Novel motif:21

name:	motif21_TCTTGA

Association to promoter expression in human samples<b>Summary:</b>Significance of the correlation with CAGE expression, human <br><b>Analyst:</b> Michiel de Hoon<br><br>link to source dataset <br>data

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Association to promoter expression in mouse samples <b>Summary:</b>Significance of the correlation with CAGE expression, mouse <br><b>Analyst:</b> Michiel de Hoon<br><br>link to source dataset <br>data

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GREAT analysis results for human <b>Summary:</b>Genomic Enrichment of Annotations Tool (GREAT, Nat Biotechnol. 2010 May;28(5):495-501) is used to identify, both in human and in mouse, the gene ontology terms of biological processes enriched given the predicted TFBSs, and evaluated the overlap in the top-500 gene ontology terms between human and mouse. For each novel motif, the P value for the overlap was then evaluated by calculating its relative rank with respect to this background distribution.<br>Analyst: Michiel de Hoon<br><br>link to source dataset <br>data

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GO ID	GO Term	p-value
GO:0032501	multicellular organismal process	1.482335e-50
GO:0048739	cardiac muscle fiber development	5.645841e-38
GO:0050896	response to stimulus	1.357165e-37
GO:0009611	response to wounding	7.162540e-34
GO:0030241	skeletal muscle myosin thick filament assembly	3.222029e-33
GO:0032502	developmental process	5.060910e-33
GO:0009888	tissue development	1.617381e-32
GO:0030049	muscle filament sliding	2.625726e-32
GO:0070252	actin-mediated cell contraction	7.265380e-32
GO:0048856	anatomical structure development	7.689115e-32
GO:0042060	wound healing	1.962419e-31
GO:0006950	response to stress	1.017978e-30
GO:0007275	multicellular organismal development	1.104514e-30
GO:0030048	actin filament-based movement	1.903066e-30
GO:0048731	system development	9.782549e-30
GO:0065007	biological regulation	5.888240e-29
GO:0050789	regulation of biological process	6.522777e-29
GO:0065008	regulation of biological quality	2.814580e-28
GO:0051716	cellular response to stimulus	3.799079e-28
GO:0042221	response to chemical stimulus	4.460475e-27
GO:0010035	response to inorganic substance	4.968180e-27
GO:0007599	hemostasis	1.246588e-26
GO:0007596	blood coagulation	1.391294e-26
GO:0050790	regulation of catalytic activity	1.226097e-25
GO:0007076	mitotic chromosome condensation	3.852647e-25
GO:0048513	organ development	7.314743e-25
GO:0006941	striated muscle contraction	7.762315e-25
GO:0048769	sarcomerogenesis	7.841586e-25
GO:0002576	platelet degranulation	1.560080e-24
GO:0007165	signal transduction	1.781432e-24
GO:0050878	regulation of body fluid levels	8.778448e-24
GO:0006936	muscle contraction	1.348147e-23
GO:0016192	vesicle-mediated transport	1.684397e-23
GO:0051179	localization	1.070439e-22
GO:0048747	muscle fiber development	1.114415e-22
GO:0048646	anatomical structure formation involved in morphogenesis	2.960861e-22
GO:0030261	chromosome condensation	6.271419e-22
GO:0051641	cellular localization	6.954203e-22
GO:0007154	cell communication	1.059239e-21
GO:0051234	establishment of localization	1.226671e-21
GO:0003012	muscle system process	1.593751e-21
GO:0007320	insemination	1.858068e-21
GO:0014866	skeletal myofibril assembly	2.158605e-21
GO:0030168	platelet activation	5.759231e-21
GO:0050794	regulation of cellular process	7.902961e-21
GO:0071840	cellular component organization or biogenesis	1.037649e-20
GO:0016043	cellular component organization	3.320539e-20
GO:0023052	signaling	5.849900e-20
GO:0006928	cellular component movement	6.520470e-20
GO:0006810	transport	6.800528e-20
GO:0021509	roof plate formation	7.620749e-20
GO:0065009	regulation of molecular function	9.708318e-20
GO:0072358	cardiovascular system development	3.211032e-19
GO:0007166	cell surface receptor linked signaling pathway	8.914531e-19
GO:0071379	cellular response to prostaglandin stimulus	1.758569e-18
GO:0051592	response to calcium ion	2.123465e-18
GO:0051649	establishment of localization in cell	4.048849e-18
GO:0032940	secretion by cell	4.496965e-18
GO:0045214	sarcomere organization	6.804492e-18
GO:0006887	exocytosis	7.761351e-18
GO:0010038	response to metal ion	1.300608e-17
GO:0055008	cardiac muscle tissue morphogenesis	2.080172e-17
GO:0051704	multi-organism process	3.001185e-17
GO:0048468	cell development	5.186434e-17
GO:0007155	cell adhesion	5.762977e-17
GO:0034383	low-density lipoprotein particle clearance	1.243080e-16
GO:0000070	mitotic sister chromatid segregation	2.951461e-16
GO:0007620	copulation	3.047724e-16
GO:0042159	lipoprotein catabolic process	3.070647e-16
GO:0000819	sister chromatid segregation	3.075952e-16
GO:0071842	cellular component organization at cellular level	5.395066e-16
GO:0030240	skeletal muscle thin filament assembly	5.757230e-16
GO:0010033	response to organic substance	7.370861e-16
GO:0030239	myofibril assembly	1.256569e-15
GO:0048869	cellular developmental process	1.628214e-15
GO:0001775	cell activation	1.962605e-15
GO:0010927	cellular component assembly involved in morphogenesis	1.982800e-15
GO:0071841	cellular component organization or biogenesis at cellular level	2.251644e-15
GO:0030154	cell differentiation	2.348898e-15
GO:0009653	anatomical structure morphogenesis	2.513254e-15
GO:0046903	secretion	3.034244e-15
GO:0060415	muscle tissue morphogenesis	4.082027e-15
GO:0007517	muscle organ development	4.291802e-15
GO:0007507	heart development	4.296037e-15
GO:0010886	positive regulation of cholesterol storage	5.970454e-15
GO:0051239	regulation of multicellular organismal process	9.451360e-15
GO:0048729	tissue morphogenesis	1.309280e-14
GO:0014706	striated muscle tissue development	1.451650e-14
GO:0019220	regulation of phosphate metabolic process	1.552312e-14
GO:0006323	DNA packaging	1.573026e-14
GO:0051915	induction of synaptic plasticity by chemical substance	1.638487e-14
GO:0022607	cellular component assembly	1.758799e-14
GO:0050808	synapse organization	2.922922e-14
GO:0042325	regulation of phosphorylation	3.093374e-14
GO:0032924	activin receptor signaling pathway	3.528193e-14
GO:0009743	response to carbohydrate stimulus	6.323141e-14
GO:0010951	negative regulation of endopeptidase activity	9.163812e-14
GO:0009607	response to biotic stimulus	9.473236e-14
GO:0048853	forebrain morphogenesis	9.819375e-14
GO:0044085	cellular component biogenesis	1.057093e-13
GO:0001932	regulation of protein phosphorylation	1.149158e-13
GO:0007416	synapse assembly	1.170657e-13
GO:0007049	cell cycle	1.178422e-13
GO:0044057	regulation of system process	1.182845e-13
GO:0052547	regulation of peptidase activity	1.219621e-13
GO:0052548	regulation of endopeptidase activity	1.416557e-13
GO:0003008	system process	1.500038e-13
GO:0051707	response to other organism	1.516637e-13
GO:0030029	actin filament-based process	1.646483e-13
GO:0048854	brain morphogenesis	2.255439e-13
GO:0032989	cellular component morphogenesis	2.868887e-13
GO:0071103	DNA conformation change	3.138860e-13
GO:0040011	locomotion	3.540850e-13
GO:0060571	morphogenesis of an epithelial fold	4.128005e-13
GO:0031032	actomyosin structure organization	4.949988e-13
GO:0022612	gland morphogenesis	5.428480e-13
GO:0048519	negative regulation of biological process	6.784569e-13
GO:0000278	mitotic cell cycle	6.876829e-13
GO:0060537	muscle tissue development	7.207309e-13
GO:0001763	morphogenesis of a branching structure	7.492964e-13
