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Coexpression cluster:C4804: Difference between revisions

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|tf_chipseq_enrich=EGR1#1958;3:4.98817909481014:0.00805648813738344:0.0322862347791792!IRF1#3659;3:7.6371637535639:0.00224469274729724:0.012883791263738!MAX#4149;3:6.45255550900712:0.00372191383426551:0.0187584672781032!MYC#4609;3:5.2222818716094:0.00702084375574015:0.0296430263990033!RAD21#5885;3:10.3550338954563:0.000900491207356542:0.00669369403595088!TFAP2A#7020;3:16.518634373045:0.000221803388076634:0.00249783524340474!TFAP2C#7022;3:10.8092286098602:0.000791674657575313:0.00619524273658835
|tf_chipseq_enrich=EGR1#1958;3:4.98817909481014:0.00805648813738344:0.0322862347791792!IRF1#3659;3:7.6371637535639:0.00224469274729724:0.012883791263738!MAX#4149;3:6.45255550900712:0.00372191383426551:0.0187584672781032!MYC#4609;3:5.2222818716094:0.00702084375574015:0.0296430263990033!RAD21#5885;3:10.3550338954563:0.000900491207356542:0.00669369403595088!TFAP2A#7020;3:16.518634373045:0.000221803388076634:0.00249783524340474!TFAP2C#7022;3:10.8092286098602:0.000791674657575313:0.00619524273658835
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}}
}}

Revision as of 16:58, 26 November 2012


Full id: C4804_Placental_amniotic_Smooth_chorionic_Amniotic_Mesothelial_Fibroblast



Phase1 CAGE Peaks

Hg19::chr9:132515289..132515300,-p3@PTGES
Hg19::chr9:132515302..132515338,-p1@PTGES
Hg19::chr9:132515340..132515357,-p2@PTGES


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
muscle precursor cell6.02e-0858
myoblast6.02e-0858
multi-potent skeletal muscle stem cell6.02e-0858
muscle cell7.81e-0855
non-terminally differentiated cell1.07e-07106
contractile cell1.53e-0759
extraembryonic cell3.61e-0719
Uber Anatomy
Ontology termp-valuen
organism subdivision8.04e-17264
organ component layer5.86e-1366
multi-cellular organism9.59e-12656
trunk5.88e-11199
multi-tissue structure1.58e-10342
organ2.91e-10503
organ part5.20e-10218
anatomical system6.77e-10624
surface structure8.89e-1099
anatomical group9.72e-10625
multilaminar epithelium1.06e-0983
extraembryonic membrane1.34e-0914
membranous layer1.34e-0914
mesenchyme6.02e-09160
entire embryonic mesenchyme6.02e-09160
somite1.63e-0871
presomitic mesoderm1.63e-0871
presumptive segmental plate1.63e-0871
dermomyotome1.63e-0871
trunk paraxial mesoderm1.63e-0871
subdivision of head2.62e-0849
dense mesenchyme tissue3.23e-0873
paraxial mesoderm3.34e-0872
presumptive paraxial mesoderm3.34e-0872
epithelial vesicle1.03e-0778
head2.39e-0756
skeletal muscle tissue3.55e-0762
striated muscle tissue3.55e-0762
myotome3.55e-0762
muscle tissue4.45e-0764
musculature4.45e-0764
musculature of body4.45e-0764
trunk mesenchyme6.61e-07122
orifice8.33e-0736
endoderm-derived structure9.57e-07160
endoderm9.57e-07160
presumptive endoderm9.57e-07160


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
EGR1#195834.988179094810140.008056488137383440.0322862347791792
IRF1#365937.63716375356390.002244692747297240.012883791263738
MAX#414936.452555509007120.003721913834265510.0187584672781032
MYC#460935.22228187160940.007020843755740150.0296430263990033
RAD21#5885310.35503389545630.0009004912073565420.00669369403595088
TFAP2A#7020316.5186343730450.0002218033880766340.00249783524340474
TFAP2C#7022310.80922860986020.0007916746575753130.00619524273658835



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.