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{{CL
{{CL
|id=CL:0000182
|alt_id=
|name=hepatocyte
|namespace=cell;;efo
|def="The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated." [GOC:tfm, ISBN:0412046911, MESH:A.11.436.348, PMID:19717280]
|xref=BTO:0000575;;FMA:14515
|is_a=CL:0000066;;CL:0000181;;CL:0000417;;CL:0000668;;CL:0002371
|synonym=
|comment=
|comment=
|alt_id=
|disjoint_from=
|union_of=
|created_by=
|created_by=
|obo_creation_date=
|def="The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated." [GOC:tfm, ISBN:0412046911, MESH:A.11.436.348, PMID:19717280]
|subset=
|derives_from=
|derives_from=
|develops_from=CL:0000134;;CL:0000223
|develops_from=CL:0005026
|disjoint_from=
|has_quality=
|has_quality=
|id=CL:0000182
|is_a=CL:0000066 ;;CL:0000181 ;;CL:0000417 ;;CL:0002371
|is_obsolete=
|located_in=
|located_in=
|name=hepatocyte
|namespace=cell;;efo
|obo_creation_date=
|part_of=UBERON:0002107
|part_of=UBERON:0002107
|preceded_by=
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl-to-uberon.owl;;IAO:0000412 http://purl.obolibrary.org/obo/cl.owl;;IAO:0000412 http://purl.obolibrary.org/obo/efo.owl
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl-to-uberon.owl;;IAO:0000412 http://purl.obolibrary.org/obo/cl.owl;;IAO:0000412 http://purl.obolibrary.org/obo/efo.owl
|is_obsolete=
|subset=
|preceded_by=
|synonym=
|union_of=
|xref=BTO:0000575;;FMA:14515
}}
}}

Revision as of 10:15, 12 September 2014

Name:hepatocyte
Namespace:cell;;efo
Definition:"The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated." [GOC:tfm, ISBN:0412046911, MESH:A.11.436.348, PMID:19717280]
Xrefs:
links:

BTO:0000575

FMA:14515


Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:CL:0000066(epithelial cell),CL:0000181(metabolising cell),CL:0000417(endopolyploid cell),CL:0002371(somatic cell)
develops_from:CL:0005026(hepatoblast)
part_of:UBERON:0002107(liver)



Children


is a:FF:0000018 (canine hepatocyte),FF:0000034 (chicken hepatocyte),FF:0000150 (rat hepatocyte),CL:0002538 (intrahepatic bile duct epithelial cell),CL:1000398 (endothelial cell of hepatic sinusoid),FF:13580-146C7 (hepatocytes, sham operation, biol_rep1),FF:13581-146C8 (hepatocytes, sham operation, biol_rep2),FF:13582-146C9 (hepatocytes, sham operation, biol_rep3),FF:13583-146D1 (hepatocytes, partial hepatectomy, 02hr, biol_rep1),FF:13584-146D2 (hepatocytes, partial hepatectomy, 02hr, biol_rep2),FF:13585-146D3 (hepatocytes, partial hepatectomy, 02hr, biol_rep3),FF:13586-146D4 (hepatocytes, partial hepatectomy, 30hr, biol_rep1)
derives from:FF:0000078 (human hepatocyte sample),FF:0000109 (mouse hepatocyte sample),FF:0100578 (hepatoma cell line sample)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)


FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.

Human (Homo sapiens)

... further results Mouse (Mus musculus)

