CL:0000860: Difference between revisions
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|id=CL:0000860 | |id=CL:0000860 | ||
|name=classical monocyte | |name=classical monocyte | ||
|namespace=efo | |namespace=cell;;efo | ||
|def="A type of monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors. This cell type is characterized by high expression of CCR2 in both rodents and humans, and of being larger size than non-classical monocytes." [GO_REF:0000031, PMID:16322748, PMID:18303997, PMID:20628149, PMID:20870168] | |def="A type of monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors. This cell type is characterized by high expression of CCR2 in both rodents and humans, and of being larger size than non-classical monocytes." [GO_REF:0000031, PMID:16322748, PMID:18303997, PMID:20628149, PMID:20870168] | ||
|xref= | |xref= | ||
|is_a=CL:0000576 | |is_a=CL:0000234;;CL:0000576 | ||
|synonym="inflammatory monocyte" EXACT [] | |synonym="inflammatory monocyte" EXACT [] | ||
|comment=Markers: CCR2+CXCCR1<low> (human, mouse, rat). | |comment=Markers: CCR2+CXCCR1<low> (human, mouse, rat). | ||
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|obo_creation_date= | |obo_creation_date= | ||
|subset= | |subset= | ||
|derives_from= | |derives_from= | ||
|develops_from= | |develops_from= | ||
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|located_in= | |located_in= | ||
|part_of= | |part_of= | ||
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl.owl;;IAO:0000412 http://purl.obolibrary.org/obo/efo | |property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl.owl;;IAO:0000412 http://purl.obolibrary.org/obo/efo.owl | ||
|is_obsolete= | |is_obsolete= | ||
|preceded_by= | |preceded_by= | ||
}} | }} | ||
Revision as of 17:26, 26 June 2012
| Name: | classical monocyte |
|---|---|
| Namespace: | cell;;efo |
| Definition: | "A type of monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors. This cell type is characterized by high expression of CCR2 in both rodents and humans, and of being larger size than non-classical monocytes." [GO_REF:0000031, PMID:16322748, PMID:18303997, PMID:20628149, PMID:20870168] |
| Synonyms: | "inflammatory monocyte" EXACT [] |
| Comments: | Markers: CCR2+CXCCR1<low> (human, mouse, rat). |
Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data
Parents
| is_a: | CL:0000234(phagocyte),CL:0000576(monocyte) |
|---|
Children
| is a: | CL:0002057 (CD14-positive, CD16-negative classical monocyte) |
|---|
Ontology Tree: Loaded from BioPortal
Ontorolgy tree(Small window open)
FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.
Human (Homo sapiens)
- 11788-124B6 (CD14+CD16- Monocytes, donor1)
- 11799-124C8 (CD14+CD16- Monocytes, donor2)
- 11857-125A3
