MCL coexpression mm9:1102

Phase1 CAGE Peaks

	Short description
Mm9::chr12:17273377..17273407,+	p1@Pdia6
Mm9::chr12:17273415..17273424,+	p1@LOC100046302 p2@Pdia6
Mm9::chr13:38085980..38086053,-	p1@Ssr1
Mm9::chr15:100246175..100246190,-	p@chr15:100246175..100246190 -
Mm9::chr2:34627609..34627614,+	p1@Hspa5
Mm9::chr9:89599731..89599742,-	p@chr9:89599731..89599742 -
Mm9::chr9:89599745..89599851,-	p1@Tmed3

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005783	endoplasmic reticulum	0.0140907646314896
GO:0044444	cytoplasmic part	0.0177715855052601
GO:0043022	ribosome binding	0.0177715855052601
GO:0006983	ER overload response	0.0177715855052601
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	0.0177715855052601
GO:0003756	protein disulfide isomerase activity	0.0177715855052601
GO:0016862	intramolecular oxidoreductase activity, interconverting keto- and enol-groups	0.0177715855052601
GO:0043021	ribonucleoprotein binding	0.0258913450988841
GO:0033554	cellular response to stress	0.0258913450988841
GO:0006984	ER-nuclear signaling pathway	0.0258913450988841
GO:0008320	protein transmembrane transporter activity	0.0258913450988841
GO:0051716	cellular response to stimulus	0.0258913450988841
GO:0005737	cytoplasm	0.0392027454275295
GO:0045454	cell redox homeostasis	0.0444489900098845
GO:0016860	intramolecular oxidoreductase activity	0.0444489900098845

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
immaterial anatomical entity	6.98e-13	79
trunk	3.91e-12	90
trunk region element	2.85e-10	79
pancreas	5.09e-09	12
anatomical cavity	2.14e-08	39
anatomical space	2.42e-08	57
body cavity precursor	6.57e-08	38
trunk mesenchyme	8.05e-08	45
body cavity	2.13e-07	37
body cavity or lining	2.13e-07	37
mesenchyme	5.13e-07	61
entire embryonic mesenchyme	5.13e-07	61

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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