... further results


Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000182 (hepatocyte), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
4.17e-100FFCP PHASE2:Hg19::chr8:144417558..144417572,-#_2974b40250489bc45f20db3ecf938793p7@TOP1MT
4.17e-100FFCP PHASE1:Hg19::chr8:144417558..144417572,-#_2974b40250489bc45f20db3ecf938793p7@TOP1MT
3.95e-89FFCP PHASE1:Hg19::chr20:22566089..22566097,-#_f0f0ee65556efa66005c2e1af9460cb1p6@FOXA2
3.95e-89FFCP PHASE2:Hg19::chr20:22566089..22566097,-#_f0f0ee65556efa66005c2e1af9460cb1p6@FOXA2
2.29e-84FFCP PHASE2:Hg19::chr2:21232865..21232870,-#_9e2e6823a3c994cfd331c4f6643a42a2p10@BC172787
2.29e-84FFCP PHASE2:Hg19::chr2:44066386..44066398,-#_9e2e6823a3c994cfd331c4f6643a42a2p6@ABCG5
2.29e-84FFCP PHASE1:Hg19::chr2:21232865..21232870,-#_9e2e6823a3c994cfd331c4f6643a42a2p10@BC172787
2.29e-84FFCP PHASE2:Hg19::chr2:21234502..21234510,-#_9e2e6823a3c994cfd331c4f6643a42a2p43@APOB
2.29e-84FFCP PHASE1:Hg19::chr2:44066386..44066398,-#_9e2e6823a3c994cfd331c4f6643a42a2p6@ABCG5
2.29e-84FFCP PHASE1:Hg19::chr2:21234502..21234510,-#_9e2e6823a3c994cfd331c4f6643a42a2p43@APOB
2.65e-84FFCP PHASE2:Hg19::chr10:7763609..7763619,+#_5dcc33756ba050484247ffd195c229e4p@chr10:7763609..7763619, +
2.65e-84FFCP PHASE1:Hg19::chr10:7763609..7763619,+#_5dcc33756ba050484247ffd195c229e4p@chr10:7763609..7763619, +
3.05e-84FFCP PHASE2:Hg19::chr2:21230675..21230682,-#_426e280c142806c86d76fef893d3e9c5p51@APOB
3.05e-84FFCP PHASE1:Hg19::chr2:21230675..21230682,-#_426e280c142806c86d76fef893d3e9c5p51@APOB
4.43e-82FFCP PHASE1:Hg19::chr20:62655876..62655885,+#_8d3669c8dfefc139128946a391aacd62p@chr20:62655876..62655885, +
4.43e-82FFCP PHASE2:Hg19::chr20:62655876..62655885,+#_8d3669c8dfefc139128946a391aacd62p@chr20:62655876..62655885, +
5.2e-74FFCP PHASE1:Hg19::chr2:21233797..21233804,-#_ea5aafee6b63bed74dc1d4bd96c2f5cfp58@APOB
5.2e-74FFCP PHASE2:Hg19::chr2:21236080..21236092,-#_ea5aafee6b63bed74dc1d4bd96c2f5cfp3@BC172786
5.2e-74FFCP PHASE1:Hg19::chr2:21236080..21236092,-#_ea5aafee6b63bed74dc1d4bd96c2f5cfp3@BC172786
5.2e-74FFCP PHASE2:Hg19::chr2:21233797..21233804,-#_ea5aafee6b63bed74dc1d4bd96c2f5cfp58@APOB
5.9e-74FFCP PHASE2:Hg19::chr2:21233959..21233966,-#_ba2961f01356059e8d45f3dced61d3ebp50@APOB
5.9e-74FFCP PHASE1:Hg19::chr2:21229230..21229239,-#_ba2961f01356059e8d45f3dced61d3ebp@chr2:21229230..21229239, -
5.9e-74FFCP PHASE2:Hg19::chr2:21242732..21242744,-#_ba2961f01356059e8d45f3dced61d3ebp@chr2:21242732..21242744, -
5.9e-74FFCP PHASE1:Hg19::chr2:21233959..21233966,-#_ba2961f01356059e8d45f3dced61d3ebp50@APOB
5.9e-74FFCP PHASE1:Hg19::chr2:21242732..21242744,-#_ba2961f01356059e8d45f3dced61d3ebp@chr2:21242732..21242744, -
