UBERON:0002227: Difference between revisions
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|namespace= | |namespace= | ||
|def="The organ of Corti (or spiral organ) is the organ in the inner ear of mammals that contains auditory sensory cells, or 'hair cells.' [WP,unvetted]." [Wikipedia:Organ_of_Corti] | |def="The organ of Corti (or spiral organ) is the organ in the inner ear of mammals that contains auditory sensory cells, or 'hair cells.' [WP,unvetted]." [Wikipedia:Organ_of_Corti] | ||
|xref=AAO:0011018;;BTO:0001691;;EFO:0001364;;EMAPA:19061;;EMAPA:19151;;EV:0100364;;FMA:75715;;GAID:772;;http://upload.wikimedia.org/wikipedia/commons/thumb/c/c7/Cochlea-crosssection.png/200px-Cochlea-crosssection.png;;MA:0001193;;ncithesaurus:Organ_of_Corti;;ncithesaurus:Spiral_Organ_of_Corti;;NIF_GrossAnatomy:birnlex_2526;;XAO:0003145 | |xref=AAO:0011018;;BTO:0001691;;EFO:0001364;;EMAPA:19061;;EMAPA:19151;;EV:0100364;;FMA:75715;;GAID:772;;http://upload.wikimedia.org/wikipedia/commons/c/cb/Cochlea-crosssection.svg;;http://upload.wikimedia.org/wikipedia/commons/thumb/c/c7/Cochlea-crosssection.png/200px-Cochlea-crosssection.png;;MA:0001193;;ncithesaurus:Organ_of_Corti;;ncithesaurus:Spiral_Organ_of_Corti;;NIF_GrossAnatomy:birnlex_2526;;XAO:0003145 | ||
|is_a=UBERON:0000064;;UBERON:0004120;;UBERON:0004121 | |is_a=UBERON:0000064;;UBERON:0004120;;UBERON:0004121;;UBERON:0010314 | ||
|synonym="basilar papilla" RELATED [BTO:0001691];;"cochlear spiral organ" EXACT [];;"Corti's organ" RELATED [BTO:0001691];;"organ of corti" RELATED [];;"organum spirale" RELATED [BTO:0001691];;"spiral organ" EXACT [];;"spiral organ of corti" EXACT [] | |synonym="basilar papilla" RELATED [BTO:0001691];;"cochlear spiral organ" EXACT [];;"Corti's organ" RELATED [BTO:0001691];;"organ of corti" RELATED [];;"organum spirale" RELATED [BTO:0001691];;"organum spirale" RELATED LATIN [Wikipedia:Organ_of_Corti];;"spiral organ" EXACT [];;"spiral organ of corti" EXACT [] | ||
|comment=Todo - check XAO, taxon constraints | |comment=Todo - check XAO, taxon constraints | ||
|alt_id=UBERON:FMA_75715-MA_0001193 | |alt_id=UBERON:FMA_75715-MA_0001193 | ||
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|obo_creation_date= | |obo_creation_date= | ||
|subset=uberon_slim | |subset=uberon_slim | ||
|derives_from= | |derives_from= | ||
|develops_from= | |develops_from= | ||
|has_quality= | |has_quality= | ||
|located_in= | |located_in= | ||
|part_of= | |part_of= | ||
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl-to-uberon | |property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl-to-uberon.owl;;IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl;;UBPROP:0000001 "A sensory structure in the lagenar portion of an amphibian's membranous labyrinth between the oval and round windows.[AAO]" xsd:string | ||