GO:0050793	regulation of developmental process	7.648375e-13
GO:0014012	peripheral nervous system axon regeneration	7.767848e-13
GO:0019953	sexual reproduction	8.089440e-13
GO:0071844	cellular component assembly at cellular level	8.094568e-13
GO:0055003	cardiac myofibril assembly	1.017198e-12
GO:0009617	response to bacterium	1.055125e-12
GO:0051336	regulation of hydrolase activity	1.213859e-12
GO:0042953	lipoprotein transport	1.252781e-12
GO:0030010	establishment of cell polarity	1.441598e-12
GO:0031099	regeneration	1.512165e-12
GO:0009987	cellular process	1.715937e-12
GO:0048644	muscle organ morphogenesis	1.779422e-12
GO:0060429	epithelium development	1.981104e-12
GO:0048676	axon extension involved in development	2.092643e-12
GO:0046709	IDP catabolic process	2.495802e-12
GO:0046032	ADP catabolic process	2.495802e-12
GO:0008219	cell death	2.938763e-12
GO:0034097	response to cytokine stimulus	2.960634e-12
GO:0055002	striated muscle cell development	4.030316e-12
GO:0048583	regulation of response to stimulus	4.064013e-12
GO:0055001	muscle cell development	4.295998e-12
GO:0048523	negative regulation of cellular process	5.282320e-12
GO:0002376	immune system process	5.492683e-12
GO:0016265	death	9.225715e-12
GO:0061024	membrane organization	1.770664e-11
GO:0051246	regulation of protein metabolic process	1.780607e-11
GO:0048285	organelle fission	1.852754e-11
GO:0010885	regulation of cholesterol storage	1.975897e-11
GO:0010884	positive regulation of lipid storage	2.143209e-11
GO:0031110	regulation of microtubule polymerization or depolymerization	2.327771e-11
GO:0000087	M phase of mitotic cell cycle	2.366954e-11
GO:0016044	cellular membrane organization	2.468276e-11
GO:0019222	regulation of metabolic process	3.109512e-11
GO:0047497	mitochondrion transport along microtubule	3.538221e-11
GO:0010466	negative regulation of peptidase activity	3.627622e-11
GO:0044255	cellular lipid metabolic process	3.815659e-11
GO:0000003	reproduction	3.836894e-11
GO:0010744	positive regulation of macrophage derived foam cell differentiation	4.611075e-11
GO:0007067	mitosis	4.695056e-11
GO:0045666	positive regulation of neuron differentiation	6.192738e-11
GO:0022414	reproductive process	6.234390e-11
GO:0048738	cardiac muscle tissue development	6.792369e-11
GO:0055013	cardiac muscle cell development	7.163513e-11
GO:2000026	regulation of multicellular organismal development	7.326457e-11
GO:0012501	programmed cell death	7.375292e-11
GO:0032268	regulation of cellular protein metabolic process	7.883722e-11
GO:0031399	regulation of protein modification process	9.282491e-11
GO:0031644	regulation of neurological system process	1.056218e-10
GO:0060389	pathway-restricted SMAD protein phosphorylation	1.095258e-10
GO:0007010	cytoskeleton organization	1.245011e-10
GO:0070482	response to oxygen levels	1.267174e-10
GO:0006642	triglyceride mobilization	1.269433e-10
GO:0019538	protein metabolic process	1.332650e-10
GO:0007186	G-protein coupled receptor protein signaling pathway	1.410986e-10
GO:0035239	tube morphogenesis	1.516452e-10
GO:0051640	organelle localization	1.579531e-10
GO:0040008	regulation of growth	1.606154e-10
GO:0021527	spinal cord association neuron differentiation	2.052634e-10
GO:0007417	central nervous system development	2.078373e-10
GO:0034612	response to tumor necrosis factor	2.105520e-10
GO:0032879	regulation of localization	2.732700e-10
GO:0071356	cellular response to tumor necrosis factor	3.103693e-10
GO:0009605	response to external stimulus	3.258981e-10
GO:0007522	visceral muscle development	3.337636e-10
GO:0051346	negative regulation of hydrolase activity	3.420250e-10
GO:0051654	establishment of mitochondrion localization	3.547034e-10
GO:0007059	chromosome segregation	3.630313e-10
GO:0002237	response to molecule of bacterial origin	3.733464e-10
GO:0030901	midbrain development	3.797108e-10
GO:0018149	peptide cross-linking	3.941493e-10
GO:0034694	response to prostaglandin stimulus	4.177976e-10
GO:0051969	regulation of transmission of nerve impulse	4.206842e-10
GO:0006897	endocytosis	4.223716e-10
GO:0048609	multicellular organismal reproductive process	4.487648e-10
GO:0048518	positive regulation of biological process	4.849282e-10
GO:0022402	cell cycle process	4.955388e-10
GO:0002009	morphogenesis of an epithelium	5.073029e-10
GO:0006629	lipid metabolic process	5.664266e-10
GO:0003007	heart morphogenesis	6.246901e-10
GO:0010876	lipid localization	6.797999e-10
GO:0045540	regulation of cholesterol biosynthetic process	6.951075e-10
GO:0044242	cellular lipid catabolic process	7.110622e-10
GO:0006955	immune response	7.659192e-10
GO:0034381	plasma lipoprotein particle clearance	8.940640e-10
GO:0016337	cell-cell adhesion	1.038934e-9
GO:0006875	cellular metal ion homeostasis	1.306663e-9
GO:0009181	purine ribonucleoside diphosphate catabolic process	1.412861e-9
GO:0001666	response to hypoxia	1.487190e-9
GO:0032496	response to lipopolysaccharide	1.652218e-9
GO:0051971	positive regulation of transmission of nerve impulse	1.681406e-9
GO:0055080	cation homeostasis	1.837811e-9
GO:0007618	mating	2.124625e-9
GO:0031581	hemidesmosome assembly	2.210443e-9
GO:0042327	positive regulation of phosphorylation	2.378538e-9
GO:0022403	cell cycle phase	2.500329e-9
GO:0070555	response to interleukin-1	2.768536e-9
GO:0006952	defense response	2.787505e-9
GO:0071310	cellular response to organic substance	2.813565e-9
GO:0045937	positive regulation of phosphate metabolic process	2.859062e-9
GO:0010269	response to selenium ion	2.956752e-9
GO:0070887	cellular response to chemical stimulus	3.107094e-9
GO:0009566	fertilization	3.155919e-9
GO:0051646	mitochondrion localization	3.347362e-9
GO:0023051	regulation of signaling	3.376784e-9
GO:0009719	response to endogenous stimulus	3.388143e-9
GO:0002027	regulation of heart rate	3.412544e-9
GO:0051240	positive regulation of multicellular organismal process	3.464201e-9
GO:0033036	macromolecule localization	3.547235e-9
GO:0048608	reproductive structure development	3.784644e-9
GO:0055065	metal ion homeostasis	3.821228e-9
GO:0050806	positive regulation of synaptic transmission	4.041403e-9
GO:0006200	ATP catabolic process	4.418895e-9
GO:0034379	very-low-density lipoprotein particle assembly	4.718950e-9
GO:0031175	neuron projection development	5.015029e-9
GO:0030182	neuron differentiation	5.301414e-9
GO:0048878	chemical homeostasis	5.550618e-9
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	5.559109e-9
GO:0031116	positive regulation of microtubule polymerization	5.735935e-9
GO:0007420	brain development	5.777184e-9
GO:0090181	regulation of cholesterol metabolic process	6.073468e-9
GO:0061061	muscle structure development	6.126262e-9
GO:0046503	glycerolipid catabolic process	6.186768e-9
GO:0046464	acylglycerol catabolic process	6.389266e-9
GO:0051293	establishment of spindle localization	6.824088e-9
GO:0006915	apoptosis	6.839722e-9
GO:0019433	triglyceride catabolic process	7.093283e-9
GO:0014912	negative regulation of smooth muscle cell migration	7.290883e-9
GO:0030003	cellular cation homeostasis	7.800461e-9
GO:0048666	neuron development	8.007167e-9
GO:0044248	cellular catabolic process	9.058933e-9
GO:0034374	low-density lipoprotein particle remodeling	9.413901e-9
GO:0070507	regulation of microtubule cytoskeleton organization	9.941357e-9
GO:0007399	nervous system development	1.002751e-8
GO:0044267	cellular protein metabolic process	1.027142e-8
GO:0030036	actin cytoskeleton organization	1.027151e-8