5.9e-74FFCP PHASE2:Hg19::chr2:21229230..21229239,-#_ba2961f01356059e8d45f3dced61d3ebp@chr2:21229230..21229239, -
6.69e-74FFCP PHASE2:Hg19::chr2:21225230..21225237,-#_4c1c37f1e85f3f51f800e426bdcf6f3dp60@APOB
6.69e-74FFCP PHASE1:Hg19::chr2:21225230..21225237,-#_4c1c37f1e85f3f51f800e426bdcf6f3dp60@APOB
7.59e-74FFCP PHASE2:Hg19::chr2:21228952..21228959,-#_c7031b2c84e4995e7f11917c30543096p66@APOB
7.59e-74FFCP PHASE1:Hg19::chr2:21228952..21228959,-#_c7031b2c84e4995e7f11917c30543096p66@APOB
8.6e-74FFCP PHASE2:Hg19::chr14:94759387..94759403,-#_35d2506dc042ade728b8c8e2b7e0e8fap4@SERPINA10
8.6e-74FFCP PHASE1:Hg19::chr14:94759387..94759403,-#_35d2506dc042ade728b8c8e2b7e0e8fap4@SERPINA10
8.6e-74FFCP PHASE1:Hg19::chr2:21234262..21234269,-#_35d2506dc042ade728b8c8e2b7e0e8fap70@APOB
8.6e-74FFCP PHASE2:Hg19::chr2:21234262..21234269,-#_35d2506dc042ade728b8c8e2b7e0e8fap70@APOB
2.07e-73FFCP PHASE2:Hg19::chr2:21257701..21257711,+#_71724f7700544024cb7104e7f5f92ef4p@chr2:21257701..21257711, +
2.07e-73FFCP PHASE1:Hg19::chr2:21257701..21257711,+#_71724f7700544024cb7104e7f5f92ef4p@chr2:21257701..21257711, +
6.33e-73FFCP PHASE2:Hg19::chrX:153769426..153769436,+#_45fb0bb6d20688a35c439fbefc854b27p18@IKBKG
6.33e-73FFCP PHASE2:Hg19::chr10:7745167..7745178,+#_45fb0bb6d20688a35c439fbefc854b27p3@ITIH2
6.33e-73FFCP PHASE1:Hg19::chrX:153769426..153769436,+#_45fb0bb6d20688a35c439fbefc854b27p18@IKBKG
6.33e-73FFCP PHASE1:Hg19::chr10:7745167..7745178,+#_45fb0bb6d20688a35c439fbefc854b27p3@ITIH2
1.49e-72FFCP PHASE2:Hg19::chr2:97216132..97216143,+#_6133edde72e1af8547069d18351f7743p@chr2:97216132..97216143, +
1.49e-72FFCP PHASE1:Hg19::chr2:97216132..97216143,+#_6133edde72e1af8547069d18351f7743p@chr2:97216132..97216143, +
5.78e-72FFCP PHASE2:Mm9::chr4:60016350..60016358,+#_d134f5d5b25084c520ade697a4332005p1@Mup6
5.78e-72FFCP PHASE1:Mm9::chr4:60016350..60016358,+#_d134f5d5b25084c520ade697a4332005p1@Mup6
1.06e-69FFCP PHASE2:Hg19::chr12:24191262..24191291,-#_a4d64177f8f7cafd24bdce6efb31d6c4p@chr12:24191262..24191291, -
1.06e-69FFCP PHASE1:Hg19::chr12:24191262..24191291,-#_a4d64177f8f7cafd24bdce6efb31d6c4p@chr12:24191262..24191291, -
1.65e-69FFCP PHASE1:Mm9::chr9:46038167..46038172,-#_047b5ae1011dc3571ab68d5e15a0c1a5p@chr9:46038167..46038172, -
1.65e-69FFCP PHASE1:Mm9::chr2:104426232..104426235,+#_047b5ae1011dc3571ab68d5e15a0c1a5p@chr2:104426232..104426235, +
1.65e-69FFCP PHASE2:Mm9::chr15:54650539..54650542,-#_047b5ae1011dc3571ab68d5e15a0c1a5p@chr15:54650539..54650542, -
1.65e-69FFCP PHASE1:Mm9::chr15:54650539..54650542,-#_047b5ae1011dc3571ab68d5e15a0c1a5p@chr15:54650539..54650542, -
