CL:0000453: Difference between revisions
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|located_in= | |located_in= | ||
|name=Langerhans cell | |name=Langerhans cell | ||
|namespace= | |namespace=FANTOM | ||
|obo_creation_date= | |obo_creation_date= | ||
|part_of= | |part_of= | ||
Latest revision as of 16:33, 12 September 2014
| Name: | Langerhans cell | ||
|---|---|---|---|
| Namespace: | FANTOM | ||
| Definition: | "Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus." [GO_REF:0000031, GOC:add, GOC:amm, ISBN:0721601464, ISBN:0781735149, PMCID:PMC2346585, PMID:17850486] | ||
| Xrefs: |
| ||
| Synonyms: |
"Langerhans' cell" EXACT [] "LC" EXACT [] | ||
| Comments: | Originally described in the dendritic cell ontology (DC_CL:0000021 )(PMID: 19243617). These cells are also CD1a-high, CD14-negative, CD207-positive (langerin), CD324-positive (E-cadherin), and DCIR-positive. They reside in the epidermis. |
Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data
Parents
| is_a: | CL:0000766(myeloid leukocyte),CL:0000990(conventional dendritic cell) |
|---|---|
| develops_from: | CL:0000763(myeloid cell) |
Children
| is a: | CL:0001014 (CD1a-positive Langerhans cell),FF:10457-106G7 (squamous cell lung carcinoma cell line:LC-1F),FF:10501-107C6 (squamous cell lung carcinoma cell line:RERF-LC-AI) |
|---|---|
| derives from: | FF:0011136 (human migratory langerhans cells sample) |
Ontology Tree: Loaded from BioPortal
Ontorolgy tree(Small window open)
FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.
Human (Homo sapiens)
- 10457-106G7 (squamous cell lung carcinoma cell line:LC-1F)
- 10501-107C6 (squamous cell lung carcinoma cell line:RERF-LC-AI)
- 11901-125F2 (migratory langerhans cells, donor1)
- 11902-125F3 (migratory langerhans cells, donor2)
- 11903-125F4 (migratory langerhans cells, donor3)
- 11904-125F5 (immature langerhans cells, donor1)
- 11905-125F6 (immature langerhans cells, donor2)
Mouse (Mus musculus)
- 10457-106G7 (squamous cell lung carcinoma cell line:LC-1F)
- 10501-107C6 (squamous cell lung carcinoma cell line:RERF-LC-AI)
- 11901-125F2 (migratory langerhans cells, donor1)
- 11902-125F3 (migratory langerhans cells, donor2)
- 11903-125F4 (migratory langerhans cells, donor3)
- 11904-125F5 (immature langerhans cells, donor1)
- 11905-125F6 (immature langerhans cells, donor2)
Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000453 (Langerhans cell), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data
| P-value | FFCP | Short description |
|---|---|---|
| 2.45e-195 | FFCP PHASE2:Hg19::chr16:10959868..10959879,+#_d47dca2e8d01064a77a7d1ddb1ceff04 | p2@AB463580 |
| 2.45e-195 | FFCP PHASE2:Hg19::chr6:32726761..32726781,-#_d47dca2e8d01064a77a7d1ddb1ceff04 | p@chr6:32726761..32726781, - |
| 2.45e-195 | FFCP PHASE1:Hg19::chr16:10959880..10959887,+#_d47dca2e8d01064a77a7d1ddb1ceff04 | p6@AB463580 |
