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CL:0000453

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Name:Langerhans cell
Namespace:cell
Definition:"Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus." [GO_REF:0000031, GOC:add, GOC:amm, ISBN:0721601464, ISBN:0781735149, PMCID:PMC2346585, PMID:17850486]
Xrefs:
links:

BTO:0000705

FMA:63072
Synonyms: "Langerhans' cell" EXACT []
"LC" EXACT []
Comments:Originally described in the dendritic cell ontology (DC_CL:0000021 )(PMID: 19243617). These cells are also CD1a-high, CD14-negative, CD207-positive (langerin), CD324-positive (E-cadherin), and DCIR-positive. They reside in the epidermis.


Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:CL:0000990(conventional dendritic cell)
develops_from:CL:0000763(myeloid cell)



Children


is a:CL:0001014 (CD1a-positive Langerhans cell),FF:10457-106G7 (squamous cell lung carcinoma cell line:LC-1F),FF:10501-107C6 (squamous cell lung carcinoma cell line:RERF-LC-AI)
derives from:FF:0011136 (human migratory langerhans cells sample)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)


FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.

Human (Homo sapiens)

Mouse (Mus musculus)


Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000453 (Langerhans cell), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
2.45e-195FFCP PHASE2:Hg19::chr3:119188705..119188718,+#_d47dca2e8d01064a77a7d1ddb1ceff04p@chr3:119188705..119188718, +
2.45e-195FFCP PHASE1:Hg19::chr19:45487650..45487661,+#_d47dca2e8d01064a77a7d1ddb1ceff04p@chr19:45487650..45487661, +
2.45e-195FFCP PHASE1:Hg19::chr16:10959868..10959879,+#_d47dca2e8d01064a77a7d1ddb1ceff04p2@AB463580
2.45e-195FFCP PHASE2:Hg19::chr3:52813932..52813943,+#_d47dca2e8d01064a77a7d1ddb1ceff04p11@ITIH1
2.45e-195FFCP PHASE2:Hg19::chr13:75884392..75884395,-#_d47dca2e8d01064a77a7d1ddb1ceff04p@chr13:75884392..75884395, -
2.45e-195FFCP PHASE2:Hg19::chr16:10959868..10959879,+#_d47dca2e8d01064a77a7d1ddb1ceff04p2@AB463580
2.45e-195FFCP PHASE1:Hg19::chr16:10959880..10959887,+#_d47dca2e8d01064a77a7d1ddb1ceff04p6@AB463580
2.45e-195FFCP PHASE1:Hg19::chr16:10885979..10885991,+#_d47dca2e8d01064a77a7d1ddb1ceff04p@chr16:10885979..10885991, +
2.45e-195FFCP PHASE2:Hg19::chr6:32729529..32729536,-#_d47dca2e8d01064a77a7d1ddb1ceff04p3@M95729
2.45e-195FFCP PHASE2:Hg19::chr16:10959880..10959887,+#_d47dca2e8d01064a77a7d1ddb1ceff04p6@AB463580
2.45e-195FFCP PHASE2:Hg19::chr16:10885979..10885991,+#_d47dca2e8d01064a77a7d1ddb1ceff04p@chr16:10885979..10885991, +
2.45e-195FFCP PHASE1:Hg19::chr6:32726761..32726781,-#_d47dca2e8d01064a77a7d1ddb1ceff04p@chr6:32726761..32726781, -
2.45e-195FFCP PHASE2:Hg19::chr1:201376546..201376550,+#_d47dca2e8d01064a77a7d1ddb1ceff04p@chr1:201376546..201376550, +
2.45e-195FFCP PHASE2:Hg19::chr8:120974832..120974840,+#_d47dca2e8d01064a77a7d1ddb1ceff04p@chr8:120974832..120974840, +
2.45e-195FFCP PHASE1:Hg19::chr3:119188705..119188718,+#_d47dca2e8d01064a77a7d1ddb1ceff04p@chr3:119188705..119188718, +
2.45e-195FFCP PHASE1:Hg19::chr3:52813932..52813943,+#_d47dca2e8d01064a77a7d1ddb1ceff04p11@ITIH1
