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Coexpression cluster:C118

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Full id: C118_cerebellum_parietal_occipital_medial_middle_frontal_insula



Phase1 CAGE Peaks

Hg19::chr10:105037220..105037227,+p12@INA
Hg19::chr10:18689498..18689550,+p6@CACNB2
Hg19::chr10:24911746..24911793,-p6@ARHGAP21
Hg19::chr10:25463662..25463680,+p1@GPR158
Hg19::chr10:25463691..25463702,+p5@GPR158
Hg19::chr10:25463726..25463735,+p6@GPR158
Hg19::chr10:62149714..62149724,-p34@ANK3
Hg19::chr10:65281549..65281566,-p@chr10:65281549..65281566
-
Hg19::chr11:105480715..105480735,+p6@GRIA4
Hg19::chr11:105480793..105480845,+p3@GRIA4
Hg19::chr11:119019778..119019795,+p2@ABCG4
Hg19::chr11:132714823..132714843,-p@chr11:132714823..132714843
-
Hg19::chr11:132813716..132813736,-p14@OPCML
Hg19::chr11:17172291..17172318,-p@chr11:17172291..17172318
-
Hg19::chr11:17756279..17756367,+p1@KCNC1
Hg19::chr11:47616210..47616237,-p4@C1QTNF4
Hg19::chr11:66025938..66025957,+p9@KLC2
Hg19::chr11:66790693..66790733,+p2@SYT12
Hg19::chr11:94134581..94134594,-p1@GPR83
Hg19::chr12:100378459..100378530,-p6@ANKS1B
Hg19::chr12:108523053..108523101,+p1@WSCD2
Hg19::chr12:108525551..108525568,+p4@WSCD2
Hg19::chr12:119419159..119419192,+p5@SRRM4
Hg19::chr12:132904597..132904617,+p@chr12:132904597..132904617
+
Hg19::chr12:132906118..132906180,-p1@GALNT9
Hg19::chr12:3601977..3601990,-p1@uc001qmd.1
Hg19::chr12:52214727..52214749,-p@chr12:52214727..52214749
-
Hg19::chr13:103054704..103054731,-p2@FGF14-IT1
Hg19::chr14:24047796..24047818,-p10@JPH4
Hg19::chr14:27067258..27067276,-p3@NOVA1
Hg19::chr15:31658288..31658338,+p4@KLF13
Hg19::chr15:31658340..31658347,+p34@KLF13
Hg19::chr15:37391438..37391479,+p1@ENST00000559509
Hg19::chr15:40650463..40650527,+p1@DISP2
Hg19::chr16:31004138..31004144,+p@chr16:31004138..31004144
+
Hg19::chr16:330675..330686,+p3@PDIA2
p4@ARHGDIG
Hg19::chr16:6069299..6069316,+p18@RBFOX1
Hg19::chr16:6069333..6069361,+p10@RBFOX1
Hg19::chr16:6069840..6069851,+p31@RBFOX1
Hg19::chr16:87636569..87636577,+p6@JPH3
Hg19::chr17:19314532..19314563,+p1@RNF112
Hg19::chr17:2658922..2658963,+p@chr17:2658922..2658963
+
Hg19::chr17:43319081..43319146,-p1@AK096807
Hg19::chr17:48207115..48207152,-p4@SAMD14
Hg19::chr17:50235163..50235180,-p16@CA10
Hg19::chr17:50235879..50235899,-p14@CA10
Hg19::chr17:50237348..50237373,-p5@CA10
Hg19::chr17:50237374..50237388,-p9@CA10
Hg19::chr17:72857858..72857869,-p@chr17:72857858..72857869
-
Hg19::chr17:7452189..7452207,+p3@TNFSF12-TNFSF13
p3@TNFSF12
Hg19::chr17:77090555..77090587,-p@chr17:77090555..77090587
-
Hg19::chr17:79373129..79373161,+p3@BAHCC1
Hg19::chr17:80656875..80656912,+p@chr17:80656875..80656912
+
Hg19::chr18:3874247..3874262,-p9@DLGAP1
Hg19::chr18:3874271..3874337,-p3@DLGAP1
Hg19::chr18:44336896..44336907,+p@chr18:44336896..44336907
+
Hg19::chr19:13106465..13106477,+p27@NFIX
Hg19::chr19:13616887..13616912,-p10@CACNA1A
Hg19::chr19:13617037..13617069,-p4@CACNA1A
Hg19::chr19:13618233..13618292,-p@chr19:13618233..13618292
-
Hg19::chr19:30019801..30019814,+p@chr19:30019801..30019814
+
Hg19::chr19:3987889..3987898,-p@chr19:3987889..3987898
-
Hg19::chr19:41036371..41036417,+p1@SPTBN4
Hg19::chr19:42817511..42817522,+p6@TMEM145
Hg19::chr19:42817550..42817569,+p3@TMEM145
Hg19::chr19:44139537..44139540,+p@chr19:44139537..44139540
+
Hg19::chr1:11714458..11714482,+p2@FBXO44
Hg19::chr1:174768671..174768682,+p29@RABGAP1L
Hg19::chr1:174769436..174769459,+p15@RABGAP1L
Hg19::chr1:205414261..205414293,-p@chr1:205414261..205414293
-
Hg19::chr1:2398876..2398928,+p1@PLCH2
Hg19::chr1:244211767..244211800,+p@chr1:244211767..244211800
+
