Coexpression cluster:C470

Full id: C470_Adipocyte_Preadipocyte_Smooth_Fibroblast_aorta_normal_Mesenchymal

Phase1 CAGE Peaks

Hg19::chr14:92336119..92336144,-	p18@FBLN5
Hg19::chr14:92336334..92336351,-	p22@FBLN5
Hg19::chr14:92336363..92336402,-	p17@FBLN5
Hg19::chr14:92343879..92343891,-	p@chr14:92343879..92343891 -
Hg19::chr14:92347684..92347698,-	p@chr14:92347684..92347698 -
Hg19::chr14:92349351..92349365,-	p@chr14:92349351..92349365 -
Hg19::chr14:92361339..92361353,-	p@chr14:92361339..92361353 -
Hg19::chr14:92403359..92403409,+	p@chr14:92403359..92403409 +
Hg19::chr14:92403378..92403403,-	p@chr14:92403378..92403403 -
Hg19::chr14:92403405..92403440,-	p@chr14:92403405..92403440 -
Hg19::chr14:92403450..92403483,-	p@chr14:92403450..92403483 -
Hg19::chr14:92413677..92413688,-	p12@FBLN5
Hg19::chr14:92413727..92413738,-	p7@FBLN5
Hg19::chr14:92413748..92413762,-	p1@FBLN5
Hg19::chr14:92413764..92413794,-	p2@FBLN5
Hg19::chr14:92413800..92413837,-	p4@FBLN5
Hg19::chr14:92414294..92414355,-	p9@FBLN5
Hg19::chr15:89442263..89442298,-	p@chr15:89442263..89442298 -
Hg19::chr19:38812519..38812533,-	p@chr19:38812519..38812533 -
Hg19::chr4:88928828..88928841,+	p3@PKD2
Hg19::chr5:151047146..151047178,-	p4@SPARC

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0007160	cell-matrix adhesion	0.00182617469241869
GO:0031589	cell-substrate adhesion	0.00182617469241869
GO:0005509	calcium ion binding	0.00352400893404339
GO:0050982	detection of mechanical stimulus	0.0088744333492283
GO:0005932	basal body	0.0101810085027996
GO:0005578	proteinaceous extracellular matrix	0.0101810085027996
GO:0009612	response to mechanical stimulus	0.0204284640188069
GO:0007368	determination of left/right symmetry	0.0204284640188069
GO:0009799	determination of symmetry	0.0204284640188069
GO:0009855	determination of bilateral symmetry	0.0204284640188069
GO:0005518	collagen binding	0.0204284640188069
GO:0005248	voltage-gated sodium channel activity	0.0209774322652129
GO:0044421	extracellular region part	0.0209774322652129
GO:0022610	biological adhesion	0.0209774322652129
GO:0007155	cell adhesion	0.0209774322652129
GO:0048513	organ development	0.0241483101232616
GO:0007259	JAK-STAT cascade	0.0241483101232616
GO:0005247	voltage-gated chloride channel activity	0.0241483101232616
GO:0005178	integrin binding	0.0241483101232616
GO:0005929	cilium	0.0241483101232616
GO:0022844	voltage-gated anion channel activity	0.0241483101232616
GO:0009582	detection of abiotic stimulus	0.0241483101232616
GO:0044463	cell projection part	0.0241483101232616
GO:0009581	detection of external stimulus	0.0246171127198746
GO:0005272	sodium channel activity	0.0269354144139597
GO:0048731	system development	0.0305550245877575
GO:0008022	protein C-terminus binding	0.0305550245877575
GO:0005604	basement membrane	0.0305550245877575
GO:0043169	cation binding	0.0305550245877575
GO:0051606	detection of stimulus	0.0305550245877575
GO:0005254	chloride channel activity	0.0305550245877575
GO:0001503	ossification	0.0305550245877575
GO:0031214	biomineral formation	0.0305550245877575
GO:0046872	metal ion binding	0.0305550245877575
GO:0046849	bone remodeling	0.0305550245877575
GO:0043167	ion binding	0.0305550245877575
GO:0005253	anion channel activity	0.0305550245877575
GO:0007050	cell cycle arrest	0.0305550245877575
GO:0032403	protein complex binding	0.0305550245877575
GO:0048771	tissue remodeling	0.030967346229515
GO:0048856	anatomical structure development	0.0311067998750359
GO:0006874	cellular calcium ion homeostasis	0.0311067998750359
GO:0055074	calcium ion homeostasis	0.0311067998750359
GO:0005507	copper ion binding	0.0311067998750359
GO:0006875	cellular metal ion homeostasis	0.0311067998750359
GO:0055065	metal ion homeostasis	0.0311067998750359
GO:0007389	pattern specification process	0.0311067998750359
GO:0044420	extracellular matrix part	0.0321715484447625
GO:0005815	microtubule organizing center	0.0351465779076556
GO:0007275	multicellular organismal development	0.0351465779076556
GO:0009628	response to abiotic stimulus	0.0380995966342028
GO:0030005	cellular di-, tri-valent inorganic cation homeostasis	0.0398871888862169
GO:0055066	di-, tri-valent inorganic cation homeostasis	0.0398871888862169
GO:0006816	calcium ion transport	0.0398871888862169
GO:0030003	cellular cation homeostasis	0.0415848374287668
GO:0055080	cation homeostasis	0.0415848374287668
GO:0001501	skeletal development	0.0415848374287668
GO:0008509	anion transmembrane transporter activity	0.0415848374287668
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	0.0415848374287668
GO:0005515	protein binding	0.0415848374287668
GO:0045786	negative regulation of progression through cell cycle	0.0433601492881494
GO:0005625	soluble fraction	0.0435163738114841
GO:0055082	cellular chemical homeostasis	0.0435163738114841
GO:0006873	cellular ion homeostasis	0.0435163738114841
GO:0015674	di-, tri-valent inorganic cation transport	0.0446416026002452
GO:0022843	voltage-gated cation channel activity	0.0453784752599863
GO:0050801	ion homeostasis	0.0467881969022059