GO:0032787	monocarboxylic acid metabolic process	1.068533e-8
GO:0000302	response to reactive oxygen species	1.139506e-8
GO:0031646	positive regulation of neurological system process	1.169969e-8
GO:0035295	tube development	1.177360e-8
GO:0001841	neural tube formation	1.181834e-8
GO:0061162	establishment of monopolar cell polarity	1.303648e-8
GO:0042904	9-cis-retinoic acid biosynthetic process	1.345844e-8
GO:0009887	organ morphogenesis	1.525621e-8
GO:0030900	forebrain development	1.556629e-8
GO:0051656	establishment of organelle localization	1.647730e-8
GO:0006935	chemotaxis	1.684777e-8
GO:0071396	cellular response to lipid	1.819183e-8
GO:0033993	response to lipid	1.885366e-8
GO:0048662	negative regulation of smooth muscle cell proliferation	1.940424e-8
GO:0001568	blood vessel development	2.005262e-8
GO:0048522	positive regulation of cellular process	2.054908e-8
GO:0048251	elastic fiber assembly	2.089187e-8
GO:0030850	prostate gland development	2.170827e-8
GO:0048732	gland development	2.201935e-8
GO:0015918	sterol transport	2.240871e-8
GO:0007409	axonogenesis	2.484057e-8
GO:0071345	cellular response to cytokine stimulus	2.501035e-8
GO:0031114	regulation of microtubule depolymerization	2.591433e-8
GO:0051960	regulation of nervous system development	2.657516e-8
GO:0010646	regulation of cell communication	2.752016e-8
GO:0046486	glycerolipid metabolic process	2.834729e-8
GO:0031102	neuron projection regeneration	2.852899e-8
GO:0009191	ribonucleoside diphosphate catabolic process	3.113172e-8
GO:0048667	cell morphogenesis involved in neuron differentiation	3.142542e-8
GO:0006464	protein modification process	3.307328e-8
GO:0042632	cholesterol homeostasis	3.478304e-8
GO:0048699	generation of neurons	3.594238e-8
GO:0030030	cell projection organization	3.780282e-8
GO:0007026	negative regulation of microtubule depolymerization	3.905926e-8
GO:0008104	protein localization	3.953972e-8
GO:0042574	retinal metabolic process	4.016694e-8
GO:0031112	positive regulation of microtubule polymerization or depolymerization	4.080750e-8
GO:0030155	regulation of cell adhesion	4.200245e-8
GO:0048812	neuron projection morphogenesis	4.201597e-8
GO:0048262	determination of dorsal/ventral asymmetry	4.322305e-8
GO:0031640	killing of cells of other organism	4.758668e-8
GO:0043623	cellular protein complex assembly	5.367414e-8
GO:0048754	branching morphogenesis of a tube	5.538610e-8
GO:0006662	glycerol ether metabolic process	5.625259e-8
GO:0048858	cell projection morphogenesis	5.861775e-8
GO:0045664	regulation of neuron differentiation	6.371221e-8
GO:0060740	prostate gland epithelium morphogenesis	6.820916e-8
GO:0043085	positive regulation of catalytic activity	6.860554e-8
GO:0040001	establishment of mitotic spindle localization	6.978757e-8
GO:0085029	extracellular matrix assembly	7.138275e-8
GO:0048263	determination of dorsal identity	7.837064e-8
GO:0022002	negative regulation of anterior neural cell fate commitment of the neural plate by Wnt receptor signaling pathway	7.837064e-8
GO:0000132	establishment of mitotic spindle orientation	7.854126e-8
GO:0018904	organic ether metabolic process	7.932329e-8
GO:0032990	cell part morphogenesis	8.544468e-8
GO:0022008	neurogenesis	8.839130e-8
GO:0009056	catabolic process	8.978296e-8
GO:0035148	tube formation	9.084758e-8
GO:0016042	lipid catabolic process	1.056803e-7
GO:0050804	regulation of synaptic transmission	1.123995e-7
GO:0048514	blood vessel morphogenesis	1.157110e-7
GO:0060638	mesenchymal-epithelial cell signaling	1.157661e-7
GO:0006776	vitamin A metabolic process	1.184859e-7
GO:0015721	bile acid and bile salt transport	1.200389e-7
GO:0006811	ion transport	1.200401e-7
GO:0010743	regulation of macrophage derived foam cell differentiation	1.275347e-7
GO:0046485	ether lipid metabolic process	1.291367e-7
GO:0042592	homeostatic process	1.296436e-7
GO:0003006	developmental process involved in reproduction	1.297978e-7
GO:0090100	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	1.322929e-7
GO:0035690	cellular response to drug	1.337467e-7
GO:0032768	regulation of monooxygenase activity	1.412591e-7
GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	1.444914e-7
GO:0065003	macromolecular complex assembly	1.457662e-7
GO:0001934	positive regulation of protein phosphorylation	1.508136e-7
GO:0007163	establishment or maintenance of cell polarity	1.520960e-7
GO:0006775	fat-soluble vitamin metabolic process	1.540982e-7
GO:0060512	prostate gland morphogenesis	1.569635e-7
GO:0009725	response to hormone stimulus	1.628200e-7
GO:0072503	cellular divalent inorganic cation homeostasis	1.641421e-7
GO:0071233	cellular response to leucine	1.685452e-7
GO:0010941	regulation of cell death	1.724175e-7
GO:0042493	response to drug	1.800676e-7
GO:0034329	cell junction assembly	1.875444e-7
GO:0030301	cholesterol transport	1.913787e-7
GO:2000836	positive regulation of androgen secretion	1.989017e-7
GO:2000500	positive regulation of induction of apoptosis in response to chemical stimulus	1.989017e-7
GO:0071363	cellular response to growth factor stimulus	2.232353e-7
GO:0042753	positive regulation of circadian rhythm	2.429476e-7
GO:0006996	organelle organization	2.531360e-7
GO:0055009	atrial cardiac muscle tissue morphogenesis	2.659615e-7
GO:0021516	dorsal spinal cord development	2.908263e-7
GO:0001944	vasculature development	2.958245e-7
GO:0032270	positive regulation of cellular protein metabolic process	3.008437e-7
GO:0034377	plasma lipoprotein particle assembly	3.053577e-7
GO:0042362	fat-soluble vitamin biosynthetic process	3.139521e-7
GO:0048167	regulation of synaptic plasticity	3.164728e-7
GO:0072507	divalent inorganic cation homeostasis	3.215383e-7
GO:0071495	cellular response to endogenous stimulus	3.384726e-7
GO:0006916	anti-apoptosis	3.395723e-7
GO:0043549	regulation of kinase activity	3.730582e-7
GO:0050801	ion homeostasis	3.776347e-7
GO:0051657	maintenance of organelle location	3.951319e-7
GO:0042692	muscle cell differentiation	3.990335e-7
GO:0051146	striated muscle cell differentiation	4.064042e-7
GO:0031111	negative regulation of microtubule polymerization or depolymerization	4.149000e-7
GO:0045938	positive regulation of circadian sleep/wake cycle, sleep	4.152262e-7
GO:0045663	positive regulation of myoblast differentiation	4.323718e-7
GO:0042180	cellular ketone metabolic process	4.401999e-7
GO:0055007	cardiac muscle cell differentiation	4.515733e-7
GO:0042448	progesterone metabolic process	4.664401e-7
GO:0070848	response to growth factor stimulus	4.829681e-7
GO:0055074	calcium ion homeostasis	4.873978e-7
GO:0008037	cell recognition	4.902922e-7
GO:0051341	regulation of oxidoreductase activity	4.941346e-7
GO:0043412	macromolecule modification	4.958845e-7
GO:0006873	cellular ion homeostasis	5.008167e-7
GO:0034622	cellular macromolecular complex assembly	5.071935e-7
GO:0043933	macromolecular complex subunit organization	5.080969e-7
GO:0031103	axon regeneration	5.205035e-7
GO:0021915	neural tube development	5.237112e-7
GO:0061138	morphogenesis of a branching epithelium	5.293554e-7
GO:0032886	regulation of microtubule-based process	5.326277e-7
GO:0050767	regulation of neurogenesis	5.768560e-7
GO:0055088	lipid homeostasis	5.779804e-7
GO:0006874	cellular calcium ion homeostasis	5.975531e-7
GO:0019725	cellular homeostasis	6.061260e-7
GO:0051338	regulation of transferase activity	6.129438e-7
GO:0006869	lipid transport	6.282454e-7
GO:0030317	sperm motility	6.616104e-7
