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UBERON:0004134

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Name:proximal tubule
Definition:"In mammals, the proximal tubule is a nephron tubule that connects Bowman's capsule to the loop of Henle. It has a brush border epithelial morphology[GO]." [GO:0072014]
Xrefs:
links:

BTO:0001498
EMAPA:28281
MA:0002611

MESH:A.05.810.453.736.560.570
Synonyms: "proximal kidney tubule" EXACT [MESH:A.05.810.453.736.560.570]
"renal proximal tubule" EXACT []
Comments:todo - ensure definition works across species.

Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:UBERON:0006853(renal cortex tubule),UBERON:0007685(region of nephron tubule)
part_of:UBERON:0001225(cortex of kidney),UBERON:0001231(nephron tubule)



Children

part of:CL:0002306 (epithelial cell of proximal tubule)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)

FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology

Human (Homo sapiens)

  • 11515-119H3 (Renal Proximal Tubular Epithelial Cell, donor1)
  • 11595-120H2 (Renal Proximal Tubular Epithelial Cell, donor2)
  • 11676-122H2 (Renal Proximal Tubular Epithelial Cell, donor3)


Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0004134 (proximal tubule), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
8.98e-131FFCP PHASE1:Hg19::chr5:167718782..167718785,+#_a8e05a71ad4e312b6f59f8f65b66ad1dp10@WWC1
8.98e-131FFCP PHASE2:Hg19::chr5:167718782..167718785,+#_a8e05a71ad4e312b6f59f8f65b66ad1dp10@WWC1
1.01e-74FFCP PHASE2:Hg19::chr3:149260147..149260154,-#_2f9104baa243103a488eda0a0c9efb87p39@WWTR1
1.01e-74FFCP PHASE1:Hg19::chr3:149260147..149260154,-#_2f9104baa243103a488eda0a0c9efb87p39@WWTR1
1.24e-73FFCP PHASE2:Hg19::chr17:46679250..46679298,+#_a95ac0c1d6533b1b18388fefc770ee52p1@ENST00000491264
1.24e-73FFCP PHASE1:Hg19::chr17:46679250..46679298,+#_a95ac0c1d6533b1b18388fefc770ee52p1@ENST00000491264
2.39e-66FFCP PHASE1:Hg19::chr8:6614884..6614885,+#_0bb7f79c09131bdf2fa9d1662e91db7dp@chr8:6614884..6614885, +
2.39e-66FFCP PHASE2:Hg19::chr3:123667850..123667851,+#_0bb7f79c09131bdf2fa9d1662e91db7dp@chr3:123667850..123667851, +
2.39e-66FFCP PHASE2:Hg19::chr8:6614884..6614885,+#_0bb7f79c09131bdf2fa9d1662e91db7dp@chr8:6614884..6614885, +
2.39e-66FFCP PHASE1:Hg19::chr3:123667850..123667851,+#_0bb7f79c09131bdf2fa9d1662e91db7dp@chr3:123667850..123667851, +
2.39e-66FFCP PHASE2:Hg19::chr16:61687533..61687551,-#_0bb7f79c09131bdf2fa9d1662e91db7dp@chr16:61687533..61687551, -
2.39e-66FFCP PHASE1:Hg19::chr16:61687533..61687551,-#_0bb7f79c09131bdf2fa9d1662e91db7dp@chr16:61687533..61687551, -
2.39e-66FFCP PHASE2:Hg19::chr16:62055187..62055188,+#_0bb7f79c09131bdf2fa9d1662e91db7dp@chr16:62055187..62055188, +