| 2.45e-195 | FFCP PHASE1:Hg19::chr16:10885979..10885991,+#_d47dca2e8d01064a77a7d1ddb1ceff04 | p@chr16:10885979..10885991, + |
| 2.45e-195 | FFCP PHASE2:Hg19::chr16:10959880..10959887,+#_d47dca2e8d01064a77a7d1ddb1ceff04 | p6@AB463580 |
| 2.45e-195 | FFCP PHASE2:Hg19::chr16:10885979..10885991,+#_d47dca2e8d01064a77a7d1ddb1ceff04 | p@chr16:10885979..10885991, + |
| 2.45e-195 | FFCP PHASE2:Hg19::chr3:119188705..119188718,+#_d47dca2e8d01064a77a7d1ddb1ceff04 | p@chr3:119188705..119188718, + |
| 2.45e-195 | FFCP PHASE1:Hg19::chr6:32726761..32726781,-#_d47dca2e8d01064a77a7d1ddb1ceff04 | p@chr6:32726761..32726781, - |
| 2.45e-195 | FFCP PHASE2:Hg19::chr3:52813932..52813943,+#_d47dca2e8d01064a77a7d1ddb1ceff04 | p11@ITIH1 |
| 2.45e-195 | FFCP PHASE1:Hg19::chr3:119188705..119188718,+#_d47dca2e8d01064a77a7d1ddb1ceff04 | p@chr3:119188705..119188718, + |
| 2.45e-195 | FFCP PHASE1:Hg19::chr3:52813932..52813943,+#_d47dca2e8d01064a77a7d1ddb1ceff04 | p11@ITIH1 |
| 2.45e-195 | FFCP PHASE2:Hg19::chr6:32729529..32729536,-#_d47dca2e8d01064a77a7d1ddb1ceff04 | p3@M95729 |
| 2.45e-195 | FFCP PHASE2:Hg19::chr1:201376546..201376550,+#_d47dca2e8d01064a77a7d1ddb1ceff04 | p@chr1:201376546..201376550, + |
| 2.45e-195 | FFCP PHASE1:Hg19::chr16:10959804..10959811,+#_d47dca2e8d01064a77a7d1ddb1ceff04 | p5@AB463580 |
| 2.45e-195 | FFCP PHASE1:Hg19::chr6:32729529..32729536,-#_d47dca2e8d01064a77a7d1ddb1ceff04 | p3@M95729 |
| 2.45e-195 | FFCP PHASE1:Hg19::chr8:120974832..120974840,+#_d47dca2e8d01064a77a7d1ddb1ceff04 | p@chr8:120974832..120974840, + |
| 2.45e-195 | FFCP PHASE2:Hg19::chr8:120974832..120974840,+#_d47dca2e8d01064a77a7d1ddb1ceff04 | p@chr8:120974832..120974840, + |
| 2.45e-195 | FFCP PHASE1:Hg19::chr13:75884392..75884395,-#_d47dca2e8d01064a77a7d1ddb1ceff04 | p@chr13:75884392..75884395, - |
| 2.45e-195 | FFCP PHASE2:Hg19::chr16:10959804..10959811,+#_d47dca2e8d01064a77a7d1ddb1ceff04 | p5@AB463580 |
| 2.45e-195 | FFCP PHASE1:Hg19::chr1:201376546..201376550,+#_d47dca2e8d01064a77a7d1ddb1ceff04 | p@chr1:201376546..201376550, + |
| 2.45e-195 | FFCP PHASE2:Hg19::chr19:45487650..45487661,+#_d47dca2e8d01064a77a7d1ddb1ceff04 | p@chr19:45487650..45487661, + |
| 2.45e-195 | FFCP PHASE1:Hg19::chr16:10959868..10959879,+#_d47dca2e8d01064a77a7d1ddb1ceff04 | p2@AB463580 |
| 2.45e-195 | FFCP PHASE1:Hg19::chr19:45487650..45487661,+#_d47dca2e8d01064a77a7d1ddb1ceff04 | p@chr19:45487650..45487661, + |
| 2.45e-195 | FFCP PHASE2:Hg19::chr13:75884392..75884395,-#_d47dca2e8d01064a77a7d1ddb1ceff04 | p@chr13:75884392..75884395, - |
| 2.34e-163 | FFCP PHASE1:Hg19::chr2:173867941..173867955,+#_5f832a398139202c420820cc3c4f60ff | p@chr2:173867941..173867955, + |
| 2.34e-163 | FFCP PHASE2:Hg19::chr2:173867941..173867955,+#_5f832a398139202c420820cc3c4f60ff | p@chr2:173867941..173867955, + |
| 2.34e-163 | FFCP PHASE1:Hg19::chr13:75884255..75884262,-#_5f832a398139202c420820cc3c4f60ff | p@chr13:75884255..75884262, - |