GO:0048870	cell motility	6.925868e-7
GO:0045926	negative regulation of growth	7.379916e-7
GO:0043067	regulation of programmed cell death	7.530345e-7
GO:0007413	axonal fasciculation	7.607865e-7
GO:0050900	leukocyte migration	8.322869e-7
GO:0006468	protein phosphorylation	8.378253e-7
GO:0055082	cellular chemical homeostasis	9.799257e-7
GO:0044093	positive regulation of molecular function	1.018921e-6
GO:0019752	carboxylic acid metabolic process	1.130063e-6
GO:0035162	embryonic hemopoiesis	1.153336e-6
GO:0007044	cell-substrate junction assembly	1.218264e-6
GO:0009628	response to abiotic stimulus	1.297097e-6
GO:0016477	cell migration	1.320865e-6
GO:0009267	cellular response to starvation	1.323757e-6
GO:0009792	embryo development ending in birth or egg hatching	1.341242e-6
GO:0050999	regulation of nitric-oxide synthase activity	1.424246e-6
GO:0060164	regulation of timing of neuron differentiation	1.427432e-6
GO:0030258	lipid modification	1.431557e-6
GO:0051049	regulation of transport	1.470221e-6
GO:0043086	negative regulation of catalytic activity	1.552010e-6
GO:0031100	organ regeneration	1.556363e-6
GO:0001933	negative regulation of protein phosphorylation	1.561585e-6
GO:0019915	lipid storage	1.563966e-6
GO:0072175	epithelial tube formation	1.635078e-6
GO:0001732	formation of translation initiation complex	1.656568e-6
GO:0060393	regulation of pathway-restricted SMAD protein phosphorylation	1.731446e-6
GO:0030516	regulation of axon extension	1.746602e-6
GO:0051247	positive regulation of protein metabolic process	1.764451e-6
GO:0050701	interleukin-1 secretion	1.810884e-6
GO:0042594	response to starvation	1.886541e-6
GO:0031349	positive regulation of defense response	1.908016e-6
GO:0001558	regulation of cell growth	1.935778e-6
GO:0001838	embryonic epithelial tube formation	1.956502e-6
GO:0007160	cell-matrix adhesion	1.964943e-6
GO:0031953	negative regulation of protein autophosphorylation	2.104556e-6
GO:0045595	regulation of cell differentiation	2.255882e-6
GO:2000534	positive regulation of renal albumin absorption	2.267339e-6
GO:2000481	positive regulation of cAMP-dependent protein kinase activity	2.267339e-6
GO:0070994	detection of oxidative stress	2.267339e-6
GO:2000461	negative regulation of eukaryotic cell surface binding	2.267339e-6
GO:2000478	positive regulation of metanephric glomerular visceral epithelial cell development	2.267339e-6
GO:0000279	M phase	2.284576e-6
GO:0042981	regulation of apoptosis	2.298685e-6
GO:0061387	regulation of extent of cell growth	2.348782e-6
GO:0006909	phagocytosis	2.365572e-6
GO:0007411	axon guidance	2.403581e-6
GO:0031113	regulation of microtubule polymerization	2.412696e-6
GO:0015031	protein transport	2.524856e-6
GO:0051051	negative regulation of transport	2.545199e-6
GO:0048660	regulation of smooth muscle cell proliferation	2.559453e-6
GO:0051659	maintenance of mitochondrion location	2.565126e-6
GO:0000904	cell morphogenesis involved in differentiation	2.718598e-6
GO:0044092	negative regulation of molecular function	2.726228e-6
GO:0051128	regulation of cellular component organization	2.788420e-6
GO:0045785	positive regulation of cell adhesion	2.871771e-6
GO:0009966	regulation of signal transduction	2.881435e-6
GO:0060562	epithelial tube morphogenesis	2.891762e-6
GO:0033554	cellular response to stress	2.994287e-6
GO:0044238	primary metabolic process	3.029412e-6
GO:0000902	cell morphogenesis	3.110020e-6
GO:0006082	organic acid metabolic process	3.137768e-6
GO:0031401	positive regulation of protein modification process	3.158154e-6
GO:0002651	positive regulation of tolerance induction to self antigen	3.175829e-6
GO:0071347	cellular response to interleukin-1	3.241982e-6
GO:0010766	negative regulation of sodium ion transport	3.246219e-6
GO:0048678	response to axon injury	3.295766e-6
GO:0034621	cellular macromolecular complex subunit organization	3.373409e-6
GO:0032387	negative regulation of intracellular transport	3.519569e-6
GO:0048610	cellular process involved in reproduction	3.536149e-6
GO:0040007	growth	3.634281e-6
GO:0009235	cobalamin metabolic process	3.661269e-6
GO:0048496	maintenance of organ identity	3.715190e-6
GO:0048584	positive regulation of response to stimulus	3.866968e-6
GO:0030509	BMP signaling pathway	3.885392e-6
GO:0030521	androgen receptor signaling pathway	4.027741e-6
GO:0045069	regulation of viral genome replication	4.039661e-6
GO:0043201	response to leucine	4.129230e-6
GO:0002709	regulation of T cell mediated immunity	4.164254e-6
GO:0035051	cardiac cell differentiation	4.228821e-6
GO:0044111	development involved in symbiotic interaction	4.309157e-6
GO:0010768	negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage	4.309157e-6
GO:0019089	transmission of virus	4.309157e-6
GO:0042158	lipoprotein biosynthetic process	4.327311e-6
GO:2000833	positive regulation of steroid hormone secretion	4.402892e-6
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	4.502764e-6
GO:0045859	regulation of protein kinase activity	4.543719e-6
GO:0060442	branching involved in prostate gland morphogenesis	4.558063e-6
GO:0042127	regulation of cell proliferation	4.630726e-6
GO:0016320	endoplasmic reticulum membrane fusion	4.793153e-6
GO:0001578	microtubule bundle formation	4.908863e-6
GO:0008285	negative regulation of cell proliferation	4.997401e-6
GO:0043009	chordate embryonic development	5.065853e-6
GO:0045661	regulation of myoblast differentiation	5.259398e-6
GO:0051046	regulation of secretion	5.412124e-6
GO:0016310	phosphorylation	5.740482e-6
GO:0010883	regulation of lipid storage	5.903755e-6
GO:0009082	branched chain family amino acid biosynthetic process	6.118226e-6
GO:0007584	response to nutrient	6.413125e-6
GO:0072384	organelle transport along microtubule	6.509568e-6
GO:0010647	positive regulation of cell communication	6.716656e-6
GO:0055114	oxidation-reduction process	6.750265e-6
GO:0031341	regulation of cell killing	6.763853e-6
GO:0008360	regulation of cell shape	6.772186e-6
GO:0055072	iron ion homeostasis	6.910957e-6
GO:0023056	positive regulation of signaling	6.933596e-6
GO:0070167	regulation of biomineral tissue development	7.110896e-6
GO:0051129	negative regulation of cellular component organization	7.136136e-6
GO:0006638	neutral lipid metabolic process	7.329091e-6
GO:0030500	regulation of bone mineralization	7.510873e-6
GO:0071822	protein complex subunit organization	7.770863e-6
GO:0032612	interleukin-1 production	7.996379e-6
GO:0031323	regulation of cellular metabolic process	8.158010e-6
GO:0060452	positive regulation of cardiac muscle contraction	8.217751e-6
GO:0006796	phosphate-containing compound metabolic process	8.228557e-6
GO:0006687	glycosphingolipid metabolic process	8.306000e-6

GREAT analysis results for mouseGenomic Enrichment of Annotations Tool (GREAT, Nat Biotechnol. 2010 May;28(5):495-501) is used to identify, both in human and in mouse, the gene ontology terms of biological processes enriched given the predicted TFBSs, and evaluated the overlap in the top-500 gene ontology terms between human and mouse. For each novel motif, the P value for the overlap was then evaluated by calculating its relative rank with respect to this background distribution.<br>Analyst: Michiel de Hoon <br><br>link to source dataset <br>data

---

GO ID	GO Term	p-value
GO:0021700	developmental maturation	1.363731e-14
GO:0045214	sarcomere organization	2.721375e-13
GO:0019218	regulation of steroid metabolic process	3.393450e-13
GO:0019915	lipid storage	5.549282e-13
