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|namespace=
|namespace=
|def="An endolymph filled cavity inside the cochlea, located in between the scala tympani and the scala vestibuli, separated by the basilar membrane and Reissner's membrane (the vestibular membrane) respectively. Houses the organ of Corti[WP]." [Wikipedia:Cochlear_duct]
|def="An endolymph filled cavity inside the cochlea, located in between the scala tympani and the scala vestibuli, separated by the basilar membrane and Reissner's membrane (the vestibular membrane) respectively. Houses the organ of Corti[WP]." [Wikipedia:Cochlear_duct]
|xref=BTO:0001692;;EHDAA:4718;;EHDAA2:0000262;;EMAPA:17598;;FMA:61119;;GAID:874;;http://upload.wikimedia.org/wikipedia/commons/thumb/b/bc/Gray928.png/200px-Gray928.png;;MA:0000243;;MESH:A.09.246.631.246.292;;ncithesaurus:Cochlear_Duct;;NIF_GrossAnatomy:birnlex_2562;;SCTID:279849006;;VHOG:0000507
|xref=BTO:0001692;;EHDAA2:0000262;;EHDAA:4718;;EMAPA:17598;;FMA:61119;;GAID:874;;http://upload.wikimedia.org/wikipedia/commons/b/bc/Gray928.png;;http://upload.wikimedia.org/wikipedia/commons/thumb/b/bc/Gray928.png/200px-Gray928.png;;MA:0000243;;MESH:A.09.246.631.246.292;;ncithesaurus:Cochlear_Duct;;NIF_GrossAnatomy:birnlex_2562;;SCTID:279849006;;VHOG:0000507
|is_a=UBERON:0000058;;UBERON:0004121;;UBERON:0005744
|is_a=UBERON:0000058;;UBERON:0004120;;UBERON:0004121;;UBERON:0005744;;UBERON:0010314
|synonym="cochlea duct" EXACT [NIF_GrossAnatomy:birnlex_2562];;"cochlear aqueduct" RELATED [];;"cochlear duct" EXACT [];;"ductus cochlearis" RELATED [BTO:0001692];;"membranous cochlea" RELATED [BTO:0001692];;"Reissner's canal" EXACT [];;"reissners canal" EXACT [NIF_GrossAnatomy:birnlex_2562];;"scala media" RELATED [Wikipedia:Cochlear_duct];;"scala medias" EXACT [NIF_GrossAnatomy:birnlex_2562];;"scala of Loewenberg" RELATED [BTO:0001692]
|synonym="cochlea duct" EXACT [NIF_GrossAnatomy:birnlex_2562];;"cochlear aqueduct" RELATED [];;"cochlear duct" EXACT [];;"ductus cochlearis" RELATED LATIN [Wikipedia:Cochlear_duct];;"ductus cochlearis" RELATED [BTO:0001692];;"membranous cochlea" RELATED [BTO:0001692];;"Reissner's canal" EXACT [];;"reissners canal" EXACT [NIF_GrossAnatomy:birnlex_2562];;"scala media" RELATED [Wikipedia:Cochlear_duct];;"scala medias" EXACT [NIF_GrossAnatomy:birnlex_2562];;"scala of Loewenberg" RELATED [BTO:0001692]
|comment=TODO: check cochlear duct vs cochlear aqueduct vs scala media
|comment=TODO: check cochlear duct vs cochlear aqueduct vs scala media
|alt_id=UBERON:FMA_61119-MA_0000243
|alt_id=UBERON:FMA_61119-MA_0000243
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|obo_creation_date=
|obo_creation_date=
|subset=uberon_slim
|subset=uberon_slim
|adjacent_to=
|derives_from=
|derives_from=
|develops_from=
|develops_from=
|has_quality=
|has_quality=
|located_in=
|located_in=
|part_of=UBERON:0001844;;UBERON:0001849;;UBERON:0002499
|part_of=
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl
|is_obsolete=
|is_obsolete=
|preceded_by=
|preceded_by=
}}
}}