| 2.34e-163 | FFCP PHASE2:Hg19::chr13:75884255..75884262,-#_5f832a398139202c420820cc3c4f60ff | p@chr13:75884255..75884262, - |
| 1.5e-156 | FFCP PHASE2:Hg19::chr14:65641128..65641129,-#_87b3c6e0e65bd78c3cfb363906c5012f | p@chr14:65641128..65641129, - |
| 1.5e-156 | FFCP PHASE2:Hg19::chr16:10870586..10870591,-#_87b3c6e0e65bd78c3cfb363906c5012f | p@chr16:10870586..10870591, - |
| 1.5e-156 | FFCP PHASE1:Hg19::chr12:112513578..112513587,-#_87b3c6e0e65bd78c3cfb363906c5012f | p@chr12:112513578..112513587, - |
| 1.5e-156 | FFCP PHASE1:Hg19::chr4:14845952..14845956,-#_87b3c6e0e65bd78c3cfb363906c5012f | p@chr4:14845952..14845956, - |
| 1.5e-156 | FFCP PHASE2:Hg19::chr12:112513578..112513587,-#_87b3c6e0e65bd78c3cfb363906c5012f | p@chr12:112513578..112513587, - |
| 1.5e-156 | FFCP PHASE1:Hg19::chr18:22537624..22537627,-#_87b3c6e0e65bd78c3cfb363906c5012f | p@chr18:22537624..22537627, - |
| 1.5e-156 | FFCP PHASE2:Hg19::chr10:112109413..112109419,-#_87b3c6e0e65bd78c3cfb363906c5012f | p@chr10:112109413..112109419, - |
| 1.5e-156 | FFCP PHASE2:Hg19::chr6:32729494..32729506,-#_87b3c6e0e65bd78c3cfb363906c5012f | p1@M95729 |
| 1.5e-156 | FFCP PHASE2:Hg19::chr18:22537624..22537627,-#_87b3c6e0e65bd78c3cfb363906c5012f | p@chr18:22537624..22537627, - |
| 1.5e-156 | FFCP PHASE1:Hg19::chr12:95264953..95264971,-#_87b3c6e0e65bd78c3cfb363906c5012f | p@chr12:95264953..95264971, - |
| 1.5e-156 | FFCP PHASE1:Hg19::chr13:32672504..32672512,-#_87b3c6e0e65bd78c3cfb363906c5012f | p@chr13:32672504..32672512, - |
| 1.5e-156 | FFCP PHASE2:Hg19::chr12:95264953..95264971,-#_87b3c6e0e65bd78c3cfb363906c5012f | p@chr12:95264953..95264971, - |
| 1.5e-156 | FFCP PHASE1:Hg19::chr10:112109413..112109419,-#_87b3c6e0e65bd78c3cfb363906c5012f | p@chr10:112109413..112109419, - |
| 1.5e-156 | FFCP PHASE1:Hg19::chr6:32729494..32729506,-#_87b3c6e0e65bd78c3cfb363906c5012f | p1@M95729 |
| 1.5e-156 | FFCP PHASE2:Hg19::chr13:32672504..32672512,-#_87b3c6e0e65bd78c3cfb363906c5012f | p@chr13:32672504..32672512, - |
| 1.5e-156 | FFCP PHASE2:Hg19::chr3:52813951..52813958,+#_87b3c6e0e65bd78c3cfb363906c5012f | p13@ITIH1 |
| 1.5e-156 | FFCP PHASE1:Hg19::chr12:112590221..112590232,+#_87b3c6e0e65bd78c3cfb363906c5012f | p@chr12:112590221..112590232, + |
| 1.5e-156 | FFCP PHASE1:Hg19::chr3:52813951..52813958,+#_87b3c6e0e65bd78c3cfb363906c5012f | p13@ITIH1 |
| 1.5e-156 | FFCP PHASE2:Hg19::chr3:52813997..52814015,+#_87b3c6e0e65bd78c3cfb363906c5012f | p9@ITIH1 |
| 1.5e-156 | FFCP PHASE2:Hg19::chr12:112590221..112590232,+#_87b3c6e0e65bd78c3cfb363906c5012f | p@chr12:112590221..112590232, + |
| 1.5e-156 | FFCP PHASE1:Hg19::chr2:71056842..71056868,+#_87b3c6e0e65bd78c3cfb363906c5012f | p@chr2:71056842..71056868, + |
| 1.5e-156 | FFCP PHASE2:Hg19::chr2:71056842..71056868,+#_87b3c6e0e65bd78c3cfb363906c5012f | p@chr2:71056842..71056868, + |
| 1.5e-156 | FFCP PHASE2:Hg19::chr4:14845952..14845956,-#_87b3c6e0e65bd78c3cfb363906c5012f | p@chr4:14845952..14845956, - |