- 11858-125A4
- 11859-125A5
- 11860-125A6 (CD14+ monocytes - treated with BCG, donor1)
- 11861-125A7 (CD14+ monocytes - treated with IFN + N-hexane, donor1)
- 11862-125A8 (CD14+ monocytes - treated with Trehalose dimycolate (TDM), donor1)
- 11863-125A9 (CD14+ monocytes - mock treated, donor1)
- 11864-125B1 (CD14+ monocytes - treated with Group A streptococci, donor1)
... further results Mouse (Mus musculus)
- 11788-124B6 (CD14+CD16- Monocytes, donor1)
- 11799-124C8 (CD14+CD16- Monocytes, donor2)
- 11857-125A3
- 11858-125A4
- 11859-125A5
- 11860-125A6 (CD14+ monocytes - treated with BCG, donor1)
- 11861-125A7 (CD14+ monocytes - treated with IFN + N-hexane, donor1)
- 11862-125A8 (CD14+ monocytes - treated with Trehalose dimycolate (TDM), donor1)
- 11863-125A9 (CD14+ monocytes - mock treated, donor1)
- 11864-125B1 (CD14+ monocytes - treated with Group A streptococci, donor1)
Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000860 (classical monocyte), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data
| P-value | FFCP | Short description |
|---|---|---|
| 2.95e-173 | FFCP PHASE1:Hg19::chr7:44661060..44661101,-#_ffbc737bdb0d846e2b2d96cdac5cadd2 | p@chr7:44661060..44661101, - |
| 2.95e-173 | FFCP PHASE2:Hg19::chr7:44661060..44661101,-#_ffbc737bdb0d846e2b2d96cdac5cadd2 | p@chr7:44661060..44661101, - |
| 5.66e-173 | FFCP PHASE2:Hg19::chr17:72628050..72628077,-#_d6c779249e86f4b4bb7374339c1734c2 | p@chr17:72628050..72628077, - |
| 5.66e-173 | FFCP PHASE1:Hg19::chr17:72628050..72628077,-#_d6c779249e86f4b4bb7374339c1734c2 | p@chr17:72628050..72628077, - |
| 3.48e-171 | FFCP PHASE1:Hg19::chr17:72607002..72607029,+#_ae67142d915a0edc97e83f4a20361e33 | p@chr17:72607002..72607029, + |
| 3.48e-171 | FFCP PHASE2:Hg19::chr17:72607002..72607029,+#_ae67142d915a0edc97e83f4a20361e33 | p@chr17:72607002..72607029, + |
| 2.61e-167 | FFCP PHASE2:Hg19::chr17:72606825..72606838,-#_96d6e8e066691da134ad971237814f0d | p@chr17:72606825..72606838, - |
| 2.61e-167 | FFCP PHASE1:Hg19::chr17:72606825..72606838,-#_96d6e8e066691da134ad971237814f0d | p@chr17:72606825..72606838, - |
| 1.41e-166 | FFCP PHASE2:Hg19::chr17:72607152..72607174,-#_29cff9f06f98ec8f6612669a9c8ad35e | p@chr17:72607152..72607174, - |
| 1.41e-166 | FFCP PHASE1:Hg19::chr17:72607152..72607174,-#_29cff9f06f98ec8f6612669a9c8ad35e | p@chr17:72607152..72607174, - |
| 1.31e-165 | FFCP PHASE2:Hg19::chr17:72607351..72607373,-#_5213725da8543b8dee4af44602cbfff9 | p@chr17:72607351..72607373, - |
| 1.31e-165 | FFCP PHASE1:Hg19::chr17:72607351..72607373,-#_5213725da8543b8dee4af44602cbfff9 | p@chr17:72607351..72607373, - |
| 8.2e-165 | FFCP PHASE1:Hg19::chr1:120593738..120593745,+#_86600724e49c9d36db217b867d3cc53a | p@chr1:120593738..120593745, + |