2.45e-195FFCP PHASE2:Hg19::chr19:45487650..45487661,+#_d47dca2e8d01064a77a7d1ddb1ceff04p@chr19:45487650..45487661, +
2.45e-195FFCP PHASE1:Hg19::chr16:10959804..10959811,+#_d47dca2e8d01064a77a7d1ddb1ceff04p5@AB463580
2.45e-195FFCP PHASE1:Hg19::chr13:75884392..75884395,-#_d47dca2e8d01064a77a7d1ddb1ceff04p@chr13:75884392..75884395, -
2.45e-195FFCP PHASE1:Hg19::chr6:32729529..32729536,-#_d47dca2e8d01064a77a7d1ddb1ceff04p3@M95729
2.45e-195FFCP PHASE1:Hg19::chr8:120974832..120974840,+#_d47dca2e8d01064a77a7d1ddb1ceff04p@chr8:120974832..120974840, +
2.45e-195FFCP PHASE2:Hg19::chr6:32726761..32726781,-#_d47dca2e8d01064a77a7d1ddb1ceff04p@chr6:32726761..32726781, -
2.45e-195FFCP PHASE2:Hg19::chr16:10959804..10959811,+#_d47dca2e8d01064a77a7d1ddb1ceff04p5@AB463580
2.45e-195FFCP PHASE1:Hg19::chr1:201376546..201376550,+#_d47dca2e8d01064a77a7d1ddb1ceff04p@chr1:201376546..201376550, +
2.34e-163FFCP PHASE2:Hg19::chr13:75884255..75884262,-#_5f832a398139202c420820cc3c4f60ffp@chr13:75884255..75884262, -
2.34e-163FFCP PHASE2:Hg19::chr2:173867941..173867955,+#_5f832a398139202c420820cc3c4f60ffp@chr2:173867941..173867955, +
2.34e-163FFCP PHASE1:Hg19::chr2:173867941..173867955,+#_5f832a398139202c420820cc3c4f60ffp@chr2:173867941..173867955, +
2.34e-163FFCP PHASE1:Hg19::chr13:75884255..75884262,-#_5f832a398139202c420820cc3c4f60ffp@chr13:75884255..75884262, -
1.5e-156FFCP PHASE1:Hg19::chr2:71056842..71056868,+#_87b3c6e0e65bd78c3cfb363906c5012fp@chr2:71056842..71056868, +
1.5e-156FFCP PHASE1:Hg19::chr3:52813997..52814015,+#_87b3c6e0e65bd78c3cfb363906c5012fp9@ITIH1
1.5e-156FFCP PHASE1:Hg19::chr14:65641128..65641129,-#_87b3c6e0e65bd78c3cfb363906c5012fp@chr14:65641128..65641129, -
1.5e-156FFCP PHASE1:Hg19::chr16:10870586..10870591,-#_87b3c6e0e65bd78c3cfb363906c5012fp@chr16:10870586..10870591, -
1.5e-156FFCP PHASE2:Hg19::chr6:32729494..32729506,-#_87b3c6e0e65bd78c3cfb363906c5012fp1@M95729
1.5e-156FFCP PHASE2:Hg19::chr14:65641128..65641129,-#_87b3c6e0e65bd78c3cfb363906c5012fp@chr14:65641128..65641129, -
1.5e-156FFCP PHASE2:Hg19::chr16:10870586..10870591,-#_87b3c6e0e65bd78c3cfb363906c5012fp@chr16:10870586..10870591, -
1.5e-156FFCP PHASE1:Hg19::chr12:112513578..112513587,-#_87b3c6e0e65bd78c3cfb363906c5012fp@chr12:112513578..112513587, -
1.5e-156FFCP PHASE1:Hg19::chr4:14845952..14845956,-#_87b3c6e0e65bd78c3cfb363906c5012fp@chr4:14845952..14845956, -
1.5e-156FFCP PHASE1:Hg19::chr10:112109413..112109419,-#_87b3c6e0e65bd78c3cfb363906c5012fp@chr10:112109413..112109419, -
1.5e-156FFCP PHASE2:Hg19::chr12:112513578..112513587,-#_87b3c6e0e65bd78c3cfb363906c5012fp@chr12:112513578..112513587, -
1.5e-156FFCP PHASE1:Hg19::chr18:22537624..22537627,-#_87b3c6e0e65bd78c3cfb363906c5012fp@chr18:22537624..22537627, -
1.5e-156FFCP PHASE2:Hg19::chr3:52813951..52813958,+#_87b3c6e0e65bd78c3cfb363906c5012fp13@ITIH1
1.5e-156FFCP PHASE2:Hg19::chr10:112109413..112109419,-#_87b3c6e0e65bd78c3cfb363906c5012fp@chr10:112109413..112109419, -
1.5e-156FFCP PHASE2:Hg19::chr18:22537624..22537627,-#_87b3c6e0e65bd78c3cfb363906c5012fp@chr18:22537624..22537627, -
1.5e-156FFCP PHASE2:Hg19::chr3:52813997..52814015,+#_87b3c6e0e65bd78c3cfb363906c5012fp9@ITIH1