| 1.5e-156 | FFCP PHASE1:Hg19::chr14:65641128..65641129,-#_87b3c6e0e65bd78c3cfb363906c5012f | p@chr14:65641128..65641129, - |
| 1.5e-156 | FFCP PHASE1:Hg19::chr3:52813997..52814015,+#_87b3c6e0e65bd78c3cfb363906c5012f | p9@ITIH1 |
| 1.5e-156 | FFCP PHASE1:Hg19::chr16:10870586..10870591,-#_87b3c6e0e65bd78c3cfb363906c5012f | p@chr16:10870586..10870591, - |
| 1.65e-140 | FFCP PHASE1:Hg19::chr13:75884448..75884459,-#_5946a585098cbbea1410fea50db91d4d | p@chr13:75884448..75884459, - |
| 1.65e-140 | FFCP PHASE2:Hg19::chr13:75884448..75884459,-#_5946a585098cbbea1410fea50db91d4d | p@chr13:75884448..75884459, - |
| 1.65e-140 | FFCP PHASE2:Hg19::chr6:32731327..32731340,-#_5946a585098cbbea1410fea50db91d4d | p3@HLA-DQB2 |
| 1.65e-140 | FFCP PHASE1:Hg19::chr6:32731327..32731340,-#_5946a585098cbbea1410fea50db91d4d | p3@HLA-DQB2 |
| 1.65e-140 | FFCP PHASE2:Hg19::chr6:32782930..32782943,-#_5946a585098cbbea1410fea50db91d4d | p@chr6:32782930..32782943, - |
| 1.65e-140 | FFCP PHASE1:Hg19::chr6:32782930..32782943,-#_5946a585098cbbea1410fea50db91d4d | p@chr6:32782930..32782943, - |
| 2.94e-140 | FFCP PHASE2:Hg19::chr4:103478257..103478273,+#_9b2a26dee728aeff7f293d70838be27c | p28@NFKB1 |
| 2.94e-140 | FFCP PHASE1:Hg19::chr4:103478257..103478273,+#_9b2a26dee728aeff7f293d70838be27c | p28@NFKB1 |
| 2.94e-140 | FFCP PHASE2:Hg19::chr19:45487573..45487606,+#_9b2a26dee728aeff7f293d70838be27c | p@chr19:45487573..45487606, + |
| 2.94e-140 | FFCP PHASE1:Hg19::chr19:45487573..45487606,+#_9b2a26dee728aeff7f293d70838be27c | p@chr19:45487573..45487606, + |
| 9.01e-126 | FFCP PHASE1:Hg19::chr18:53548086..53548099,-#_847765afb00b16102bfb169d40dc523f | p@chr18:53548086..53548099, - |
| 9.01e-126 | FFCP PHASE2:Hg19::chr18:53548086..53548099,-#_847765afb00b16102bfb169d40dc523f | p@chr18:53548086..53548099, - |
| 9.01e-126 | FFCP PHASE1:Hg19::chr11:64784128..64784143,+#_847765afb00b16102bfb169d40dc523f | p@chr11:64784128..64784143, + |
| 9.01e-126 | FFCP PHASE2:Hg19::chr11:64784128..64784143,+#_847765afb00b16102bfb169d40dc523f | p@chr11:64784128..64784143, + |
| 9.01e-126 | FFCP PHASE1:Hg19::chr16:10869031..10869038,-#_847765afb00b16102bfb169d40dc523f | p12@FAM18A |
| 9.01e-126 | FFCP PHASE2:Hg19::chr16:10869031..10869038,-#_847765afb00b16102bfb169d40dc523f | p12@FAM18A |
| 1.24e-125 | FFCP PHASE1:Hg19::chr1:25194616..25194628,-#_cfab44c5edd791d47bb0f4290612ab07 | p@chr1:25194616..25194628, - |
| 1.24e-125 | FFCP PHASE2:Hg19::chr1:25194616..25194628,-#_cfab44c5edd791d47bb0f4290612ab07 | p@chr1:25194616..25194628, - |
| 1.24e-125 | FFCP PHASE1:Hg19::chr1:156123108..156123151,+#_cfab44c5edd791d47bb0f4290612ab07 | p18@SEMA4A |
| 1.24e-125 | FFCP PHASE2:Hg19::chr1:156123108..156123151,+#_cfab44c5edd791d47bb0f4290612ab07 | p18@SEMA4A |
| 3.26e-125 | FFCP PHASE2:Hg19::chr6:169770365..169770377,-#_d117976080631f3c0c288b34dc7f9c50 | p@chr6:169770365..169770377, - |
| 3.26e-125 | FFCP PHASE1:Hg19::chr6:169770365..169770377,-#_d117976080631f3c0c288b34dc7f9c50 | p@chr6:169770365..169770377, - |