1.65e-69FFCP PHASE2:Mm9::chr2:104426232..104426235,+#_047b5ae1011dc3571ab68d5e15a0c1a5p@chr2:104426232..104426235, +
1.65e-69FFCP PHASE2:Mm9::chr9:46038167..46038172,-#_047b5ae1011dc3571ab68d5e15a0c1a5p@chr9:46038167..46038172, -
1.26e-68FFCP PHASE2:Hg19::chr2:21228923..21228930,-#_8d5025425504cdf8ebe515509653bd79p94@APOB
1.26e-68FFCP PHASE1:Hg19::chr10:7755243..7755254,-#_8d5025425504cdf8ebe515509653bd79p@chr10:7755243..7755254, -
1.26e-68FFCP PHASE2:Hg19::chr9:107651917..107651931,-#_8d5025425504cdf8ebe515509653bd79p11@ABCA1
1.26e-68FFCP PHASE2:Hg19::chr20:62655807..62655838,+#_8d5025425504cdf8ebe515509653bd79p@chr20:62655807..62655838, +
1.26e-68FFCP PHASE1:Hg19::chr2:21228923..21228930,-#_8d5025425504cdf8ebe515509653bd79p94@APOB
1.26e-68FFCP PHASE1:Hg19::chr9:107651917..107651931,-#_8d5025425504cdf8ebe515509653bd79p11@ABCA1
1.26e-68FFCP PHASE1:Hg19::chr20:62655807..62655838,+#_8d5025425504cdf8ebe515509653bd79p@chr20:62655807..62655838, +
1.26e-68FFCP PHASE2:Hg19::chr10:7755243..7755254,-#_8d5025425504cdf8ebe515509653bd79p@chr10:7755243..7755254, -
1.45e-68FFCP PHASE2:Hg19::chr2:21229212..21229220,-#_9c043e1af5ab272f136ee1f8387baeffp@chr2:21229212..21229220, -
1.45e-68FFCP PHASE2:Hg19::chr2:21232174..21232177,-#_9c043e1af5ab272f136ee1f8387baeffp13@BC172787
1.45e-68FFCP PHASE1:Hg19::chr2:21229212..21229220,-#_9c043e1af5ab272f136ee1f8387baeffp@chr2:21229212..21229220, -
1.45e-68FFCP PHASE1:Hg19::chr2:21232174..21232177,-#_9c043e1af5ab272f136ee1f8387baeffp13@BC172787
1.67e-68FFCP PHASE2:Hg19::chr2:21234575..21234582,-#_6ed393ba617f39f1c52cacde2dd43037p78@APOB
1.67e-68FFCP PHASE1:Hg19::chr2:21234575..21234582,-#_6ed393ba617f39f1c52cacde2dd43037p78@APOB
1.67e-68FFCP PHASE1:Hg19::chr2:219613831..219613849,+#_6ed393ba617f39f1c52cacde2dd43037p@chr2:219613831..219613849, +
1.67e-68FFCP PHASE2:Hg19::chr2:219613831..219613849,+#_6ed393ba617f39f1c52cacde2dd43037p@chr2:219613831..219613849, +
2.21e-68FFCP PHASE2:Hg19::chr14:94759408..94759416,-#_62ec3fe3f7faf56c0c3cef456664957bp6@SERPINA10
2.21e-68FFCP PHASE1:Hg19::chr14:94759408..94759416,-#_62ec3fe3f7faf56c0c3cef456664957bp6@SERPINA10
2.21e-68FFCP PHASE2:Hg19::chr2:21231259..21231266,-#_62ec3fe3f7faf56c0c3cef456664957bp84@APOB
2.21e-68FFCP PHASE1:Hg19::chr2:21231259..21231266,-#_62ec3fe3f7faf56c0c3cef456664957bp84@APOB
2.54e-68FFCP PHASE1:Hg19::chr18:32508476..32508518,-#_e59668b3806123412b5917247bd77fadp@chr18:32508476..32508518, -
2.54e-68FFCP PHASE2:Hg19::chr18:32508476..32508518,-#_e59668b3806123412b5917247bd77fadp@chr18:32508476..32508518, -
2.71e-67FFCP PHASE1:Hg19::chr17:7082560..7082572,-#_49838dcf808d1f905c43e3f94b2cc7bbp4@ASGR1
