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|id=CL:0000557
|id=CL:0000557
|name=granulocyte monocyte progenitor cell
|name=granulocyte monocyte progenitor cell
|namespace=efo
|namespace=cell;;efo
|def="A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata-1, Gata2 but do express C/EBPa, and Pu.1." [GO_REF:0000031, GOC:amm, GOC:dsd, GOC:tfm, http://www.copewithcytokines.de, ISBN:0721601464, MESH:D055014, PMCID:PMC2213186, PMCID:PMC548021, PMID:16551251]
|def="A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata-1, Gata2 but do express C/EBPa, and Pu.1." [GO_REF:0000031, GOC:amm, GOC:dsd, GOC:tfm, http://www.copewithcytokines.de, ISBN:0721601464, MESH:D055014, PMCID:PMC2213186, PMCID:PMC548021, PMID:16551251]
|xref=
|xref=
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|obo_creation_date=
|obo_creation_date=
|subset=
|subset=
|adjacent_to=
|derives_from=
|derives_from=
|develops_from=CL:0000049
|develops_from=
|has_quality=
|has_quality=
|located_in=
|located_in=
|part_of=UBERON:0002371
|part_of=
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl-to-uberon.obo.owl;;IAO:0000412 http://purl.obolibrary.org/obo/cl.owl;;IAO:0000412 http://purl.obolibrary.org/obo/efo.obo.owl
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl-to-uberon.owl;;IAO:0000412 http://purl.obolibrary.org/obo/cl.owl;;IAO:0000412 http://purl.obolibrary.org/obo/efo.owl
|is_obsolete=
|is_obsolete=
|preceded_by=
|preceded_by=
}}
}}

Revision as of 17:25, 26 June 2012

Name:granulocyte monocyte progenitor cell
Namespace:cell;;efo
Definition:"A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata-1, Gata2 but do express C/EBPa, and Pu.1." [GO_REF:0000031, GOC:amm, GOC:dsd, GOC:tfm, http://www.copewithcytokines.de, ISBN:0721601464, MESH:D055014, PMCID:PMC2213186, PMCID:PMC548021, PMID:16551251]
Synonyms: "CFU-C , Colony forming unit in culture" BROAD [1]
"CFU-GM" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
"colony forming unit granulocyte macrophage" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
"GMP" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
"granulocyte-macrophage progenitor" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
Comments:Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID: 19243617). GMPs are reportedly CD34-positive, CD38-positive, CD45RA-positive, and CD123-positive.


Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:CL:0000763(myeloid cell),CL:0002032(hematopoietic oligopotent progenitor cell)



Children


disjoint from:CL:0000049 (common myeloid progenitor),CL:0000050 (megakaryocyte-erythroid progenitor cell)
derives from:FF:0000070 (granulocyte macrophage progenitor cell sample)
develops from:CL:0000835 (myeloblast),CL:0002009 (macrophage dendritic cell progenitor),CL:0002028 (basophil mast progenitor cell)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)


FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.

Human (Homo sapiens)

  • 12123-128C8 (granulocyte macrophage progenitor GMP, biol_rep1)
  • 12126-128D2 (granulocyte macrophage progenitor GMP, biol_rep2)
  • 12129-128D5 (granulocyte macrophage progenitor GMP, biol_rep3)
  • 12131-128D7 (granulocyte macrophage progenitor, donor1)
  • 12135-128E2 (granulocyte macrophage progenitor, donor2)
  • 12139-128E6 (granulocyte macrophage progenitor, donor3)

Mouse (Mus musculus)

  • 12123-128C8 (granulocyte macrophage progenitor GMP, biol_rep1)
  • 12126-128D2 (granulocyte macrophage progenitor GMP, biol_rep2)
  • 12129-128D5 (granulocyte macrophage progenitor GMP, biol_rep3)
  • 12131-128D7 (granulocyte macrophage progenitor, donor1)
  • 12135-128E2 (granulocyte macrophage progenitor, donor2)
  • 12139-128E6 (granulocyte macrophage progenitor, donor3)


Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000557 (granulocyte monocyte progenitor cell), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
1.22e-136FFCP PHASE2:Hg19::chr1:161187824..161187847,+#_a11ccc43e34d0b48429aa8ea50fb7bd1p@chr1:161187824..161187847, +
1.22e-136FFCP PHASE1:Hg19::chr1:161187824..161187847,+#_a11ccc43e34d0b48429aa8ea50fb7bd1p@chr1:161187824..161187847, +
6.46e-132FFCP PHASE2:Hg19::chr16:50313426..50313459,+#_24bf4e1d003a175beb60951b15c26690p@chr16:50313426..50313459, +
6.46e-132FFCP PHASE1:Hg19::chr16:50313426..50313459,+#_24bf4e1d003a175beb60951b15c26690p@chr16:50313426..50313459, +
1.98e-131FFCP PHASE2:Hg19::chr1:161188661..161188679,+#_0cd7adf95883f31a4e11aec714e9d502p@chr1:161188661..161188679, +
1.98e-131FFCP PHASE1:Hg19::chr1:161188661..161188679,+#_0cd7adf95883f31a4e11aec714e9d502p@chr1:161188661..161188679, +
6.11e-130FFCP PHASE1:Hg19::chr18:2847062..2847071,+#_edf397f59b453398022e9f69333c6441p7@EMILIN2
6.11e-130FFCP PHASE2:Hg19::chr18:2847062..2847071,+#_edf397f59b453398022e9f69333c6441p7@EMILIN2
4.57e-129FFCP PHASE2:Hg19::chr7:77050554..77050601,+#_d2dc56dcc174792eac79892dfc152325p@chr7:77050554..77050601, +
4.57e-129FFCP PHASE1:Hg19::chr7:77050554..77050601,+#_d2dc56dcc174792eac79892dfc152325p@chr7:77050554..77050601, +
9.16e-128FFCP PHASE2:Hg19::chr1:161188746..161188758,+#_a5086834f8a8e902bfc00c1ea6446a93p@chr1:161188746..161188758, +
9.16e-128FFCP PHASE1:Hg19::chr1:161188746..161188758,+#_a5086834f8a8e902bfc00c1ea6446a93p@chr1:161188746..161188758, +
8.22e-127FFCP PHASE1:Hg19::chr17:7482481..7482508,-#_cf49226623cce6110a28f7f564fd9d4bp@chr17:7482481..7482508, -
8.22e-127FFCP PHASE2:Hg19::chr17:7482481..7482508,-#_cf49226623cce6110a28f7f564fd9d4bp@chr17:7482481..7482508, -
1.66e-126FFCP PHASE1:Hg19::chr19:18288651..18288682,+#_9fe797cdfa67f5df82073d304674d271p5@IFI30
1.66e-126FFCP PHASE2:Hg19::chr19:18288651..18288682,+#_9fe797cdfa67f5df82073d304674d271p5@IFI30
1.87e-125FFCP PHASE1:Hg19::chr4:3387239..3387324,-#_9ca27ea82a3341168c7b27a765c662a2p@chr4:3387239..3387324, -
1.87e-125FFCP PHASE2:Hg19::chr4:3387239..3387324,-#_9ca27ea82a3341168c7b27a765c662a2p@chr4:3387239..3387324, -
1.83e-123FFCP PHASE2:Hg19::chr7:2832730..2832791,+#_214513c8cc313667afb0e2059bbc7d77p@chr7:2832730..2832791, +
1.83e-123FFCP PHASE1:Hg19::chr7:2832730..2832791,+#_214513c8cc313667afb0e2059bbc7d77p@chr7:2832730..2832791, +
2.42e-122FFCP PHASE1:Hg19::chr5:180242646..180242657,-#_3d6795bff4765484f0d06fb37b4bec5ep15@MGAT1
2.42e-122FFCP PHASE2:Hg19::chr5:180242646..180242657,-#_3d6795bff4765484f0d06fb37b4bec5ep15@MGAT1
4.19e-122FFCP PHASE1:Hg19::chr19:18288828..18288861,+#_9be0fa50ddec0d252e25307b3c21ecf1p7@IFI30
4.19e-122FFCP PHASE2:Hg19::chr19:18288828..18288861,+#_9be0fa50ddec0d252e25307b3c21ecf1p7@IFI30
