Novel motif:49

name:	motif49_ACAGRG

Association to promoter expression in human samples<b>Summary:</b>Significance of the correlation with CAGE expression, human <br><b>Analyst:</b> Michiel de Hoon<br><br>link to source dataset <br>data

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Association to promoter expression in mouse samples <b>Summary:</b>Significance of the correlation with CAGE expression, mouse <br><b>Analyst:</b> Michiel de Hoon<br><br>link to source dataset <br>data

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GREAT analysis results for human <b>Summary:</b>Genomic Enrichment of Annotations Tool (GREAT, Nat Biotechnol. 2010 May;28(5):495-501) is used to identify, both in human and in mouse, the gene ontology terms of biological processes enriched given the predicted TFBSs, and evaluated the overlap in the top-500 gene ontology terms between human and mouse. For each novel motif, the P value for the overlap was then evaluated by calculating its relative rank with respect to this background distribution.<br>Analyst: Michiel de Hoon<br><br>link to source dataset <br>data

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GO ID	GO Term	p-value
GO:0050896	response to stimulus	2.662629e-43
GO:0007154	cell communication	2.255728e-41
GO:0023052	signaling	2.313434e-41
GO:0048583	regulation of response to stimulus	4.633373e-41
GO:0007165	signal transduction	1.137537e-40
GO:0006955	immune response	4.535971e-39
GO:0051716	cellular response to stimulus	1.203345e-37
GO:0006952	defense response	1.432362e-37
GO:0002376	immune system process	1.808973e-34
GO:0007166	cell surface receptor linked signaling pathway	1.639951e-30
GO:0065007	biological regulation	5.006086e-29
GO:0048584	positive regulation of response to stimulus	4.095686e-27
GO:0002684	positive regulation of immune system process	5.148641e-27
GO:0002682	regulation of immune system process	7.826931e-27
GO:0050789	regulation of biological process	3.670727e-26
GO:0006954	inflammatory response	3.382461e-25
GO:0006909	phagocytosis	3.298994e-22
GO:0048518	positive regulation of biological process	5.329200e-22
GO:0023051	regulation of signaling	2.028599e-21
GO:0042221	response to chemical stimulus	2.191983e-21
GO:0009966	regulation of signal transduction	2.763244e-21
GO:0032501	multicellular organismal process	3.801703e-21
GO:0006950	response to stress	2.996636e-19
GO:0035556	intracellular signal transduction	4.372925e-19
GO:0032101	regulation of response to external stimulus	8.656977e-19
GO:0065008	regulation of biological quality	1.251789e-18
GO:0050776	regulation of immune response	1.424161e-18
GO:0070613	regulation of protein processing	2.095519e-18
GO:0050794	regulation of cellular process	6.613466e-18
GO:0007155	cell adhesion	1.948671e-17
GO:0009628	response to abiotic stimulus	3.100842e-17
GO:0009605	response to external stimulus	7.622679e-17
GO:0010466	negative regulation of peptidase activity	2.368275e-16
GO:0050778	positive regulation of immune response	3.934298e-16
GO:0010951	negative regulation of endopeptidase activity	6.407896e-16
GO:0043067	regulation of programmed cell death	1.491756e-15
GO:0001817	regulation of cytokine production	2.946184e-15
GO:0051346	negative regulation of hydrolase activity	3.754706e-15
GO:0010941	regulation of cell death	4.261596e-15
GO:0042981	regulation of apoptosis	4.970008e-15
GO:0048522	positive regulation of cellular process	1.170524e-14
GO:0032103	positive regulation of response to external stimulus	1.399675e-14
GO:0010955	negative regulation of protein processing	1.970096e-14
GO:0002696	positive regulation of leukocyte activation	4.873963e-14
GO:0001819	positive regulation of cytokine production	5.013294e-14
GO:0009611	response to wounding	5.060214e-14
GO:0045087	innate immune response	7.356274e-14
GO:0003008	system process	8.113644e-14
GO:0010646	regulation of cell communication	1.025065e-13
GO:0002253	activation of immune response	1.026676e-13
GO:0061024	membrane organization	1.758147e-13
GO:0050867	positive regulation of cell activation	1.847178e-13
GO:0016044	cellular membrane organization	1.991379e-13
GO:0007586	digestion	2.100270e-13
GO:0051897	positive regulation of protein kinase B signaling cascade	2.330916e-13
GO:0002460	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	3.412716e-13
GO:0010740	positive regulation of intracellular protein kinase cascade	3.585449e-13
GO:0051896	regulation of protein kinase B signaling cascade	4.123303e-13
GO:0009987	cellular process	4.214668e-13
GO:0002697	regulation of immune effector process	5.033348e-13
GO:0002577	regulation of antigen processing and presentation	5.038727e-13
GO:0051336	regulation of hydrolase activity	5.055207e-13
GO:0030449	regulation of complement activation	5.203989e-13
GO:0016064	immunoglobulin mediated immune response	5.340259e-13
GO:0031347	regulation of defense response	6.001832e-13
GO:0002407	dendritic cell chemotaxis	7.462457e-13
GO:0072376	protein activation cascade	8.298594e-13
GO:0002604	regulation of dendritic cell antigen processing and presentation	8.407073e-13
GO:0034754	cellular hormone metabolic process	1.045209e-12
GO:0050920	regulation of chemotaxis	1.453443e-12
GO:0050795	regulation of behavior	1.823680e-12
GO:0016192	vesicle-mediated transport	2.193722e-12
GO:0080134	regulation of response to stress	2.385770e-12
GO:0051234	establishment of localization	3.028698e-12
GO:0010288	response to lead ion	3.076140e-12
GO:0019221	cytokine-mediated signaling pathway	3.462865e-12
GO:0032879	regulation of localization	3.631918e-12
GO:0048520	positive regulation of behavior	4.217991e-12
GO:0051179	localization	4.697349e-12
GO:0050727	regulation of inflammatory response	5.765037e-12
GO:0006953	acute-phase response	6.795879e-12
GO:0006956	complement activation	7.029872e-12
GO:0030335	positive regulation of cell migration	8.369835e-12
GO:0010033	response to organic substance	8.547848e-12
GO:0002250	adaptive immune response	8.642303e-12
GO:2000147	positive regulation of cell motility	8.879649e-12
GO:0019724	B cell mediated immunity	9.050831e-12
GO:0042445	hormone metabolic process	1.098122e-11
GO:0006897	endocytosis	1.455855e-11
GO:0002690	positive regulation of leukocyte chemotaxis	1.816538e-11
GO:0002687	positive regulation of leukocyte migration	2.166431e-11
GO:0007167	enzyme linked receptor protein signaling pathway	3.503099e-11
GO:0006810	transport	3.916732e-11
GO:0030198	extracellular matrix organization	3.920989e-11
GO:0000093	mitotic telophase	3.926441e-11
GO:0046626	regulation of insulin receptor signaling pathway	4.096876e-11
GO:0032908	regulation of transforming growth factor beta1 production	4.637483e-11
GO:0000302	response to reactive oxygen species	4.807728e-11
GO:0045321	leukocyte activation	5.666786e-11
GO:0050921	positive regulation of chemotaxis	6.623734e-11
GO:0002920	regulation of humoral immune response	6.701273e-11
GO:0006775	fat-soluble vitamin metabolic process	7.133440e-11
GO:0043206	fibril organization	9.759097e-11
GO:0002449	lymphocyte mediated immunity	1.171223e-10
GO:0002252	immune effector process	1.268274e-10
GO:0050870	positive regulation of T cell activation	1.289057e-10
GO:0006959	humoral immune response	1.305235e-10
GO:0044281	small molecule metabolic process	1.377214e-10
GO:0051272	positive regulation of cellular component movement	1.671124e-10
GO:0031295	T cell costimulation	1.766607e-10
GO:0009607	response to biotic stimulus	2.246957e-10
GO:0040017	positive regulation of locomotion	2.259519e-10
GO:0007600	sensory perception	2.343225e-10
GO:0009266	response to temperature stimulus	2.522262e-10
GO:0051251	positive regulation of lymphocyte activation	2.716920e-10
GO:0002443	leukocyte mediated immunity	2.882733e-10
GO:0006935	chemotaxis	3.035946e-10