Revision as of 17:00, 26 June 2012

Name:cochlear duct of membranous labyrinth
Definition:"An endolymph filled cavity inside the cochlea, located in between the scala tympani and the scala vestibuli, separated by the basilar membrane and Reissner's membrane (the vestibular membrane) respectively. Houses the organ of Corti[WP]." [Wikipedia:Cochlear_duct]
Xrefs:
links:

BTO:0001692
EHDAA2:0000262
EHDAA:4718
EMAPA:17598
FMA:61119
GAID:874
[ Gray928.png Gray928.png]
[ 200px-Gray928.png 200px-Gray928.png]
MA:0000243
MESH:A.09.246.631.246.292
ncithesaurus:Cochlear_Duct
NIF_GrossAnatomy:birnlex_2562
SCTID:279849006

VHOG:0000507
Synonyms: "cochlea duct" EXACT [NIF_GrossAnatomy:birnlex_2562]
"cochlear aqueduct" RELATED []
"cochlear duct" EXACT []
"ductus cochlearis" RELATED LATIN [Wikipedia:Cochlear_duct]
"ductus cochlearis" RELATED [BTO:0001692]
"membranous cochlea" RELATED [BTO:0001692]
"Reissner's canal" EXACT []
"reissners canal" EXACT [NIF_GrossAnatomy:birnlex_2562]
"scala media" RELATED [Wikipedia:Cochlear_duct]
"scala medias" EXACT [NIF_GrossAnatomy:birnlex_2562]
"scala of Loewenberg" RELATED [BTO:0001692]
Comments:TODO: check cochlear duct vs cochlear aqueduct vs scala media
Alt_id: UBERON:FMA_61119-MA_0000243
Subset: uberon_slim

Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:UBERON:0000058(duct),UBERON:0004120(mesoderm-derived structure),UBERON:0004121(ectoderm-derived structure),UBERON:0005744(cranial conduit),UBERON:0010314(structure with developmental contribution from neural crest)



Children

part of:UBERON:0002227 (spiral organ of cochlea)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)

FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology

Mouse (Mus musculus)

  • 12157-128G6 (Sox2+ Supporting cells - organ of corti, pool1)
  • 12158-128G7 (Atoh+ Inner ear hair cells - organ of corti, pool1)
  • 12215-129E1 (Inner ear stem cells, 1st generation stem cells, pool1)
  • 12216-129E2 (Inner ear stem cells, 4th generation stem cells, pool1)
  • 12217-129E3 (Inner ear stem cells, differentiation, day03, pool1)
  • 12218-129E4 (Inner ear stem cells, differentiation, day10, pool1)


Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0001855 (cochlear duct of membranous labyrinth), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
1.87e-86FFCP PHASE2:Mm9::chr7:88068153..88068160,-#_1eba4701f2dfc2ab7dc48555b485e41ep10@Sec11a
1.87e-86FFCP PHASE1:Mm9::chr11:4689837..4689845,-#_1eba4701f2dfc2ab7dc48555b485e41ep@chr11:4689837..4689845, -
1.87e-86FFCP PHASE1:Mm9::chr5:3909290..3909299,+#_1eba4701f2dfc2ab7dc48555b485e41ep@chr5:3909290..3909299, +
1.87e-86FFCP PHASE1:Mm9::chr4:115556939..115556945,+#_1eba4701f2dfc2ab7dc48555b485e41ep4@Kncn
1.87e-86FFCP PHASE2:Mm9::chr1:194818647..194818660,-#_1eba4701f2dfc2ab7dc48555b485e41ep@chr1:194818647..194818660, -
1.87e-86FFCP PHASE2:Mm9::chr5:68423014..68423037,+#_1eba4701f2dfc2ab7dc48555b485e41ep1@Grxcr1
1.87e-86FFCP PHASE1:Mm9::chr9:42207697..42207705,-#_1eba4701f2dfc2ab7dc48555b485e41ep@chr9:42207697..42207705, -
1.87e-86FFCP PHASE1:Mm9::chr7:27964761..27964768,+#_1eba4701f2dfc2ab7dc48555b485e41ep@chr7:27964761..27964768, +
1.87e-86FFCP PHASE2:Mm9::chr9:50968647..50968668,-#_1eba4701f2dfc2ab7dc48555b485e41ep@chr9:50968647..50968668, -
1.87e-86FFCP PHASE1:Mm9::chr14:47293496..47293510,-#_1eba4701f2dfc2ab7dc48555b485e41ep@chr14:47293496..47293510, -
1.87e-86FFCP PHASE1:Mm9::chr3:154693281..154693317,-#_1eba4701f2dfc2ab7dc48555b485e41ep@chr3:154693281..154693317, -
1.87e-86FFCP PHASE1:Mm9::chr7:109265277..109265288,-#_1eba4701f2dfc2ab7dc48555b485e41ep4@Chrna10
1.87e-86FFCP PHASE1:Mm9::chr13:78257454..78257465,+#_1eba4701f2dfc2ab7dc48555b485e41ep@chr13:78257454..78257465, +
1.87e-86FFCP PHASE1:Mm9::chr5:150945209..150945220,+#_1eba4701f2dfc2ab7dc48555b485e41ep@chr5:150945209..150945220, +
1.87e-86FFCP PHASE1:Mm9::chr9:41495920..41495928,-#_1eba4701f2dfc2ab7dc48555b485e41ep@chr9:41495920..41495928, -
1.87e-86FFCP PHASE1:Mm9::chr2:53464178..53464186,+#_1eba4701f2dfc2ab7dc48555b485e41ep@chr2:53464178..53464186, +
1.87e-86FFCP PHASE1:Mm9::chr14:20649897..20649907,+#_1eba4701f2dfc2ab7dc48555b485e41ep@chr14:20649897..20649907, +
1.87e-86FFCP PHASE2:Mm9::chr10:80806047..80806059,-#_1eba4701f2dfc2ab7dc48555b485e41ep4@Gipc3
1.87e-86FFCP PHASE1:Mm9::chr12:13572961..13572974,+#_1eba4701f2dfc2ab7dc48555b485e41ep@chr12:13572961..13572974, +
1.87e-86FFCP PHASE1:Mm9::chr4:151505798..151505818,-#_1eba4701f2dfc2ab7dc48555b485e41ep21@Espn
1.87e-86FFCP PHASE2:Mm9::chr9:92087926..92087938,+#_1eba4701f2dfc2ab7dc48555b485e41ep2@Plscr5
1.87e-86FFCP PHASE2:Mm9::chr3:58626291..58626298,-#_1eba4701f2dfc2ab7dc48555b485e41ep@chr3:58626291..58626298, -
1.87e-86FFCP PHASE1:Mm9::chr9:56208792..56208814,-#_1eba4701f2dfc2ab7dc48555b485e41ep@chr9:56208792..56208814, -
1.87e-86FFCP PHASE2:Mm9::chr5:3909290..3909299,+#_1eba4701f2dfc2ab7dc48555b485e41ep@chr5:3909290..3909299, +