1.2e-121FFCP PHASE2:Hg19::chr1:111743000..111743011,+#_78d1a4bd88b85f42876d3c7385eb1407p8@CHI3L2
1.2e-121FFCP PHASE1:Hg19::chr1:111743000..111743011,+#_78d1a4bd88b85f42876d3c7385eb1407p8@CHI3L2
3.34e-121FFCP PHASE2:Hg19::chr17:40168698..40168726,-#_24dd7c92172312785d7b9a859b0af497p1@AK126179
3.34e-121FFCP PHASE1:Hg19::chr17:40168698..40168726,-#_24dd7c92172312785d7b9a859b0af497p1@AK126179
3.43e-120FFCP PHASE1:Hg19::chr19:18286116..18286156,+#_fea4df9e87cfff344f1b16237862724cp@chr19:18286116..18286156, +
3.43e-120FFCP PHASE2:Hg19::chr19:18286116..18286156,+#_fea4df9e87cfff344f1b16237862724cp@chr19:18286116..18286156, +
1.26e-119FFCP PHASE2:Hg19::chr17:72542163..72542182,-#_f5182f03712a03bd92c23e7d9d9b5d91p2@CD300C
1.26e-119FFCP PHASE1:Hg19::chr17:72542163..72542182,-#_f5182f03712a03bd92c23e7d9d9b5d91p2@CD300C
1.37e-118FFCP PHASE2:Hg19::chr2:38358217..38358244,+#_39b203bbe6a3dd0c86757cfd75a3ab7cp1@CYP1B1-AS1
1.37e-118FFCP PHASE1:Hg19::chr2:38358217..38358244,+#_39b203bbe6a3dd0c86757cfd75a3ab7cp1@CYP1B1-AS1
1.51e-118FFCP PHASE1:Hg19::chr15:65174546..65174583,-#_17f36752570be8be38771f7a9aac0cc3p@chr15:65174546..65174583, -
1.51e-118FFCP PHASE2:Hg19::chr15:65174546..65174583,-#_17f36752570be8be38771f7a9aac0cc3p@chr15:65174546..65174583, -
3.4e-118FFCP PHASE2:Hg19::chr4:159727272..159727307,+#_5a5aebb1de2cd58d6057663e0a14dadap7@FNIP2
3.4e-118FFCP PHASE1:Hg19::chr4:159727272..159727307,+#_5a5aebb1de2cd58d6057663e0a14dadap7@FNIP2
1.14e-117FFCP PHASE1:Hg19::chr4:185314125..185314143,-#_fc42dc1f210fe44375815a72b1301e36p@chr4:185314125..185314143, -
1.14e-117FFCP PHASE2:Hg19::chr4:185314125..185314143,-#_fc42dc1f210fe44375815a72b1301e36p@chr4:185314125..185314143, -
4.04e-117FFCP PHASE2:Hg19::chr3:149531627..149531651,+#_44d68d7e0ab0d15e307f056bcec34bafp7@RNF13
4.04e-117FFCP PHASE1:Hg19::chr3:149531627..149531651,+#_44d68d7e0ab0d15e307f056bcec34bafp7@RNF13
7.68e-117FFCP PHASE2:Hg19::chr1:161188686..161188721,+#_12fb7373cd683929d62fe8f184860ef9p@chr1:161188686..161188721, +
7.68e-117FFCP PHASE1:Hg19::chr1:161188686..161188721,+#_12fb7373cd683929d62fe8f184860ef9p@chr1:161188686..161188721, +
1.34e-116FFCP PHASE2:Hg19::chr2:119726719..119726744,+#_5b3fbdb5f0242d8b7929a4cb26d41b11p@chr2:119726719..119726744, +
1.34e-116FFCP PHASE1:Hg19::chr2:119726719..119726744,+#_5b3fbdb5f0242d8b7929a4cb26d41b11p@chr2:119726719..119726744, +
1.55e-116FFCP PHASE1:Hg19::chr19:52299474..52299504,-#_ad75fad916de90af2d89686b92630a32p@chr19:52299474..52299504, -
1.55e-116FFCP PHASE2:Hg19::chr19:52299474..52299504,-#_ad75fad916de90af2d89686b92630a32p@chr19:52299474..52299504, -
5.12e-116FFCP PHASE1:Hg19::chr5:131280548..131280574,-#_72e5cc66b7417f91917ea204887d60f5p1@ENST00000425320
5.12e-116FFCP PHASE2:Hg19::chr5:131280548..131280574,-#_72e5cc66b7417f91917ea204887d60f5p1@ENST00000425320
