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Coexpression cluster:C442

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Full id: C442_diffuse_xeroderma_lymphoma_Burkitt_plasma_b_lymphangiectasia



Phase1 CAGE Peaks

Hg19::chr11:111224162..111224190,-p@chr11:111224162..111224190
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Hg19::chr11:111224819..111224845,+p2@CU689419
Hg19::chr11:111224843..111224854,-p@chr11:111224843..111224854
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Hg19::chr11:111224975..111224995,-p@chr11:111224975..111224995
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Hg19::chr11:111225012..111225024,-p@chr11:111225012..111225024
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Hg19::chr11:111225030..111225046,-p@chr11:111225030..111225046
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Hg19::chr11:111225132..111225169,-p@chr11:111225132..111225169
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Hg19::chr11:111225158..111225201,+p1@CU689419
Hg19::chr11:111225198..111225226,-p@chr11:111225198..111225226
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Hg19::chr11:111225243..111225260,-p@chr11:111225243..111225260
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Hg19::chr11:111228213..111228235,-p@chr11:111228213..111228235
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Hg19::chr11:111228281..111228290,-p@chr11:111228281..111228290
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Hg19::chr11:111228348..111228370,-p@chr11:111228348..111228370
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Hg19::chr11:111228555..111228566,-p@chr11:111228555..111228566
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Hg19::chr11:111249993..111250006,-p1@POU2AF1
Hg19::chr12:6554021..6554040,+p4@CD27
Hg19::chr19:19258534..19258541,-p@chr19:19258534..19258541
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Hg19::chr22:39843178..39843224,+p@chr22:39843178..39843224
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Hg19::chr22:39843234..39843241,+p@chr22:39843234..39843241
+
Hg19::chr5:133880112..133880133,+p20@PHF15
Hg19::chr6:107078354..107078388,-p4@RTN4IP1
Hg19::chr9:37034469..37034474,-p1@PAX5


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0006959humoral immune response0.00861922938102902
GO:0007283spermatogenesis0.0141234610606639
GO:0048232male gamete generation0.0141234610606639
GO:0006955immune response0.0141234610606639
GO:0045579positive regulation of B cell differentiation0.0141234610606639
GO:0008588release of cytoplasmic sequestered NF-kappaB0.0141234610606639
GO:0007276gamete generation0.0141234610606639
GO:0002376immune system process0.0141234610606639
GO:0019953sexual reproduction0.0141234610606639
GO:0043027caspase inhibitor activity0.0141234610606639
GO:0042346positive regulation of NF-kappaB import into nucleus0.0141234610606639
GO:0045621positive regulation of lymphocyte differentiation0.0141234610606639
GO:0042993positive regulation of transcription factor import into nucleus0.0141234610606639
GO:0045577regulation of B cell differentiation0.0141234610606639
GO:0042307positive regulation of protein import into nucleus0.0141234610606639
GO:0046824positive regulation of nucleocytoplasmic transport0.0165489821573171
GO:0051222positive regulation of protein transport0.0167212129148552
GO:0042345regulation of NF-kappaB import into nucleus0.0167212129148552
GO:0042348NF-kappaB import into nucleus0.0167212129148552
GO:0046330positive regulation of JNK cascade0.0172079018049975
GO:0045619regulation of lymphocyte differentiation0.0201668720331968
GO:0050871positive regulation of B cell activation0.0207897414522421
GO:0046328regulation of JNK cascade0.0207897414522421
GO:0043028caspase regulator activity0.0207897414522421
GO:0042990regulation of transcription factor import into nucleus0.0207897414522421
GO:0042991transcription factor import into nucleus0.0207897414522421
GO:0042306regulation of protein import into nucleus0.0207897414522421
GO:0033157regulation of intracellular protein transport0.0207897414522421
GO:0006366transcription from RNA polymerase II promoter0.0211804672829906
GO:0050864regulation of B cell activation0.0213346757061976
GO:0032386regulation of intracellular transport0.0213346757061976
GO:0051223regulation of protein transport0.0225592436426157
GO:0046822regulation of nucleocytoplasmic transport0.0225592436426157
GO:0030183B cell differentiation0.0225592436426157
GO:0051050positive regulation of transport0.0287005938275852
GO:0051251positive regulation of lymphocyte activation0.0361440743964373
GO:0016064immunoglobulin mediated immune response0.0361440743964373
GO:0019724B cell mediated immunity0.0361440743964373
GO:0042113B cell activation0.0412907208792365
GO:0030098lymphocyte differentiation0.0418421950910473
GO:0007254JNK cascade0.0418421950910473
GO:0031098stress-activated protein kinase signaling pathway0.0426500390204998
GO:0048513organ development0.0426500390204998
GO:0002449lymphocyte mediated immunity0.0426500390204998
GO:0002250adaptive immune response0.0426500390204998
GO:0002460adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains0.0426500390204998
GO:0051249regulation of lymphocyte activation0.0426500390204998
GO:0002443leukocyte mediated immunity0.0428554367391758
GO:0050865regulation of cell activation0.0430521979591859
GO:0002521leukocyte differentiation0.0474371112883045
GO:0006606protein import into nucleus0.0495899158326127
GO:0051170nuclear import0.049643673186528



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Uber Anatomy
Ontology termp-valuen
adult organism1.21e-13115
blood1.08e-0715
haemolymphatic fluid1.08e-0715
organism substance1.08e-0715
Disease
Ontology termp-valuen
hematologic cancer1.25e-0851
immune system cancer1.25e-0851


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
POLR2A#5430171.659395636431240.003374401144947360.0172357353732654



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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