|is_obsolete= | |is_obsolete= | ||
|preceded_by= | |preceded_by= | ||
}} | }} |
Revision as of 17:01, 26 June 2012
Name: | spiral organ of cochlea | ||
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Definition: | "The organ of Corti (or spiral organ) is the organ in the inner ear of mammals that contains auditory sensory cells, or 'hair cells.' [WP,unvetted]." [Wikipedia:Organ_of_Corti] | ||
Xrefs: |
| ||
Synonyms: |
"basilar papilla" RELATED [BTO:0001691] "cochlear spiral organ" EXACT [] "Corti's organ" RELATED [BTO:0001691] "organ of corti" RELATED [] "organum spirale" RELATED [BTO:0001691] "organum spirale" RELATED LATIN [Wikipedia:Organ_of_Corti] "spiral organ" EXACT [] "spiral organ of corti" EXACT [] | ||
Comments: | Todo - check XAO, taxon constraints | ||
Alt_id: | UBERON:FMA_75715-MA_0001193 | ||
Subset: | uberon_slim |
Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data
Parents
is_a: | UBERON:0000064(organ part),UBERON:0004120(mesoderm-derived structure),UBERON:0004121(ectoderm-derived structure),UBERON:0010314(structure with developmental contribution from neural crest) |
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Children
part of: | CL:0000202 (auditory hair cell),CL:0000589 (cochlear inner hair cell),CL:0002490 (organ of Corti supporting cell) |
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Ontology Tree: Loaded from BioPortal
Ontorolgy tree(Small window open)
FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology
Mouse (Mus musculus)
- 12157-128G6 (Sox2+ Supporting cells - organ of corti, pool1)
- 12158-128G7 (Atoh+ Inner ear hair cells - organ of corti, pool1)
- 12215-129E1 (Inner ear stem cells, 1st generation stem cells, pool1)
- 12216-129E2 (Inner ear stem cells, 4th generation stem cells, pool1)
- 12217-129E3 (Inner ear stem cells, differentiation, day03, pool1)
- 12218-129E4 (Inner ear stem cells, differentiation, day10, pool1)
Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0002227 (spiral organ of cochlea), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data
P-value | FFCP | Short description |
---|---|---|
1.87e-86 | FFCP PHASE1:Mm9::chrX:154140781..154140788,+#_94b85a8110f1309d0c218c5f692a21e0 | p@chrX:154140781..154140788, + |
1.87e-86 | FFCP PHASE1:Mm9::chr3:69811606..69811616,+#_94b85a8110f1309d0c218c5f692a21e0 | p2@Otol1 |
1.87e-86 | FFCP PHASE1:Mm9::chr2:29935952..29935993,+#_94b85a8110f1309d0c218c5f692a21e0 | p7@Pkn3 |
1.87e-86 | FFCP PHASE1:Mm9::chr13:58283583..58283607,-#_94b85a8110f1309d0c218c5f692a21e0 | p@chr13:58283583..58283607, - |
1.87e-86 | FFCP PHASE2:Mm9::chr18:38104702..38104718,-#_94b85a8110f1309d0c218c5f692a21e0 | p@chr18:38104702..38104718, - |
1.87e-86 | FFCP PHASE1:Mm9::chr3:106986057..106986062,+#_94b85a8110f1309d0c218c5f692a21e0 | p1@Kcna10 |