| 8.2e-165 | FFCP PHASE2:Hg19::chr1:120593738..120593745,+#_86600724e49c9d36db217b867d3cc53a | p@chr1:120593738..120593745, + |
| 1.7e-164 | FFCP PHASE1:Hg19::chr14:55249943..55249971,+#_d74dca48b1bd4ae3156cfb4d0dbecd7d | p@chr14:55249943..55249971, + |
| 1.7e-164 | FFCP PHASE2:Hg19::chr14:55249943..55249971,+#_d74dca48b1bd4ae3156cfb4d0dbecd7d | p@chr14:55249943..55249971, + |
| 6.24e-163 | FFCP PHASE2:Hg19::chr8:11754835..11754867,-#_a4a7cbc2f8c28833875fcee564473e8c | p1@ENST00000525252 |
| 6.24e-163 | FFCP PHASE1:Hg19::chr8:11754835..11754867,-#_a4a7cbc2f8c28833875fcee564473e8c | p1@ENST00000525252 |
| 2.9e-162 | FFCP PHASE1:Hg19::chr12:125197870..125197907,+#_f6a32b395ee9429ce85960dd439c6806 | p@chr12:125197870..125197907, + |
| 2.9e-162 | FFCP PHASE2:Hg19::chr12:125197870..125197907,+#_f6a32b395ee9429ce85960dd439c6806 | p@chr12:125197870..125197907, + |
| 2.93e-162 | FFCP PHASE1:Hg19::chr17:72606678..72606702,-#_394e23847828a95efd4fc989d640ddbf | p@chr17:72606678..72606702, - |
| 2.93e-162 | FFCP PHASE2:Hg19::chr17:72606678..72606702,-#_394e23847828a95efd4fc989d640ddbf | p@chr17:72606678..72606702, - |
| 3.23e-162 | FFCP PHASE2:Hg19::chr22:17717917..17717939,-#_f21b07a2c036c835d3561176aee82451 | p@chr22:17717917..17717939, - |
| 3.23e-162 | FFCP PHASE1:Hg19::chr22:17717917..17717939,-#_f21b07a2c036c835d3561176aee82451 | p@chr22:17717917..17717939, - |
| 4.13e-162 | FFCP PHASE2:Hg19::chr5:156534439..156534470,+#_53777fbc6887569dfb38a1a437f5090e | p@chr5:156534439..156534470, + |
| 4.13e-162 | FFCP PHASE1:Hg19::chr5:156534439..156534470,+#_53777fbc6887569dfb38a1a437f5090e | p@chr5:156534439..156534470, + |
| 1.23e-161 | FFCP PHASE1:Hg19::chr9:137300477..137300490,+#_284eb9189d2ae304f76303b2a379566f | p@chr9:137300477..137300490, + |
| 1.23e-161 | FFCP PHASE2:Hg19::chr9:137300477..137300490,+#_284eb9189d2ae304f76303b2a379566f | p@chr9:137300477..137300490, + |
| 6.16e-160 | FFCP PHASE2:Hg19::chr1:149901972..149901989,-#_e32e3fb4cc49a5d7342f2f458930f90f | p@chr1:149901972..149901989, - |
| 6.16e-160 | FFCP PHASE1:Hg19::chr1:149901972..149901989,-#_e32e3fb4cc49a5d7342f2f458930f90f | p@chr1:149901972..149901989, - |
| 3.22e-159 | FFCP PHASE2:Hg19::chr2:145276939..145276960,+#_d18873c889e7628e74a9694666eba060 | p2@ZEB2-AS1 |
| 3.22e-159 | FFCP PHASE1:Hg19::chr2:145276939..145276960,+#_d18873c889e7628e74a9694666eba060 | p2@ZEB2-AS1 |
| 4.01e-159 | FFCP PHASE1:Hg19::chr11:68847955..68847972,-#_b688994235a5e3395b51aea5c028e85e | p@chr11:68847955..68847972, - |
| 4.01e-159 | FFCP PHASE2:Hg19::chr11:68847955..68847972,-#_b688994235a5e3395b51aea5c028e85e | p@chr11:68847955..68847972, - |
| 1.14e-158 | FFCP PHASE2:Hg19::chr11:68847043..68847057,+#_565e9c6849022f194d9ee15a3e06a75e | p@chr11:68847043..68847057, + |
