MCL coexpression mm9:2272

Phase1 CAGE Peaks

	Short description
Mm9::chr19:60866520..60866575,-	p1@Eif3a
Mm9::chr1:187186955..187187029,+	p1@Eprs p1@LOC100504962
Mm9::chr7:133709878..133709930,-	p1@Eif3c
Mm9::chr8:82235530..82235594,-	p1@Abce1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0006412	translation	0.00376893364516052
GO:0003743	translation initiation factor activity	0.00376893364516052
GO:0009059	macromolecule biosynthetic process	0.00376893364516052
GO:0008135	translation factor activity, nucleic acid binding	0.00376893364516052
GO:0044249	cellular biosynthetic process	0.00376893364516052
GO:0005852	eukaryotic translation initiation factor 3 complex	0.00376893364516052
GO:0004827	proline-tRNA ligase activity	0.00376893364516052
GO:0006433	prolyl-tRNA aminoacylation	0.00376893364516052
GO:0006424	glutamyl-tRNA aminoacylation	0.00376893364516052
GO:0004818	glutamate-tRNA ligase activity	0.00376893364516052
GO:0043022	ribosome binding	0.00660666148335938
GO:0009058	biosynthetic process	0.00660666148335938
GO:0043021	ribonucleoprotein binding	0.0231667648280763
GO:0051536	iron-sulfur cluster binding	0.0376124820187361
GO:0051540	metal cluster binding	0.0376124820187361
GO:0006413	translational initiation	0.0376124820187361
GO:0043038	amino acid activation	0.0376124820187361
GO:0043039	tRNA aminoacylation	0.0376124820187361
GO:0006418	tRNA aminoacylation for protein translation	0.0376124820187361
GO:0044267	cellular protein metabolic process	0.0376124820187361
GO:0016875	ligase activity, forming carbon-oxygen bonds	0.0376124820187361
GO:0016876	ligase activity, forming aminoacyl-tRNA and related compounds	0.0376124820187361
GO:0004812	aminoacyl-tRNA ligase activity	0.0376124820187361
GO:0044260	cellular macromolecule metabolic process	0.0376124820187361
GO:0010467	gene expression	0.0376124820187361
GO:0019538	protein metabolic process	0.0386103724222805
GO:0022618	protein-RNA complex assembly	0.0485841810583763

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
organism subdivision	3.31e-11	150
viscus	8.14e-08	19
endocrine system	8.69e-08	72
surface structure	1.94e-07	22
foregut	2.65e-07	80
exocrine gland	3.98e-07	25
exocrine system	3.98e-07	25
pancreas	8.25e-07	12

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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