1.87e-86 | FFCP PHASE2:Mm9::chr3:154459246..154459253,+#_94b85a8110f1309d0c218c5f692a21e0 | p@chr3:154459246..154459253, + |
1.87e-86 | FFCP PHASE2:Mm9::chr9:42208023..42208043,-#_94b85a8110f1309d0c218c5f692a21e0 | p4@Tecta |
1.87e-86 | FFCP PHASE1:Mm9::chr6:86746562..86746579,-#_94b85a8110f1309d0c218c5f692a21e0 | p@chr6:86746562..86746579, - |
1.87e-86 | FFCP PHASE2:Mm9::chr1:63733478..63733491,-#_94b85a8110f1309d0c218c5f692a21e0 | p1@Dytn |
1.87e-86 | FFCP PHASE2:Mm9::chrX:154140800..154140810,+#_94b85a8110f1309d0c218c5f692a21e0 | p@chrX:154140800..154140810, + |
1.87e-86 | FFCP PHASE1:Mm9::chr1:172843885..172843890,-#_94b85a8110f1309d0c218c5f692a21e0 | p@chr1:172843885..172843890, - |
1.87e-86 | FFCP PHASE2:Mm9::chr18:59222033..59222043,+#_94b85a8110f1309d0c218c5f692a21e0 | p7@A730017C20Rik |
1.87e-86 | FFCP PHASE2:Mm9::chr1:43454162..43454170,-#_94b85a8110f1309d0c218c5f692a21e0 | p@chr1:43454162..43454170, - |
1.87e-86 | FFCP PHASE2:Mm9::chr10:107349418..107349423,-#_94b85a8110f1309d0c218c5f692a21e0 | p5@Otogl |
1.87e-86 | FFCP PHASE1:Mm9::chr11:120222470..120222516,+#_94b85a8110f1309d0c218c5f692a21e0 | p2@Fscn2 |
1.87e-86 | FFCP PHASE2:Mm9::chr17:31335869..31335899,-#_94b85a8110f1309d0c218c5f692a21e0 | p1@Tmprss3 |
1.87e-86 | FFCP PHASE2:Mm9::chr14:47293487..47293493,-#_94b85a8110f1309d0c218c5f692a21e0 | p@chr14:47293487..47293493, - |
1.87e-86 | FFCP PHASE1:Mm9::chr9:42208023..42208043,-#_94b85a8110f1309d0c218c5f692a21e0 | p4@Tecta |
1.87e-86 | FFCP PHASE2:Mm9::chr6:86745686..86745727,-#_94b85a8110f1309d0c218c5f692a21e0 | p@chr6:86745686..86745727, - |
1.87e-86 | FFCP PHASE2:Mm9::chr9:42207697..42207705,-#_94b85a8110f1309d0c218c5f692a21e0 | p@chr9:42207697..42207705, - |
1.87e-86 | FFCP PHASE1:Mm9::chr2:121206695..121206711,-#_94b85a8110f1309d0c218c5f692a21e0 | p1@Strc |
1.87e-86 | FFCP PHASE1:Mm9::chr12:13508015..13508019,+#_94b85a8110f1309d0c218c5f692a21e0 | p@chr12:13508015..13508019, + |
1.87e-86 | FFCP PHASE1:Mm9::chr7:109265277..109265288,-#_94b85a8110f1309d0c218c5f692a21e0 | p4@Chrna10 |
1.87e-86 | FFCP PHASE2:Mm9::chr7:88068153..88068160,-#_94b85a8110f1309d0c218c5f692a21e0 | p10@Sec11a |
1.87e-86 | FFCP PHASE1:Mm9::chr5:3909290..3909299,+#_94b85a8110f1309d0c218c5f692a21e0 | p@chr5:3909290..3909299, + |
1.87e-86 | FFCP PHASE1:Mm9::chr4:115556939..115556945,+#_94b85a8110f1309d0c218c5f692a21e0 | p4@Kncn |
1.87e-86 | FFCP PHASE2:Mm9::chr1:194818647..194818660,-#_94b85a8110f1309d0c218c5f692a21e0 | p@chr1:194818647..194818660, - |
1.87e-86 | FFCP PHASE2:Mm9::chr5:68423014..68423037,+#_94b85a8110f1309d0c218c5f692a21e0 | p1@Grxcr1 |
1.87e-86 | FFCP PHASE1:Mm9::chr9:42207697..42207705,-#_94b85a8110f1309d0c218c5f692a21e0 | p@chr9:42207697..42207705, - |
1.87e-86 | FFCP PHASE1:Mm9::chr7:27964761..27964768,+#_94b85a8110f1309d0c218c5f692a21e0 | p@chr7:27964761..27964768, + |
