Coexpression cluster:C878

Full id: C878_Preadipocyte_Adipocyte_Mast_CD14_CD8_CD4_Fibroblast

Phase1 CAGE Peaks

Hg19::chr11:114167586..114167599,+	p16@NNMT
Hg19::chr15:39486361..39486371,-	p5@ENST00000560743
Hg19::chr15:39486372..39486387,-	p4@ENST00000560743
Hg19::chr15:39486389..39486413,-	p1@ENST00000560743
Hg19::chr15:39486417..39486445,-	p2@ENST00000560743
Hg19::chr15:39486488..39486494,-	p6@ENST00000560743
Hg19::chr15:39486515..39486531,-	p3@ENST00000560743
Hg19::chr1:100503682..100503729,+	p2@HIAT1
Hg19::chr1:185614334..185614338,-	p@chr1:185614334..185614338 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0008112	nicotinamide N-methyltransferase activity	0.00223713646532438
GO:0015904	tetracycline transport	0.0031954858870987
GO:0015307	drug:hydrogen antiporter activity	0.0031954858870987
GO:0015520	tetracycline:hydrogen antiporter activity	0.0031954858870987
GO:0008493	tetracycline transporter activity	0.0031954858870987
GO:0046677	response to antibiotic	0.0031954858870987
GO:0042895	antibiotic transporter activity	0.0031954858870987
GO:0015893	drug transport	0.0047527954656943
GO:0015238	drug transporter activity	0.00546686554372937
GO:0015299	solute:hydrogen antiporter activity	0.0060379569704045
GO:0015298	solute:cation antiporter activity	0.00876999965365704
GO:0008170	N-methyltransferase activity	0.00876999965365704
GO:0015300	solute:solute antiporter activity	0.00876999965365704
GO:0042493	response to drug	0.0100579274189454
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	0.0127068590613247
GO:0015297	antiporter activity	0.0127068590613247
GO:0008168	methyltransferase activity	0.0344104638445509
GO:0016741	transferase activity, transferring one-carbon groups	0.0344104638445509
GO:0015291	secondary active transmembrane transporter activity	0.0421638748723498

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
skin fibroblast	7.25e-31	23
fibroblast	5.11e-27	76
preadipocyte of the breast	1.45e-15	3
omentum preadipocyte	2.83e-15	3
adipocyte of omentum tissue	2.97e-15	3
preadipocyte	3.25e-14	12
receptor cell	3.95e-12	6
sensory epithelial cell	3.95e-12	6
olfactory epithelial cell	3.95e-12	6
fat cell	3.03e-11	15
adipocyte of breast	5.28e-11	2

Uber Anatomy

Ontology term	p-value	n
omentum	9.42e-29	6
peritoneum	9.42e-29	6
abdominal cavity	9.42e-29	6
visceral peritoneum	9.42e-29	6
skin of body	9.69e-22	41
integument	5.20e-19	46
integumental system	5.20e-19	46
cavity lining	4.59e-14	12
serous membrane	4.59e-14	12
breast	2.94e-12	10
chest	4.11e-11	11
surface structure	3.10e-08	99

Disease

Ontology term	p-value	n
musculoskeletal system disease	5.76e-15	5
myotonic disease	5.76e-15	5
muscle tissue disease	5.76e-15	5
myopathy	5.76e-15	5
muscular disease	5.76e-15	5
myotonic dystrophy	5.76e-15	5

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.