2.71e-67FFCP PHASE2:Hg19::chr17:7082560..7082572,-#_49838dcf808d1f905c43e3f94b2cc7bbp4@ASGR1
3.3e-67FFCP PHASE2:Hg19::chr10:72083665..72083701,-#_052fab90428e93d3c888629720328455p2@LRRC20
3.3e-67FFCP PHASE1:Hg19::chr10:72083665..72083701,-#_052fab90428e93d3c888629720328455p2@LRRC20
5.39e-67FFCP PHASE1:Hg19::chr2:21233386..21233397,-#_206d5723072dd22e52b5c38a0789ecaep22@APOB
5.39e-67FFCP PHASE2:Hg19::chr2:21233386..21233397,-#_206d5723072dd22e52b5c38a0789ecaep22@APOB
5.94e-67FFCP PHASE2:Hg19::chr12:24191210..24191221,-#_ee3a6cbbb7d47a692e766e81b263d4cbp@chr12:24191210..24191221, -
5.94e-67FFCP PHASE1:Hg19::chr12:24191210..24191221,-#_ee3a6cbbb7d47a692e766e81b263d4cbp@chr12:24191210..24191221, -
6.56e-67FFCP PHASE2:Hg19::chr6:30130969..30131007,+#_d9e28319635314d50e83be12c2b8499bp3@TRIM15
6.56e-67FFCP PHASE1:Hg19::chr6:30130969..30131007,+#_d9e28319635314d50e83be12c2b8499bp3@TRIM15
7.97e-67FFCP PHASE1:Hg19::chr9:116838918..116838930,-#_d789e448e3f08dc8eb72cfedc6c87260p@chr9:116838918..116838930, -
7.97e-67FFCP PHASE2:Hg19::chr9:116838918..116838930,-#_d789e448e3f08dc8eb72cfedc6c87260p@chr9:116838918..116838930, -
1.07e-66FFCP PHASE1:Hg19::chr3:197300199..197300219,-#_16857e3dafc8878eeea246dacfd5c9bfp2@BDH1
1.07e-66FFCP PHASE2:Hg19::chr3:197300199..197300219,-#_16857e3dafc8878eeea246dacfd5c9bfp2@BDH1
1.18e-66FFCP PHASE2:Hg19::chr1:11107289..11107304,-#_45884abe20a3825517415604f2f0ec9fp1@MASP2
1.18e-66FFCP PHASE1:Hg19::chr1:11107289..11107304,-#_45884abe20a3825517415604f2f0ec9fp1@MASP2
1.3e-66FFCP PHASE2:Hg19::chr19:45430057..45430062,+#_fe09b2506314102d42197764537baa3dp1@APOC1P1
1.3e-66FFCP PHASE1:Hg19::chr19:45430057..45430062,+#_fe09b2506314102d42197764537baa3dp1@APOC1P1
1.58e-66FFCP PHASE2:Hg19::chr9:116838988..116838999,-#_ab69eafe34b5cae4f1e0a31f259f0a56p@chr9:116838988..116838999, -
1.58e-66FFCP PHASE1:Hg19::chr4:155528001..155528060,-#_ab69eafe34b5cae4f1e0a31f259f0a56p@chr4:155528001..155528060, -
1.58e-66FFCP PHASE1:Hg19::chr9:116838988..116838999,-#_ab69eafe34b5cae4f1e0a31f259f0a56p@chr9:116838988..116838999, -
1.58e-66FFCP PHASE2:Hg19::chr4:155528001..155528060,-#_ab69eafe34b5cae4f1e0a31f259f0a56p@chr4:155528001..155528060, -
2.12e-66FFCP PHASE2:Hg19::chr11:116662593..116662620,-#_781b9565b0c947becd10d556f3ddda22p1@APOA5
2.12e-66FFCP PHASE1:Hg19::chr11:116662593..116662620,-#_781b9565b0c947becd10d556f3ddda22p1@APOA5
2.34e-66FFCP PHASE1:Hg19::chr17:7017634..7017649,-#_eb2cf291ad114667cb90c45ac9230918p7@ASGR2
2.34e-66FFCP PHASE2:Hg19::chr17:7017634..7017649,-#_eb2cf291ad114667cb90c45ac9230918p7@ASGR2

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