1.87e-86 | FFCP PHASE2:Mm9::chr9:50968647..50968668,-#_94b85a8110f1309d0c218c5f692a21e0 | p@chr9:50968647..50968668, - |
1.87e-86 | FFCP PHASE1:Mm9::chr10:67371994..67372010,+#_94b85a8110f1309d0c218c5f692a21e0 | p@chr10:67371994..67372010, + |
1.87e-86 | FFCP PHASE1:Mm9::chr3:154693281..154693317,-#_94b85a8110f1309d0c218c5f692a21e0 | p@chr3:154693281..154693317, - |
1.87e-86 | FFCP PHASE1:Mm9::chr5:150945209..150945220,+#_94b85a8110f1309d0c218c5f692a21e0 | p@chr5:150945209..150945220, + |
1.87e-86 | FFCP PHASE1:Mm9::chr9:41495920..41495928,-#_94b85a8110f1309d0c218c5f692a21e0 | p@chr9:41495920..41495928, - |
1.87e-86 | FFCP PHASE1:Mm9::chr2:53464178..53464186,+#_94b85a8110f1309d0c218c5f692a21e0 | p@chr2:53464178..53464186, + |
1.87e-86 | FFCP PHASE2:Mm9::chr10:80806047..80806059,-#_94b85a8110f1309d0c218c5f692a21e0 | p4@Gipc3 |
1.87e-86 | FFCP PHASE1:Mm9::chr4:151505798..151505818,-#_94b85a8110f1309d0c218c5f692a21e0 | p21@Espn |
1.87e-86 | FFCP PHASE2:Mm9::chr9:92087926..92087938,+#_94b85a8110f1309d0c218c5f692a21e0 | p2@Plscr5 |
1.87e-86 | FFCP PHASE2:Mm9::chr3:58626291..58626298,-#_94b85a8110f1309d0c218c5f692a21e0 | p@chr3:58626291..58626298, - |
1.87e-86 | FFCP PHASE1:Mm9::chr9:56208792..56208814,-#_94b85a8110f1309d0c218c5f692a21e0 | p@chr9:56208792..56208814, - |
1.87e-86 | FFCP PHASE1:Mm9::chr15:58480061..58480066,+#_94b85a8110f1309d0c218c5f692a21e0 | p5@Fer1l6 |
1.87e-86 | FFCP PHASE2:Mm9::chr5:3909290..3909299,+#_94b85a8110f1309d0c218c5f692a21e0 | p@chr5:3909290..3909299, + |
1.87e-86 | FFCP PHASE2:Mm9::chr1:172843813..172843834,-#_94b85a8110f1309d0c218c5f692a21e0 | p@chr1:172843813..172843834, - |
1.87e-86 | FFCP PHASE1:Mm9::chr1:182528371..182528385,+#_94b85a8110f1309d0c218c5f692a21e0 | p@chr1:182528371..182528385, + |
1.87e-86 | FFCP PHASE1:Mm9::chr14:31283085..31283097,-#_94b85a8110f1309d0c218c5f692a21e0 | p@chr14:31283085..31283097, - |
1.87e-86 | FFCP PHASE2:Mm9::chr4:130461150..130461185,+#_94b85a8110f1309d0c218c5f692a21e0 | p@chr4:130461150..130461185, + |
1.87e-86 | FFCP PHASE1:Mm9::chr6:113251614..113251623,+#_94b85a8110f1309d0c218c5f692a21e0 | p@chr6:113251614..113251623, + |
1.87e-86 | FFCP PHASE1:Mm9::chr19:10536767..10536777,-#_94b85a8110f1309d0c218c5f692a21e0 | p@chr19:10536767..10536777, - |
1.87e-86 | FFCP PHASE1:Mm9::chr17:13983102..13983126,+#_94b85a8110f1309d0c218c5f692a21e0 | p@chr17:13983102..13983126, + |
1.87e-86 | FFCP PHASE2:Mm9::chr3:100724698..100724706,+#_94b85a8110f1309d0c218c5f692a21e0 | p@chr3:100724698..100724706, + |
1.87e-86 | FFCP PHASE2:Mm9::chr6:30619378..30619412,-#_94b85a8110f1309d0c218c5f692a21e0 | p11@Tsga14 |
1.87e-86 | FFCP PHASE1:Mm9::chr15:103146966..103146971,-#_94b85a8110f1309d0c218c5f692a21e0 | p@chr15:103146966..103146971, - |
