MCL coexpression mm9:2132

Phase1 CAGE Peaks

	Short description
Mm9::chr15:25870451..25870487,+	p9@Fam134b
Mm9::chr19:10020382..10020393,-	p@chr19:10020382..10020393 -
Mm9::chr1:172989521..172989536,-	p2@Fcgr3
Mm9::chr4:149375404..149375413,-	p8@H6pd

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0047936	glucose 1-dehydrogenase activity	0.00701043274445327
GO:0019770	IgG receptor activity	0.00701043274445327
GO:0017057	6-phosphogluconolactonase activity	0.00701043274445327
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	0.00701043274445327
GO:0001802	type III hypersensitivity	0.00701043274445327
GO:0001803	regulation of type III hypersensitivity	0.00701043274445327
GO:0004345	glucose-6-phosphate dehydrogenase activity	0.00701043274445327
GO:0001805	positive regulation of type III hypersensitivity	0.00701043274445327
GO:0001820	serotonin secretion	0.00701043274445327
GO:0019763	immunoglobulin receptor activity	0.00701043274445327
GO:0042535	positive regulation of tumor necrosis factor biosynthetic process	0.00701043274445327
GO:0001788	antibody-dependent cellular cytotoxicity	0.00701043274445327
GO:0019864	IgG binding	0.00701043274445327
GO:0042534	regulation of tumor necrosis factor biosynthetic process	0.00701043274445327
GO:0042533	tumor necrosis factor biosynthetic process	0.00701043274445327
GO:0001812	positive regulation of type I hypersensitivity	0.00701043274445327
GO:0006098	pentose-phosphate shunt	0.00701043274445327
GO:0001810	regulation of type I hypersensitivity	0.00701043274445327
GO:0001798	positive regulation of type IIa hypersensitivity	0.00701043274445327
GO:0002894	positive regulation of type II hypersensitivity	0.00701043274445327
GO:0006740	NADPH regeneration	0.00701043274445327
GO:0001796	regulation of type IIa hypersensitivity	0.00701043274445327
GO:0002445	type II hypersensitivity	0.00701043274445327
GO:0002886	regulation of myeloid leukocyte mediated immunity	0.00701043274445327
GO:0002888	positive regulation of myeloid leukocyte mediated immunity	0.00701043274445327
GO:0001794	type IIa hypersensitivity	0.00701043274445327
GO:0016068	type I hypersensitivity	0.00701043274445327
GO:0002892	regulation of type II hypersensitivity	0.00701043274445327
GO:0019865	immunoglobulin binding	0.00701043274445327
GO:0002675	positive regulation of acute inflammatory response	0.00701043274445327
GO:0002885	positive regulation of hypersensitivity	0.00701043274445327
GO:0002866	positive regulation of acute inflammatory response to antigenic stimulus	0.00701043274445327
GO:0002891	positive regulation of immunoglobulin mediated immune response	0.00701043274445327
GO:0002714	positive regulation of B cell mediated immunity	0.00701043274445327
GO:0006910	phagocytosis, recognition	0.00701043274445327
GO:0045576	mast cell activation	0.00701043274445327
GO:0002889	regulation of immunoglobulin mediated immune response	0.00701043274445327
GO:0002883	regulation of hypersensitivity	0.00701043274445327
GO:0002673	regulation of acute inflammatory response	0.00701043274445327
GO:0002712	regulation of B cell mediated immunity	0.00701043274445327
GO:0002438	acute inflammatory response to antigenic stimulus	0.00701043274445327
GO:0002864	regulation of acute inflammatory response to antigenic stimulus	0.00701043274445327
GO:0030593	neutrophil chemotaxis	0.00701043274445327
GO:0002524	hypersensitivity	0.00701043274445327
GO:0002863	positive regulation of inflammatory response to antigenic stimulus	0.00701043274445327
GO:0006739	NADP metabolic process	0.00743970612096549
GO:0002861	regulation of inflammatory response to antigenic stimulus	0.00743970612096549
GO:0002437	inflammatory response to antigenic stimulus	0.00743970612096549
GO:0006911	phagocytosis, engulfment	0.00743970612096549
GO:0002705	positive regulation of leukocyte mediated immunity	0.00743970612096549
GO:0002444	myeloid leukocyte mediated immunity	0.00743970612096549
GO:0032640	tumor necrosis factor production	0.00743970612096549
GO:0002708	positive regulation of lymphocyte mediated immunity	0.00743970612096549
GO:0050766	positive regulation of phagocytosis	0.00744756424117877
GO:0050764	regulation of phagocytosis	0.00744756424117877
GO:0002699	positive regulation of immune effector process	0.00744756424117877
GO:0050729	positive regulation of inflammatory response	0.00744756424117877
GO:0002703	regulation of leukocyte mediated immunity	0.00744756424117877
GO:0031349	positive regulation of defense response	0.00744756424117877
GO:0002706	regulation of lymphocyte mediated immunity	0.00744756424117877
GO:0002824	positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	0.00750994298946373
GO:0002821	positive regulation of adaptive immune response	0.00750994298946373
GO:0002478	antigen processing and presentation of exogenous peptide antigen	0.00750994298946373
GO:0002697	regulation of immune effector process	0.00756662911250776
GO:0030595	leukocyte chemotaxis	0.00756662911250776
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	0.00756662911250776
GO:0045807	positive regulation of endocytosis	0.0080305863338368
GO:0001906	cell killing	0.0080305863338368
GO:0006769	nicotinamide metabolic process	0.0080305863338368
GO:0002819	regulation of adaptive immune response	0.0080305863338368
GO:0002822	regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains.	0.0080305863338368
GO:0001909	leukocyte mediated cytotoxicity	0.0080305863338368
