Coexpression cluster:C2985

Full id: C2985_Melanocyte_CD19_Natural_Dendritic_CD8_thalamus_blood

Phase1 CAGE Peaks

Hg19::chr10:126432849..126432931,-	p1@FAM53B
Hg19::chr10:126432932..126432958,-	p2@FAM53B
Hg19::chr10:126432968..126432979,-	p5@FAM53B

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
hematopoietic stem cell	1.99e-24	172
angioblastic mesenchymal cell	1.99e-24	172
leukocyte	4.20e-23	140
hematopoietic cell	1.98e-22	182
hematopoietic oligopotent progenitor cell	1.08e-21	165
hematopoietic multipotent progenitor cell	1.08e-21	165
hematopoietic lineage restricted progenitor cell	4.16e-17	124
nongranular leukocyte	1.17e-16	119
lymphoid lineage restricted progenitor cell	7.32e-15	52
lymphocyte	9.64e-15	53
common lymphoid progenitor	9.64e-15	53
myeloid cell	7.21e-09	112
common myeloid progenitor	7.21e-09	112
B cell	6.81e-08	14
lymphocyte of B lineage	1.12e-07	24
pro-B cell	1.12e-07	24
T cell	7.30e-07	25
pro-T cell	7.30e-07	25

Uber Anatomy

Ontology term	p-value	n
adult organism	1.61e-26	115
neural tube	1.29e-11	57
neural rod	1.29e-11	57
future spinal cord	1.29e-11	57
neural keel	1.29e-11	57
gray matter	1.25e-09	34
brain grey matter	1.25e-09	34
telencephalon	1.48e-09	34
regional part of telencephalon	2.76e-09	33
anterior neural tube	7.97e-09	42
regional part of forebrain	1.23e-08	41
forebrain	1.23e-08	41
future forebrain	1.23e-08	41
cerebral hemisphere	1.63e-08	32
central nervous system	2.86e-08	82
regional part of brain	3.47e-08	59
hematopoietic system	5.00e-08	102
blood island	5.00e-08	102
regional part of cerebral cortex	4.03e-07	22
hemolymphoid system	4.60e-07	112
regional part of nervous system	5.58e-07	94
nervous system	5.58e-07	94
neocortex	8.23e-07	20

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
BHLHE40#8553	3	44.8718135469774	1.10603738662898e-05	0.000283607755026133
CCNT2#905	3	6.33620157696263	0.00393075003576489	0.0189024589273989
CTCF#10664	3	5.36025637307503	0.006492509252767	0.0278114586706753
CTCFL#140690	3	19.7464743589744	0.000129837200555116	0.00170997066693264
E2F1#1869	3	4.90738921487932	0.00846098534723939	0.0323340352255968
E2F4#1874	3	12.6680603152844	0.000491798700629898	0.00435058144122361
E2F6#1876	3	5.01715573169739	0.0079176980688633	0.0320199987846666
ELF1#1997	3	4.25809795880754	0.0129517987505461	0.0459748796719558
HMGN3#9324	3	8.17854772335059	0.00182776694216421	0.0108251191829811
MYC#4609	3	5.2222818716094	0.00702084375574015	0.0293042083368934
PAX5#5079	3	6.66956553117783	0.00337029099967726	0.0172189522412334
TCF7L2#6934	3	10.7701765631373	0.000800318129839838	0.00611444222109311
TFAP2A#7020	3	16.518634373045	0.000221803388076634	0.00247277156781977
TFAP2C#7022	3	10.8092286098602	0.000791674657575313	0.00612729432062458

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.