1.5e-156FFCP PHASE1:Hg19::chr12:95264953..95264971,-#_87b3c6e0e65bd78c3cfb363906c5012fp@chr12:95264953..95264971, -
1.5e-156FFCP PHASE1:Hg19::chr13:32672504..32672512,-#_87b3c6e0e65bd78c3cfb363906c5012fp@chr13:32672504..32672512, -
1.5e-156FFCP PHASE2:Hg19::chr12:95264953..95264971,-#_87b3c6e0e65bd78c3cfb363906c5012fp@chr12:95264953..95264971, -
1.5e-156FFCP PHASE1:Hg19::chr6:32729494..32729506,-#_87b3c6e0e65bd78c3cfb363906c5012fp1@M95729
1.5e-156FFCP PHASE2:Hg19::chr2:71056842..71056868,+#_87b3c6e0e65bd78c3cfb363906c5012fp@chr2:71056842..71056868, +
1.5e-156FFCP PHASE2:Hg19::chr13:32672504..32672512,-#_87b3c6e0e65bd78c3cfb363906c5012fp@chr13:32672504..32672512, -
1.5e-156FFCP PHASE2:Hg19::chr4:14845952..14845956,-#_87b3c6e0e65bd78c3cfb363906c5012fp@chr4:14845952..14845956, -
1.5e-156FFCP PHASE1:Hg19::chr3:52813951..52813958,+#_87b3c6e0e65bd78c3cfb363906c5012fp13@ITIH1
1.5e-156FFCP PHASE1:Hg19::chr12:112590221..112590232,+#_87b3c6e0e65bd78c3cfb363906c5012fp@chr12:112590221..112590232, +
1.5e-156FFCP PHASE2:Hg19::chr12:112590221..112590232,+#_87b3c6e0e65bd78c3cfb363906c5012fp@chr12:112590221..112590232, +
1.65e-140FFCP PHASE2:Hg19::chr6:32731327..32731340,-#_5946a585098cbbea1410fea50db91d4dp3@HLA-DQB2
1.65e-140FFCP PHASE1:Hg19::chr13:75884448..75884459,-#_5946a585098cbbea1410fea50db91d4dp@chr13:75884448..75884459, -
1.65e-140FFCP PHASE2:Hg19::chr6:32782930..32782943,-#_5946a585098cbbea1410fea50db91d4dp@chr6:32782930..32782943, -
1.65e-140FFCP PHASE2:Hg19::chr13:75884448..75884459,-#_5946a585098cbbea1410fea50db91d4dp@chr13:75884448..75884459, -
1.65e-140FFCP PHASE1:Hg19::chr6:32731327..32731340,-#_5946a585098cbbea1410fea50db91d4dp3@HLA-DQB2
1.65e-140FFCP PHASE1:Hg19::chr6:32782930..32782943,-#_5946a585098cbbea1410fea50db91d4dp@chr6:32782930..32782943, -
2.94e-140FFCP PHASE1:Hg19::chr4:103478257..103478273,+#_9b2a26dee728aeff7f293d70838be27cp28@NFKB1
2.94e-140FFCP PHASE2:Hg19::chr19:45487573..45487606,+#_9b2a26dee728aeff7f293d70838be27cp@chr19:45487573..45487606, +
2.94e-140FFCP PHASE2:Hg19::chr4:103478257..103478273,+#_9b2a26dee728aeff7f293d70838be27cp28@NFKB1
2.94e-140FFCP PHASE1:Hg19::chr19:45487573..45487606,+#_9b2a26dee728aeff7f293d70838be27cp@chr19:45487573..45487606, +
9.01e-126FFCP PHASE1:Hg19::chr18:53548086..53548099,-#_847765afb00b16102bfb169d40dc523fp@chr18:53548086..53548099, -
9.01e-126FFCP PHASE2:Hg19::chr18:53548086..53548099,-#_847765afb00b16102bfb169d40dc523fp@chr18:53548086..53548099, -
9.01e-126FFCP PHASE1:Hg19::chr11:64784128..64784143,+#_847765afb00b16102bfb169d40dc523fp@chr11:64784128..64784143, +
9.01e-126FFCP PHASE2:Hg19::chr11:64784128..64784143,+#_847765afb00b16102bfb169d40dc523fp@chr11:64784128..64784143, +
9.01e-126FFCP PHASE1:Hg19::chr16:10869031..10869038,-#_847765afb00b16102bfb169d40dc523fp12@FAM18A
9.01e-126FFCP PHASE2:Hg19::chr16:10869031..10869038,-#_847765afb00b16102bfb169d40dc523fp12@FAM18A
1.24e-125FFCP PHASE1:Hg19::chr1:156123108..156123151,+#_cfab44c5edd791d47bb0f4290612ab07p18@SEMA4A
1.24e-125FFCP PHASE2:Hg19::chr1:25194616..25194628,-#_cfab44c5edd791d47bb0f4290612ab07p@chr1:25194616..25194628, -
