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UBERON:0002062

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Name:endocardial cushion
Definition:"The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves[GO]. Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves[ZFA]." [GO:0003197, Wikipedia:Endocardial_cushion, ZFIN:curator]
Xrefs:
links:

EHDAA:2586
EHDAA2:0000434
EHDAA2:0004028
EMAPA:16696
FMA:70302
[ 200px-Gray465.png 200px-Gray465.png]
MA:0000078
TAO:0001317
VHOG:0000932
XAO:0004189

ZFA:0001317
Synonyms: "atrioventricular cushion" RELATED [Wikipedia:Endocardial_cushion]
"cardiac cushion" EXACT [PMID:15797462]
"endocardial cushion tissue" EXACT [EHDAA2:0000434]
"endocardial cushions" RELATED []
Comments:GO graph seems to suggest this is an endothelium. WP: The endocardial cushions are thought to arise from a subset of endothelial cells that undergo epithelial to mesenchymal transformation, a process whereby these cells break cell-to-cell contacts and migrate into the cardiac jelly (towards to interior of the heart tube). Latest (2010-06-01) new def suggested for GO, added above. Note that EHDAA2 has a more detailed model which we may later adopt
Alt_id: UBERON:FMA_70302-MA_0000078-ZFA_0001317
Subset: uberon_slim
vertebrate_core

Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:UBERON:0003104(mesenchyme),UBERON:0004121(ectoderm-derived structure),UBERON:0005291(embryonic tissue),UBERON:0005423(developing anatomical structure),UBERON:0009751(cardiac mesenchyme)
develops_from:UBERON:0002342(neural crest)
part_of:UBERON:0000922(embryo),UBERON:0000948(heart),UBERON:0002165(endocardium)



Children

develops from:UBERON:0000946 (cardial valve),UBERON:0002133 (atrioventricular valve)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)

FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology



Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0002062 (endocardial cushion), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
5.41e-147FFCP PHASE1:Hg19::chr7:25815812..25815822,-#_762ae4977c5b9bd324fb358280f418bfp@chr7:25815812..25815822, -
5.41e-147FFCP PHASE2:Hg19::chr7:25815812..25815822,-#_762ae4977c5b9bd324fb358280f418bfp@chr7:25815812..25815822, -
8.98e-131FFCP PHASE2:Hg19::chr12:3373147..3373149,-#_635dfec0fe0be947f436d2464039a74cp@chr12:3373147..3373149, -
8.98e-131FFCP PHASE1:Hg19::chr12:3373147..3373149,-#_635dfec0fe0be947f436d2464039a74cp@chr12:3373147..3373149, -
7.78e-118FFCP PHASE1:Hg19::chr1:20355975..20355980,-#_9d4ffbe77040424cb79c5ff4438cf931p@chr1:20355975..20355980, -
7.78e-118FFCP PHASE2:Hg19::chr1:20355975..20355980,-#_9d4ffbe77040424cb79c5ff4438cf931p@chr1:20355975..20355980, -
5.69e-99FFCP PHASE1:Hg19::chr1:237331032..237331036,+#_835fa8341d0c262fdfd6e0626569968bp@chr1:237331032..237331036, +
5.69e-99FFCP PHASE2:Hg19::chr1:237331032..237331036,+#_835fa8341d0c262fdfd6e0626569968bp@chr1:237331032..237331036, +
1.52e-87FFCP PHASE1:Hg19::chr6:6739548..6739577,-#_614cf3e9e3ccaa6d6992f7bbe160d5e7p@chr6:6739548..6739577, -
1.52e-87FFCP PHASE1:Hg19::chr1:11907265..11907271,-#_614cf3e9e3ccaa6d6992f7bbe160d5e7p9@NPPA
1.52e-87FFCP PHASE2:Hg19::chr1:11907265..11907271,-#_614cf3e9e3ccaa6d6992f7bbe160d5e7p9@NPPA
1.52e-87FFCP PHASE2:Hg19::chr6:6739548..6739577,-#_614cf3e9e3ccaa6d6992f7bbe160d5e7p@chr6:6739548..6739577, -
1.52e-87FFCP PHASE1:Hg19::chr2:18116344..18116353,+#_614cf3e9e3ccaa6d6992f7bbe160d5e7p@chr2:18116344..18116353, +
1.52e-87FFCP PHASE2:Hg19::chr2:18116344..18116353,+#_614cf3e9e3ccaa6d6992f7bbe160d5e7p@chr2:18116344..18116353, +
7.21e-85FFCP PHASE1:Hg19::chrX:112324334..112324339,-#_1838e9c018ff4fd86f1a9025a8b8f460p@chrX:112324334..112324339, -
7.21e-85FFCP PHASE2:Hg19::chrX:112324334..112324339,-#_1838e9c018ff4fd86f1a9025a8b8f460p@chrX:112324334..112324339, -
1.71e-84FFCP PHASE1:Hg19::chr2:220491902..220491915,+#_b6923c5d443c2311ba1de622c00a817dp11@SLC4A3
1.71e-84FFCP PHASE2:Hg19::chr2:220491902..220491915,+#_b6923c5d443c2311ba1de622c00a817dp11@SLC4A3
2.27e-84FFCP PHASE1:Hg19::chr2:179533457..179533461,-#_3712d16c33f17b194ef04727d80c5105p@chr2:179533457..179533461, -
2.27e-84FFCP PHASE2:Hg19::chr2:179533457..179533461,-#_3712d16c33f17b194ef04727d80c5105p@chr2:179533457..179533461, -
3.03e-84FFCP PHASE1:Hg19::chr2:179398102..179398109,-#_6d355795341c965d833156528609129cp@chr2:179398102..179398109, -
3.03e-84FFCP PHASE2:Hg19::chr2:179398102..179398109,-#_6d355795341c965d833156528609129cp@chr2:179398102..179398109, -
7.81e-75FFCP PHASE2:Hg19::chr5:123739302..123739319,-#_34e1c5ae416c19fc71c6f5e25c3eb0a7p@chr5:123739302..123739319, -
7.81e-75FFCP PHASE1:Hg19::chr5:123739302..123739319,-#_34e1c5ae416c19fc71c6f5e25c3eb0a7p@chr5:123739302..123739319, -
