regulation of branching morphogenesis of a nerve	2.336904e-3
GO:0060359	response to ammonium ion	2.336904e-3
GO:0010624	regulation of Schwann cell proliferation	2.336904e-3
GO:0050920	regulation of chemotaxis	2.347832e-3
GO:0042662	negative regulation of mesodermal cell fate specification	2.398775e-3
GO:0044242	cellular lipid catabolic process	2.424707e-3
GO:0016477	cell migration	2.429565e-3
GO:0033131	regulation of glucokinase activity	2.434973e-3
GO:0034421	post-translational protein acetylation	2.461518e-3
GO:0021915	neural tube development	2.463680e-3
GO:0032656	regulation of interleukin-13 production	2.478163e-3
GO:0051608	histamine transport	2.534382e-3
GO:0001707	mesoderm formation	2.564305e-3
GO:0015914	phospholipid transport	2.583702e-3
GO:0031558	induction of apoptosis in response to chemical stimulus	2.628403e-3
GO:0071287	cellular response to manganese ion	2.628403e-3
GO:0051085	chaperone mediated protein folding requiring cofactor	2.630705e-3
GO:0018958	phenol-containing compound metabolic process	2.642602e-3
GO:0019722	calcium-mediated signaling	2.712146e-3
GO:0006145	purine base catabolic process	2.739812e-3
GO:0002687	positive regulation of leukocyte migration	2.767659e-3
GO:0001777	T cell homeostatic proliferation	2.799780e-3
GO:0034770	histone H4-K20 methylation	2.832402e-3
GO:0048513	organ development	2.861433e-3
GO:0007200	activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	2.884726e-3
GO:0043181	vacuolar sequestering	2.888306e-3
GO:0032383	regulation of intracellular cholesterol transport	2.888306e-3
GO:0001811	negative regulation of type I hypersensitivity	2.888306e-3
GO:0002638	negative regulation of immunoglobulin production	2.888306e-3
GO:0051917	regulation of fibrinolysis	2.950692e-3
GO:0061037	negative regulation of cartilage development	2.970826e-3
GO:0048016	inositol phosphate-mediated signaling	2.979953e-3
GO:2000227	negative regulation of pancreatic A cell differentiation	2.983908e-3
GO:2000978	negative regulation of forebrain neuron differentiation	2.983908e-3
GO:0061106	negative regulation of stomach neuroendocrine cell differentiation	2.983908e-3
GO:0046331	lateral inhibition	2.983908e-3
GO:0048597	post-embryonic camera-type eye morphogenesis	2.983908e-3
GO:0050918	positive chemotaxis	2.992418e-3
GO:0002688	regulation of leukocyte chemotaxis	2.996597e-3
GO:0061002	negative regulation of dendritic spine morphogenesis	3.025986e-3
GO:0043420	anthranilate metabolic process	3.072476e-3
GO:0050861	positive regulation of B cell receptor signaling pathway	3.072476e-3
GO:0034516	response to vitamin B6	3.072476e-3
GO:0002430	complement receptor mediated signaling pathway	3.072476e-3
GO:0043462	regulation of ATPase activity	3.145498e-3
GO:0003230	cardiac atrium development	3.165372e-3
GO:0006939	smooth muscle contraction	3.215021e-3
GO:0045619	regulation of lymphocyte differentiation	3.252948e-3
GO:0051496	positive regulation of stress fiber assembly	3.256527e-3
GO:0002251	organ or tissue specific immune response	3.264714e-3
GO:0051336	regulation of hydrolase activity	3.356419e-3
GO:0050818	regulation of coagulation	3.385672e-3
GO:0060068	vagina development	3.391306e-3
GO:0010898	positive regulation of triglyceride catabolic process	3.402448e-3
GO:0001505	regulation of neurotransmitter levels	3.408106e-3
GO:0002572	pro-T cell differentiation	3.428985e-3
GO:0050996	positive regulation of lipid catabolic process	3.442618e-3
GO:0031345	negative regulation of cell projection organization	3.524403e-3
GO:0050801	ion homeostasis	3.573888e-3
GO:0048144	fibroblast proliferation	3.711761e-3
GO:0035725	sodium ion transmembrane transport	3.716780e-3
GO:0051901	positive regulation of mitochondrial depolarization	3.739019e-3
GO:0031579	membrane raft organization	3.763018e-3
GO:0010350	cellular response to magnesium starvation	3.785919e-3
GO:0007340	acrosome reaction	3.795627e-3
GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	3.827984e-3
GO:0035094	response to nicotine	3.844164e-3
GO:0030048	actin filament-based movement	3.844164e-3
GO:0010518	positive regulation of phospholipase activity	3.892285e-3
GO:0046847	filopodium assembly	3.918147e-3
GO:0010951	negative regulation of endopeptidase activity	4.024809e-3
GO:0071242	cellular response to ammonium ion	4.038928e-3