1.87e-86FFCP PHASE2:Mm9::chr1:172843813..172843834,-#_1eba4701f2dfc2ab7dc48555b485e41ep@chr1:172843813..172843834, -
1.87e-86FFCP PHASE1:Mm9::chr10:107349378..107349390,-#_1eba4701f2dfc2ab7dc48555b485e41ep1@Otogl
1.87e-86FFCP PHASE1:Mm9::chr1:182528371..182528385,+#_1eba4701f2dfc2ab7dc48555b485e41ep@chr1:182528371..182528385, +
1.87e-86FFCP PHASE2:Mm9::chr4:130461150..130461185,+#_1eba4701f2dfc2ab7dc48555b485e41ep@chr4:130461150..130461185, +
1.87e-86FFCP PHASE1:Mm9::chr11:94371127..94371139,-#_1eba4701f2dfc2ab7dc48555b485e41ep@chr11:94371127..94371139, -
1.87e-86FFCP PHASE1:Mm9::chr6:113251614..113251623,+#_1eba4701f2dfc2ab7dc48555b485e41ep@chr6:113251614..113251623, +
1.87e-86FFCP PHASE1:Mm9::chr19:10536767..10536777,-#_1eba4701f2dfc2ab7dc48555b485e41ep@chr19:10536767..10536777, -
1.87e-86FFCP PHASE2:Mm9::chr3:100724698..100724706,+#_1eba4701f2dfc2ab7dc48555b485e41ep@chr3:100724698..100724706, +
1.87e-86FFCP PHASE2:Mm9::chr6:30619378..30619412,-#_1eba4701f2dfc2ab7dc48555b485e41ep11@Tsga14
1.87e-86FFCP PHASE2:Mm9::chr19:10536797..10536802,-#_1eba4701f2dfc2ab7dc48555b485e41ep@chr19:10536797..10536802, -
1.87e-86FFCP PHASE2:Mm9::chr9:56208792..56208814,-#_1eba4701f2dfc2ab7dc48555b485e41ep@chr9:56208792..56208814, -
1.87e-86FFCP PHASE2:Mm9::chr9:42207887..42207960,-#_1eba4701f2dfc2ab7dc48555b485e41ep1@Tecta
1.87e-86FFCP PHASE1:Mm9::chr19:55256373..55256384,+#_1eba4701f2dfc2ab7dc48555b485e41ep@chr19:55256373..55256384, +
1.87e-86FFCP PHASE2:Mm9::chr11:102123535..102123544,+#_1eba4701f2dfc2ab7dc48555b485e41ep5@BC030867
1.87e-86FFCP PHASE1:Mm9::chr15:65641741..65641748,+#_1eba4701f2dfc2ab7dc48555b485e41ep@chr15:65641741..65641748, +
1.87e-86FFCP PHASE2:Mm9::chr3:35012425..35012439,+#_1eba4701f2dfc2ab7dc48555b485e41ep@chr3:35012425..35012439, +
1.87e-86FFCP PHASE2:Mm9::chr4:115556989..115556997,+#_1eba4701f2dfc2ab7dc48555b485e41ep1@Kncn
1.87e-86FFCP PHASE2:Mm9::chr17:13983160..13983167,+#_1eba4701f2dfc2ab7dc48555b485e41ep@chr17:13983160..13983167, +
1.87e-86FFCP PHASE1:Mm9::chr9:42207887..42207960,-#_1eba4701f2dfc2ab7dc48555b485e41ep1@Tecta
1.87e-86FFCP PHASE1:Mm9::chr1:93235253..93235264,+#_1eba4701f2dfc2ab7dc48555b485e41ep@chr1:93235253..93235264, +
1.87e-86FFCP PHASE2:Mm9::chr9:42206745..42206774,-#_1eba4701f2dfc2ab7dc48555b485e41ep@chr9:42206745..42206774, -
1.87e-86FFCP PHASE2:Mm9::chr19:55255206..55255223,+#_1eba4701f2dfc2ab7dc48555b485e41ep1@Tectb
1.87e-86FFCP PHASE2:Mm9::chr3:106986057..106986062,+#_1eba4701f2dfc2ab7dc48555b485e41ep1@Kcna10
1.87e-86FFCP PHASE1:Mm9::chr11:102123535..102123544,+#_1eba4701f2dfc2ab7dc48555b485e41ep5@BC030867
1.87e-86FFCP PHASE1:Mm9::chr3:35012397..35012405,+#_1eba4701f2dfc2ab7dc48555b485e41ep@chr3:35012397..35012405, +