Hg19::chr20:10289444..10289460,+p@chr20:10289444..10289460
+
Hg19::chr20:3767547..3767623,+p4@CDC25B
Hg19::chr20:3767689..3767696,+p8@CDC25B
Hg19::chr20:44036054..44036086,-p1@AK098015
Hg19::chr20:44937047..44937095,-p1@CDH22
Hg19::chr20:44937096..44937105,-p7@CDH22
Hg19::chr20:45980455..45980466,-p24@ZMYND8
Hg19::chr20:9819653..9819663,-p5@PAK7
Hg19::chr22:18958039..18958055,+p2@DGCR5
Hg19::chr22:37099555..37099599,-p2@CACNG2
Hg19::chr22:51066685..51066719,+p@chr22:51066685..51066719
+
Hg19::chr2:100721281..100721307,-p5@AFF3
Hg19::chr2:152830428..152830439,-p7@CACNB4
Hg19::chr2:152830441..152830472,-p2@CACNB4
Hg19::chr2:152830479..152830503,-p3@CACNB4
Hg19::chr2:155553962..155553969,+p@chr2:155553962..155553969
+
Hg19::chr2:155554040..155554063,+p@chr2:155554040..155554063
+
Hg19::chr2:155555201..155555272,+p1@KCNJ3
Hg19::chr2:173600040..173600056,+p20@RAPGEF4
Hg19::chr2:17773946..17773949,+p@chr2:17773946..17773949
+
Hg19::chr2:183387533..183387548,-p7@PDE1A
Hg19::chr2:197457394..197457421,-p12@HECW2
Hg19::chr2:210636313..210636335,+p3@UNC80
Hg19::chr2:2328418..2328441,-p13@MYT1L
Hg19::chr2:39893140..39893164,+p8@TMEM178
Hg19::chr2:39893171..39893182,+p13@TMEM178
Hg19::chr2:47798782..47798832,-p@chr2:47798782..47798832
-
Hg19::chr2:50201327..50201339,-p18@NRXN1
Hg19::chr3:113251885..113251917,+p4@SIDT1
Hg19::chr3:120627034..120627102,+p1@STXBP5L
Hg19::chr3:120627517..120627530,+p2@STXBP5L
Hg19::chr3:120989095..120989099,+p@chr3:120989095..120989099
+
Hg19::chr3:132843652..132843709,+p3@TMEM108
Hg19::chr3:138153411..138153433,+p2@ESYT3
Hg19::chr3:173113898..173113949,+p4@NLGN1
Hg19::chr3:182833946..182833990,-p5@MCCC1
Hg19::chr3:184098065..184098119,+p1@CHRD
Hg19::chr3:186080012..186080030,-p1@DGKG
Hg19::chr3:186080056..186080061,-p5@DGKG
Hg19::chr3:35722538..35722559,+p27@ARPP21
Hg19::chr3:37903001..37903039,+p6@CTDSPL
Hg19::chr3:52489503..52489540,+p2@NISCH
Hg19::chr3:96532248..96532290,+p@chr3:96532248..96532290
+
Hg19::chr4:103998320..103998345,-p10@SLC9B2
Hg19::chr4:114038052..114038059,+p34@ANK2
Hg19::chr4:118955635..118955655,+p3@NDST3
Hg19::chr5:110559790..110559803,+p11@CAMK4
Hg19::chr5:110559929..110559940,+p8@CAMK4
Hg19::chr5:110559941..110559952,+p4@CAMK4
Hg19::chr5:138211051..138211072,-p3@LRRTM2
Hg19::chr5:156772748..156772774,-p3@FNDC9
Hg19::chr5:160975364..160975379,-p5@GABRB2
Hg19::chr5:19873309..19873311,-p@chr5:19873309..19873311
-
Hg19::chr5:19988288..19988330,-p1@CDH18
Hg19::chr5:41510865..41510886,-p4@PLCXD3
Hg19::chr5:87981322..87981337,-p@chr5:87981322..87981337
-
Hg19::chr5:94620239..94620258,-p6@MCTP1
Hg19::chr6:101846679..101846702,+p1@GRIK2
Hg19::chr6:101846725..101846734,+p17@GRIK2
Hg19::chr6:69345285..69345308,+p2@BAI3
Hg19::chr6:69345833..69345845,+p8@BAI3
Hg19::chr6:72596229..72596272,+p2@RIMS1
Hg19::chr6:72596410..72596454,+p4@RIMS1
Hg19::chr6:72596604..72596697,+p1@RIMS1
Hg19::chr7:151511911..151511962,-p9@PRKAG2
Hg19::chr7:28997721..28997738,-p3@TRIL
Hg19::chr7:71801984..71802013,-p3@CALN1
Hg19::chr8:10158687..10158707,+p4@MSRA
Hg19::chr8:132928997..132929025,+p@chr8:132928997..132929025
+
Hg19::chr8:15095883..15095918,-p1@SGCZ
Hg19::chr8:15095933..15095945,-p3@SGCZ
Hg19::chr8:85095907..85095910,+p5@RALYL
Hg19::chr8:9761882..9761897,-p3@ENST00000521863
Hg19::chr8:9776628..9776670,-p@chr8:9776628..9776670
-
Hg19::chr8:9911618..9911629,+p8@MSRA
Hg19::chr8:9953920..9953944,+p@chr8:9953920..9953944
+
Hg19::chr9:100264031..100264042,+p4@TMOD1
Hg19::chr9:15250159..15250231,-p2@TTC39B
Hg19::chr9:79307096..79307129,-p2@PRUNE2
Hg19::chrX:123510693..123510711,-p1@ODZ1
Hg19::chrX:21392356..21392365,+p7@CNKSR2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