GO:0051918	negative regulation of fibrinolysis	4.045739e-3
GO:0050710	negative regulation of cytokine secretion	4.056604e-3
GO:0006704	glucocorticoid biosynthetic process	4.077509e-3
GO:0072182	regulation of nephron tubule epithelial cell differentiation	4.223896e-3
GO:0016055	Wnt receptor signaling pathway	4.260256e-3
GO:0046031	ADP metabolic process	4.283959e-3
GO:0007527	adult somatic muscle development	4.295869e-3
GO:0044240	multicellular organismal lipid catabolic process	4.318692e-3
GO:0043954	cellular component maintenance	4.419253e-3
GO:2000273	positive regulation of receptor activity	4.419253e-3
GO:0052548	regulation of endopeptidase activity	4.450670e-3
GO:0030509	BMP signaling pathway	4.523783e-3
GO:0001906	cell killing	4.556816e-3
GO:0042157	lipoprotein metabolic process	4.566867e-3
GO:2000043	regulation of cardiac cell fate specification	4.593309e-3
GO:0070367	negative regulation of hepatocyte differentiation	4.616354e-3
GO:0021501	prechordal plate formation	4.616354e-3
GO:0021547	midbrain-hindbrain boundary initiation	4.616354e-3
GO:0019725	cellular homeostasis	4.636969e-3
GO:0034097	response to cytokine stimulus	4.647271e-3
GO:0009132	nucleoside diphosphate metabolic process	4.726839e-3
GO:0046653	tetrahydrofolate metabolic process	4.728110e-3
GO:0045833	negative regulation of lipid metabolic process	4.737008e-3
GO:0050917	sensory perception of umami taste	4.741076e-3
GO:0072272	proximal/distal pattern formation involved in metanephric nephron development	4.885381e-3
GO:0060480	lung goblet cell differentiation	4.885381e-3
GO:0010611	regulation of cardiac muscle hypertrophy	4.886372e-3
GO:0010989	negative regulation of low-density lipoprotein particle clearance	4.914465e-3
GO:0006760	folic acid-containing compound metabolic process	4.951239e-3
GO:0060841	venous blood vessel development	4.960797e-3
GO:0061326	renal tubule development	5.013260e-3
GO:0048489	synaptic vesicle transport	5.043564e-3
GO:0048870	cell motility	5.105548e-3
GO:0051656	establishment of organelle localization	5.145333e-3
GO:0010638	positive regulation of organelle organization	5.146969e-3
GO:0032844	regulation of homeostatic process	5.261497e-3
GO:0035814	negative regulation of renal sodium excretion	5.324152e-3
GO:0051602	response to electrical stimulus	5.368274e-3
GO:0035121	tail morphogenesis	5.369774e-3
GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway	5.387925e-3
GO:0035813	regulation of renal sodium excretion	5.390544e-3
GO:0043434	response to peptide hormone stimulus	5.505051e-3
GO:0060627	regulation of vesicle-mediated transport	5.508982e-3
GO:0032836	glomerular basement membrane development	5.511302e-3
GO:0071316	cellular response to nicotine	5.511302e-3
GO:0009972	cytidine deamination	5.511302e-3
GO:0002507	tolerance induction	5.538235e-3
GO:0090189	regulation of branching involved in ureteric bud morphogenesis	5.582139e-3
GO:0043406	positive regulation of MAP kinase activity	5.601325e-3
GO:0032674	regulation of interleukin-5 production	5.615846e-3
GO:0014743	regulation of muscle hypertrophy	5.615846e-3
GO:0085029	extracellular matrix assembly	5.654362e-3
GO:0042035	regulation of cytokine biosynthetic process	5.702327e-3
GO:0009258	10-formyltetrahydrofolate catabolic process	5.738922e-3
GO:0072337	modified amino acid transport	5.741887e-3
GO:0070307	lens fiber cell development	5.743327e-3
GO:0010641	positive regulation of platelet-derived growth factor receptor signaling pathway	5.767065e-3
GO:0002115	store-operated calcium entry	5.767065e-3
GO:0006941	striated muscle contraction	5.847240e-3
GO:0006507	GPI anchor release	5.852559e-3
GO:0060807	regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification	5.852559e-3
GO:0003142	cardiogenic plate morphogenesis	5.852559e-3
GO:0001828	inner cell mass cellular morphogenesis	5.852559e-3
GO:0009435	NAD biosynthetic process	5.859169e-3
GO:0009612	response to mechanical stimulus	5.878115e-3
GO:0051055	negative regulation of lipid biosynthetic process	5.908151e-3
GO:0006694	steroid biosynthetic process	5.942785e-3
GO:0060913	cardiac cell fate determination	5.943137e-3
GO:0030001	metal ion transport	5.960999e-3
GO:0032869	cellular response to insulin stimulus	6.032884e-3
GO:0032754	positive regulation of interleukin-5 production	6.117746e-3
GO:0070933	histone H4 deacetylation	6.145784e-3