GO:0030334	regulation of cell migration	3.168612e-10
GO:0030595	leukocyte chemotaxis	3.293251e-10
GO:0042592	homeostatic process	3.404881e-10
GO:0044258	intestinal lipid catabolic process	3.923704e-10
GO:0018350	protein esterification	3.923704e-10
GO:0009749	response to glucose stimulus	4.645109e-10
GO:0050877	neurological system process	5.840463e-10
GO:0031667	response to nutrient levels	5.931567e-10
GO:2000145	regulation of cell motility	6.379312e-10
GO:0045834	positive regulation of lipid metabolic process	8.533962e-10
GO:0007186	G-protein coupled receptor protein signaling pathway	8.598613e-10
GO:0071636	positive regulation of transforming growth factor beta production	9.438701e-10
GO:0002455	humoral immune response mediated by circulating immunoglobulin	9.880513e-10
GO:0050790	regulation of catalytic activity	1.079107e-9
GO:0010817	regulation of hormone levels	1.160536e-9
GO:0002861	regulation of inflammatory response to antigenic stimulus	1.194595e-9
GO:0006917	induction of apoptosis	1.225991e-9
GO:0071622	regulation of granulocyte chemotaxis	1.229261e-9
GO:0002688	regulation of leukocyte chemotaxis	1.252898e-9
GO:0010627	regulation of intracellular protein kinase cascade	1.261972e-9
GO:0051049	regulation of transport	1.405015e-9
GO:0003334	keratinocyte development	1.425836e-9
GO:0048545	response to steroid hormone stimulus	1.430835e-9
GO:0043086	negative regulation of catalytic activity	1.463341e-9
GO:0002685	regulation of leukocyte migration	1.624668e-9
GO:0034097	response to cytokine stimulus	1.797293e-9
GO:0008228	opsonization	1.799320e-9
GO:0051270	regulation of cellular component movement	1.872094e-9
GO:0006958	complement activation, classical pathway	1.901454e-9
GO:0052547	regulation of peptidase activity	1.983015e-9
GO:0046314	phosphocreatine biosynthetic process	2.044602e-9
GO:0002526	acute inflammatory response	2.158028e-9
GO:0007243	intracellular protein kinase cascade	2.193298e-9
GO:0008202	steroid metabolic process	2.334563e-9
GO:0002579	positive regulation of antigen processing and presentation	2.482332e-9
GO:0012502	induction of programmed cell death	2.521046e-9
GO:0045916	negative regulation of complement activation	2.540888e-9
GO:0051707	response to other organism	2.562073e-9
GO:0009967	positive regulation of signal transduction	2.609757e-9
GO:0002606	positive regulation of dendritic cell antigen processing and presentation	2.665939e-9
GO:0009408	response to heat	2.913020e-9
GO:0043085	positive regulation of catalytic activity	3.273912e-9
GO:0043405	regulation of MAP kinase activity	3.307683e-9
GO:0007264	small GTPase mediated signal transduction	3.337601e-9
GO:0071902	positive regulation of protein serine/threonine kinase activity	3.341233e-9
GO:0010759	positive regulation of macrophage chemotaxis	3.537352e-9
GO:0040012	regulation of locomotion	3.751581e-9
GO:0043900	regulation of multi-organism process	3.908968e-9
GO:0002764	immune response-regulating signaling pathway	4.047644e-9
GO:0043277	apoptotic cell clearance	4.166856e-9
GO:0070887	cellular response to chemical stimulus	4.365455e-9
GO:0016525	negative regulation of angiogenesis	4.755084e-9
GO:0002694	regulation of leukocyte activation	4.884613e-9
GO:0071702	organic substance transport	5.043639e-9
GO:0071634	regulation of transforming growth factor beta production	5.190808e-9
GO:0042108	positive regulation of cytokine biosynthetic process	5.350021e-9
GO:0050729	positive regulation of inflammatory response	5.454441e-9
GO:0042137	sequestering of neurotransmitter	6.110616e-9
GO:0060696	regulation of phospholipid catabolic process	6.151291e-9
GO:0006968	cellular defense response	6.480506e-9
GO:0033189	response to vitamin A	6.998545e-9
GO:0051480	cytosolic calcium ion homeostasis	7.129520e-9
GO:0007267	cell-cell signaling	7.318684e-9
GO:0042363	fat-soluble vitamin catabolic process	7.393902e-9
GO:0051239	regulation of multicellular organismal process	7.767068e-9
GO:0009617	response to bacterium	7.821952e-9
GO:0050865	regulation of cell activation	8.230419e-9
GO:0032914	positive regulation of transforming growth factor beta1 production	9.876844e-9
GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase cascade	1.012546e-8
GO:0060739	mesenchymal-epithelial cell signaling involved in prostate gland development	1.348522e-8
GO:0006629	lipid metabolic process	1.432202e-8
GO:0010758	regulation of macrophage chemotaxis	1.435735e-8
GO:0048585	negative regulation of response to stimulus	1.481847e-8
GO:0051051	negative regulation of transport	1.499125e-8
GO:0000165	MAPKKK cascade	1.581930e-8
GO:0043406	positive regulation of MAP kinase activity	1.744686e-8
GO:0021984	adenohypophysis development	1.843660e-8
GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	1.976968e-8
GO:0015872	dopamine transport	2.151563e-8
GO:0030155	regulation of cell adhesion	2.357828e-8
GO:0042790	transcription of nuclear large rRNA transcript from RNA polymerase I promoter	2.435076e-8
GO:0032456	endocytic recycling	2.437485e-8
GO:2000465	regulation of glycogen (starch) synthase activity	2.440514e-8
GO:0051591	response to cAMP	2.578382e-8
GO:0007522	visceral muscle development	2.858260e-8
GO:0000090	mitotic anaphase	3.005079e-8
GO:0051657	maintenance of organelle location	3.414288e-8
GO:0051704	multi-organism process	3.481408e-8
GO:0033273	response to vitamin	3.612947e-8
GO:0060326	cell chemotaxis	3.664916e-8
GO:0032368	regulation of lipid transport	3.788049e-8
GO:0006776	vitamin A metabolic process	3.966484e-8
GO:0019882	antigen processing and presentation	4.194731e-8
GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production	4.229884e-8
GO:0031349	positive regulation of defense response	4.273058e-8
GO:0045112	integrin biosynthetic process	4.333959e-8
GO:0023056	positive regulation of signaling	4.404613e-8
GO:0043068	positive regulation of programmed cell death	4.429085e-8
GO:0010812	negative regulation of cell-substrate adhesion	4.605864e-8
GO:0007204	elevation of cytosolic calcium ion concentration	4.619901e-8
GO:0042742	defense response to bacterium	4.815001e-8
GO:0032536	regulation of cell projection size	4.865207e-8
GO:0044240	multicellular organismal lipid catabolic process	5.260233e-8
GO:0008219	cell death	5.599776e-8
GO:0010757	negative regulation of plasminogen activation	5.826039e-8
GO:0002757	immune response-activating signal transduction	5.898467e-8
GO:0002544	chronic inflammatory response	6.096515e-8
GO:0015849	organic acid transport	6.229272e-8
GO:0042104	positive regulation of activated T cell proliferation	6.377400e-8
GO:0010755	regulation of plasminogen activation	6.540082e-8
GO:0009746	response to hexose stimulus	6.703632e-8
GO:0044236	multicellular organismal metabolic process	6.753439e-8
GO:0006820	anion transport	6.816041e-8
GO:0032502	developmental process	6.958514e-8
GO:0010647	positive regulation of cell communication	7.266258e-8
GO:2000467	positive regulation of glycogen (starch) synthase activity	7.825251e-8
GO:0016265	death	8.189529e-8
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	8.797780e-8
GO:0045730	respiratory burst	8.875120e-8
GO:0052548	regulation of endopeptidase activity	9.166014e-8
GO:0001503	ossification	9.323522e-8
GO:0046942	carboxylic acid transport	9.370548e-8
GO:0050764	regulation of phagocytosis	9.839418e-8
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	9.889370e-8
GO:0061025	membrane fusion	1.046112e-7
GO:0050863	regulation of T cell activation	1.077906e-7
GO:0033674	positive regulation of kinase activity	1.085229e-7
GO:0006944	cellular membrane fusion	1.091377e-7
GO:0002149	hypochlorous acid biosynthetic process	1.096679e-7
GO:0035411	catenin import into nucleus	1.100971e-7
GO:0002821	positive regulation of adaptive immune response	1.132814e-7
GO:0043410	positive regulation of MAPKKK cascade	1.161912e-7