p.valueFDRnGenesnPathwayName
3.21588558482119e-050.006785518583972715126Glutamatergic synapse (KEGG):04724
9.77861502511732e-050.0123824018731482483Hypertrophic cardiomyopathy (HCM) (KEGG):05410
0.0001066964919002110.0123824018731482332Hypothetical Network for Drug Addiction (Wikipathways):WP666
2.70775915789819e-101.71401154694955e-0710197Synaptic Transmission (Reactome):REACT_13685
0.0004706991269927620.04256464962663124125Integration of energy metabolism (Reactome):REACT_1505
0.0001173687381341060.01238240187314826265Axon guidance (Reactome):REACT_18266
9.00885823625835e-070.000285130363177577426{RASGRF1,26} (Static Module):NA



Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0005886plasma membrane2.52069622669271e-06
GO:0030054cell junction1.17290317297813e-05
GO:0044425membrane part1.73607675976265e-05
GO:0044459plasma membrane part1.96924833961766e-05
GO:0016021integral to membrane2.96607884633392e-05
GO:0031224intrinsic to membrane2.96607884633392e-05
GO:0016020membrane2.96607884633392e-05
GO:0019226transmission of nerve impulse5.52398222233686e-05
GO:0005891voltage-gated calcium channel complex9.62884579184354e-05
GO:0044456synapse part0.000100003913961408
GO:0022836gated channel activity0.000100003913961408
GO:0007268synaptic transmission0.000195909142086055
GO:0005245voltage-gated calcium channel activity0.000735829937860229
GO:0005216ion channel activity0.000774514386210364
GO:0045211postsynaptic membrane0.000774514386210364
GO:0022838substrate specific channel activity0.000774514386210364
GO:0022843voltage-gated cation channel activity0.000774514386210364
GO:0022803passive transmembrane transporter activity0.000774514386210364
GO:0015267channel activity0.000774514386210364
GO:0005509calcium ion binding0.00232511436195309
GO:0022832voltage-gated channel activity0.00232511436195309
GO:0005244voltage-gated ion channel activity0.00232511436195309
GO:0007267cell-cell signaling0.00232511436195309
GO:0050808synapse organization and biogenesis0.00235257978902726
GO:0016079synaptic vesicle exocytosis0.00325202505564878
GO:0007154cell communication0.00325202505564878
GO:0005262calcium channel activity0.00336573353867295
GO:0007528neuromuscular junction development0.00483663614046024
GO:0005261cation channel activity0.00737641660664985
GO:0048489synaptic vesicle transport0.015006921745046
GO:0006816calcium ion transport0.015006921745046
GO:0046873metal ion transmembrane transporter activity0.0164919554253955
GO:0043062extracellular structure organization and biogenesis0.0166120175719292
GO:0005200structural constituent of cytoskeleton0.0166869234776399
GO:0006790sulfur metabolic process0.0166902838132157
GO:0005515protein binding0.0166902838132157
GO:0007215glutamate signaling pathway0.0168140216446291
GO:0044464cell part0.0192693977562345
GO:0008066glutamate receptor activity0.0194643442025702
GO:0006887exocytosis0.0305731989543396
GO:0006810transport0.0318329478143315
GO:0048172regulation of short-term neuronal synaptic plasticity0.0318329478143315
GO:0031557induction of programmed cell death in response to chemical stimulus0.0318329478143315