| 1.14e-158 | FFCP PHASE1:Hg19::chr11:68847043..68847057,+#_565e9c6849022f194d9ee15a3e06a75e | p@chr11:68847043..68847057, + |
| 5.8e-158 | FFCP PHASE2:Hg19::chr1:108592890..108592921,-#_07a9d05e8316865ff88ec0a8f0ef7cdb | p@chr1:108592890..108592921, - |
| 5.8e-158 | FFCP PHASE1:Hg19::chr1:108592890..108592921,-#_07a9d05e8316865ff88ec0a8f0ef7cdb | p@chr1:108592890..108592921, - |
| 2.44e-157 | FFCP PHASE1:Hg19::chr7:949680..949694,-#_a574669749cf64fdb44c1a71c14a1f37 | p@chr7:949680..949694, - |
| 2.44e-157 | FFCP PHASE2:Hg19::chr7:949680..949694,-#_a574669749cf64fdb44c1a71c14a1f37 | p@chr7:949680..949694, - |
| 4.86e-157 | FFCP PHASE2:Hg19::chr7:48009999..48010016,+#_90e77a1129ad14b389ef32958f956e55 | p@chr7:48009999..48010016, + |
| 4.86e-157 | FFCP PHASE1:Hg19::chr7:48009999..48010016,+#_90e77a1129ad14b389ef32958f956e55 | p@chr7:48009999..48010016, + |
| 5.49e-157 | FFCP PHASE2:Hg19::chr4:185314351..185314392,+#_6ea6b970863c9664450ca82ad42dc3aa | p@chr4:185314351..185314392, + |
| 5.49e-157 | FFCP PHASE1:Hg19::chr4:185314351..185314392,+#_6ea6b970863c9664450ca82ad42dc3aa | p@chr4:185314351..185314392, + |
| 8.29e-157 | FFCP PHASE2:Hg19::chr16:82229835..82229848,+#_86369d6017555b78569029bae13ab551 | p@chr16:82229835..82229848, + |
| 8.29e-157 | FFCP PHASE1:Hg19::chr16:82229835..82229848,+#_86369d6017555b78569029bae13ab551 | p@chr16:82229835..82229848, + |
| 2.1e-156 | FFCP PHASE2:Hg19::chr20:5634031..5634046,+#_c7f419cf50c9661dd717328183ea10df | p@chr20:5634031..5634046, + |
| 2.1e-156 | FFCP PHASE1:Hg19::chr20:5634031..5634046,+#_c7f419cf50c9661dd717328183ea10df | p@chr20:5634031..5634046, + |
| 4.29e-156 | FFCP PHASE2:Hg19::chr4:159731607..159731627,+#_b55323b0f8cf3c1374749e44da1ed96c | p@chr4:159731607..159731627, + |
| 4.29e-156 | FFCP PHASE1:Hg19::chr4:159731607..159731627,+#_b55323b0f8cf3c1374749e44da1ed96c | p@chr4:159731607..159731627, + |
| 1.66e-155 | FFCP PHASE1:Hg19::chr9:102353301..102353315,-#_c0129b1405e22923d148a7909705668b | p@chr9:102353301..102353315, - |
| 1.66e-155 | FFCP PHASE2:Hg19::chr9:102353301..102353315,-#_c0129b1405e22923d148a7909705668b | p@chr9:102353301..102353315, - |
| 3.6e-155 | FFCP PHASE1:Hg19::chr2:145450907..145450928,-#_d171907a6acc31860bfc2019088c9715 | p@chr2:145450907..145450928, - |
| 3.6e-155 | FFCP PHASE2:Hg19::chr2:145450907..145450928,-#_d171907a6acc31860bfc2019088c9715 | p@chr2:145450907..145450928, - |
| 3.76e-155 | FFCP PHASE2:Hg19::chr17:72628206..72628246,+#_83af5762cbb69d6efd42b5a8d0faf227 | p@chr17:72628206..72628246, + |
| 3.76e-155 | FFCP PHASE1:Hg19::chr17:72628206..72628246,+#_83af5762cbb69d6efd42b5a8d0faf227 | p@chr17:72628206..72628246, + |
| 1.6e-154 | FFCP PHASE2:Hg19::chr8:11755021..11755054,+#_2a5a54194ff3cb1b167614a8f69424ae | p@chr8:11755021..11755054, + |