9.64e-116FFCP PHASE1:Hg19::chr10:73648356..73648408,-#_0ce618f8285f33af865d16ed310d79edp@chr10:73648356..73648408, -
9.64e-116FFCP PHASE2:Hg19::chr10:73648356..73648408,-#_0ce618f8285f33af865d16ed310d79edp@chr10:73648356..73648408, -
9.84e-116FFCP PHASE1:Hg19::chr4:185314151..185314178,-#_94c6f6a7d52c066869db179f7a78538cp@chr4:185314151..185314178, -
9.84e-116FFCP PHASE2:Hg19::chr4:185314151..185314178,-#_94c6f6a7d52c066869db179f7a78538cp@chr4:185314151..185314178, -
1.24e-115FFCP PHASE1:Hg19::chr2:145429606..145429658,+#_99ff12aa13396b3d8b19283b2734df50p@chr2:145429606..145429658, +
1.24e-115FFCP PHASE2:Hg19::chr2:145429606..145429658,+#_99ff12aa13396b3d8b19283b2734df50p@chr2:145429606..145429658, +
3.24e-115FFCP PHASE1:Hg19::chr19:18288064..18288080,+#_2456ed7b3af590b72e7384db85e26732p@chr19:18288064..18288080, +
3.24e-115FFCP PHASE2:Hg19::chr19:18288064..18288080,+#_2456ed7b3af590b72e7384db85e26732p@chr19:18288064..18288080, +
4.02e-115FFCP PHASE1:Hg19::chrX:153286067..153286101,-#_6f07e392e342ff5ab8a2ffea4b586f41p@chrX:153286067..153286101, -
4.02e-115FFCP PHASE2:Hg19::chrX:153286067..153286101,-#_6f07e392e342ff5ab8a2ffea4b586f41p@chrX:153286067..153286101, -
1.44e-114FFCP PHASE2:Hg19::chr4:185314188..185314207,-#_46014b0d1434df2a679006680ca89561p@chr4:185314188..185314207, -
1.44e-114FFCP PHASE1:Hg19::chr4:185314188..185314207,-#_46014b0d1434df2a679006680ca89561p@chr4:185314188..185314207, -
1.54e-114FFCP PHASE2:Hg19::chrX:37664331..37664352,+#_bd9877b2f7ff42599e300623f50e74c2p@chrX:37664331..37664352, +
1.54e-114FFCP PHASE1:Hg19::chrX:37664331..37664352,+#_bd9877b2f7ff42599e300623f50e74c2p@chrX:37664331..37664352, +
1.59e-114FFCP PHASE2:Hg19::chr1:161188826..161188842,+#_ba6090bb00a3c8d1e36e4c4616645866p@chr1:161188826..161188842, +
1.59e-114FFCP PHASE1:Hg19::chr1:161188826..161188842,+#_ba6090bb00a3c8d1e36e4c4616645866p@chr1:161188826..161188842, +
1.87e-114FFCP PHASE2:Hg19::chr1:150724282..150724308,-#_2e8feb13f2bfbe65ed2dcb5b11cec14cp8@CTSS
1.87e-114FFCP PHASE1:Hg19::chr1:150724282..150724308,-#_2e8feb13f2bfbe65ed2dcb5b11cec14cp8@CTSS
5.37e-114FFCP PHASE2:Hg19::chr2:145276939..145276960,+#_d5526812523aeb2ba54037baf3542b11p2@ZEB2-AS1
5.37e-114FFCP PHASE1:Hg19::chr2:145276939..145276960,+#_d5526812523aeb2ba54037baf3542b11p2@ZEB2-AS1
6.51e-114FFCP PHASE1:Hg19::chr19:18285955..18285972,+#_449b747ceba67a5a019fcb5409c2d137p@chr19:18285955..18285972, +
6.51e-114FFCP PHASE2:Hg19::chr19:18285955..18285972,+#_449b747ceba67a5a019fcb5409c2d137p@chr19:18285955..18285972, +
9.3e-114FFCP PHASE1:Hg19::chr8:116588888..116588904,+#_c6d2ce9ebfe03a69507efaf4d0a39dfep@chr8:116588888..116588904, +
9.3e-114FFCP PHASE2:Hg19::chr8:116588888..116588904,+#_c6d2ce9ebfe03a69507efaf4d0a39dfep@chr8:116588888..116588904, +
1.42e-113FFCP PHASE2:Hg19::chr1:145610717..145610730,+#_dc4b750e1157c55dde9fc37a7f56c0dcp4@RNF115