GO:0019433	triglyceride catabolic process	1.099995e-12
GO:0046464	acylglycerol catabolic process	5.894727e-12
GO:0019216	regulation of lipid metabolic process	1.132216e-11
GO:0007512	adult heart development	1.275481e-11
GO:0006694	steroid biosynthetic process	2.056911e-11
GO:0048469	cell maturation	3.217952e-11
GO:0007522	visceral muscle development	6.396502e-11
GO:0046503	glycerolipid catabolic process	1.466273e-10
GO:0002740	negative regulation of cytokine secretion involved in immune response	4.914724e-10
GO:0030239	myofibril assembly	5.704284e-10
GO:0002891	positive regulation of immunoglobulin mediated immune response	7.000565e-10
GO:0043434	response to peptide hormone stimulus	9.388717e-10
GO:0045475	locomotor rhythm	2.197460e-9
GO:0045834	positive regulation of lipid metabolic process	2.462949e-9
GO:0010876	lipid localization	2.478452e-9
GO:0002920	regulation of humoral immune response	2.787193e-9
GO:0010901	regulation of very-low-density lipoprotein particle remodeling	3.862149e-9
GO:0046890	regulation of lipid biosynthetic process	4.265404e-9
GO:0007166	cell surface receptor linked signaling pathway	6.507678e-9
GO:0055009	atrial cardiac muscle tissue morphogenesis	8.661335e-9
GO:0050713	negative regulation of interleukin-1 beta secretion	9.212863e-9
GO:0045577	regulation of B cell differentiation	1.593696e-8
GO:0031032	actomyosin structure organization	1.640136e-8
GO:0030049	muscle filament sliding	1.693116e-8
GO:0071827	plasma lipoprotein particle organization	1.727957e-8
GO:0006642	triglyceride mobilization	2.316270e-8
GO:0097006	regulation of plasma lipoprotein particle levels	2.554326e-8
GO:0048739	cardiac muscle fiber development	2.803895e-8
GO:0009725	response to hormone stimulus	3.381006e-8
GO:0042221	response to chemical stimulus	3.637967e-8
GO:0030300	regulation of intestinal cholesterol absorption	4.341613e-8
GO:0002923	regulation of humoral immune response mediated by circulating immunoglobulin	4.584090e-8
GO:0034097	response to cytokine stimulus	4.768477e-8
GO:0007159	leukocyte cell-cell adhesion	5.000540e-8
GO:0030301	cholesterol transport	5.801355e-8
GO:0051915	induction of synaptic plasticity by chemical substance	6.134564e-8
GO:0008202	steroid metabolic process	6.152977e-8
GO:0006810	transport	6.514761e-8
GO:0000302	response to reactive oxygen species	6.687388e-8
GO:0009605	response to external stimulus	8.924885e-8
GO:0055114	oxidation-reduction process	9.427233e-8
GO:0003012	muscle system process	9.865121e-8
GO:0006936	muscle contraction	1.012641e-7
GO:0002922	positive regulation of humoral immune response	1.167732e-7
GO:0010033	response to organic substance	1.476549e-7
GO:0047497	mitochondrion transport along microtubule	1.567685e-7
GO:0051646	mitochondrion localization	1.608474e-7
GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin	1.616910e-7
GO:0034369	plasma lipoprotein particle remodeling	1.768053e-7
GO:0072091	regulation of stem cell proliferation	1.860178e-7
GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling	1.882626e-7
GO:0033275	actin-myosin filament sliding	2.449300e-7
GO:0016126	sterol biosynthetic process	2.730618e-7
GO:0070328	triglyceride homeostasis	2.904361e-7
GO:0043056	forward locomotion	3.186668e-7
GO:0046184	aldehyde biosynthetic process	3.452049e-7
GO:0006695	cholesterol biosynthetic process	3.518855e-7
GO:0018206	peptidyl-methionine modification	3.545540e-7
GO:0045940	positive regulation of steroid metabolic process	3.803218e-7
GO:0002861	regulation of inflammatory response to antigenic stimulus	4.046453e-7
GO:0009719	response to endogenous stimulus	4.194066e-7
GO:0033058	directional locomotion	4.195200e-7
GO:0006874	cellular calcium ion homeostasis	4.195332e-7
GO:0050711	negative regulation of interleukin-1 secretion	4.693016e-7
GO:0002889	regulation of immunoglobulin mediated immune response	4.958651e-7
GO:0010873	positive regulation of cholesterol esterification	5.223584e-7
GO:0055088	lipid homeostasis	5.632636e-7
GO:0045588	positive regulation of gamma-delta T cell differentiation	6.291850e-7
GO:0055001	muscle cell development	6.584251e-7
GO:0017196	N-terminal peptidyl-methionine acetylation	6.908766e-7
GO:0051234	establishment of localization	6.987937e-7
GO:0072384	organelle transport along microtubule	6.988373e-7
GO:0055002	striated muscle cell development	7.268780e-7
GO:0065005	protein-lipid complex assembly	9.210144e-7
GO:0006641	triglyceride metabolic process	9.629353e-7
GO:0051179	localization	1.192564e-6
GO:0006869	lipid transport	1.536545e-6
GO:0010872	regulation of cholesterol esterification	1.580468e-6
GO:0042445	hormone metabolic process	1.581965e-6
GO:0006720	isoprenoid metabolic process	1.597262e-6
GO:0006837	serotonin transport	1.601086e-6
GO:0042632	cholesterol homeostasis	1.703396e-6
GO:0051654	establishment of mitochondrion localization	1.781478e-6
GO:0050730	regulation of peptidyl-tyrosine phosphorylation	1.783554e-6
GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	1.787829e-6
GO:0031116	positive regulation of microtubule polymerization	1.791275e-6
GO:0002739	regulation of cytokine secretion involved in immune response	1.870543e-6
GO:0034754	cellular hormone metabolic process	1.934354e-6
GO:0006875	cellular metal ion homeostasis	1.941575e-6
GO:0044236	multicellular organismal metabolic process	1.960438e-6
GO:0031112	positive regulation of microtubule polymerization or depolymerization	2.048406e-6
GO:0010269	response to selenium ion	2.048406e-6
GO:0006629	lipid metabolic process	2.294132e-6
GO:0034383	low-density lipoprotein particle clearance	2.320987e-6
GO:0046952	ketone body catabolic process	2.348721e-6
GO:0043462	regulation of ATPase activity	2.459765e-6
GO:0051146	striated muscle cell differentiation	2.468031e-6
GO:0002708	positive regulation of lymphocyte mediated immunity	2.533916e-6
GO:0034374	low-density lipoprotein particle remodeling	2.537533e-6
GO:0072358	cardiovascular system development	2.586833e-6
GO:0051209	release of sequestered calcium ion into cytosol	2.627416e-6
GO:0055074	calcium ion homeostasis	2.980124e-6
GO:0051716	cellular response to stimulus	3.020238e-6
GO:0032501	multicellular organismal process	3.305238e-6
GO:0070537	histone H2A K63-linked deubiquitination	3.369096e-6
GO:0050776	regulation of immune response	3.395104e-6
GO:0033144	negative regulation of steroid hormone receptor signaling pathway	3.626952e-6
GO:0042493	response to drug	3.807267e-6
GO:0010927	cellular component assembly involved in morphogenesis	3.808155e-6
GO:0070252	actin-mediated cell contraction	4.039579e-6
GO:0045471	response to ethanol	4.297128e-6
GO:0048675	axon extension	4.567043e-6
GO:0050709	negative regulation of protein secretion	4.814760e-6
GO:2000648	positive regulation of stem cell proliferation	4.880967e-6
GO:0002863	positive regulation of inflammatory response to antigenic stimulus	4.957918e-6
GO:0006014	D-ribose metabolic process	4.961081e-6
GO:0006952	defense response	5.124253e-6
GO:0002673	regulation of acute inflammatory response	5.974813e-6
GO:0044259	multicellular organismal macromolecule metabolic process	6.153005e-6
GO:0050777	negative regulation of immune response	6.291804e-6
GO:0014848	urinary tract smooth muscle contraction	6.356386e-6
GO:0009887	organ morphogenesis	6.669531e-6
GO:0060402	calcium ion transport into cytosol	6.758197e-6
GO:0051561	elevation of mitochondrial calcium ion concentration	7.379668e-6
GO:0048676	axon extension involved in development	7.558198e-6