GO:0015674di-, tri-valent inorganic cation transport0.0318329478143315
GO:0015075ion transmembrane transporter activity0.0348655253979806
GO:0004970ionotropic glutamate receptor activity0.0399196833593958
GO:0006811ion transport0.0399196833593958
GO:0051234establishment of localization0.0399196833593958
GO:0005230extracellular ligand-gated ion channel activity0.0399196833593958
GO:0051179localization0.0414994901283276
GO:0005234extracellular-glutamate-gated ion channel activity0.0419511124508003
GO:0007269neurotransmitter secretion0.042722762846028
GO:0008081phosphoric diester hydrolase activity0.042722762846028
GO:0048741skeletal muscle fiber development0.0443533759491619
GO:0048747muscle fiber development0.0443533759491619
GO:0005856cytoskeleton0.0443533759491619
GO:0030001metal ion transport0.0443533759491619
GO:0006552leucine catabolic process0.0457689282451179
GO:0006768biotin metabolic process0.0457689282451179
GO:0016080synaptic vesicle targeting0.0457689282451179
GO:0004485methylcrotonoyl-CoA carboxylase activity0.0457689282451179



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
neural cell4.40e-0725
Uber Anatomy
Ontology termp-valuen
adult organism1.25e-48115
regional part of nervous system1.53e-3994
nervous system1.53e-3994
central nervous system7.00e-3882
neural tube3.67e-3457
neural rod3.67e-3457
future spinal cord3.67e-3457
neural keel3.67e-3457
neurectoderm7.81e-3290
neural plate3.05e-3186
presumptive neural plate3.05e-3186
brain5.61e-3169
future brain5.61e-3169
regional part of brain3.91e-2959
anterior neural tube3.26e-2642
regional part of forebrain5.94e-2641
forebrain5.94e-2641
future forebrain5.94e-2641
ectoderm2.97e-24173
presumptive ectoderm2.97e-24173
ectoderm-derived structure1.77e-23169
telencephalon6.34e-2234
gray matter6.55e-2234
brain grey matter6.55e-2234
pre-chordal neural plate2.10e-2161
regional part of telencephalon2.89e-2133
cerebral hemisphere7.92e-2132
anterior region of body9.33e-20129
craniocervical region9.33e-20129
head5.17e-19123
cerebral cortex1.50e-1625
pallium1.50e-1625
regional part of cerebral cortex5.37e-1622
neocortex8.69e-1520
organism subdivision2.96e-09365
posterior neural tube5.26e-0915
chordal neural plate5.26e-0915
tube3.88e-08194
multi-cellular organism4.32e-08659
segmental subdivision of nervous system7.10e-0813
segmental subdivision of hindbrain2.32e-0712
hindbrain2.32e-0712
presumptive hindbrain2.32e-0712
basal ganglion7.02e-079
nuclear complex of neuraxis7.02e-079
aggregate regional part of brain7.02e-079
collection of basal ganglia7.02e-079
cerebral subcortex7.02e-079
nucleus of brain8.21e-079
neural nucleus8.21e-079


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTBP2#1488124.918980418770837.36337494877413e-060.000211386343121226
CTCF#10664451.576545992080890.0008376231428620510.00631902076115066
RAD21#5885332.233438683333728.74177219459004e-060.00023597362270116
SUZ12#23512103.275541236017180.001075595966564580.00759579195023588
ZNF263#10127321.719600865257140.001484676973091750.00949529567622349



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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