Coexpression cluster:C300
From FANTOM5_SSTAR
Full id: C300_CD4_CD8_NK_Natural_blood_mycosis_Basophils
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
No results for this coexpression
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0019957 | C-C chemokine binding | 0.00203275243585207 |
GO:0016493 | C-C chemokine receptor activity | 0.00203275243585207 |
GO:0004950 | chemokine receptor activity | 0.00203275243585207 |
GO:0001637 | G-protein chemoattractant receptor activity | 0.00203275243585207 |
GO:0019956 | chemokine binding | 0.00203275243585207 |
GO:0007165 | signal transduction | 0.00203275243585207 |
GO:0007242 | intracellular signaling cascade | 0.00236279697749897 |
GO:0007154 | cell communication | 0.00257076988205919 |
GO:0044459 | plasma membrane part | 0.00378351305242138 |
GO:0005887 | integral to plasma membrane | 0.00438007771105616 |
GO:0031226 | intrinsic to plasma membrane | 0.00438007771105616 |
GO:0031727 | CCR2 chemokine receptor binding | 0.00438007771105616 |
GO:0048020 | CCR chemokine receptor binding | 0.00438007771105616 |
GO:0004277 | granzyme A activity | 0.00438007771105616 |
GO:0005174 | CD40 receptor binding | 0.00438007771105616 |
GO:0019955 | cytokine binding | 0.00462889244648079 |
GO:0001816 | cytokine production | 0.00567214870023238 |
GO:0032735 | positive regulation of interleukin-12 production | 0.0072992699464958 |
GO:0001653 | peptide receptor activity | 0.00824820650737661 |
GO:0008528 | peptide receptor activity, G-protein coupled | 0.00824820650737661 |
GO:0006922 | cleavage of lamin | 0.00856769927397956 |
GO:0006923 | cleavage of cytoskeletal proteins during apoptosis | 0.00856769927397956 |
GO:0032655 | regulation of interleukin-12 production | 0.00856769927397956 |
GO:0006915 | apoptosis | 0.0120987350741618 |
GO:0012501 | programmed cell death | 0.0120987350741618 |
GO:0042277 | peptide binding | 0.0124533973568257 |
GO:0008219 | cell death | 0.0125502845118458 |
GO:0016265 | death | 0.0125502845118458 |
GO:0005886 | plasma membrane | 0.0130053297491197 |
GO:0032615 | interleukin-12 production | 0.0131324991110303 |
GO:0005625 | soluble fraction | 0.013179067182002 |
GO:0005515 | protein binding | 0.0151343927086091 |
GO:0006954 | inflammatory response | 0.0185092915895833 |
GO:0007159 | leukocyte adhesion | 0.0185092915895833 |
GO:0016494 | C-X-C chemokine receptor activity | 0.0185092915895833 |
GO:0002208 | somatic diversification of immunoglobulins during immune response | 0.0185092915895833 |
GO:0002381 | immunoglobulin production during immune response | 0.0185092915895833 |
GO:0002204 | somatic recombination of immunoglobulin genes during immune response | 0.0185092915895833 |
GO:0045190 | isotype switching | 0.0185092915895833 |
GO:0006955 | immune response | 0.0190092271228569 |
GO:0019958 | C-X-C chemokine binding | 0.0192047199434155 |
GO:0016447 | somatic recombination of immunoglobulin gene segments | 0.0197993162207085 |
GO:0048468 | cell development | 0.0197993162207085 |
GO:0031280 | negative regulation of cyclase activity | 0.0197993162207085 |
GO:0016444 | somatic cell DNA recombination | 0.0197993162207085 |
GO:0007194 | negative regulation of adenylate cyclase activity | 0.0197993162207085 |
GO:0051350 | negative regulation of lyase activity | 0.0197993162207085 |
GO:0016445 | somatic diversification of immunoglobulins | 0.0197993162207085 |
GO:0002562 | somatic diversification of immune receptors via germline recombination within a single locus | 0.0197993162207085 |
GO:0007243 | protein kinase cascade | 0.0197993162207085 |
GO:0015026 | coreceptor activity | 0.0197993162207085 |
GO:0002200 | somatic diversification of immune receptors | 0.0197993162207085 |
GO:0019835 | cytolysis | 0.0197993162207085 |
GO:0001772 | immunological synapse | 0.0206447731653015 |
GO:0002376 | immune system process | 0.020706251242198 |
GO:0002377 | immunoglobulin production | 0.020706251242198 |
GO:0042100 | B cell proliferation | 0.020706251242198 |
GO:0009611 | response to wounding | 0.0224701169761612 |
GO:0006921 | cell structure disassembly during apoptosis | 0.0233301615954918 |
GO:0001819 | positive regulation of cytokine production | 0.0251202993534965 |
GO:0005100 | Rho GTPase activator activity | 0.0257797388481279 |
GO:0030168 | platelet activation | 0.026417657728311 |
GO:0002440 | production of molecular mediator of immune response | 0.0280715875138972 |
GO:0019079 | viral genome replication | 0.0296728701447912 |
GO:0042981 | regulation of apoptosis | 0.0356996152922203 |
GO:0043067 | regulation of programmed cell death | 0.0357711508412229 |
GO:0006952 | defense response | 0.0357711508412229 |
GO:0048869 | cellular developmental process | 0.0357711508412229 |
GO:0030154 | cell differentiation | 0.0357711508412229 |
GO:0005164 | tumor necrosis factor receptor binding | 0.0359283039721178 |
GO:0007259 | JAK-STAT cascade | 0.0359283039721178 |
GO:0001817 | regulation of cytokine production | 0.0361337348780551 |
GO:0045761 | regulation of adenylate cyclase activity | 0.0361337348780551 |
GO:0032813 | tumor necrosis factor receptor superfamily binding | 0.0361337348780551 |
GO:0031279 | regulation of cyclase activity | 0.0361337348780551 |
GO:0051339 | regulation of lyase activity | 0.0361337348780551 |
GO:0019221 | cytokine and chemokine mediated signaling pathway | 0.0363786717589302 |
GO:0009605 | response to external stimulus | 0.0363786717589302 |
GO:0022411 | cellular component disassembly | 0.0405217762126783 |
GO:0019058 | viral infectious cycle | 0.0408270885386266 |
GO:0016064 | immunoglobulin mediated immune response | 0.0411246731931978 |
GO:0019724 | B cell mediated immunity | 0.0412013747883468 |
GO:0032943 | mononuclear cell proliferation | 0.0412013747883468 |
GO:0046651 | lymphocyte proliferation | 0.0412013747883468 |
GO:0022415 | viral reproductive process | 0.0437690085605704 |
GO:0042113 | B cell activation | 0.0462740844094532 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>
Ontology term | p-value | n |
---|
Ontology term | p-value | n |
---|
Ontology term | p-value | n |
---|
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
{{{tfbs_overrepresentation_jaspar}}} |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
No analysis results for this cluster
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
"{{{coexpression_dpi_cluster_scores_median}}}" is not a number.