1.24e-125FFCP PHASE2:Hg19::chr1:156123108..156123151,+#_cfab44c5edd791d47bb0f4290612ab07p18@SEMA4A
1.24e-125FFCP PHASE1:Hg19::chr1:25194616..25194628,-#_cfab44c5edd791d47bb0f4290612ab07p@chr1:25194616..25194628, -
3.26e-125FFCP PHASE2:Hg19::chr6:169770365..169770377,-#_d117976080631f3c0c288b34dc7f9c50p@chr6:169770365..169770377, -
3.26e-125FFCP PHASE1:Hg19::chr6:169770365..169770377,-#_d117976080631f3c0c288b34dc7f9c50p@chr6:169770365..169770377, -
2.28e-123FFCP PHASE1:Hg19::chr6:32731284..32731295,-#_8b02fa52da416350fe727541add822bdp2@HLA-DQB2
2.28e-123FFCP PHASE1:Hg19::chr13:75884363..75884374,-#_8b02fa52da416350fe727541add822bdp@chr13:75884363..75884374, -
2.28e-123FFCP PHASE2:Hg19::chr13:75884363..75884374,-#_8b02fa52da416350fe727541add822bdp@chr13:75884363..75884374, -
2.28e-123FFCP PHASE1:Hg19::chr13:75884379..75884384,-#_8b02fa52da416350fe727541add822bdp@chr13:75884379..75884384, -
2.28e-123FFCP PHASE2:Hg19::chr6:32731284..32731295,-#_8b02fa52da416350fe727541add822bdp2@HLA-DQB2
2.28e-123FFCP PHASE2:Hg19::chr13:75884379..75884384,-#_8b02fa52da416350fe727541add822bdp@chr13:75884379..75884384, -
2.94e-123FFCP PHASE1:Hg19::chr16:66528108..66528115,+#_da7ea1bab7563d0a270810d705df69ecp@chr16:66528108..66528115, +
2.94e-123FFCP PHASE2:Hg19::chr16:66528108..66528115,+#_da7ea1bab7563d0a270810d705df69ecp@chr16:66528108..66528115, +
4.86e-123FFCP PHASE1:Hg19::chr17:4643317..4643359,-#_62f083e4e8ae916ad5ed26f15aa8e870p15@CXCL16
4.86e-123FFCP PHASE2:Hg19::chr17:4643317..4643359,-#_62f083e4e8ae916ad5ed26f15aa8e870p15@CXCL16
8.05e-123FFCP PHASE1:Hg19::chr12:131576196..131576201,+#_8aea782a80f9eaf3493a99a185e47117p9@GPR133
8.05e-123FFCP PHASE2:Hg19::chr12:131576196..131576201,+#_8aea782a80f9eaf3493a99a185e47117p9@GPR133
4.68e-122FFCP PHASE1:Hg19::chr15:101535004..101535045,+#_96698fcce1521d07e708631d9895f840p@chr15:101535004..101535045, +
4.68e-122FFCP PHASE2:Hg19::chr15:101535004..101535045,+#_96698fcce1521d07e708631d9895f840p@chr15:101535004..101535045, +
7.76e-118FFCP PHASE1:Hg19::chr16:10850527..10850548,+#_f67b6e4f003f65ceb025aff6bde3772ep@chr16:10850527..10850548, +
7.76e-118FFCP PHASE2:Hg19::chr20:20406322..20406332,-#_f67b6e4f003f65ceb025aff6bde3772ep@chr20:20406322..20406332, -
7.76e-118FFCP PHASE2:Hg19::chr1:66779048..66779059,-#_f67b6e4f003f65ceb025aff6bde3772ep@chr1:66779048..66779059, -
7.76e-118FFCP PHASE2:Hg19::chr6:6862008..6862024,-#_f67b6e4f003f65ceb025aff6bde3772ep@chr6:6862008..6862024, -
7.76e-118FFCP PHASE1:Hg19::chr6:32729634..32729642,-#_f67b6e4f003f65ceb025aff6bde3772ep2@M95729
7.76e-118FFCP PHASE2:Hg19::chr1:101610610..101610659,-#_f67b6e4f003f65ceb025aff6bde3772ep@chr1:101610610..101610659, -
7.76e-118FFCP PHASE2:Hg19::chr13:51382017..51382022,+#_f67b6e4f003f65ceb025aff6bde3772ep3@DLEU7-AS1
7.76e-118FFCP PHASE1:Hg19::chr13:51382041..51382048,+#_f67b6e4f003f65ceb025aff6bde3772ep2@DLEU7-AS1
7.76e-118FFCP PHASE1:Hg19::chr1:25197198..25197207,+#_f67b6e4f003f65ceb025aff6bde3772ep@chr1:25197198..25197207, +
7.76e-118FFCP PHASE1:Hg19::chr9:35227753..35227762,+#_f67b6e4f003f65ceb025aff6bde3772ep6@UNC13B

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