1.01e-74FFCP PHASE1:Hg19::chr18:64271475..64271484,-#_9cf5a366e88a7fe3a00e0a2f8700b81ep6@CDH19
1.01e-74FFCP PHASE2:Hg19::chr18:64271475..64271484,-#_9cf5a366e88a7fe3a00e0a2f8700b81ep6@CDH19
1.29e-74FFCP PHASE2:Hg19::chr7:35286774..35286778,-#_81f4a059026a07aacc21db93a7efefe7p@chr7:35286774..35286778, -
1.29e-74FFCP PHASE1:Hg19::chr7:35286774..35286778,-#_81f4a059026a07aacc21db93a7efefe7p@chr7:35286774..35286778, -
1.66e-74FFCP PHASE2:Hg19::chr6:129355052..129355056,+#_ad0d0bce36c8d290d1ce627c25061ca2p@chr6:129355052..129355056, +
1.66e-74FFCP PHASE1:Hg19::chr6:129355052..129355056,+#_ad0d0bce36c8d290d1ce627c25061ca2p@chr6:129355052..129355056, +
2.75e-74FFCP PHASE2:Hg19::chr3:16940540..16940554,+#_f4cf4c24f5f8a8d9a052066bdba31cb3p@chr3:16940540..16940554, +
2.75e-74FFCP PHASE1:Hg19::chr3:16940540..16940554,+#_f4cf4c24f5f8a8d9a052066bdba31cb3p@chr3:16940540..16940554, +
3.54e-74FFCP PHASE1:Hg19::chr3:131523446..131523459,-#_2d4de84d93e740177f9bae24c7ae3cafp@chr3:131523446..131523459, -
3.54e-74FFCP PHASE2:Hg19::chr1:201328779..201328797,-#_2d4de84d93e740177f9bae24c7ae3cafp@chr1:201328779..201328797, -
3.54e-74FFCP PHASE1:Hg19::chr20:33565465..33565475,+#_2d4de84d93e740177f9bae24c7ae3cafp9@MYH7B
3.54e-74FFCP PHASE2:Hg19::chr3:131523446..131523459,-#_2d4de84d93e740177f9bae24c7ae3cafp@chr3:131523446..131523459, -
3.54e-74FFCP PHASE1:Hg19::chr19:55661803..55661807,-#_2d4de84d93e740177f9bae24c7ae3cafp@chr19:55661803..55661807, -
3.54e-74FFCP PHASE2:Hg19::chr20:33565465..33565475,+#_2d4de84d93e740177f9bae24c7ae3cafp9@MYH7B
3.54e-74FFCP PHASE2:Hg19::chr19:55661803..55661807,-#_2d4de84d93e740177f9bae24c7ae3cafp@chr19:55661803..55661807, -
3.54e-74FFCP PHASE1:Hg19::chr1:201328779..201328797,-#_2d4de84d93e740177f9bae24c7ae3cafp@chr1:201328779..201328797, -
5.84e-74FFCP PHASE1:Hg19::chr6:36812121..36812130,-#_4585aca20afb02706bb3f0ed71ac21d6p@chr6:36812121..36812130, -
5.84e-74FFCP PHASE2:Hg19::chr6:36812121..36812130,-#_4585aca20afb02706bb3f0ed71ac21d6p@chr6:36812121..36812130, -
7.51e-74FFCP PHASE2:Hg19::chr14:105939326..105939337,+#_c6336d4cc8876434a4bcc8abd2610fafp16@CRIP2
7.51e-74FFCP PHASE1:Hg19::chr14:105939326..105939337,+#_c6336d4cc8876434a4bcc8abd2610fafp16@CRIP2
9.64e-74FFCP PHASE1:Hg19::chr1:206838422..206838456,+#_9c84b2e6afc7cd2e0ab422820dbb961bp@chr1:206838422..206838456, +
9.64e-74FFCP PHASE2:Hg19::chr1:206838422..206838456,+#_9c84b2e6afc7cd2e0ab422820dbb961bp@chr1:206838422..206838456, +
1.24e-73FFCP PHASE2:Hg19::chr1:231983543..231983554,-#_f3429bb285901c3571949a3976ea4396p@chr1:231983543..231983554, -
1.24e-73FFCP PHASE1:Hg19::chr1:231983543..231983554,-#_f3429bb285901c3571949a3976ea4396p@chr1:231983543..231983554, -
1.54e-66FFCP PHASE1:Hg19::chr1:201328328..201328343,-#_32adff27e8827c4cf61244dfd8d4515bp@chr1:201328328..201328343, -