GO:0072503	cellular divalent inorganic cation homeostasis	8.554051e-6
GO:0043589	skin morphogenesis	8.664999e-6
GO:0070887	cellular response to chemical stimulus	8.723766e-6
GO:0002026	regulation of the force of heart contraction	9.325152e-6
GO:0055065	metal ion homeostasis	1.014821e-5
GO:0032825	positive regulation of natural killer cell differentiation	1.037482e-5
GO:0006663	platelet activating factor biosynthetic process	1.116800e-5
GO:0008207	C21-steroid hormone metabolic process	1.117768e-5
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	1.120414e-5
GO:0031113	regulation of microtubule polymerization	1.127310e-5
GO:0050710	negative regulation of cytokine secretion	1.325850e-5
GO:0018904	organic ether metabolic process	1.348509e-5
GO:0006950	response to stress	1.357939e-5
GO:0055090	acylglycerol homeostasis	1.464484e-5
GO:0032816	positive regulation of natural killer cell activation	1.487304e-5
GO:0046186	acetaldehyde biosynthetic process	1.521742e-5
GO:0042304	regulation of fatty acid biosynthetic process	1.525836e-5
GO:0019217	regulation of fatty acid metabolic process	1.621384e-5
GO:0050896	response to stimulus	1.672924e-5
GO:0071379	cellular response to prostaglandin stimulus	1.741679e-5
GO:0032101	regulation of response to external stimulus	1.790170e-5
GO:0010897	negative regulation of triglyceride catabolic process	1.796342e-5
GO:0010987	negative regulation of high-density lipoprotein particle clearance	1.796342e-5
GO:0061162	establishment of monopolar cell polarity	1.822934e-5
GO:0051282	regulation of sequestering of calcium ion	1.876175e-5
GO:0050810	regulation of steroid biosynthetic process	1.896854e-5
GO:0002706	regulation of lymphocyte mediated immunity	1.903844e-5
GO:0051480	cytosolic calcium ion homeostasis	1.927394e-5
GO:0008211	glucocorticoid metabolic process	2.018150e-5
GO:0044130	negative regulation of growth of symbiont in host	2.110623e-5
GO:0009052	pentose-phosphate shunt, non-oxidative branch	2.227405e-5
GO:0050778	positive regulation of immune response	2.234690e-5
GO:0060401	cytosolic calcium ion transport	2.235162e-5
GO:0006639	acylglycerol metabolic process	2.259334e-5
GO:0001906	cell killing	2.288739e-5
GO:0016078	tRNA catabolic process	2.396956e-5
GO:0001682	tRNA 5'-leader removal	2.396956e-5
GO:0006739	NADP metabolic process	2.481478e-5
GO:0007204	elevation of cytosolic calcium ion concentration	2.646669e-5
GO:0070508	cholesterol import	2.681855e-5
GO:0071702	organic substance transport	2.687240e-5
GO:0001701	in utero embryonic development	2.852567e-5
GO:0032814	regulation of natural killer cell activation	2.857528e-5
GO:0048513	organ development	2.859147e-5
GO:0010565	regulation of cellular ketone metabolic process	2.871662e-5
GO:0071345	cellular response to cytokine stimulus	2.982711e-5
GO:0008610	lipid biosynthetic process	3.173688e-5
GO:0006979	response to oxidative stress	3.189503e-5
GO:0032963	collagen metabolic process	3.228003e-5
GO:0071310	cellular response to organic substance	3.234611e-5
GO:0045428	regulation of nitric oxide biosynthetic process	3.279124e-5
GO:0007595	lactation	3.375034e-5
GO:0007338	single fertilization	3.436839e-5
GO:0022603	regulation of anatomical structure morphogenesis	3.517447e-5
GO:0043903	regulation of symbiosis, encompassing mutualism through parasitism	3.540792e-5
GO:0018879	biphenyl metabolic process	3.612659e-5
GO:0003008	system process	3.660946e-5
GO:0050706	regulation of interleukin-1 beta secretion	3.840662e-5
GO:0045932	negative regulation of muscle contraction	3.850542e-5
GO:0065008	regulation of biological quality	3.892063e-5
GO:0045579	positive regulation of B cell differentiation	4.002072e-5
GO:0060082	eye blink reflex	4.173958e-5
GO:0006958	complement activation, classical pathway	4.187102e-5
GO:0030449	regulation of complement activation	4.230950e-5
GO:0006429	leucyl-tRNA aminoacylation	4.329131e-5
GO:0006816	calcium ion transport	4.456313e-5
GO:0045773	positive regulation of axon extension	4.507245e-5
GO:0014832	urinary bladder smooth muscle contraction	4.624842e-5
GO:0008217	regulation of blood pressure	4.701528e-5
GO:0031347	regulation of defense response	4.843843e-5
GO:0090076	relaxation of skeletal muscle	4.907425e-5
GO:0032470	elevation of endoplasmic reticulum calcium ion concentration	4.907425e-5
GO:0071902	positive regulation of protein serine/threonine kinase activity	4.970666e-5
GO:0009888	tissue development	5.040385e-5
GO:0006278	RNA-dependent DNA replication	5.090554e-5
GO:0019693	ribose phosphate metabolic process	5.244971e-5
GO:0010896	regulation of triglyceride catabolic process	5.387599e-5
GO:0009611	response to wounding	5.407102e-5
GO:0002703	regulation of leukocyte mediated immunity	5.411804e-5
GO:0002697	regulation of immune effector process	5.456300e-5
GO:0010744	positive regulation of macrophage derived foam cell differentiation	5.481304e-5
GO:0072507	divalent inorganic cation homeostasis	5.604681e-5
GO:0071495	cellular response to endogenous stimulus	5.933726e-5
GO:0009612	response to mechanical stimulus	5.947057e-5
GO:0045721	negative regulation of gluconeogenesis	6.009399e-5
GO:0042984	regulation of amyloid precursor protein biosynthetic process	6.076702e-5
GO:0031667	response to nutrient levels	6.190513e-5
GO:0010677	negative regulation of cellular carbohydrate metabolic process	6.542536e-5
GO:0002874	regulation of chronic inflammatory response to antigenic stimulus	6.548511e-5
GO:0033615	mitochondrial proton-transporting ATP synthase complex assembly	6.648163e-5
GO:0006721	terpenoid metabolic process	6.686055e-5
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	6.763878e-5
GO:0051239	regulation of multicellular organismal process	6.790000e-5
GO:0006069	ethanol oxidation	6.815508e-5
GO:0002876	positive regulation of chronic inflammatory response to antigenic stimulus	6.815508e-5
GO:0048588	developmental cell growth	6.909721e-5
GO:0030540	female genitalia development	6.914753e-5
GO:0006638	neutral lipid metabolic process	7.094798e-5
GO:0050673	epithelial cell proliferation	7.241070e-5
GO:0009991	response to extracellular stimulus	7.365757e-5
GO:0090201	negative regulation of release of cytochrome c from mitochondria	7.739663e-5
GO:0042159	lipoprotein catabolic process	7.959881e-5
GO:0031349	positive regulation of defense response	8.048792e-5
GO:0032103	positive regulation of response to external stimulus	8.179530e-5
GO:0043255	regulation of carbohydrate biosynthetic process	8.287836e-5
GO:0006117	acetaldehyde metabolic process	8.515217e-5
GO:0032962	positive regulation of inositol trisphosphate biosynthetic process	8.515217e-5
GO:0050707	regulation of cytokine secretion	8.707301e-5
GO:0042474	middle ear morphogenesis	8.738239e-5
GO:0019370	leukotriene biosynthetic process	8.752216e-5
GO:0090075	relaxation of muscle	8.759076e-5
GO:0048304	positive regulation of isotype switching to IgG isotypes	8.859025e-5
GO:0001820	serotonin secretion	9.014034e-5
GO:0002027	regulation of heart rate	9.232988e-5
GO:0002455	humoral immune response mediated by circulating immunoglobulin	9.607189e-5
GO:0042692	muscle cell differentiation	9.626462e-5
GO:0006066	alcohol metabolic process	9.690109e-5
GO:0032691	negative regulation of interleukin-1 beta production	9.821483e-5
GO:0010743	regulation of macrophage derived foam cell differentiation	9.865399e-5
GO:0050727	regulation of inflammatory response	9.869732e-5
GO:0048302	regulation of isotype switching to IgG isotypes	1.022294e-4