GO:0019884	antigen processing and presentation of exogenous antigen	0.00828037761672297
GO:0019362	pyridine nucleotide metabolic process	0.00852339831390692
GO:0002274	myeloid leukocyte activation	0.00946019410929288
GO:0031347	regulation of defense response	0.00989648583932346
GO:0050727	regulation of inflammatory response	0.00989648583932346
GO:0050900	leukocyte migration	0.0104428012558215
GO:0042108	positive regulation of cytokine biosynthetic process	0.010509886011911
GO:0006733	oxidoreduction coenzyme metabolic process	0.010509886011911
GO:0051050	positive regulation of transport	0.0107042200392035
GO:0048002	antigen processing and presentation of peptide antigen	0.0107625460797819
GO:0030100	regulation of endocytosis	0.0107625460797819
GO:0006909	phagocytosis	0.0118842252695908
GO:0006767	water-soluble vitamin metabolic process	0.0120531437671891
GO:0045727	positive regulation of translation	0.0122181171744225
GO:0031328	positive regulation of cellular biosynthetic process	0.0129824368127697
GO:0008037	cell recognition	0.0129854729932073
GO:0048583	regulation of response to stimulus	0.0129854729932073
GO:0032403	protein complex binding	0.014298455035278
GO:0042035	regulation of cytokine biosynthetic process	0.0144295318923336
GO:0006007	glucose catabolic process	0.0146500853118655
GO:0009891	positive regulation of biosynthetic process	0.0146500853118655
GO:0046365	monosaccharide catabolic process	0.0146500853118655
GO:0019320	hexose catabolic process	0.0146500853118655
GO:0046164	alcohol catabolic process	0.0153168316673578
GO:0019882	antigen processing and presentation	0.0154291979758798
GO:0042089	cytokine biosynthetic process	0.0160742107120935
GO:0042107	cytokine metabolic process	0.0161765984876201
GO:0006766	vitamin metabolic process	0.0162769240998742
GO:0044275	cellular carbohydrate catabolic process	0.0171536103076992
GO:0016064	immunoglobulin mediated immune response	0.0179183655045773
GO:0019724	B cell mediated immunity	0.0179183655045773
GO:0051247	positive regulation of protein metabolic process	0.0179183655045773
GO:0016052	carbohydrate catabolic process	0.0179971882326395
GO:0002526	acute inflammatory response	0.0190628010616963
GO:0051049	regulation of transport	0.0205974710962379
GO:0003001	generation of a signal involved in cell-cell signaling	0.0211338254680621
GO:0002250	adaptive immune response	0.0212254100803507
GO:0002460	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	0.0212254100803507
GO:0002449	lymphocyte mediated immunity	0.0217414165806211
GO:0050778	positive regulation of immune response	0.0223829177043655
GO:0006006	glucose metabolic process	0.0223829177043655
GO:0002684	positive regulation of immune system process	0.0223829177043655
GO:0002443	leukocyte mediated immunity	0.0223829177043655
GO:0001816	cytokine production	0.0223829177043655
GO:0042330	taxis	0.0228900631349165
GO:0006935	chemotaxis	0.0228900631349165
GO:0004091	carboxylesterase activity	0.0229174461935555
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.0240336476950901
GO:0050776	regulation of immune response	0.0240510436784332
GO:0002682	regulation of immune system process	0.0242823695583694
GO:0051240	positive regulation of multicellular organismal process	0.0249347756005532
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	0.025155104117616
GO:0006917	induction of apoptosis	0.0268175387162677
GO:0012502	induction of programmed cell death	0.0268175387162677
GO:0019318	hexose metabolic process	0.0268175387162677
GO:0006417	regulation of translation	0.0268175387162677
GO:0005996	monosaccharide metabolic process	0.0272082271734108
GO:0002252	immune effector process	0.0272082271734108
GO:0031326	regulation of cellular biosynthetic process	0.0277974889846219
GO:0005792	microsome	0.0303537488994884
GO:0009889	regulation of biosynthetic process	0.0305176438388193
GO:0042598	vesicular fraction	0.0306790495767813
GO:0006732	coenzyme metabolic process	0.0308380214289605
GO:0043065	positive regulation of apoptosis	0.0313779125208623
GO:0043068	positive regulation of programmed cell death	0.0315293362273279
GO:0010324	membrane invagination	0.0316380769624637
GO:0006897	endocytosis	0.0316380769624637
GO:0009117	nucleotide metabolic process	0.0338306805273247
GO:0051186	cofactor metabolic process	0.0346985195858322
GO:0055086	nucleobase, nucleoside and nucleotide metabolic process	0.0357370025259997
GO:0007626	locomotory behavior	0.0369423378237362
GO:0045321	leukocyte activation	0.0371501358980471
GO:0032940	secretion by cell	0.0371501358980471
GO:0006954	inflammatory response	0.0372518408134996
GO:0001775	cell activation	0.0392967491917958
GO:0044265	cellular macromolecule catabolic process	0.0397332974907156
GO:0051246	regulation of protein metabolic process	0.0403381072681309
GO:0016044	membrane organization and biogenesis	0.040588471108217
GO:0044262	cellular carbohydrate metabolic process	0.0428976130983566
GO:0006066	alcohol metabolic process	0.0436391866684175
GO:0046903	secretion	0.0442012902965828
GO:0016477	cell migration	0.0462701344748131
GO:0051239	regulation of multicellular organismal process	0.0468071282397463
GO:0009611	response to wounding	0.0481666997116998
GO:0009057	macromolecule catabolic process	0.0485192670346343

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
trunk	1.25e-08	90
trunk region element	1.11e-07	79

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}