| 2.28e-123 | FFCP PHASE2:Hg19::chr6:32731284..32731295,-#_8b02fa52da416350fe727541add822bd | p2@HLA-DQB2 |
| 2.28e-123 | FFCP PHASE1:Hg19::chr6:32731284..32731295,-#_8b02fa52da416350fe727541add822bd | p2@HLA-DQB2 |
| 2.28e-123 | FFCP PHASE1:Hg19::chr13:75884363..75884374,-#_8b02fa52da416350fe727541add822bd | p@chr13:75884363..75884374, - |
| 2.28e-123 | FFCP PHASE1:Hg19::chr13:75884379..75884384,-#_8b02fa52da416350fe727541add822bd | p@chr13:75884379..75884384, - |
| 2.28e-123 | FFCP PHASE2:Hg19::chr13:75884363..75884374,-#_8b02fa52da416350fe727541add822bd | p@chr13:75884363..75884374, - |
| 2.28e-123 | FFCP PHASE2:Hg19::chr13:75884379..75884384,-#_8b02fa52da416350fe727541add822bd | p@chr13:75884379..75884384, - |
| 2.94e-123 | FFCP PHASE1:Hg19::chr16:66528108..66528115,+#_da7ea1bab7563d0a270810d705df69ec | p@chr16:66528108..66528115, + |
| 2.94e-123 | FFCP PHASE2:Hg19::chr16:66528108..66528115,+#_da7ea1bab7563d0a270810d705df69ec | p@chr16:66528108..66528115, + |
| 4.86e-123 | FFCP PHASE1:Hg19::chr17:4643317..4643359,-#_62f083e4e8ae916ad5ed26f15aa8e870 | p15@CXCL16 |
| 4.86e-123 | FFCP PHASE2:Hg19::chr17:4643317..4643359,-#_62f083e4e8ae916ad5ed26f15aa8e870 | p15@CXCL16 |
| 8.05e-123 | FFCP PHASE1:Hg19::chr12:131576196..131576201,+#_8aea782a80f9eaf3493a99a185e47117 | p9@GPR133 |
| 8.05e-123 | FFCP PHASE2:Hg19::chr12:131576196..131576201,+#_8aea782a80f9eaf3493a99a185e47117 | p9@GPR133 |
| 4.68e-122 | FFCP PHASE1:Hg19::chr15:101535004..101535045,+#_96698fcce1521d07e708631d9895f840 | p@chr15:101535004..101535045, + |
| 4.68e-122 | FFCP PHASE2:Hg19::chr15:101535004..101535045,+#_96698fcce1521d07e708631d9895f840 | p@chr15:101535004..101535045, + |
| 7.76e-118 | FFCP PHASE1:Hg19::chr13:51382041..51382048,+#_f67b6e4f003f65ceb025aff6bde3772e | p2@DLEU7-AS1 |
| 7.76e-118 | FFCP PHASE2:Hg19::chr13:51382017..51382022,+#_f67b6e4f003f65ceb025aff6bde3772e | p3@DLEU7-AS1 |
| 7.76e-118 | FFCP PHASE2:Hg19::chr1:172751007..172751015,+#_f67b6e4f003f65ceb025aff6bde3772e | p@chr1:172751007..172751015, + |
| 7.76e-118 | FFCP PHASE1:Hg19::chr1:25197198..25197207,+#_f67b6e4f003f65ceb025aff6bde3772e | p@chr1:25197198..25197207, + |
| 7.76e-118 | FFCP PHASE2:Hg19::chr1:25197198..25197207,+#_f67b6e4f003f65ceb025aff6bde3772e | p@chr1:25197198..25197207, + |
| 7.76e-118 | FFCP PHASE1:Hg19::chr9:35227753..35227762,+#_f67b6e4f003f65ceb025aff6bde3772e | p6@UNC13B |
| 7.76e-118 | FFCP PHASE1:Hg19::chr2:238810193..238810202,+#_f67b6e4f003f65ceb025aff6bde3772e | p@chr2:238810193..238810202, + |
| 7.76e-118 | FFCP PHASE2:Hg19::chr9:35227753..35227762,+#_f67b6e4f003f65ceb025aff6bde3772e | p6@UNC13B |
| 7.76e-118 | FFCP PHASE1:Hg19::chr12:131543197..131543202,+#_f67b6e4f003f65ceb025aff6bde3772e | p@chr12:131543197..131543202, + |
| 7.76e-118 | FFCP PHASE2:Hg19::chr16:10850527..10850548,+#_f67b6e4f003f65ceb025aff6bde3772e | p@chr16:10850527..10850548, + |
