Coexpression cluster:C1510

Full id: C1510_heart_left_aorta_retina_penis_cerebral_nucleus

Phase1 CAGE Peaks

Hg19::chr3:123168551..123168642,-	p1@ADCY5
Hg19::chr6:46459112..46459132,-	p4@RCAN2
Hg19::chr6:46459144..46459155,-	p9@RCAN2
Hg19::chr6:46459168..46459217,-	p2@RCAN2
Hg19::chr6:46459218..46459241,-	p5@RCAN2
Hg19::chr6:46459675..46459716,-	p6@RCAN2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0019932	second-messenger-mediated signaling	0.00235484582965663
GO:0007195	dopamine receptor, adenylate cyclase inhibiting pathway	0.00235484582965663
GO:0001973	adenosine receptor signaling pathway	0.00235484582965663
GO:0030346	protein phosphatase 2B binding	0.00264916256568538
GO:0007191	dopamine receptor, adenylate cyclase activating pathway	0.00282573181120752
GO:0004016	adenylate cyclase activity	0.005801219274165
GO:0019903	protein phosphatase binding	0.005801219274165
GO:0007212	dopamine receptor signaling pathway	0.005801219274165
GO:0050885	neuromuscular process controlling balance	0.005801219274165
GO:0007193	G-protein signaling, adenylate cyclase inhibiting pathway	0.005801219274165
GO:0006171	cAMP biosynthetic process	0.005801219274165
GO:0019902	phosphatase binding	0.005801219274165
GO:0046058	cAMP metabolic process	0.005801219274165
GO:0050905	neuromuscular process	0.005801219274165
GO:0016849	phosphorus-oxygen lyase activity	0.00725703423266822
GO:0009975	cyclase activity	0.00725703423266822
GO:0007189	G-protein signaling, adenylate cyclase activating pathway	0.00725703423266822
GO:0019722	calcium-mediated signaling	0.00725703423266822
GO:0009190	cyclic nucleotide biosynthetic process	0.00743219603252548
GO:0009187	cyclic nucleotide metabolic process	0.00882443303267968
GO:0007242	intracellular signaling cascade	0.00955446881071249
GO:0007188	G-protein signaling, coupled to cAMP nucleotide second messenger	0.0133444744766028
GO:0019933	cAMP-mediated signaling	0.0133444744766028
GO:0007187	G-protein signaling, coupled to cyclic nucleotide second messenger	0.017190663102313
GO:0019935	cyclic-nucleotide-mediated signaling	0.0172070259898471
GO:0007626	locomotory behavior	0.0245252388860843
GO:0032501	multicellular organismal process	0.0281206762138235
GO:0007417	central nervous system development	0.0295441581958837
GO:0009165	nucleotide biosynthetic process	0.0309439441259926
GO:0016829	lyase activity	0.0325993868001008
GO:0007610	behavior	0.0333556049337517
GO:0019899	enzyme binding	0.0335167902888808
GO:0009117	nucleotide metabolic process	0.0362120198484877
GO:0055086	nucleobase, nucleoside and nucleotide metabolic process	0.0379228904977998
GO:0007165	signal transduction	0.0392675165512817
GO:0000287	magnesium ion binding	0.0434301715857959
GO:0007154	cell communication	0.0434301715857959

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.