GO:0031214	biomineral tissue development	1.027047e-4
GO:0045833	negative regulation of lipid metabolic process	1.033088e-4
GO:0002820	negative regulation of adaptive immune response	1.033719e-4
GO:0046640	regulation of alpha-beta T cell proliferation	1.036030e-4
GO:0007229	integrin-mediated signaling pathway	1.079803e-4
GO:0002707	negative regulation of lymphocyte mediated immunity	1.104380e-4
GO:0010232	vascular transport	1.105949e-4
GO:0090162	establishment of epithelial cell polarity	1.145102e-4
GO:0045540	regulation of cholesterol biosynthetic process	1.165424e-4
GO:0033700	phospholipid efflux	1.165424e-4
GO:0030325	adrenal gland development	1.178265e-4
GO:0034392	negative regulation of smooth muscle cell apoptosis	1.203940e-4
GO:0002227	innate immune response in mucosa	1.203940e-4
GO:0001523	retinoid metabolic process	1.224680e-4
GO:0070995	NADPH oxidation	1.230121e-4
GO:0009790	embryo development	1.257921e-4
GO:0034381	plasma lipoprotein particle clearance	1.275677e-4
GO:0046456	icosanoid biosynthetic process	1.296955e-4
GO:0006690	icosanoid metabolic process	1.308994e-4
GO:0007155	cell adhesion	1.325131e-4
GO:0001910	regulation of leukocyte mediated cytotoxicity	1.332060e-4
GO:0045595	regulation of cell differentiation	1.343225e-4
GO:0051224	negative regulation of protein transport	1.376827e-4
GO:0034612	response to tumor necrosis factor	1.392247e-4
GO:0034721	histone H3-K4 demethylation, trimethyl-H3-K4-specific	1.433700e-4
GO:0009236	cobalamin biosynthetic process	1.433700e-4
GO:0055013	cardiac muscle cell development	1.465930e-4
GO:0050729	positive regulation of inflammatory response	1.482268e-4
GO:0010975	regulation of neuron projection development	1.484231e-4
GO:0050704	regulation of interleukin-1 secretion	1.495552e-4
GO:0034505	tooth mineralization	1.503379e-4
GO:0001676	long-chain fatty acid metabolic process	1.567103e-4
GO:0090209	negative regulation of triglyceride metabolic process	1.569489e-4
GO:0010823	negative regulation of mitochondrion organization	1.569489e-4
GO:0001911	negative regulation of leukocyte mediated cytotoxicity	1.592674e-4
GO:0001969	regulation of activation of membrane attack complex	1.593289e-4
GO:0007584	response to nutrient	1.600189e-4
GO:0031953	negative regulation of protein autophosphorylation	1.630125e-4
GO:0002253	activation of immune response	1.634046e-4
GO:0018963	phthalate metabolic process	1.644018e-4
GO:0002823	negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	1.657217e-4
GO:0033344	cholesterol efflux	1.661194e-4
GO:0044281	small molecule metabolic process	1.684745e-4
GO:0014012	peripheral nervous system axon regeneration	1.696930e-4
GO:0060621	negative regulation of cholesterol import	1.713399e-4
GO:0007210	serotonin receptor signaling pathway	1.713399e-4
GO:0022610	biological adhesion	1.718266e-4
GO:0010817	regulation of hormone levels	1.745452e-4
GO:0006398	histone mRNA 3'-end processing	1.801497e-4
GO:0051241	negative regulation of multicellular organismal process	1.805200e-4
GO:0031342	negative regulation of cell killing	1.812058e-4
GO:0007026	negative regulation of microtubule depolymerization	1.814242e-4
GO:0060620	regulation of cholesterol import	1.855031e-4
GO:0090181	regulation of cholesterol metabolic process	1.865552e-4
GO:0010828	positive regulation of glucose transport	1.902874e-4
GO:0006776	vitamin A metabolic process	1.964510e-4
GO:0042953	lipoprotein transport	1.975027e-4
GO:0031341	regulation of cell killing	2.001265e-4
GO:0051004	regulation of lipoprotein lipase activity	2.006332e-4
GO:0044057	regulation of system process	2.031215e-4
GO:0006068	ethanol catabolic process	2.036686e-4
GO:0048646	anatomical structure formation involved in morphogenesis	2.054454e-4
GO:0009653	anatomical structure morphogenesis	2.058102e-4
GO:0042446	hormone biosynthetic process	2.123004e-4
GO:0030307	positive regulation of cell growth	2.131393e-4
GO:2001021	negative regulation of response to DNA damage stimulus	2.184060e-4
GO:0019321	pentose metabolic process	2.211682e-4
GO:0071354	cellular response to interleukin-6	2.364757e-4
GO:0071375	cellular response to peptide hormone stimulus	2.374247e-4
GO:0034377	plasma lipoprotein particle assembly	2.389006e-4
GO:0060537	muscle tissue development	2.406915e-4
GO:0032387	negative regulation of intracellular transport	2.487134e-4
GO:0016125	sterol metabolic process	2.589431e-4
GO:0032787	monocarboxylic acid metabolic process	2.595574e-4
GO:0045923	positive regulation of fatty acid metabolic process	2.600471e-4
GO:0044255	cellular lipid metabolic process	2.607161e-4
GO:0034113	heterotypic cell-cell adhesion	2.634963e-4
GO:0016337	cell-cell adhesion	2.659069e-4
GO:0014706	striated muscle tissue development	2.728688e-4
GO:0007600	sensory perception	2.775284e-4
GO:0044058	regulation of digestive system process	2.786743e-4
GO:0010821	regulation of mitochondrion organization	2.833130e-4
GO:0060557	positive regulation of vitamin D biosynthetic process	2.840962e-4
GO:0044205	'de novo' UMP biosynthetic process	2.840962e-4
GO:0042537	benzene-containing compound metabolic process	2.935898e-4
GO:0048240	sperm capacitation	3.018149e-4
GO:0032350	regulation of hormone metabolic process	3.037717e-4
GO:0007589	body fluid secretion	3.048822e-4
GO:0043406	positive regulation of MAP kinase activity	3.059409e-4
GO:0048545	response to steroid hormone stimulus	3.118026e-4
GO:0043901	negative regulation of multi-organism process	3.132762e-4
GO:0002921	negative regulation of humoral immune response	3.146372e-4
GO:0007186	G-protein coupled receptor protein signaling pathway	3.155468e-4
GO:0006691	leukotriene metabolic process	3.173012e-4
GO:0043486	histone exchange	3.197947e-4
GO:0050864	regulation of B cell activation	3.261347e-4
GO:0001912	positive regulation of leukocyte mediated cytotoxicity	3.344904e-4
GO:0060788	ectodermal placode formation	3.367915e-4
GO:0050994	regulation of lipid catabolic process	3.394052e-4
GO:0045840	positive regulation of mitosis	3.396896e-4
GO:0010982	regulation of high-density lipoprotein particle clearance	3.399740e-4
GO:0031647	regulation of protein stability	3.424506e-4
GO:0034372	very-low-density lipoprotein particle remodeling	3.444531e-4
GO:0032692	negative regulation of interleukin-1 production	3.496877e-4
GO:0031448	positive regulation of fast-twitch skeletal muscle fiber contraction	3.507258e-4
GO:0019221	cytokine-mediated signaling pathway	3.514243e-4
GO:0010885	regulation of cholesterol storage	3.564170e-4
GO:0001101	response to acid	3.655430e-4
GO:0008203	cholesterol metabolic process	3.660594e-4
GO:0031114	regulation of microtubule depolymerization	3.697443e-4
GO:0010035	response to inorganic substance	3.781214e-4
GO:0046950	cellular ketone body metabolic process	3.781725e-4
GO:0016101	diterpenoid metabolic process	3.796569e-4
GO:0006636	unsaturated fatty acid biosynthetic process	3.858420e-4
GO:0070509	calcium ion import	3.894723e-4
GO:0071396	cellular response to lipid	3.906731e-4
GO:0043112	receptor metabolic process	3.932787e-4
GO:0034509	centromeric core chromatin assembly	3.940287e-4
GO:0034080	CenH3-containing nucleosome assembly at centromere	3.940287e-4
GO:0006662	glycerol ether metabolic process	4.012816e-4
GO:0032488	Cdc42 protein signal transduction	4.051711e-4
GO:0048671	negative regulation of collateral sprouting	4.077391e-4
GO:0006927	transformed cell apoptosis	4.077391e-4
GO:0090199	regulation of release of cytochrome c from mitochondria	4.113195e-4