GO:0002922	positive regulation of humoral immune response	1.172766e-7
GO:0009991	response to extracellular stimulus	1.199156e-7
GO:0002824	positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	1.199565e-7
GO:0042535	positive regulation of tumor necrosis factor biosynthetic process	1.219335e-7
GO:0065009	regulation of molecular function	1.319294e-7
GO:0010942	positive regulation of cell death	1.367116e-7
GO:0032946	positive regulation of mononuclear cell proliferation	1.420314e-7
GO:0071345	cellular response to cytokine stimulus	1.457338e-7
GO:0051240	positive regulation of multicellular organismal process	1.536556e-7
GO:0043065	positive regulation of apoptosis	1.545834e-7
GO:0014012	peripheral nervous system axon regeneration	1.565243e-7
GO:0051056	regulation of small GTPase mediated signal transduction	1.599525e-7
GO:0034284	response to monosaccharide stimulus	1.601024e-7
GO:0045717	negative regulation of fatty acid biosynthetic process	1.688709e-7
GO:0044093	positive regulation of molecular function	1.707065e-7
GO:0050829	defense response to Gram-negative bacterium	1.732389e-7
GO:0048878	chemical homeostasis	1.738716e-7
GO:0010763	positive regulation of fibroblast migration	1.754288e-7
GO:0071675	regulation of mononuclear cell migration	1.762402e-7
GO:0009071	serine family amino acid catabolic process	1.811338e-7
GO:0010631	epithelial cell migration	1.816352e-7
GO:0046724	oxalic acid secretion	1.905134e-7
GO:0019265	glycine biosynthetic process, by transamination of glyoxylate	1.905134e-7
GO:0060600	dichotomous subdivision of an epithelial terminal unit	2.001382e-7
GO:0051347	positive regulation of transferase activity	2.019055e-7
GO:0008624	induction of apoptosis by extracellular signals	2.039008e-7
GO:0046628	positive regulation of insulin receptor signaling pathway	2.404449e-7
GO:0043030	regulation of macrophage activation	2.454578e-7
GO:0002886	regulation of myeloid leukocyte mediated immunity	2.464667e-7
GO:0006915	apoptosis	2.586908e-7
GO:0005979	regulation of glycogen biosynthetic process	2.667813e-7
GO:0071732	cellular response to nitric oxide	2.687527e-7
GO:0044130	negative regulation of growth of symbiont in host	2.764253e-7
GO:0051534	negative regulation of NFAT protein import into nucleus	2.822977e-7
GO:0034763	negative regulation of transmembrane transport	2.931220e-7
GO:0000187	activation of MAPK activity	2.949649e-7
GO:0009612	response to mechanical stimulus	2.951681e-7
GO:0040011	locomotion	3.026593e-7
GO:0015721	bile acid and bile salt transport	3.052631e-7
GO:0045766	positive regulation of angiogenesis	3.061120e-7
GO:0006720	isoprenoid metabolic process	3.142136e-7
GO:0044341	sodium-dependent phosphate transport	3.483256e-7
GO:0070208	protein heterotrimerization	3.631755e-7
GO:0010900	negative regulation of phosphatidylcholine catabolic process	3.766380e-7
GO:0001775	cell activation	4.165970e-7
GO:0006721	terpenoid metabolic process	4.436866e-7
GO:0002883	regulation of hypersensitivity	4.509744e-7
GO:0050671	positive regulation of lymphocyte proliferation	4.583826e-7
GO:0032680	regulation of tumor necrosis factor production	4.785730e-7
GO:0007009	plasma membrane organization	4.811748e-7
GO:0009303	rRNA transcription	4.918293e-7
GO:0051937	catecholamine transport	5.058337e-7
GO:0071705	nitrogen compound transport	5.115689e-7
GO:0012501	programmed cell death	5.175916e-7
GO:0007584	response to nutrient	5.404254e-7
GO:0032370	positive regulation of lipid transport	5.453088e-7
GO:0001869	negative regulation of complement activation, lectin pathway	5.643841e-7
GO:0034762	regulation of transmembrane transport	6.059147e-7
GO:0044092	negative regulation of molecular function	6.327923e-7
GO:0051322	anaphase	6.376032e-7
GO:0006875	cellular metal ion homeostasis	6.407626e-7
GO:0010944	negative regulation of transcription by competitive promoter binding	6.601201e-7
GO:0035691	macrophage migration inhibitory factor signaling pathway	6.781648e-7
GO:0002673	regulation of acute inflammatory response	6.959888e-7
GO:0002699	positive regulation of immune effector process	6.995953e-7
GO:0045765	regulation of angiogenesis	7.099095e-7
GO:0002237	response to molecule of bacterial origin	7.120029e-7
GO:0090130	tissue migration	7.391799e-7
GO:0045725	positive regulation of glycogen biosynthetic process	7.444224e-7
GO:0055065	metal ion homeostasis	7.489950e-7
GO:0042990	regulation of transcription factor import into nucleus	7.588041e-7
GO:0043537	negative regulation of blood vessel endothelial cell migration	7.639601e-7
GO:0030100	regulation of endocytosis	7.909319e-7
GO:2000097	regulation of smooth muscle cell-matrix adhesion	8.109547e-7
GO:0003051	angiotensin-mediated drinking behavior	8.500477e-7
GO:0050690	regulation of defense response to virus by virus	8.516622e-7
GO:0016043	cellular component organization	8.674808e-7
GO:0032787	monocarboxylic acid metabolic process	8.934138e-7
GO:0010872	regulation of cholesterol esterification	9.051300e-7
GO:0006811	ion transport	9.410215e-7
GO:0042866	pyruvate biosynthetic process	9.637766e-7
GO:0043903	regulation of symbiosis, encompassing mutualism through parasitism	9.753446e-7
GO:0006707	cholesterol catabolic process	9.947721e-7
GO:0006911	phagocytosis, engulfment	1.020873e-6
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	1.046683e-6
GO:0045860	positive regulation of protein kinase activity	1.071193e-6
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	1.103155e-6
GO:0006766	vitamin metabolic process	1.120265e-6
GO:0002274	myeloid leukocyte activation	1.133223e-6
GO:0032526	response to retinoic acid	1.171011e-6
GO:0030277	maintenance of gastrointestinal epithelium	1.201207e-6
GO:2000191	regulation of fatty acid transport	1.231398e-6
GO:0042396	phosphagen biosynthetic process	1.322504e-6
GO:0042493	response to drug	1.356121e-6
GO:0060263	regulation of respiratory burst	1.358223e-6
GO:0070873	regulation of glycogen metabolic process	1.362380e-6
GO:0060346	bone trabecula formation	1.372568e-6
GO:0015844	monoamine transport	1.406564e-6
GO:0071310	cellular response to organic substance	1.421756e-6
GO:0010770	positive regulation of cell morphogenesis involved in differentiation	1.508348e-6
GO:0007292	female gamete generation	1.603796e-6
GO:0002891	positive regulation of immunoglobulin mediated immune response	1.606887e-6
GO:0002679	respiratory burst involved in defense response	1.609131e-6
GO:0009052	pentose-phosphate shunt, non-oxidative branch	1.627163e-6
GO:0002768	immune response-regulating cell surface receptor signaling pathway	1.630107e-6
GO:0051482	elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger	1.662422e-6
GO:0003009	skeletal muscle contraction	1.743280e-6
GO:0051246	regulation of protein metabolic process	1.782520e-6
GO:0060548	negative regulation of cell death	1.837748e-6
GO:0071840	cellular component organization or biogenesis	1.861580e-6
GO:0010985	negative regulation of lipoprotein particle clearance	1.913511e-6
GO:0034014	response to triglyceride	1.947415e-6
GO:0070665	positive regulation of leukocyte proliferation	1.976846e-6
GO:0007601	visual perception	1.986315e-6
GO:0048519	negative regulation of biological process	2.017704e-6
GO:0031064	negative regulation of histone deacetylation	2.019141e-6
GO:0043588	skin development	2.054862e-6
GO:0002863	positive regulation of inflammatory response to antigenic stimulus	2.069969e-6
GO:0050953	sensory perception of light stimulus	2.116564e-6
GO:0031133	regulation of axon diameter	2.147441e-6
GO:0031640	killing of cells of other organism	2.219993e-6
GO:0006140	regulation of nucleotide metabolic process	2.247920e-6
GO:0042534	regulation of tumor necrosis factor biosynthetic process	2.266293e-6
GO:0001953	negative regulation of cell-matrix adhesion	2.304058e-6
