MCL coexpression mm9:743

Phase1 CAGE Peaks

	Short description
Mm9::chr2:104966636..104966641,+	p12@Wt1
Mm9::chr2:104966659..104966672,-	p1@AI314831
Mm9::chr2:104966683..104966700,-	p3@AI314831
Mm9::chr2:104966713..104966727,-	p2@AI314831
Mm9::chr2:104966874..104966907,+	p2@Wt1
Mm9::chr2:104966909..104966920,+	p8@Wt1
Mm9::chr2:104966933..104966966,+	p3@Wt1
Mm9::chr2:104966983..104966990,+	p11@Wt1
Mm9::chr7:103661125..103661139,+	p@chr7:103661125..103661139 +
Mm9::chr8:40383519..40383531,+	p2@Gm6213

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0001823	mesonephros development	0.0102996767654632
GO:0008584	male gonad development	0.0213350447284595
GO:0046546	development of primary male sexual characteristics	0.0213350447284595
GO:0007530	sex determination	0.0213350447284595
GO:0007281	germ cell development	0.0213350447284595
GO:0046661	male sex differentiation	0.0213350447284595
GO:0001570	vasculogenesis	0.0213350447284595
GO:0030855	epithelial cell differentiation	0.0231742727222922
GO:0001656	metanephros development	0.0248128576622523
GO:0008406	gonad development	0.0248128576622523
GO:0048608	reproductive structure development	0.0248128576622523
GO:0045137	development of primary sexual characteristics	0.0248908855165361
GO:0007548	sex differentiation	0.0254273270147373
GO:0001822	kidney development	0.0254273270147373
GO:0043010	camera-type eye development	0.0254273270147373
GO:0001655	urogenital system development	0.0254273270147373
GO:0003006	reproductive developmental process	0.0260521235832305
GO:0001654	eye development	0.0297546217668937
GO:0045786	negative regulation of progression through cell cycle	0.0314411185472035
GO:0002009	morphogenesis of an epithelium	0.0316715060537994
GO:0048514	blood vessel morphogenesis	0.039291359512693
GO:0000074	regulation of progression through cell cycle	0.039291359512693
GO:0007423	sensory organ development	0.039291359512693
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	0.039291359512693
GO:0001568	blood vessel development	0.039291359512693
GO:0022414	reproductive process	0.039291359512693
GO:0001944	vasculature development	0.039291359512693
GO:0045893	positive regulation of transcription, DNA-dependent	0.0434057806544521
GO:0007276	gamete generation	0.0443951584718242
GO:0009888	tissue development	0.0455682669017463
GO:0045941	positive regulation of transcription	0.0455682669017463
GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.0455682669017463
GO:0019953	sexual reproduction	0.0455682669017463

Relative expression of the co-expression cluster over median <br>Analyst:

---

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

---

Uber Anatomy

Ontology term	p-value	n
reproductive organ	4.48e-15	24
reproductive structure	5.38e-15	26
reproductive system	5.38e-15	26
body cavity	4.33e-14	37
body cavity or lining	4.33e-14	37
body cavity precursor	1.98e-13	38
gonad	3.75e-13	18
gonad primordium	3.75e-13	18
anatomical cavity	8.30e-13	39
external genitalia	3.64e-12	17
indifferent external genitalia	3.64e-12	17
indifferent gonad	3.64e-12	17
testis	1.89e-09	14
anatomical space	2.13e-09	57
male reproductive organ	1.65e-08	15
splanchnic layer of lateral plate mesoderm	5.71e-08	33
primary circulatory organ	6.06e-08	18
heart	6.06e-08	18
primitive heart tube	6.06e-08	18
primary heart field	6.06e-08	18
anterior lateral plate mesoderm	6.06e-08	18
heart tube	6.06e-08	18
heart primordium	6.06e-08	18
cardiac mesoderm	6.06e-08	18
cardiogenic plate	6.06e-08	18
heart rudiment	6.06e-08	18
female reproductive system	6.21e-08	9
male organism	1.08e-07	16
male reproductive system	1.08e-07	16
compound organ	2.20e-07	43
female reproductive organ	4.71e-07	8

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}