GO:0010827	regulation of glucose transport	4.133728e-4
GO:0045445	myoblast differentiation	4.181900e-4
GO:0044092	negative regulation of molecular function	4.228100e-4
GO:0006982	response to lipid hydroperoxide	4.290978e-4
GO:0001915	negative regulation of T cell mediated cytotoxicity	4.302923e-4
GO:0050853	B cell receptor signaling pathway	4.380135e-4
GO:0006775	fat-soluble vitamin metabolic process	4.394834e-4
GO:0017085	response to insecticide	4.398369e-4
GO:0060766	negative regulation of androgen receptor signaling pathway	4.404069e-4
GO:0040011	locomotion	4.428924e-4
GO:0003163	sinoatrial node development	4.503155e-4
GO:0002684	positive regulation of immune system process	4.584785e-4
GO:0033143	regulation of steroid hormone receptor signaling pathway	4.636428e-4
GO:0006491	N-glycan processing	4.795683e-4
GO:0048512	circadian behavior	4.867726e-4
GO:0015761	mannose transport	4.903209e-4
GO:0055010	ventricular cardiac muscle tissue morphogenesis	4.968232e-4
GO:0043129	surfactant homeostasis	4.976704e-4
GO:0046889	positive regulation of lipid biosynthetic process	5.042427e-4
GO:0016042	lipid catabolic process	5.065035e-4
GO:0031343	positive regulation of cell killing	5.191926e-4
GO:0006067	ethanol metabolic process	5.203320e-4
GO:0032800	receptor biosynthetic process	5.273883e-4
GO:0001933	negative regulation of protein phosphorylation	5.279215e-4
GO:0043086	negative regulation of catalytic activity	5.375115e-4
GO:0046541	saliva secretion	5.409101e-4
GO:0045019	negative regulation of nitric oxide biosynthetic process	5.495786e-4
GO:0030003	cellular cation homeostasis	5.717984e-4
GO:0006103	2-oxoglutarate metabolic process	5.725495e-4
GO:0060765	regulation of androgen receptor signaling pathway	6.002505e-4
GO:0010886	positive regulation of cholesterol storage	6.034068e-4
GO:0000303	response to superoxide	6.072538e-4
GO:0045069	regulation of viral genome replication	6.076561e-4
GO:0048732	gland development	6.249143e-4
GO:0006081	cellular aldehyde metabolic process	6.258873e-4
GO:0001960	negative regulation of cytokine-mediated signaling pathway	6.337940e-4
GO:0070371	ERK1 and ERK2 cascade	6.394349e-4
GO:0009100	glycoprotein metabolic process	6.526792e-4
GO:0006954	inflammatory response	6.578471e-4
GO:0010989	negative regulation of low-density lipoprotein particle clearance	6.609176e-4
GO:0030261	chromosome condensation	6.710318e-4
GO:0014014	negative regulation of gliogenesis	6.731410e-4
GO:0034380	high-density lipoprotein particle assembly	6.740894e-4
GO:0030323	respiratory tube development	6.861178e-4
GO:0071295	cellular response to vitamin	6.872160e-4
GO:0045994	positive regulation of translational initiation by iron	6.974433e-4
GO:0061048	negative regulation of branching involved in lung morphogenesis	6.974433e-4
GO:0034116	positive regulation of heterotypic cell-cell adhesion	6.974433e-4
GO:0010519	negative regulation of phospholipase activity	6.974433e-4
GO:0002037	negative regulation of L-glutamate transport	6.974433e-4
GO:0006545	glycine biosynthetic process	6.974433e-4
GO:0060214	endocardium formation	7.036965e-4
GO:0001909	leukocyte mediated cytotoxicity	7.066284e-4
GO:0021941	negative regulation of cerebellar granule cell precursor proliferation	7.272114e-4
GO:0009101	glycoprotein biosynthetic process	7.377845e-4
GO:0055006	cardiac cell development	7.402939e-4
GO:0001798	positive regulation of type IIa hypersensitivity	7.555877e-4
GO:0018894	dibenzo-p-dioxin metabolic process	7.555877e-4
GO:0001788	antibody-dependent cellular cytotoxicity	7.641651e-4
GO:0060426	lung vasculature development	7.651725e-4
GO:0061387	regulation of extent of cell growth	7.652308e-4
GO:0032469	endoplasmic reticulum calcium ion homeostasis	7.662842e-4
GO:0051005	negative regulation of lipoprotein lipase activity	7.682503e-4
GO:0045087	innate immune response	7.772271e-4
GO:0045723	positive regulation of fatty acid biosynthetic process	7.796890e-4
GO:0030324	lung development	7.857074e-4
GO:0043648	dicarboxylic acid metabolic process	7.881243e-4
GO:0071356	cellular response to tumor necrosis factor	7.920947e-4
GO:0009115	xanthine catabolic process	7.924778e-4
GO:0072376	protein activation cascade	7.965593e-4
GO:0060541	respiratory system development	8.081647e-4
GO:0033273	response to vitamin	8.188876e-4
GO:0021933	radial glia guided migration of cerebellar granule cell	8.314700e-4
GO:0006700	C21-steroid hormone biosynthetic process	8.328351e-4
GO:0071229	cellular response to acid	8.455691e-4
GO:0007507	heart development	8.592260e-4
GO:0071418	cellular response to amine stimulus	8.889301e-4
GO:0002699	positive regulation of immune effector process	9.015982e-4
GO:0030010	establishment of cell polarity	9.228192e-4
GO:0051249	regulation of lymphocyte activation	9.269273e-4
GO:0051260	protein homooligomerization	9.276034e-4
GO:0048738	cardiac muscle tissue development	9.287850e-4
GO:0048670	regulation of collateral sprouting	9.295107e-4
GO:0048712	negative regulation of astrocyte differentiation	9.389715e-4
GO:0031344	regulation of cell projection organization	9.407783e-4
GO:0071803	positive regulation of podosome assembly	9.450124e-4
GO:0032780	negative regulation of ATPase activity	9.450124e-4
GO:0051055	negative regulation of lipid biosynthetic process	9.458980e-4
GO:0080134	regulation of response to stress	9.459279e-4
GO:0060059	embryonic retina morphogenesis in camera-type eye	9.716518e-4
GO:0048856	anatomical structure development	9.812751e-4
GO:0032964	collagen biosynthetic process	9.832468e-4
GO:0031576	G2/M transition checkpoint	1.001307e-3
GO:0031915	positive regulation of synaptic plasticity	1.024202e-3
GO:0009112	nucleobase metabolic process	1.031990e-3
GO:0050854	regulation of antigen receptor-mediated signaling pathway	1.032316e-3
GO:0008299	isoprenoid biosynthetic process	1.038336e-3
GO:0048747	muscle fiber development	1.040465e-3
GO:0051347	positive regulation of transferase activity	1.041827e-3
GO:0002682	regulation of immune system process	1.045117e-3
GO:0007622	rhythmic behavior	1.059070e-3
GO:0009566	fertilization	1.073317e-3
GO:0048584	positive regulation of response to stimulus	1.075023e-3
GO:0002329	pre-B cell differentiation	1.095492e-3
GO:0003230	cardiac atrium development	1.106236e-3
GO:0001957	intramembranous ossification	1.118145e-3
GO:0060073	micturition	1.121108e-3
GO:0001869	negative regulation of complement activation, lectin pathway	1.129497e-3
GO:0070836	caveola assembly	1.129497e-3
GO:0071417	cellular response to organic nitrogen	1.130867e-3
GO:0032870	cellular response to hormone stimulus	1.149592e-3
GO:0016973	poly(A)+ mRNA export from nucleus	1.151989e-3
GO:0046641	positive regulation of alpha-beta T cell proliferation	1.154088e-3
GO:0061031	endodermal digestive tract morphogenesis	1.173764e-3
GO:0009792	embryo development ending in birth or egg hatching	1.179679e-3
GO:0046903	secretion	1.203267e-3
GO:0046219	indolalkylamine biosynthetic process	1.210265e-3
GO:0045916	negative regulation of complement activation	1.210265e-3
GO:0042427	serotonin biosynthetic process	1.210265e-3
GO:0034370	triglyceride-rich lipoprotein particle remodeling	1.218123e-3
GO:0046449	creatinine metabolic process	1.243356e-3
GO:0051591	response to cAMP	1.258379e-3
GO:0070365	hepatocyte differentiation	1.260444e-3
GO:0003013	circulatory system process	1.265356e-3
GO:0070838	divalent metal ion transport	1.265586e-3
GO:0045597	positive regulation of cell differentiation	1.277729e-3