GO:0046006	regulation of activated T cell proliferation	2.312784e-6
GO:0070417	cellular response to cold	2.462038e-6
GO:0010718	positive regulation of epithelial to mesenchymal transition	2.561413e-6
GO:0045940	positive regulation of steroid metabolic process	2.640649e-6
GO:0051895	negative regulation of focal adhesion assembly	2.656535e-6
GO:0060351	cartilage development involved in endochondral bone morphogenesis	2.700585e-6
GO:0015809	arginine transport	2.816673e-6
GO:0090218	positive regulation of lipid kinase activity	2.842108e-6
GO:0008065	establishment of blood-nerve barrier	2.874411e-6
GO:0032496	response to lipopolysaccharide	2.891833e-6
GO:0032355	response to estradiol stimulus	2.953769e-6
GO:0010954	positive regulation of protein processing	2.973020e-6
GO:0046687	response to chromate	3.129875e-6
GO:0033986	response to methanol	3.129875e-6
GO:0007162	negative regulation of cell adhesion	3.181505e-6
GO:0034505	tooth mineralization	3.206368e-6
GO:0002478	antigen processing and presentation of exogenous peptide antigen	3.293177e-6
GO:0043066	negative regulation of apoptosis	3.335605e-6
GO:0042730	fibrinolysis	3.492859e-6
GO:0001516	prostaglandin biosynthetic process	3.596744e-6
GO:0002703	regulation of leukocyte mediated immunity	3.657894e-6
GO:0031099	regeneration	3.763747e-6
GO:0009629	response to gravity	3.807951e-6
GO:0019532	oxalate transport	3.872397e-6
GO:0070482	response to oxygen levels	4.148525e-6
GO:0006690	icosanoid metabolic process	4.212579e-6
GO:0043069	negative regulation of programmed cell death	4.224624e-6
GO:0014874	response to stimulus involved in regulation of muscle adaptation	4.234729e-6
GO:0046627	negative regulation of insulin receptor signaling pathway	4.262299e-6
GO:0007275	multicellular organismal development	4.451443e-6
GO:0010746	regulation of plasma membrane long-chain fatty acid transport	4.521434e-6
GO:0006342	chromatin silencing	4.687867e-6
GO:0001523	retinoid metabolic process	4.814650e-6
GO:0042180	cellular ketone metabolic process	4.929393e-6
GO:0008207	C21-steroid hormone metabolic process	4.930655e-6
GO:0070875	positive regulation of glycogen metabolic process	4.966008e-6
GO:0042992	negative regulation of transcription factor import into nucleus	5.187550e-6
GO:0019884	antigen processing and presentation of exogenous antigen	5.207343e-6
GO:0050688	regulation of defense response to virus	5.284285e-6
GO:0006544	glycine metabolic process	5.288338e-6
GO:0043535	regulation of blood vessel endothelial cell migration	5.910776e-6
GO:0016458	gene silencing	6.047348e-6
GO:0006874	cellular calcium ion homeostasis	6.092462e-6
GO:0010754	negative regulation of cGMP-mediated signaling	6.166409e-6
GO:0043652	engulfment of apoptotic cell	6.166409e-6
GO:0010751	negative regulation of nitric oxide mediated signal transduction	6.166409e-6
GO:0002605	negative regulation of dendritic cell antigen processing and presentation	6.166409e-6
GO:0002581	negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	6.166409e-6
GO:0031960	response to corticosteroid stimulus	6.317746e-6
GO:0033121	regulation of purine nucleotide catabolic process	6.636451e-6
GO:0002906	negative regulation of mature B cell apoptosis	6.776310e-6
GO:0010916	negative regulation of very-low-density lipoprotein particle clearance	6.793656e-6
GO:0042572	retinol metabolic process	6.859940e-6
GO:0030003	cellular cation homeostasis	6.961812e-6
GO:0031103	axon regeneration	7.015411e-6
GO:0060395	SMAD protein signal transduction	7.018727e-6
GO:0015850	organic alcohol transport	7.124288e-6
GO:0016337	cell-cell adhesion	7.293868e-6
GO:0019321	pentose metabolic process	7.741938e-6
GO:0051323	metaphase	7.932825e-6
GO:2000377	regulation of reactive oxygen species metabolic process	7.952223e-6
GO:0051918	negative regulation of fibrinolysis	7.961815e-6
GO:0002864	regulation of acute inflammatory response to antigenic stimulus	8.060054e-6
GO:0042102	positive regulation of T cell proliferation	8.105557e-6
GO:0030187	melatonin biosynthetic process	8.163951e-6
GO:0042424	catecholamine catabolic process	8.181541e-6
GO:0033559	unsaturated fatty acid metabolic process	8.321715e-6
GO:0006702	androgen biosynthetic process	8.444816e-6
GO:0019226	transmission of nerve impulse	9.417965e-6
GO:0010535	positive regulation of activation of JAK2 kinase activity	9.450959e-6
GO:0046649	lymphocyte activation	9.458303e-6
GO:0019752	carboxylic acid metabolic process	9.568269e-6
GO:0006692	prostanoid metabolic process	9.929627e-6
GO:0045056	transcytosis	9.967668e-6
GO:0016101	diterpenoid metabolic process	9.993287e-6
GO:0001666	response to hypoxia	1.026605e-5
GO:0015837	amine transport	1.075393e-5
GO:0046010	positive regulation of circadian sleep/wake cycle, non-REM sleep	1.104452e-5
GO:0032890	regulation of organic acid transport	1.112230e-5
GO:0006400	tRNA modification	1.153224e-5
GO:0060014	granulosa cell differentiation	1.155611e-5
GO:0046456	icosanoid biosynthetic process	1.170753e-5
GO:0043627	response to estrogen stimulus	1.179948e-5
GO:0016477	cell migration	1.181054e-5
GO:0010873	positive regulation of cholesterol esterification	1.204274e-5
GO:0034382	chylomicron remnant clearance	1.258177e-5
GO:0043032	positive regulation of macrophage activation	1.258304e-5
GO:0051041	positive regulation of calcium-independent cell-cell adhesion	1.264294e-5
GO:0050902	leukocyte adhesive activation	1.264294e-5
GO:0061049	cell growth involved in cardiac muscle cell development	1.289804e-5
GO:0014873	response to muscle activity involved in regulation of muscle adaptation	1.289804e-5
GO:0001998	angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure	1.289804e-5
GO:0003331	positive regulation of extracellular matrix constituent secretion	1.289804e-5
GO:0045123	cellular extravasation	1.293349e-5
GO:0007097	nuclear migration	1.321003e-5
GO:0060290	transdifferentiation	1.328809e-5
GO:0002862	negative regulation of inflammatory response to antigenic stimulus	1.332050e-5
GO:0050832	defense response to fungus	1.339779e-5
GO:0002831	regulation of response to biotic stimulus	1.345654e-5
GO:0051291	protein heterooligomerization	1.364039e-5
GO:0050881	musculoskeletal movement	1.372410e-5
GO:0044282	small molecule catabolic process	1.376287e-5
GO:0042035	regulation of cytokine biosynthetic process	1.382830e-5
GO:0001649	osteoblast differentiation	1.393796e-5
GO:0019344	cysteine biosynthetic process	1.394196e-5
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	1.432682e-5
GO:0051917	regulation of fibrinolysis	1.465505e-5
GO:0048535	lymph node development	1.488799e-5
GO:0006693	prostaglandin metabolic process	1.495282e-5
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	1.514524e-5
GO:0070932	histone H3 deacetylation	1.586039e-5
GO:0050851	antigen receptor-mediated signaling pathway	1.662255e-5
GO:0002708	positive regulation of lymphocyte mediated immunity	1.692421e-5
GO:0006082	organic acid metabolic process	1.693867e-5
GO:0043252	sodium-independent organic anion transport	1.699774e-5
GO:0002429	immune response-activating cell surface receptor signaling pathway	1.709689e-5
GO:0000089	mitotic metaphase	1.715673e-5
GO:0019693	ribose phosphate metabolic process	1.717695e-5
GO:0042448	progesterone metabolic process	1.736202e-5
GO:0006349	regulation of gene expression by genetic imprinting	1.758872e-5
GO:0032964	collagen biosynthetic process	1.759806e-5
GO:0009199	ribonucleoside triphosphate metabolic process	1.777122e-5
GO:0021623	oculomotor nerve formation	1.823386e-5
GO:0003404	optic vesicle morphogenesis	1.823386e-5
GO:0003409	optic cup structural organization	1.823386e-5
GO:0042573	retinoic acid metabolic process	1.828799e-5
GO:0002885	positive regulation of hypersensitivity	1.865444e-5