| 1.6e-154 | FFCP PHASE1:Hg19::chr8:11755021..11755054,+#_2a5a54194ff3cb1b167614a8f69424ae | p@chr8:11755021..11755054, + |
| 1.99e-154 | FFCP PHASE2:Hg19::chr2:145421047..145421067,+#_39de19238b735e4b51618daea6ba14f5 | p@chr2:145421047..145421067, + |
| 1.99e-154 | FFCP PHASE1:Hg19::chr2:145421047..145421067,+#_39de19238b735e4b51618daea6ba14f5 | p@chr2:145421047..145421067, + |
| 4.18e-154 | FFCP PHASE2:Hg19::chr6:106348152..106348164,+#_622c4a545db6296b7a5bbd83d5a4fa37 | p@chr6:106348152..106348164, + |
| 4.18e-154 | FFCP PHASE1:Hg19::chr6:106348152..106348164,+#_622c4a545db6296b7a5bbd83d5a4fa37 | p@chr6:106348152..106348164, + |
| 9.99e-154 | FFCP PHASE1:Hg19::chr16:17469894..17469904,+#_1379c863a30ab032d329444812720b69 | p@chr16:17469894..17469904, + |
| 9.99e-154 | FFCP PHASE2:Hg19::chr16:17469894..17469904,+#_1379c863a30ab032d329444812720b69 | p@chr16:17469894..17469904, + |
| 1.29e-153 | FFCP PHASE1:Hg19::chr1:40006573..40006589,-#_5a89ade2a05dc44ae71e363eccba02b5 | p@chr1:40006573..40006589, - |
| 1.29e-153 | FFCP PHASE2:Hg19::chr1:40006573..40006589,-#_5a89ade2a05dc44ae71e363eccba02b5 | p@chr1:40006573..40006589, - |
| 1.38e-153 | FFCP PHASE1:Hg19::chr7:111720716..111720750,+#_034dd644ab936e3c74792e56f17b058a | p@chr7:111720716..111720750, + |
| 1.38e-153 | FFCP PHASE2:Hg19::chr7:111720716..111720750,+#_034dd644ab936e3c74792e56f17b058a | p@chr7:111720716..111720750, + |
| 1.95e-153 | FFCP PHASE2:Hg19::chr3:128943968..128943986,+#_b0eb7c500cd59d530d87db6e56e32b41 | p@chr3:128943968..128943986, + |
| 1.95e-153 | FFCP PHASE1:Hg19::chr3:128943968..128943986,+#_b0eb7c500cd59d530d87db6e56e32b41 | p@chr3:128943968..128943986, + |
| 3.44e-153 | FFCP PHASE2:Hg19::chr2:58339774..58339779,-#_4f226446a9a3e411ae7e707eed00955b | p@chr2:58339774..58339779, - |
| 3.44e-153 | FFCP PHASE1:Hg19::chr2:58339774..58339779,-#_4f226446a9a3e411ae7e707eed00955b | p@chr2:58339774..58339779, - |
| 4.04e-153 | FFCP PHASE1:Hg19::chr11:61737685..61737701,-#_b1f8761655ee19b09e94279d0ad5e65c | p@chr11:61737685..61737701, - |
| 4.04e-153 | FFCP PHASE2:Hg19::chr11:61737685..61737701,-#_b1f8761655ee19b09e94279d0ad5e65c | p@chr11:61737685..61737701, - |
| 5.57e-153 | FFCP PHASE1:Hg19::chr11:10921401..10921434,-#_efc3a5a4569338e4a29805c512b50b93 | p@chr11:10921401..10921434, - |
| 5.57e-153 | FFCP PHASE2:Hg19::chr11:10921401..10921434,-#_efc3a5a4569338e4a29805c512b50b93 | p@chr11:10921401..10921434, - |
| 2.07e-152 | FFCP PHASE1:Hg19::chr1:212659324..212659370,-#_716dd5d1ffd85c0afd08143c392c81ae | p@chr1:212659324..212659370, - |
| 2.07e-152 | FFCP PHASE2:Hg19::chr1:212659324..212659370,-#_716dd5d1ffd85c0afd08143c392c81ae | p@chr1:212659324..212659370, - |
