Coexpression cluster:C731

Full id: C731_Adipocyte_Preadipocyte_adipose_Wilms_salivary_Mesenchymal_epididymis

Phase1 CAGE Peaks

Hg19::chr11:103720186..103720199,-	p@chr11:103720186..103720199 -
Hg19::chr11:103720238..103720263,-	p@chr11:103720238..103720263 -
Hg19::chr11:103720267..103720289,-	p@chr11:103720267..103720289 -
Hg19::chr15:27111855..27111872,+	p5@GABRA5
Hg19::chr18:21464608..21464649,+	p1@X77598
Hg19::chr19:18718144..18718158,+	p@chr19:18718144..18718158 +
Hg19::chr19:18718172..18718197,+	p@chr19:18718172..18718197 +
Hg19::chr3:42885183..42885192,-	p@chr3:42885183..42885192 -
Hg19::chr3:42893935..42893942,-	p1@ENST00000449063
Hg19::chr6:36472846..36472877,-	p@chr6:36472846..36472877 -
Hg19::chr7:73483284..73483299,+	p14@ELN

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0030023	extracellular matrix constituent conferring elasticity	0.011832926126728
GO:0007214	gamma-aminobutyric acid signaling pathway	0.0322666861914272
GO:0007585	respiratory gaseous exchange	0.0322666861914272
GO:0004890	GABA-A receptor activity	0.0322666861914272
GO:0016917	GABA receptor activity	0.0322666861914272
GO:0043168	anion binding	0.0322666861914272
GO:0031404	chloride ion binding	0.0322666861914272
GO:0005254	chloride channel activity	0.0322666861914272
GO:0006821	chloride transport	0.0322666861914272
GO:0005253	anion channel activity	0.0322666861914272
GO:0005201	extracellular matrix structural constituent	0.0322666861914272
GO:0005230	extracellular ligand-gated ion channel activity	0.0322666861914272
GO:0030594	neurotransmitter receptor activity	0.0322666861914272
GO:0042165	neurotransmitter binding	0.0322666861914272
GO:0045211	postsynaptic membrane	0.0322666861914272
GO:0008015	blood circulation	0.0322666861914272
GO:0003013	circulatory system process	0.0322666861914272
GO:0044456	synapse part	0.0322666861914272
GO:0015276	ligand-gated ion channel activity	0.0322666861914272
GO:0022834	ligand-gated channel activity	0.0322666861914272
GO:0008509	anion transmembrane transporter activity	0.0391362374873183
GO:0015698	inorganic anion transport	0.0464382262756771

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.