GREAT analysis results for mouseGenomic Enrichment of Annotations Tool (GREAT, Nat Biotechnol. 2010 May;28(5):495-501) is used to identify, both in human and in mouse, the gene ontology terms of biological processes enriched given the predicted TFBSs, and evaluated the overlap in the top-500 gene ontology terms between human and mouse. For each novel motif, the P value for the overlap was then evaluated by calculating its relative rank with respect to this background distribution.<br>Analyst: Michiel de Hoon <br><br>link to source dataset <br>data

---

GO ID	GO Term	p-value
GO:0006952	defense response	1.128060e-21
GO:0023052	signaling	1.977668e-21
GO:0007165	signal transduction	4.294930e-21
GO:0007154	cell communication	2.022038e-20
GO:0050896	response to stimulus	5.244548e-19
GO:0042221	response to chemical stimulus	3.031762e-18
GO:0050776	regulation of immune response	5.574549e-17
GO:0007166	cell surface receptor linked signaling pathway	1.733756e-16
GO:0050727	regulation of inflammatory response	2.003124e-16
GO:0031347	regulation of defense response	2.130019e-16
GO:0009617	response to bacterium	2.205709e-16
GO:0051716	cellular response to stimulus	1.666121e-15
GO:0032101	regulation of response to external stimulus	4.548319e-15
GO:0009607	response to biotic stimulus	1.517895e-14
GO:0006954	inflammatory response	4.575647e-14
GO:0010033	response to organic substance	6.150766e-14
GO:0009628	response to abiotic stimulus	7.438434e-14
GO:0002684	positive regulation of immune system process	8.094378e-14
GO:0032501	multicellular organismal process	1.134411e-13
GO:0032879	regulation of localization	1.137104e-13
GO:0001817	regulation of cytokine production	2.316241e-13
GO:0051707	response to other organism	2.587713e-13
GO:0051049	regulation of transport	3.810588e-13
GO:0002673	regulation of acute inflammatory response	4.393564e-13
GO:0050790	regulation of catalytic activity	7.385831e-13
GO:0048583	regulation of response to stimulus	8.291076e-13
GO:0042742	defense response to bacterium	9.427628e-13
GO:0003008	system process	1.098282e-12
GO:0050778	positive regulation of immune response	2.382143e-12
GO:0009611	response to wounding	4.300054e-12
GO:0007186	G-protein coupled receptor protein signaling pathway	4.692151e-12
GO:0065007	biological regulation	4.776243e-12
GO:0002821	positive regulation of adaptive immune response	7.389781e-12
GO:0051241	negative regulation of multicellular organismal process	1.375285e-11
GO:0043086	negative regulation of catalytic activity	1.497070e-11
GO:0002237	response to molecule of bacterial origin	1.602723e-11
GO:0002718	regulation of cytokine production involved in immune response	1.716747e-11
GO:0045765	regulation of angiogenesis	3.317766e-11
GO:0006955	immune response	3.413609e-11
GO:0006950	response to stress	3.474920e-11
GO:0019882	antigen processing and presentation	5.445082e-11
GO:0051336	regulation of hydrolase activity	9.838035e-11
GO:0032496	response to lipopolysaccharide	1.088081e-10
GO:0065008	regulation of biological quality	1.127193e-10
GO:0055009	atrial cardiac muscle tissue morphogenesis	1.251041e-10
GO:0045833	negative regulation of lipid metabolic process	1.411496e-10
GO:0002824	positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	1.504496e-10
GO:0055008	cardiac muscle tissue morphogenesis	2.268387e-10
GO:0002708	positive regulation of lymphocyte mediated immunity	2.942186e-10
GO:0031349	positive regulation of defense response	3.906485e-10
GO:0048002	antigen processing and presentation of peptide antigen	3.969152e-10
GO:0002252	immune effector process	4.470499e-10
GO:0050789	regulation of biological process	5.388063e-10
GO:0032103	positive regulation of response to external stimulus	5.506589e-10
GO:0051704	multi-organism process	6.199741e-10
GO:0071219	cellular response to molecule of bacterial origin	6.264852e-10
GO:0071216	cellular response to biotic stimulus	7.135097e-10
GO:0002682	regulation of immune system process	7.469367e-10
GO:0050708	regulation of protein secretion	1.203222e-9
GO:0002697	regulation of immune effector process	1.332943e-9
GO:0002675	positive regulation of acute inflammatory response	1.532353e-9
GO:0080134	regulation of response to stress	1.557047e-9
GO:0002376	immune system process	1.684785e-9
GO:0070887	cellular response to chemical stimulus	1.765747e-9
GO:0032675	regulation of interleukin-6 production	1.927475e-9
GO:0002819	regulation of adaptive immune response	2.241977e-9
GO:0048585	negative regulation of response to stimulus	2.627943e-9
GO:0002739	regulation of cytokine secretion involved in immune response	2.780244e-9
GO:0014070	response to organic cyclic compound	3.312901e-9
GO:0009125	nucleoside monophosphate catabolic process	3.471176e-9
GO:0002690	positive regulation of leukocyte chemotaxis	5.077127e-9
GO:0002478	antigen processing and presentation of exogenous peptide antigen	6.259340e-9
GO:0051055	negative regulation of lipid biosynthetic process	6.476062e-9
GO:0042993	positive regulation of transcription factor import into nucleus	6.479534e-9
GO:0070201	regulation of establishment of protein localization	6.620089e-9
GO:0003013	circulatory system process	6.933888e-9
GO:0035556	intracellular signal transduction	7.848316e-9
GO:0034382	chylomicron remnant clearance	8.730183e-9
GO:0002687	positive regulation of leukocyte migration	9.650258e-9
GO:0023057	negative regulation of signaling	1.041683e-8
GO:0045321	leukocyte activation	1.163180e-8
GO:0071214	cellular response to abiotic stimulus	1.256903e-8
GO:0065009	regulation of molecular function	1.296484e-8
GO:0001775	cell activation	1.342905e-8
GO:0071310	cellular response to organic substance	1.412588e-8
GO:0042346	positive regulation of NF-kappaB import into nucleus	1.416065e-8
GO:0010574	regulation of vascular endothelial growth factor production	1.416065e-8
GO:0071222	cellular response to lipopolysaccharide	1.606630e-8
GO:0010863	positive regulation of phospholipase C activity	1.760393e-8
GO:0007586	digestion	1.828020e-8
GO:0010648	negative regulation of cell communication	1.954617e-8
GO:0048584	positive regulation of response to stimulus	2.054111e-8
GO:0006198	cAMP catabolic process	2.106358e-8
GO:0009612	response to mechanical stimulus	2.203167e-8
GO:0006810	transport	2.235972e-8
GO:0033344	cholesterol efflux	2.332970e-8
GO:0034762	regulation of transmembrane transport	2.561602e-8
GO:0050794	regulation of cellular process	2.590977e-8
GO:0060415	muscle tissue morphogenesis	2.704033e-8
GO:0051223	regulation of protein transport	2.953349e-8
GO:0051234	establishment of localization	3.127480e-8
GO:0009214	cyclic nucleotide catabolic process	3.768913e-8
GO:0046466	membrane lipid catabolic process	4.286959e-8
GO:0002720	positive regulation of cytokine production involved in immune response	4.523729e-8
GO:0043330	response to exogenous dsRNA	4.915037e-8
GO:0008015	blood circulation	5.364159e-8
GO:0051346	negative regulation of hydrolase activity	5.540014e-8
GO:0042990	regulation of transcription factor import into nucleus	5.647597e-8
GO:0007202	activation of phospholipase C activity	5.917443e-8
GO:0032374	regulation of cholesterol transport	6.038037e-8
GO:0045088	regulation of innate immune response	6.447662e-8
GO:0044092	negative regulation of molecular function	6.487220e-8
GO:0001798	positive regulation of type IIa hypersensitivity	7.119777e-8
GO:0050728	negative regulation of inflammatory response	7.539007e-8
GO:0032488	Cdc42 protein signal transduction	7.775452e-8
GO:0010518	positive regulation of phospholipase activity	7.829421e-8
GO:0002688	regulation of leukocyte chemotaxis	7.904846e-8
GO:0048739	cardiac muscle fiber development	7.960565e-8
GO:0050709	negative regulation of protein secretion	7.977038e-8
GO:0055010	ventricular cardiac muscle tissue morphogenesis	9.227813e-8
GO:0002685	regulation of leukocyte migration	9.577812e-8
GO:0050877	neurological system process	9.618487e-8