1.87e-86FFCP PHASE2:Mm9::chr2:128881546..128881553,-#_1eba4701f2dfc2ab7dc48555b485e41ep@chr2:128881546..128881553, -
1.87e-86FFCP PHASE1:Mm9::chr5:30710403..30710406,-#_1eba4701f2dfc2ab7dc48555b485e41ep10@Otof
1.87e-86FFCP PHASE2:Mm9::chr4:151505798..151505818,-#_1eba4701f2dfc2ab7dc48555b485e41ep21@Espn
1.87e-86FFCP PHASE1:Mm9::chr9:42206745..42206774,-#_1eba4701f2dfc2ab7dc48555b485e41ep@chr9:42206745..42206774, -
1.87e-86FFCP PHASE1:Mm9::chr2:67011921..67011934,+#_1eba4701f2dfc2ab7dc48555b485e41ep2@Gm1322
1.87e-86FFCP PHASE2:Mm9::chr1:93218694..93218705,+#_1eba4701f2dfc2ab7dc48555b485e41ep1@Espnl
1.87e-86FFCP PHASE2:Mm9::chr18:42158627..42158630,-#_1eba4701f2dfc2ab7dc48555b485e41ep@chr18:42158627..42158630, -
1.87e-86FFCP PHASE1:Mm9::chr17:13983179..13983190,+#_1eba4701f2dfc2ab7dc48555b485e41ep@chr17:13983179..13983190, +
1.87e-86FFCP PHASE1:Mm9::chr9:66860888..66860899,+#_1eba4701f2dfc2ab7dc48555b485e41ep@chr9:66860888..66860899, +
1.87e-86FFCP PHASE2:Mm9::chr13:78257491..78257498,+#_1eba4701f2dfc2ab7dc48555b485e41ep@chr13:78257491..78257498, +
1.87e-86FFCP PHASE1:Mm9::chr7:109052297..109052300,-#_1eba4701f2dfc2ab7dc48555b485e41ep2@Tomt
1.87e-86FFCP PHASE1:Mm9::chrX:154140800..154140810,+#_1eba4701f2dfc2ab7dc48555b485e41ep@chrX:154140800..154140810, +
1.87e-86FFCP PHASE1:Mm9::chr3:81012915..81012923,+#_1eba4701f2dfc2ab7dc48555b485e41ep@chr3:81012915..81012923, +
1.87e-86FFCP PHASE1:Mm9::chr15:89215333..89215341,+#_1eba4701f2dfc2ab7dc48555b485e41ep@chr15:89215333..89215341, +
1.87e-86FFCP PHASE2:Mm9::chr2:152453066..152453075,-#_1eba4701f2dfc2ab7dc48555b485e41ep@chr2:152453066..152453075, -
1.87e-86FFCP PHASE2:Mm9::chr12:13508046..13508055,+#_1eba4701f2dfc2ab7dc48555b485e41ep@chr12:13508046..13508055, +
1.87e-86FFCP PHASE2:Mm9::chr5:150945209..150945220,+#_1eba4701f2dfc2ab7dc48555b485e41ep@chr5:150945209..150945220, +
1.87e-86FFCP PHASE1:Mm9::chr16:93971367..93971379,-#_1eba4701f2dfc2ab7dc48555b485e41ep@chr16:93971367..93971379, -
1.87e-86FFCP PHASE1:Mm9::chr10:81091447..81091464,+#_1eba4701f2dfc2ab7dc48555b485e41ep9@Ankrd24
1.87e-86FFCP PHASE2:Mm9::chr3:154693281..154693317,-#_1eba4701f2dfc2ab7dc48555b485e41ep@chr3:154693281..154693317, -
1.87e-86FFCP PHASE2:Mm9::chr9:42208142..42208157,-#_1eba4701f2dfc2ab7dc48555b485e41ep10@Tecta
1.87e-86FFCP PHASE1:Mm9::chr2:128881546..128881553,-#_1eba4701f2dfc2ab7dc48555b485e41ep@chr2:128881546..128881553, -
1.87e-86FFCP PHASE1:Mm9::chr10:107156949..107156956,-#_1eba4701f2dfc2ab7dc48555b485e41ep3@Ptprq
1.87e-86FFCP PHASE1:Mm9::chr7:133957514..133957529,+#_1eba4701f2dfc2ab7dc48555b485e41ep@chr7:133957514..133957529, +
1.87e-86FFCP PHASE2:Mm9::chr4:63079735..63079745,-#_1eba4701f2dfc2ab7dc48555b485e41ep@chr4:63079735..63079745, -
1.87e-86FFCP PHASE1:Mm9::chr14:102297747..102297765,+#_1eba4701f2dfc2ab7dc48555b485e41ep@chr14:102297747..102297765, +