1.87e-86 | FFCP PHASE2:Mm9::chr19:10536797..10536802,-#_94b85a8110f1309d0c218c5f692a21e0 | p@chr19:10536797..10536802, - |
1.87e-86 | FFCP PHASE2:Mm9::chr9:56208792..56208814,-#_94b85a8110f1309d0c218c5f692a21e0 | p@chr9:56208792..56208814, - |
1.87e-86 | FFCP PHASE2:Mm9::chr9:42207887..42207960,-#_94b85a8110f1309d0c218c5f692a21e0 | p1@Tecta |
1.87e-86 | FFCP PHASE1:Mm9::chr19:55256373..55256384,+#_94b85a8110f1309d0c218c5f692a21e0 | p@chr19:55256373..55256384, + |
1.87e-86 | FFCP PHASE1:Mm9::chr13:78322370..78322376,-#_94b85a8110f1309d0c218c5f692a21e0 | p4@uc007rhb.1 |
1.87e-86 | FFCP PHASE2:Mm9::chr11:102123535..102123544,+#_94b85a8110f1309d0c218c5f692a21e0 | p5@BC030867 |
1.87e-86 | FFCP PHASE1:Mm9::chr16:93971325..93971337,-#_94b85a8110f1309d0c218c5f692a21e0 | p@chr16:93971325..93971337, - |
1.87e-86 | FFCP PHASE2:Mm9::chr3:35012425..35012439,+#_94b85a8110f1309d0c218c5f692a21e0 | p@chr3:35012425..35012439, + |
1.87e-86 | FFCP PHASE2:Mm9::chr4:115556989..115556997,+#_94b85a8110f1309d0c218c5f692a21e0 | p1@Kncn |
1.87e-86 | FFCP PHASE2:Mm9::chr17:13983160..13983167,+#_94b85a8110f1309d0c218c5f692a21e0 | p@chr17:13983160..13983167, + |
1.87e-86 | FFCP PHASE1:Mm9::chr9:42207887..42207960,-#_94b85a8110f1309d0c218c5f692a21e0 | p1@Tecta |
1.87e-86 | FFCP PHASE1:Mm9::chr10:107349430..107349440,-#_94b85a8110f1309d0c218c5f692a21e0 | p3@Otogl |
1.87e-86 | FFCP PHASE1:Mm9::chr1:93235253..93235264,+#_94b85a8110f1309d0c218c5f692a21e0 | p@chr1:93235253..93235264, + |
1.87e-86 | FFCP PHASE2:Mm9::chr9:42206745..42206774,-#_94b85a8110f1309d0c218c5f692a21e0 | p@chr9:42206745..42206774, - |
1.87e-86 | FFCP PHASE2:Mm9::chr19:55255206..55255223,+#_94b85a8110f1309d0c218c5f692a21e0 | p1@Tectb |
1.87e-86 | FFCP PHASE1:Mm9::chr12:109905468..109905474,+#_94b85a8110f1309d0c218c5f692a21e0 | p@chr12:109905468..109905474, + |
1.87e-86 | FFCP PHASE2:Mm9::chr3:106986057..106986062,+#_94b85a8110f1309d0c218c5f692a21e0 | p1@Kcna10 |
1.87e-86 | FFCP PHASE1:Mm9::chr3:35012397..35012405,+#_94b85a8110f1309d0c218c5f692a21e0 | p@chr3:35012397..35012405, + |
1.87e-86 | FFCP PHASE1:Mm9::chr15:89215306..89215315,+#_94b85a8110f1309d0c218c5f692a21e0 | p@chr15:89215306..89215315, + |
1.87e-86 | FFCP PHASE2:Mm9::chr2:128881546..128881553,-#_94b85a8110f1309d0c218c5f692a21e0 | p@chr2:128881546..128881553, - |
1.87e-86 | FFCP PHASE1:Mm9::chr5:30710403..30710406,-#_94b85a8110f1309d0c218c5f692a21e0 | p10@Otof |
1.87e-86 | FFCP PHASE2:Mm9::chr4:151505798..151505818,-#_94b85a8110f1309d0c218c5f692a21e0 | p21@Espn |
1.87e-86 | FFCP PHASE1:Mm9::chr9:42206745..42206774,-#_94b85a8110f1309d0c218c5f692a21e0 | p@chr9:42206745..42206774, - |
1.87e-86 | FFCP PHASE1:Mm9::chr2:67011921..67011934,+#_94b85a8110f1309d0c218c5f692a21e0 | p2@Gm1322 |
1.87e-86 | FFCP PHASE1:Mm9::chr14:63099970..63099980,-#_94b85a8110f1309d0c218c5f692a21e0 | p@chr14:63099970..63099980, - |