GO:0046700	heterocycle catabolic process	9.811070e-8
GO:0002740	negative regulation of cytokine secretion involved in immune response	1.015903e-7
GO:0033700	phospholipid efflux	1.127953e-7
GO:0019884	antigen processing and presentation of exogenous antigen	1.217247e-7
GO:0035335	peptidyl-tyrosine dephosphorylation	1.349278e-7
GO:0051764	actin crosslink formation	1.712444e-7
GO:0009605	response to external stimulus	1.730882e-7
GO:0002027	regulation of heart rate	1.761121e-7
GO:0046649	lymphocyte activation	1.791333e-7
GO:0048519	negative regulation of biological process	1.794307e-7
GO:0002253	activation of immune response	1.893998e-7
GO:0002699	positive regulation of immune effector process	1.925109e-7
GO:0002579	positive regulation of antigen processing and presentation	1.957370e-7
GO:0002700	regulation of production of molecular mediator of immune response	1.967891e-7
GO:0030814	regulation of cAMP metabolic process	2.020810e-7
GO:0002822	regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	2.024327e-7
GO:0044270	cellular nitrogen compound catabolic process	2.128718e-7
GO:0002920	regulation of humoral immune response	2.206002e-7
GO:0030817	regulation of cAMP biosynthetic process	2.209649e-7
GO:0007584	response to nutrient	2.346393e-7
GO:0002891	positive regulation of immunoglobulin mediated immune response	2.384687e-7
GO:0010575	positive regulation vascular endothelial growth factor production	2.392706e-7
GO:0051085	chaperone mediated protein folding requiring cofactor	2.658108e-7
GO:0050729	positive regulation of inflammatory response	2.688677e-7
GO:0006659	phosphatidylserine biosynthetic process	2.905525e-7
GO:0008588	release of cytoplasmic sequestered NF-kappaB	2.905525e-7
GO:0050707	regulation of cytokine secretion	2.925386e-7
GO:0032880	regulation of protein localization	3.038816e-7
GO:0003229	ventricular cardiac muscle tissue development	3.289385e-7
GO:0045471	response to ethanol	3.359488e-7
GO:0033275	actin-myosin filament sliding	4.508768e-7
GO:0006200	ATP catabolic process	4.670418e-7
GO:0019376	galactolipid catabolic process	4.685294e-7
GO:0048644	muscle organ morphogenesis	4.778047e-7
GO:0050830	defense response to Gram-positive bacterium	4.827888e-7
GO:0007600	sensory perception	5.001920e-7
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	5.206078e-7
GO:0042345	regulation of NF-kappaB import into nucleus	5.310783e-7
GO:0002366	leukocyte activation involved in immune response	5.314603e-7
GO:0032755	positive regulation of interleukin-6 production	5.394495e-7
GO:0051179	localization	5.480882e-7
GO:0002250	adaptive immune response	5.713104e-7
GO:0055085	transmembrane transport	5.836980e-7
GO:0030799	regulation of cyclic nucleotide metabolic process	5.889611e-7
GO:0009991	response to extracellular stimulus	5.910860e-7
GO:0032375	negative regulation of cholesterol transport	5.987968e-7
GO:0032729	positive regulation of interferon-gamma production	6.011042e-7
GO:0046058	cAMP metabolic process	6.206824e-7
GO:0042493	response to drug	6.266812e-7
GO:0045933	positive regulation of muscle contraction	6.434856e-7
GO:0010954	positive regulation of protein processing	6.716791e-7
GO:0002540	leukotriene production involved in inflammatory response	6.716791e-7
GO:0006690	icosanoid metabolic process	6.977996e-7
GO:0010517	regulation of phospholipase activity	7.067603e-7
GO:0030100	regulation of endocytosis	7.549554e-7
GO:0030819	positive regulation of cAMP biosynthetic process	7.663155e-7
GO:0001819	positive regulation of cytokine production	7.750344e-7
GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway	8.134274e-7
GO:0045089	positive regulation of innate immune response	8.240497e-7
GO:0016525	negative regulation of angiogenesis	8.246919e-7
GO:0072503	cellular divalent inorganic cation homeostasis	8.515337e-7
GO:0000302	response to reactive oxygen species	8.905581e-7
GO:0006140	regulation of nucleotide metabolic process	9.433703e-7
GO:0052547	regulation of peptidase activity	9.461897e-7
GO:0034097	response to cytokine stimulus	9.995188e-7
GO:0032715	negative regulation of interleukin-6 production	1.067864e-6
GO:0010916	negative regulation of very-low-density lipoprotein particle clearance	1.082856e-6
GO:0009416	response to light stimulus	1.121573e-6
GO:0007522	visceral muscle development	1.134291e-6
GO:0001969	regulation of activation of membrane attack complex	1.189393e-6
GO:0009966	regulation of signal transduction	1.216751e-6
GO:0002885	positive regulation of hypersensitivity	1.337451e-6
GO:0009968	negative regulation of signal transduction	1.348421e-6
GO:0006725	cellular aromatic compound metabolic process	1.384833e-6
GO:0030802	regulation of cyclic nucleotide biosynthetic process	1.430440e-6
GO:0006875	cellular metal ion homeostasis	1.439017e-6
GO:0044130	negative regulation of growth of symbiont in host	1.458915e-6
GO:0031663	lipopolysaccharide-mediated signaling pathway	1.470022e-6
GO:0002218	activation of innate immune response	1.557379e-6
GO:0002285	lymphocyte activation involved in immune response	1.586608e-6
GO:0034764	positive regulation of transmembrane transport	1.586608e-6
GO:0006874	cellular calcium ion homeostasis	1.592107e-6
GO:0071702	organic substance transport	1.704606e-6
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	1.767181e-6
GO:0031667	response to nutrient levels	1.769422e-6
GO:0043903	regulation of symbiosis, encompassing mutualism through parasitism	1.873968e-6
GO:0032844	regulation of homeostatic process	1.957089e-6
GO:0002696	positive regulation of leukocyte activation	1.997148e-6
GO:0060555	induction of necroptosis by extracellular signals	2.027229e-6
GO:0051591	response to cAMP	2.045985e-6
GO:0030003	cellular cation homeostasis	2.086436e-6
GO:0023051	regulation of signaling	2.112800e-6
GO:0060191	regulation of lipase activity	2.231946e-6
GO:0010243	response to organic nitrogen	2.244874e-6
GO:0010466	negative regulation of peptidase activity	2.472570e-6
GO:0002861	regulation of inflammatory response to antigenic stimulus	2.510294e-6
GO:0032369	negative regulation of lipid transport	2.584168e-6
GO:0050867	positive regulation of cell activation	2.656922e-6
GO:0040008	regulation of growth	2.760947e-6
GO:0045926	negative regulation of growth	2.788088e-6
GO:0060341	regulation of cellular localization	2.828783e-6
GO:0019374	galactolipid metabolic process	2.878041e-6
GO:0002577	regulation of antigen processing and presentation	2.898451e-6
GO:0072507	divalent inorganic cation homeostasis	2.898466e-6
GO:0032368	regulation of lipid transport	2.988137e-6
GO:0046456	icosanoid biosynthetic process	3.135453e-6
GO:0002827	positive regulation of T-helper 1 type immune response	3.185601e-6
GO:0001970	positive regulation of activation of membrane attack complex	3.305043e-6
GO:0097035	regulation of membrane lipid distribution	3.305043e-6
GO:0050710	negative regulation of cytokine secretion	3.344503e-6
GO:0009719	response to endogenous stimulus	3.447855e-6
GO:0071260	cellular response to mechanical stimulus	3.448008e-6
GO:0045087	innate immune response	3.492326e-6
GO:0007200	activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	3.521788e-6
GO:0030801	positive regulation of cyclic nucleotide metabolic process	3.530026e-6
GO:0006658	phosphatidylserine metabolic process	3.761419e-6
GO:0002863	positive regulation of inflammatory response to antigenic stimulus	3.872986e-6
GO:0031214	biomineral tissue development	3.907099e-6
GO:0002922	positive regulation of humoral immune response	3.946841e-6
GO:0003209	cardiac atrium morphogenesis	4.144235e-6
GO:0042304	regulation of fatty acid biosynthetic process	4.233019e-6
GO:0002866	positive regulation of acute inflammatory response to antigenic stimulus	4.243471e-6
GO:0010741	negative regulation of intracellular protein kinase cascade	4.552079e-6