1.54e-66FFCP PHASE2:Hg19::chr1:201328328..201328343,-#_32adff27e8827c4cf61244dfd8d4515bp@chr1:201328328..201328343, -
1.71e-66FFCP PHASE1:Hg19::chr1:237214095..237214115,+#_d0c121113f34d1b688fcb2a4a7fdbc5ap@chr1:237214095..237214115, +
1.71e-66FFCP PHASE2:Hg19::chr1:237214095..237214115,+#_d0c121113f34d1b688fcb2a4a7fdbc5ap@chr1:237214095..237214115, +
1.71e-66FFCP PHASE1:Hg19::chr11:47367243..47367257,-#_d0c121113f34d1b688fcb2a4a7fdbc5ap@chr11:47367243..47367257, -
1.71e-66FFCP PHASE2:Hg19::chr11:47367243..47367257,-#_d0c121113f34d1b688fcb2a4a7fdbc5ap@chr11:47367243..47367257, -
2.39e-66FFCP PHASE1:Hg19::chr15:86272097..86272099,+#_320cfe93e3aa96f2b04e0462a6d0a775p@chr15:86272097..86272099, +
2.39e-66FFCP PHASE1:Hg19::chr10:92678409..92678410,-#_320cfe93e3aa96f2b04e0462a6d0a775p@chr10:92678409..92678410, -
2.39e-66FFCP PHASE2:Hg19::chr15:86272097..86272099,+#_320cfe93e3aa96f2b04e0462a6d0a775p@chr15:86272097..86272099, +
2.39e-66FFCP PHASE1:Hg19::chr5:99390735..99390743,-#_320cfe93e3aa96f2b04e0462a6d0a775p@chr5:99390735..99390743, -
2.39e-66FFCP PHASE2:Hg19::chr5:99390735..99390743,-#_320cfe93e3aa96f2b04e0462a6d0a775p@chr5:99390735..99390743, -
2.39e-66FFCP PHASE2:Hg19::chr10:92678409..92678410,-#_320cfe93e3aa96f2b04e0462a6d0a775p@chr10:92678409..92678410, -
2.4e-66FFCP PHASE2:Hg19::chr1:237996521..237996532,+#_eed72d0370f737c0be448fbbd6c789bap@chr1:237996521..237996532, +
2.4e-66FFCP PHASE1:Hg19::chr12:4735761..4735787,-#_eed72d0370f737c0be448fbbd6c789bap@chr12:4735761..4735787, -
2.4e-66FFCP PHASE2:Hg19::chr12:114886577..114886589,-#_eed72d0370f737c0be448fbbd6c789bap@chr12:114886577..114886589, -
2.4e-66FFCP PHASE1:Hg19::chr2:159976509..159976519,+#_eed72d0370f737c0be448fbbd6c789bap@chr2:159976509..159976519, +
2.4e-66FFCP PHASE2:Hg19::chr12:4735761..4735787,-#_eed72d0370f737c0be448fbbd6c789bap@chr12:4735761..4735787, -
2.4e-66FFCP PHASE1:Hg19::chr12:114886577..114886589,-#_eed72d0370f737c0be448fbbd6c789bap@chr12:114886577..114886589, -
2.4e-66FFCP PHASE1:Hg19::chr1:237996521..237996532,+#_eed72d0370f737c0be448fbbd6c789bap@chr1:237996521..237996532, +
2.4e-66FFCP PHASE2:Hg19::chr2:159976509..159976519,+#_eed72d0370f737c0be448fbbd6c789bap@chr2:159976509..159976519, +
2.41e-66FFCP PHASE1:Hg19::chr1:237207955..237207959,+#_adc1ad9f0cbb8957437efc6d203881c8p@chr1:237207955..237207959, +
2.41e-66FFCP PHASE1:Hg19::chr2:40480968..40480972,-#_adc1ad9f0cbb8957437efc6d203881c8p@chr2:40480968..40480972, -
2.41e-66FFCP PHASE2:Hg19::chr2:40480968..40480972,-#_adc1ad9f0cbb8957437efc6d203881c8p@chr2:40480968..40480972, -
2.41e-66FFCP PHASE2:Hg19::chr1:237207955..237207959,+#_adc1ad9f0cbb8957437efc6d203881c8p@chr1:237207955..237207959, +
3.01e-66FFCP PHASE1:Hg19::chr4:62999501..62999517,+#_bad1e60ac900d5e49fab32830b452cf9p@chr4:62999501..62999517, +
3.01e-66FFCP PHASE2:Hg19::chr4:62999501..62999517,+#_bad1e60ac900d5e49fab32830b452cf9p@chr4:62999501..62999517, +