1.87e-86FFCP PHASE2:Mm9::chr5:147854240..147854249,-#_1eba4701f2dfc2ab7dc48555b485e41ep@chr5:147854240..147854249, -
1.87e-86FFCP PHASE2:Mm9::chr10:107349430..107349440,-#_1eba4701f2dfc2ab7dc48555b485e41ep3@Otogl
1.87e-86FFCP PHASE1:Mm9::chr18:81314626..81314636,+#_1eba4701f2dfc2ab7dc48555b485e41ep@chr18:81314626..81314636, +
1.87e-86FFCP PHASE2:Mm9::chr17:31335903..31335921,-#_1eba4701f2dfc2ab7dc48555b485e41ep2@Tmprss3
1.87e-86FFCP PHASE2:Mm9::chr14:47293496..47293510,-#_1eba4701f2dfc2ab7dc48555b485e41ep@chr14:47293496..47293510, -
1.87e-86FFCP PHASE1:Mm9::chr9:42208142..42208157,-#_1eba4701f2dfc2ab7dc48555b485e41ep10@Tecta
1.87e-86FFCP PHASE2:Mm9::chr6:86746562..86746579,-#_1eba4701f2dfc2ab7dc48555b485e41ep@chr6:86746562..86746579, -
1.87e-86FFCP PHASE2:Mm9::chr15:58480061..58480066,+#_1eba4701f2dfc2ab7dc48555b485e41ep5@Fer1l6
1.87e-86FFCP PHASE2:Mm9::chr9:42207777..42207789,-#_1eba4701f2dfc2ab7dc48555b485e41ep7@Tecta
1.87e-86FFCP PHASE1:Mm9::chr17:31335953..31335957,-#_1eba4701f2dfc2ab7dc48555b485e41ep3@Tmprss3
1.87e-86FFCP PHASE1:Mm9::chr3:58626291..58626298,-#_1eba4701f2dfc2ab7dc48555b485e41ep@chr3:58626291..58626298, -
1.87e-86FFCP PHASE2:Mm9::chr1:154246932..154246939,+#_1eba4701f2dfc2ab7dc48555b485e41ep7@Glt25d2
1.87e-86FFCP PHASE1:Mm9::chr5:3909310..3909321,+#_1eba4701f2dfc2ab7dc48555b485e41ep@chr5:3909310..3909321, +
1.87e-86FFCP PHASE1:Mm9::chr4:115556972..115556979,+#_1eba4701f2dfc2ab7dc48555b485e41ep3@Kncn
1.87e-86FFCP PHASE2:Mm9::chr8:13414266..13414279,+#_1eba4701f2dfc2ab7dc48555b485e41ep@chr8:13414266..13414279, +
1.87e-86FFCP PHASE2:Mm9::chr2:53464168..53464175,+#_1eba4701f2dfc2ab7dc48555b485e41ep@chr2:53464168..53464175, +
1.87e-86FFCP PHASE2:Mm9::chr5:72652660..72652667,+#_1eba4701f2dfc2ab7dc48555b485e41ep@chr5:72652660..72652667, +
1.87e-86FFCP PHASE2:Mm9::chr11:89702580..89702593,-#_1eba4701f2dfc2ab7dc48555b485e41ep@chr11:89702580..89702593, -
1.87e-86FFCP PHASE1:Mm9::chr9:42207777..42207789,-#_1eba4701f2dfc2ab7dc48555b485e41ep7@Tecta
1.87e-86FFCP PHASE2:Mm9::chr2:136942131..136942142,-#_1eba4701f2dfc2ab7dc48555b485e41ep6@Jag1
1.87e-86FFCP PHASE1:Mm9::chr19:4140290..4140321,+#_1eba4701f2dfc2ab7dc48555b485e41ep2@Gpr152
1.87e-86FFCP PHASE2:Mm9::chr11:114603036..114603048,+#_1eba4701f2dfc2ab7dc48555b485e41ep@chr11:114603036..114603048, +
1.87e-86FFCP PHASE2:Mm9::chr16:93971325..93971337,-#_1eba4701f2dfc2ab7dc48555b485e41ep@chr16:93971325..93971337, -
1.87e-86FFCP PHASE1:Mm9::chr13:78257491..78257498,+#_1eba4701f2dfc2ab7dc48555b485e41ep@chr13:78257491..78257498, +
1.87e-86FFCP PHASE2:Mm9::chr11:75421384..75421397,+#_1eba4701f2dfc2ab7dc48555b485e41ep@chr11:75421384..75421397, +

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