GO:0034655	nucleobase-containing compound catabolic process	4.843484e-6
GO:0051050	positive regulation of transport	4.958334e-6
GO:0050714	positive regulation of protein secretion	5.025046e-6
GO:0061081	positive regulation of myeloid leukocyte cytokine production involved in immune response	5.403634e-6
GO:0001818	negative regulation of cytokine production	5.454092e-6
GO:0070252	actin-mediated cell contraction	5.537944e-6
GO:0001932	regulation of protein phosphorylation	5.544952e-6
GO:0010985	negative regulation of lipoprotein particle clearance	5.580922e-6
GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	5.674878e-6
GO:0015914	phospholipid transport	5.881841e-6
GO:0002460	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	5.926308e-6
GO:0034380	high-density lipoprotein particle assembly	5.974111e-6
GO:0032692	negative regulation of interleukin-1 production	6.068695e-6
GO:0032642	regulation of chemokine production	6.095977e-6
GO:0010940	positive regulation of necrotic cell death	6.284239e-6
GO:0055074	calcium ion homeostasis	6.462256e-6
GO:0050995	negative regulation of lipid catabolic process	6.466923e-6
GO:0044283	small molecule biosynthetic process	6.687863e-6
GO:0051492	regulation of stress fiber assembly	6.765974e-6
GO:0002864	regulation of acute inflammatory response to antigenic stimulus	6.797283e-6
GO:0045651	positive regulation of macrophage differentiation	6.865497e-6
GO:0001961	positive regulation of cytokine-mediated signaling pathway	6.898150e-6
GO:0043068	positive regulation of programmed cell death	7.206653e-6
GO:0055065	metal ion homeostasis	7.777107e-6
GO:0050870	positive regulation of T cell activation	7.938445e-6
GO:0001558	regulation of cell growth	8.179027e-6
GO:0042306	regulation of protein import into nucleus	8.345134e-6
GO:0002702	positive regulation of production of molecular mediator of immune response	8.462640e-6
GO:0007060	male meiosis chromosome segregation	8.515923e-6
GO:0071496	cellular response to external stimulus	8.576368e-6
GO:0006909	phagocytosis	8.617132e-6
GO:0043065	positive regulation of apoptosis	8.722803e-6
GO:0019932	second-messenger-mediated signaling	8.810236e-6
GO:0042325	regulation of phosphorylation	9.061681e-6
GO:0051128	regulation of cellular component organization	9.156630e-6
GO:0019220	regulation of phosphate metabolic process	9.548984e-6
GO:0010447	response to acidity	9.847116e-6
GO:0051222	positive regulation of protein transport	1.021181e-5
GO:0043462	regulation of ATPase activity	1.030255e-5
GO:0019377	glycolipid catabolic process	1.035281e-5
GO:0006941	striated muscle contraction	1.048899e-5
GO:0051251	positive regulation of lymphocyte activation	1.065078e-5
GO:0002883	regulation of hypersensitivity	1.083134e-5
GO:0060627	regulation of vesicle-mediated transport	1.137023e-5
GO:0008217	regulation of blood pressure	1.144103e-5
GO:0050766	positive regulation of phagocytosis	1.153607e-5
GO:0051046	regulation of secretion	1.162558e-5
GO:0009895	negative regulation of catabolic process	1.164101e-5
GO:0002019	regulation of renal output by angiotensin	1.194461e-5
GO:0045428	regulation of nitric oxide biosynthetic process	1.261478e-5
GO:0055080	cation homeostasis	1.320865e-5
GO:0052548	regulation of endopeptidase activity	1.334310e-5
GO:0060193	positive regulation of lipase activity	1.356143e-5
GO:0010942	positive regulation of cell death	1.372321e-5
GO:0060907	positive regulation of macrophage cytokine production	1.401599e-5
GO:0048731	system development	1.438542e-5
GO:0042307	positive regulation of protein import into nucleus	1.463723e-5
GO:0051480	cytosolic calcium ion homeostasis	1.474882e-5
GO:0031650	regulation of heat generation	1.498400e-5
GO:0045766	positive regulation of angiogenesis	1.525609e-5
GO:0031960	response to corticosteroid stimulus	1.610947e-5
GO:0032691	negative regulation of interleukin-1 beta production	1.624879e-5
GO:0002758	innate immune response-activating signal transduction	1.625383e-5
GO:0051224	negative regulation of protein transport	1.645303e-5
GO:0007623	circadian rhythm	1.656475e-5
GO:0033239	negative regulation of cellular amine metabolic process	1.718630e-5
GO:0071312	cellular response to alkaloid	1.726982e-5
GO:0010646	regulation of cell communication	1.732956e-5
GO:0006811	ion transport	1.752025e-5
GO:0072539	T-helper 17 cell differentiation	1.789783e-5
GO:0051606	detection of stimulus	1.834082e-5
GO:0045717	negative regulation of fatty acid biosynthetic process	1.846258e-5
GO:0032102	negative regulation of response to external stimulus	1.898551e-5
GO:0045429	positive regulation of nitric oxide biosynthetic process	1.905724e-5
GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling	2.054532e-5
GO:0051345	positive regulation of hydrolase activity	2.094431e-5
GO:0010939	regulation of necrotic cell death	2.102255e-5
GO:0050921	positive regulation of chemotaxis	2.125144e-5
GO:0012502	induction of programmed cell death	2.146742e-5
GO:0046483	heterocycle metabolic process	2.147783e-5
GO:0032649	regulation of interferon-gamma production	2.193843e-5
GO:0046034	ATP metabolic process	2.230808e-5
GO:0032963	collagen metabolic process	2.262208e-5
GO:0051051	negative regulation of transport	2.318576e-5
GO:0007275	multicellular organismal development	2.353577e-5
GO:0002495	antigen processing and presentation of peptide antigen via MHC class II	2.408805e-5
GO:0002674	negative regulation of acute inflammatory response	2.447630e-5
GO:0030048	actin filament-based movement	2.451442e-5
GO:0050715	positive regulation of cytokine secretion	2.516489e-5
GO:0009308	amine metabolic process	2.545914e-5
GO:0071321	cellular response to cGMP	2.587606e-5
GO:0006917	induction of apoptosis	2.659567e-5
GO:0048523	negative regulation of cellular process	2.687876e-5
GO:0009314	response to radiation	2.718502e-5
GO:0044062	regulation of excretion	2.729670e-5
GO:0002606	positive regulation of dendritic cell antigen processing and presentation	2.773969e-5
GO:0030804	positive regulation of cyclic nucleotide biosynthetic process	2.854066e-5
GO:0031652	positive regulation of heat generation	2.919960e-5
GO:0030449	regulation of complement activation	2.919960e-5
GO:0016311	dephosphorylation	3.008837e-5
GO:0009894	regulation of catabolic process	3.060942e-5
GO:0070665	positive regulation of leukocyte proliferation	3.075724e-5
GO:0031329	regulation of cellular catabolic process	3.209572e-5
GO:0016064	immunoglobulin mediated immune response	3.225902e-5
GO:0002449	lymphocyte mediated immunity	3.275151e-5
GO:0032946	positive regulation of mononuclear cell proliferation	3.321079e-5
GO:0019724	B cell mediated immunity	3.431207e-5
GO:0051384	response to glucocorticoid stimulus	3.447989e-5
GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	3.561759e-5
GO:0006636	unsaturated fatty acid biosynthetic process	3.573423e-5
GO:0006470	protein dephosphorylation	3.618756e-5
GO:0042110	T cell activation	3.669998e-5
GO:0030098	lymphocyte differentiation	3.872666e-5
GO:0048513	organ development	3.873539e-5
GO:0006195	purine nucleotide catabolic process	4.025446e-5
GO:0002521	leukocyte differentiation	4.073400e-5
GO:0048518	positive regulation of biological process	4.099731e-5
GO:0006927	transformed cell apoptosis	4.141621e-5
GO:0002281	macrophage activation involved in immune response	4.236864e-5
GO:0032490	detection of molecule of bacterial origin	4.236864e-5
GO:0051341	regulation of oxidoreductase activity	4.241618e-5
GO:0051445	regulation of meiotic cell cycle	4.514839e-5
GO:0044259	multicellular organismal macromolecule metabolic process	4.615337e-5
GO:0006163	purine nucleotide metabolic process	4.646642e-5
GO:0048016	inositol phosphate-mediated signaling	4.753033e-5
GO:0032930	positive regulation of superoxide anion generation	4.782572e-5