1.87e-86 | FFCP PHASE2:Mm9::chr1:93218694..93218705,+#_94b85a8110f1309d0c218c5f692a21e0 | p1@Espnl |
1.87e-86 | FFCP PHASE1:Mm9::chr11:8405038..8405048,-#_94b85a8110f1309d0c218c5f692a21e0 | p@chr11:8405038..8405048, - |
1.87e-86 | FFCP PHASE1:Mm9::chr17:31335869..31335899,-#_94b85a8110f1309d0c218c5f692a21e0 | p1@Tmprss3 |
1.87e-86 | FFCP PHASE2:Mm9::chr18:42158627..42158630,-#_94b85a8110f1309d0c218c5f692a21e0 | p@chr18:42158627..42158630, - |
1.87e-86 | FFCP PHASE1:Mm9::chr9:66860888..66860899,+#_94b85a8110f1309d0c218c5f692a21e0 | p@chr9:66860888..66860899, + |
1.87e-86 | FFCP PHASE2:Mm9::chr13:78257491..78257498,+#_94b85a8110f1309d0c218c5f692a21e0 | p@chr13:78257491..78257498, + |
1.87e-86 | FFCP PHASE1:Mm9::chr7:109052297..109052300,-#_94b85a8110f1309d0c218c5f692a21e0 | p2@Tomt |
1.87e-86 | FFCP PHASE1:Mm9::chrX:154140800..154140810,+#_94b85a8110f1309d0c218c5f692a21e0 | p@chrX:154140800..154140810, + |
1.87e-86 | FFCP PHASE1:Mm9::chr3:81012915..81012923,+#_94b85a8110f1309d0c218c5f692a21e0 | p@chr3:81012915..81012923, + |
1.87e-86 | FFCP PHASE2:Mm9::chr2:152453066..152453075,-#_94b85a8110f1309d0c218c5f692a21e0 | p@chr2:152453066..152453075, - |
1.87e-86 | FFCP PHASE1:Mm9::chr14:47293487..47293493,-#_94b85a8110f1309d0c218c5f692a21e0 | p@chr14:47293487..47293493, - |
1.87e-86 | FFCP PHASE2:Mm9::chr12:13508046..13508055,+#_94b85a8110f1309d0c218c5f692a21e0 | p@chr12:13508046..13508055, + |
1.87e-86 | FFCP PHASE2:Mm9::chr5:150945209..150945220,+#_94b85a8110f1309d0c218c5f692a21e0 | p@chr5:150945209..150945220, + |
1.87e-86 | FFCP PHASE2:Mm9::chr3:154693281..154693317,-#_94b85a8110f1309d0c218c5f692a21e0 | p@chr3:154693281..154693317, - |
1.87e-86 | FFCP PHASE2:Mm9::chr9:42208142..42208157,-#_94b85a8110f1309d0c218c5f692a21e0 | p10@Tecta |
1.87e-86 | FFCP PHASE1:Mm9::chr2:128881546..128881553,-#_94b85a8110f1309d0c218c5f692a21e0 | p@chr2:128881546..128881553, - |
1.87e-86 | FFCP PHASE1:Mm9::chr12:77084875..77084885,+#_94b85a8110f1309d0c218c5f692a21e0 | p@chr12:77084875..77084885, + |
1.87e-86 | FFCP PHASE1:Mm9::chr7:133957514..133957529,+#_94b85a8110f1309d0c218c5f692a21e0 | p@chr7:133957514..133957529, + |
1.87e-86 | FFCP PHASE1:Mm9::chr13:37195838..37195870,-#_94b85a8110f1309d0c218c5f692a21e0 | p@chr13:37195838..37195870, - |
1.87e-86 | FFCP PHASE2:Mm9::chr4:63079735..63079745,-#_94b85a8110f1309d0c218c5f692a21e0 | p@chr4:63079735..63079745, - |
1.87e-86 | FFCP PHASE2:Mm9::chr5:147854240..147854249,-#_94b85a8110f1309d0c218c5f692a21e0 | p@chr5:147854240..147854249, - |
Property "Property value" (as page type) with input value "UBPROP:0000001 "A sensory structure in the lagenar portion of an amphibian's membranous labyrinth between the oval and round windows.[AAO]" xsd:string" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.