3.35e-66FFCP PHASE2:Hg19::chr7:44178491..44178498,-#_00f976b9b63b66ea4f46f7ebebd1e975p@chr7:44178491..44178498, -
3.35e-66FFCP PHASE1:Hg19::chr9:38650254..38650266,+#_00f976b9b63b66ea4f46f7ebebd1e975p@chr9:38650254..38650266, +
3.35e-66FFCP PHASE1:Hg19::chr7:44179972..44179982,-#_00f976b9b63b66ea4f46f7ebebd1e975p2@MYL7
3.35e-66FFCP PHASE1:Hg19::chr5:65736120..65736128,-#_00f976b9b63b66ea4f46f7ebebd1e975p@chr5:65736120..65736128, -
3.35e-66FFCP PHASE1:Hg19::chr1:11905830..11905839,-#_00f976b9b63b66ea4f46f7ebebd1e975p@chr1:11905830..11905839, -
3.35e-66FFCP PHASE2:Hg19::chr9:38650254..38650266,+#_00f976b9b63b66ea4f46f7ebebd1e975p@chr9:38650254..38650266, +
3.35e-66FFCP PHASE2:Hg19::chr7:44179972..44179982,-#_00f976b9b63b66ea4f46f7ebebd1e975p2@MYL7
3.35e-66FFCP PHASE2:Hg19::chr1:11905830..11905839,-#_00f976b9b63b66ea4f46f7ebebd1e975p@chr1:11905830..11905839, -
3.35e-66FFCP PHASE2:Hg19::chr5:65736120..65736128,-#_00f976b9b63b66ea4f46f7ebebd1e975p@chr5:65736120..65736128, -
3.35e-66FFCP PHASE1:Hg19::chr7:35253487..35253489,-#_00f976b9b63b66ea4f46f7ebebd1e975p@chr7:35253487..35253489, -
3.35e-66FFCP PHASE1:Hg19::chr7:44178491..44178498,-#_00f976b9b63b66ea4f46f7ebebd1e975p@chr7:44178491..44178498, -
3.35e-66FFCP PHASE2:Hg19::chr7:35253487..35253489,-#_00f976b9b63b66ea4f46f7ebebd1e975p@chr7:35253487..35253489, -
4.68e-66FFCP PHASE2:Hg19::chr10:112524543..112524547,+#_2b43ebfc718e686002f1d658707ef529p@chr10:112524543..112524547, +
4.68e-66FFCP PHASE1:Hg19::chr7:44180643..44180652,-#_2b43ebfc718e686002f1d658707ef529p3@MYL7
4.68e-66FFCP PHASE2:Hg19::chr7:44180643..44180652,-#_2b43ebfc718e686002f1d658707ef529p3@MYL7
4.68e-66FFCP PHASE1:Hg19::chr10:112524543..112524547,+#_2b43ebfc718e686002f1d658707ef529p@chr10:112524543..112524547, +
5.88e-66FFCP PHASE2:Hg19::chr6:36812225..36812238,-#_6383d00ed1700d11123d76136b0502d9p@chr6:36812225..36812238, -
5.88e-66FFCP PHASE1:Hg19::chr6:36812225..36812238,-#_6383d00ed1700d11123d76136b0502d9p@chr6:36812225..36812238, -
6.53e-66FFCP PHASE1:Hg19::chr2:168104544..168104551,+#_6706794ff9487bb2342359a937f82663p52@XIRP2
6.53e-66FFCP PHASE2:Hg19::chr2:168104544..168104551,+#_6706794ff9487bb2342359a937f82663p52@XIRP2
6.53e-66FFCP PHASE1:Hg19::chr4:62999459..62999462,+#_6706794ff9487bb2342359a937f82663p@chr4:62999459..62999462, +
6.53e-66FFCP PHASE2:Hg19::chr4:62999459..62999462,+#_6706794ff9487bb2342359a937f82663p@chr4:62999459..62999462, +
1.15e-65FFCP PHASE2:Hg19::chr10:127569398..127569410,-#_11c3f3e32e63b6f00697e6018ad79c94p5@DHX32
1.15e-65FFCP PHASE2:Hg19::chr7:123302841..123302854,+#_11c3f3e32e63b6f00697e6018ad79c94p@chr7:123302841..123302854, +
1.15e-65FFCP PHASE1:Hg19::chr10:127569398..127569410,-#_11c3f3e32e63b6f00697e6018ad79c94p5@DHX32
1.15e-65FFCP PHASE1:Hg19::chrX:121555838..121555874,+#_11c3f3e32e63b6f00697e6018ad79c94p@chrX:121555838..121555874, +

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