| 2.23e-152 | FFCP PHASE1:Hg19::chr19:4812881..4812891,-#_25387d2560781c0f7ec8a53875fcbae9 | p@chr19:4812881..4812891, - |
| 2.23e-152 | FFCP PHASE2:Hg19::chr19:4812881..4812891,-#_25387d2560781c0f7ec8a53875fcbae9 | p@chr19:4812881..4812891, - |
| 3.99e-152 | FFCP PHASE1:Hg19::chr18:13577406..13577430,-#_f86776b6e957f963101fae92d1cf8fe8 | p@chr18:13577406..13577430, - |
| 3.99e-152 | FFCP PHASE2:Hg19::chr18:13577406..13577430,-#_f86776b6e957f963101fae92d1cf8fe8 | p@chr18:13577406..13577430, - |
| 4.17e-152 | FFCP PHASE1:Hg19::chr9:137264021..137264038,+#_87f8e7f1130d48278c575bcc7e166210 | p@chr9:137264021..137264038, + |
| 4.17e-152 | FFCP PHASE2:Hg19::chr9:137264021..137264038,+#_87f8e7f1130d48278c575bcc7e166210 | p@chr9:137264021..137264038, + |
| 4.44e-152 | FFCP PHASE2:Hg19::chr8:48173159..48173173,+#_ddbdd255689cdf0e898fc03a8a6a0089 | p6@KIAA0146 |
| 4.44e-152 | FFCP PHASE1:Hg19::chr8:48173159..48173173,+#_ddbdd255689cdf0e898fc03a8a6a0089 | p6@KIAA0146 |
| 6.49e-152 | FFCP PHASE2:Hg19::chr8:71452856..71452863,+#_288968d36f395b462700da1c9ae347dc | p@chr8:71452856..71452863, + |
| 6.49e-152 | FFCP PHASE1:Hg19::chr8:71452856..71452863,+#_288968d36f395b462700da1c9ae347dc | p@chr8:71452856..71452863, + |
| 6.68e-152 | FFCP PHASE1:Hg19::chr22:28065655..28065677,+#_2db14910e199067f5af9b2fc0e57c474 | p@chr22:28065655..28065677, + |
| 6.68e-152 | FFCP PHASE2:Hg19::chr22:28065655..28065677,+#_2db14910e199067f5af9b2fc0e57c474 | p@chr22:28065655..28065677, + |
| 1.17e-151 | FFCP PHASE1:Hg19::chr20:5626328..5626343,+#_e51bdb3afd32a2ef089dd63186d0ee74 | p@chr20:5626328..5626343, + |
| 1.17e-151 | FFCP PHASE2:Hg19::chr20:5626328..5626343,+#_e51bdb3afd32a2ef089dd63186d0ee74 | p@chr20:5626328..5626343, + |
| 2.27e-151 | FFCP PHASE1:Hg19::chr7:151622937..151622965,-#_15f5ef29bac75798df76390c073f1326 | p@chr7:151622937..151622965, - |
| 2.27e-151 | FFCP PHASE2:Hg19::chr7:151622937..151622965,-#_15f5ef29bac75798df76390c073f1326 | p@chr7:151622937..151622965, - |
| 6.5e-151 | FFCP PHASE1:Hg19::chr17:72635873..72635891,-#_ba9e6bb0a14b4b25c4ba2625c93890e9 | p@chr17:72635873..72635891, - |
| 6.5e-151 | FFCP PHASE2:Hg19::chr17:72635873..72635891,-#_ba9e6bb0a14b4b25c4ba2625c93890e9 | p@chr17:72635873..72635891, - |
| 1.04e-150 | FFCP PHASE1:Hg19::chr17:72636264..72636304,+#_144f9ad38ef997e36d4d95e377c86348 | p@chr17:72636264..72636304, + |
| 1.04e-150 | FFCP PHASE2:Hg19::chr17:72636264..72636304,+#_144f9ad38ef997e36d4d95e377c86348 | p@chr17:72636264..72636304, + |
| 1.28e-150 | FFCP PHASE1:Hg19::chr7:2814742..2814772,+#_74663df81577f470ddf962a89659072b | p@chr7:2814742..2814772, + |
| 1.28e-150 | FFCP PHASE2:Hg19::chr7:2814742..2814772,+#_74663df81577f470ddf962a89659072b | p@chr7:2814742..2814772, + |