GO:0046942	carboxylic acid transport	4.895457e-5
GO:0032231	regulation of actin filament bundle assembly	5.025238e-5
GO:0045922	negative regulation of fatty acid metabolic process	5.058225e-5
GO:0050953	sensory perception of light stimulus	5.258936e-5
GO:0042592	homeostatic process	5.263654e-5
GO:2000116	regulation of cysteine-type endopeptidase activity	5.328531e-5
GO:0002876	positive regulation of chronic inflammatory response to antigenic stimulus	5.408630e-5
GO:0002706	regulation of lymphocyte mediated immunity	5.441922e-5
GO:0043901	negative regulation of multi-organism process	5.475332e-5
GO:0040020	regulation of meiosis	5.590262e-5
GO:0048878	chemical homeostasis	5.841030e-5
GO:0050865	regulation of cell activation	5.857860e-5
GO:0071827	plasma lipoprotein particle organization	6.032517e-5
GO:0051561	elevation of mitochondrial calcium ion concentration	6.150113e-5
GO:0010873	positive regulation of cholesterol esterification	6.169335e-5
GO:0072523	purine-containing compound catabolic process	6.177259e-5
GO:0032502	developmental process	6.183206e-5
GO:0003230	cardiac atrium development	6.264067e-5
GO:0044255	cellular lipid metabolic process	6.271284e-5
GO:0043434	response to peptide hormone stimulus	6.313929e-5
GO:0050711	negative regulation of interleukin-1 secretion	6.380563e-5
GO:0042488	positive regulation of odontogenesis of dentine-containing tooth	6.558781e-5
GO:0002694	regulation of leukocyte activation	6.617803e-5
GO:0031399	regulation of protein modification process	6.666462e-5
GO:0031348	negative regulation of defense response	6.689719e-5
GO:0006629	lipid metabolic process	6.803012e-5
GO:0002703	regulation of leukocyte mediated immunity	6.874497e-5
GO:0051246	regulation of protein metabolic process	6.924016e-5
GO:0010025	wax biosynthetic process	6.942153e-5
GO:0006958	complement activation, classical pathway	7.100745e-5
GO:0048535	lymph node development	7.214749e-5
GO:0010035	response to inorganic substance	7.607504e-5
GO:0046717	acid secretion	7.768875e-5
GO:0007601	visual perception	7.865519e-5
GO:0006979	response to oxidative stress	7.878875e-5
GO:0009166	nucleotide catabolic process	7.891474e-5
GO:0001890	placenta development	7.946951e-5
GO:0033574	response to testosterone stimulus	8.003056e-5
GO:0045332	phospholipid translocation	8.249085e-5
GO:0003073	regulation of systemic arterial blood pressure	8.342182e-5
GO:0043085	positive regulation of catalytic activity	8.381841e-5
GO:0042321	negative regulation of circadian sleep/wake cycle, sleep	8.409682e-5
GO:0070305	response to cGMP	8.480621e-5
GO:0015849	organic acid transport	8.507384e-5
GO:0044057	regulation of system process	8.514752e-5
GO:0009593	detection of chemical stimulus	8.576693e-5
GO:0050671	positive regulation of lymphocyte proliferation	8.588772e-5
GO:0046631	alpha-beta T cell activation	8.607627e-5
GO:0032233	positive regulation of actin filament bundle assembly	8.656527e-5
GO:0010627	regulation of intracellular protein kinase cascade	8.733379e-5
GO:0055114	oxidation-reduction process	8.737084e-5
GO:0070482	response to oxygen levels	8.749933e-5
GO:0031338	regulation of vesicle fusion	8.786735e-5
GO:0019319	hexose biosynthetic process	8.799359e-5
GO:0005976	polysaccharide metabolic process	8.863197e-5
GO:0090209	negative regulation of triglyceride metabolic process	8.894954e-5
GO:0046890	regulation of lipid biosynthetic process	9.182642e-5
GO:0030049	muscle filament sliding	9.488720e-5
GO:0006469	negative regulation of protein kinase activity	9.525522e-5
GO:0007568	aging	9.527887e-5
GO:0034284	response to monosaccharide stimulus	9.643568e-5
GO:0002221	pattern recognition receptor signaling pathway	9.787616e-5
GO:0015909	long-chain fatty acid transport	9.827605e-5
GO:0019725	cellular homeostasis	9.901011e-5
GO:2000379	positive regulation of reactive oxygen species metabolic process	9.958124e-5
GO:0006869	lipid transport	1.010548e-4
GO:0007155	cell adhesion	1.016218e-4
GO:0045080	positive regulation of chemokine biosynthetic process	1.033072e-4
GO:0000185	activation of MAPKKK activity	1.052074e-4
GO:0001702	gastrulation with mouth forming second	1.056734e-4
GO:0001101	response to acid	1.072408e-4
GO:0051348	negative regulation of transferase activity	1.098718e-4
GO:0010984	regulation of lipoprotein particle clearance	1.107538e-4
GO:0006691	leukotriene metabolic process	1.126770e-4
GO:0043407	negative regulation of MAP kinase activity	1.154088e-4
GO:0043154	negative regulation of caspase activity	1.156348e-4
GO:0045071	negative regulation of viral genome replication	1.157486e-4
GO:0048660	regulation of smooth muscle cell proliferation	1.168480e-4
GO:0000188	inactivation of MAPK activity	1.214063e-4
GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus	1.236952e-4
GO:0051353	positive regulation of oxidoreductase activity	1.239508e-4
GO:0015908	fatty acid transport	1.250163e-4
GO:0033590	response to cobalamin	1.250485e-4
GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process	1.250485e-4
GO:0002676	regulation of chronic inflammatory response	1.250837e-4
GO:0002757	immune response-activating signal transduction	1.254476e-4
GO:0070508	cholesterol import	1.269825e-4
GO:0032770	positive regulation of monooxygenase activity	1.270348e-4
GO:0022610	biological adhesion	1.312907e-4
GO:0007338	single fertilization	1.317291e-4
GO:0007204	elevation of cytosolic calcium ion concentration	1.336406e-4
GO:0006022	aminoglycan metabolic process	1.387678e-4
GO:0002483	antigen processing and presentation of endogenous peptide antigen	1.394431e-4
GO:0003018	vascular process in circulatory system	1.412430e-4
GO:0002526	acute inflammatory response	1.436614e-4
GO:0045840	positive regulation of mitosis	1.458902e-4
GO:0034447	very-low-density lipoprotein particle clearance	1.472108e-4
GO:0048671	negative regulation of collateral sprouting	1.472582e-4
GO:0006678	glucosylceramide metabolic process	1.472582e-4
GO:0045987	positive regulation of smooth muscle contraction	1.524371e-4
GO:0090023	positive regulation of neutrophil chemotaxis	1.527740e-4
GO:0060760	positive regulation of response to cytokine stimulus	1.530360e-4
GO:0009187	cyclic nucleotide metabolic process	1.542498e-4
GO:0010872	regulation of cholesterol esterification	1.548428e-4
GO:0070555	response to interleukin-1	1.558354e-4
GO:0051053	negative regulation of DNA metabolic process	1.569875e-4
GO:0006812	cation transport	1.595185e-4
GO:0009268	response to pH	1.644421e-4
GO:0048525	negative regulation of viral reproduction	1.671793e-4
GO:0002443	leukocyte mediated immunity	1.675547e-4
GO:0090022	regulation of neutrophil chemotaxis	1.722166e-4
GO:0045746	negative regulation of Notch signaling pathway	1.722166e-4
GO:0060696	regulation of phospholipid catabolic process	1.747512e-4
GO:0016055	Wnt receptor signaling pathway	1.769146e-4
GO:0048856	anatomical structure development	1.772201e-4
GO:0043279	response to alkaloid	1.775614e-4
GO:0061048	negative regulation of branching involved in lung morphogenesis	1.819699e-4
GO:0045994	positive regulation of translational initiation by iron	1.819699e-4
GO:0034116	positive regulation of heterotypic cell-cell adhesion	1.819699e-4
GO:0002037	negative regulation of L-glutamate transport	1.819699e-4
GO:0014075	response to amine stimulus	1.849127e-4
GO:0048738	cardiac muscle tissue development	1.900906e-4
GO:0045948	positive regulation of translational initiation	1.930370e-4
GO:0002724	regulation of T cell cytokine production	1.976812e-4
GO:0050713	negative regulation of interleukin-1 beta secretion	1.998405e-4
GO:0009746	response to hexose stimulus	2.054946e-4
GO:0045851	pH reduction	2.075812e-4
GO:0060338	regulation of type I interferon-mediated signaling pathway	2.110541e-4
GO:0022900	electron transport chain	2.126750e-4