1.42e-113FFCP PHASE1:Hg19::chr1:145610717..145610730,+#_dc4b750e1157c55dde9fc37a7f56c0dcp4@RNF115
4.0e-113FFCP PHASE2:Hg19::chr2:129283966..129283970,+#_d68a54eefcea00359ff54066b91d349ep@chr2:129283966..129283970, +
4.0e-113FFCP PHASE1:Hg19::chr2:129283966..129283970,+#_d68a54eefcea00359ff54066b91d349ep@chr2:129283966..129283970, +
5.85e-113FFCP PHASE1:Hg19::chr19:18283959..18283993,+#_2ba044c8a0ff09d83891675c88fff299p@chr19:18283959..18283993, +
5.85e-113FFCP PHASE2:Hg19::chr19:18283959..18283993,+#_2ba044c8a0ff09d83891675c88fff299p@chr19:18283959..18283993, +
8.33e-113FFCP PHASE2:Hg19::chr20:1517991..1518011,-#_bd89701fa99853b2ceda033fe7f59b58p@chr20:1517991..1518011, -
8.33e-113FFCP PHASE1:Hg19::chr20:1517991..1518011,-#_bd89701fa99853b2ceda033fe7f59b58p@chr20:1517991..1518011, -
1.49e-112FFCP PHASE1:Hg19::chr1:108593061..108593077,+#_c8b467d9bfef56c6da822775376fc5d8p@chr1:108593061..108593077, +
1.49e-112FFCP PHASE2:Hg19::chr1:108593061..108593077,+#_c8b467d9bfef56c6da822775376fc5d8p@chr1:108593061..108593077, +
1.89e-112FFCP PHASE1:Hg19::chr19:18288914..18288931,-#_5990873cee06711a2f86ba43a7ed2600p5@CU676849, p5@CU689079
1.89e-112FFCP PHASE2:Hg19::chr19:18288914..18288931,-#_5990873cee06711a2f86ba43a7ed2600p5@CU676849, p5@CU689079
4.76e-112FFCP PHASE1:Hg19::chr19:18288514..18288554,+#_57b23fa5e5585f31033b216f03b2dd5fp6@IFI30
4.76e-112FFCP PHASE2:Hg19::chr19:18288514..18288554,+#_57b23fa5e5585f31033b216f03b2dd5fp6@IFI30
6.25e-112FFCP PHASE1:Hg19::chr5:180242576..180242585,-#_e45d6f3c004c29ad8cce7f6a1cca3b18p12@MGAT1
6.25e-112FFCP PHASE2:Hg19::chr5:180242576..180242585,-#_e45d6f3c004c29ad8cce7f6a1cca3b18p12@MGAT1
1.15e-111FFCP PHASE2:Hg19::chr7:128503395..128503414,+#_ccea79432ea4f3dc33d5b43cc8fc97e1p@chr7:128503395..128503414, +
1.15e-111FFCP PHASE1:Hg19::chr7:128503395..128503414,+#_ccea79432ea4f3dc33d5b43cc8fc97e1p@chr7:128503395..128503414, +
1.58e-111FFCP PHASE2:Hg19::chr8:53373491..53373506,-#_ece0ae84f57e0121b4d417edadc07225p4@ST18
1.58e-111FFCP PHASE1:Hg19::chr8:53373491..53373506,-#_ece0ae84f57e0121b4d417edadc07225p4@ST18
3.68e-111FFCP PHASE1:Hg19::chr7:6066589..6066602,-#_74aae7e7528f0b4a87d6f02920a6cd60p4@EIF2AK1
3.68e-111FFCP PHASE2:Hg19::chr7:6066589..6066602,-#_74aae7e7528f0b4a87d6f02920a6cd60p4@EIF2AK1
3.91e-111FFCP PHASE2:Hg19::chr17:7483714..7483726,+#_649c3d37e3e9f1a2879eb418b36ea4d7p@chr17:7483714..7483726, +
3.91e-111FFCP PHASE1:Hg19::chr17:7483714..7483726,+#_649c3d37e3e9f1a2879eb418b36ea4d7p@chr17:7483714..7483726, +
1.05e-110FFCP PHASE1:Hg19::chr1:161187774..161187799,+#_60d9eafbb55b8e6fefad623b5cbb80f9p@chr1:161187774..161187799, +
1.05e-110FFCP PHASE2:Hg19::chr1:161187774..161187799,+#_60d9eafbb55b8e6fefad623b5cbb80f9p@chr1:161187774..161187799, +

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