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
non-terminally differentiated cell	3.75e-37	180
fibroblast	4.36e-27	75
muscle precursor cell	6.80e-14	57
myoblast	6.80e-14	57
multi-potent skeletal muscle stem cell	6.80e-14	57
muscle cell	6.14e-13	54
contractile cell	1.51e-12	59
skin fibroblast	1.52e-12	23
electrically responsive cell	6.56e-12	60
electrically active cell	6.56e-12	60
smooth muscle cell	3.44e-11	42
smooth muscle myoblast	3.44e-11	42
mesodermal cell	3.25e-10	119
preadipocyte	4.50e-08	12
fat cell	7.25e-08	15
vascular associated smooth muscle cell	5.37e-07	32

Uber Anatomy

Ontology term	p-value	n
somite	2.91e-21	83
paraxial mesoderm	2.91e-21	83
presomitic mesoderm	2.91e-21	83
presumptive segmental plate	2.91e-21	83
trunk paraxial mesoderm	2.91e-21	83
presumptive paraxial mesoderm	2.91e-21	83
organism subdivision	2.24e-19	365
dermomyotome	9.11e-19	70
surface structure	6.34e-16	95
muscle tissue	3.80e-15	63
musculature	3.80e-15	63
musculature of body	3.80e-15	63
multilaminar epithelium	5.33e-15	82
skeletal muscle tissue	9.14e-15	61
striated muscle tissue	9.14e-15	61
myotome	9.14e-15	61
trunk mesenchyme	3.77e-14	143
multi-cellular organism	1.13e-13	659
multi-tissue structure	1.21e-12	347
integument	4.85e-12	45
integumental system	4.85e-12	45
splanchnic layer of lateral plate mesoderm	5.39e-11	84
anatomical system	1.92e-10	625
trunk	2.21e-10	216
anatomical group	3.57e-10	626
skin of body	7.72e-10	40
cell layer	1.26e-09	312
epithelium	2.85e-09	309
vasculature	4.34e-09	79
vascular system	4.34e-09	79
anatomical cluster	1.00e-08	286
organ component layer	2.30e-08	57
circulatory system	2.88e-08	113
cardiovascular system	9.04e-08	110
adipose tissue	9.20e-08	14
mesenchyme	9.40e-08	238
entire embryonic mesenchyme	9.40e-08	238
artery	1.41e-07	42
arterial blood vessel	1.41e-07	42
arterial system	1.41e-07	42
systemic artery	2.49e-07	33
systemic arterial system	2.49e-07	33
blood vessel	3.13e-07	60
epithelial tube open at both ends	3.13e-07	60
blood vasculature	3.13e-07	60
vascular cord	3.13e-07	60
unilaminar epithelium	5.91e-07	138
vessel	6.97e-07	69

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.