2.39e-66FFCP PHASE1:Hg19::chr16:62055187..62055188,+#_0bb7f79c09131bdf2fa9d1662e91db7dp@chr16:62055187..62055188, +
1.22e-59FFCP PHASE1:Hg19::chr15:66420804..66420837,-#_0ac78e7d05cc1f43df1b20f15053946ap4@MEGF11
1.22e-59FFCP PHASE2:Hg19::chr15:66420804..66420837,-#_0ac78e7d05cc1f43df1b20f15053946ap4@MEGF11
3.75e-53FFCP PHASE1:Hg19::chr9:114828174..114828179,+#_217034cd625f56be739eea2a102a96cfp@chr9:114828174..114828179, +
3.75e-53FFCP PHASE2:Hg19::chr9:114828174..114828179,+#_217034cd625f56be739eea2a102a96cfp@chr9:114828174..114828179, +
1.65e-46FFCP PHASE2:Hg19::chr7:140227349..140227360,-#_f67b33414ffa32132e935d2ef4c955d9p@chr7:140227349..140227360, -
1.65e-46FFCP PHASE1:Hg19::chr7:140227349..140227360,-#_f67b33414ffa32132e935d2ef4c955d9p@chr7:140227349..140227360, -
7.81e-45FFCP PHASE2:Hg19::chr6:30890373..30890381,+#_88135949b89163fe616c1ec16c478106p9@VARS2
7.81e-45FFCP PHASE1:Hg19::chr6:30890373..30890381,+#_88135949b89163fe616c1ec16c478106p9@VARS2
6.91e-39FFCP PHASE2:Hg19::chr6:30890456..30890482,+#_e3c9ae7c8ab6abf5f054f7474f05e950p11@VARS2
6.91e-39FFCP PHASE1:Hg19::chr6:30890456..30890482,+#_e3c9ae7c8ab6abf5f054f7474f05e950p11@VARS2
1.49e-38FFCP PHASE1:Hg19::chr11:33718564..33718585,-#_d033afa505864c8101a0ec08b36e4455p1@ENST00000534431
1.49e-38FFCP PHASE2:Hg19::chr11:33718564..33718585,-#_d033afa505864c8101a0ec08b36e4455p1@ENST00000534431
2.64e-38FFCP PHASE2:Hg19::chr7:53466339..53466356,-#_5dc3df26ffd50c35a99e63450ebefc84p@chr7:53466339..53466356, -
2.64e-38FFCP PHASE1:Hg19::chr7:53466339..53466356,-#_5dc3df26ffd50c35a99e63450ebefc84p@chr7:53466339..53466356, -
3.48e-38FFCP PHASE2:Hg19::chr17:18160552..18160565,-#_959734aaf49d657c77ed166b59b2be41p@chr17:18160552..18160565, -
3.48e-38FFCP PHASE1:Hg19::chr17:18160552..18160565,-#_959734aaf49d657c77ed166b59b2be41p@chr17:18160552..18160565, -
3.86e-38FFCP PHASE2:Hg19::chr3:190105820..190105829,+#_d6f8d878e36f9f95bbb3425d72a6b06dp3@CLDN16
3.86e-38FFCP PHASE1:Hg19::chr3:190105820..190105829,+#_d6f8d878e36f9f95bbb3425d72a6b06dp3@CLDN16
5.76e-38FFCP PHASE2:Hg19::chr1:1100457..1100470,+#_d02a2df7fe96fa7389646ee35ea67769p@chr1:1100457..1100470, +
5.76e-38FFCP PHASE1:Hg19::chr1:1100457..1100470,+#_d02a2df7fe96fa7389646ee35ea67769p@chr1:1100457..1100470, +
2.08e-36FFCP PHASE1:Hg19::chr9:133986782..133986794,+#_80d8daf68375e5a382c64011aa1d2e74p4@AIF1L
2.08e-36FFCP PHASE2:Hg19::chr9:133986782..133986794,+#_80d8daf68375e5a382c64011aa1d2e74p4@AIF1L
2.25e-35FFCP PHASE2:Hg19::chr10:102495147..102495159,+#_4cbfb0fffbe5e573685cb4f84e8cf793p4@PAX2
2.25e-35FFCP PHASE1:Hg19::chr10:102495147..102495159,+#_4cbfb0fffbe5e573685cb4f84e8cf793p4@PAX2
3.2e-35FFCP PHASE1:Hg19::chr12:6485243..6485254,-#_cb582b8d04726300ba735214656a4fbap18@SCNN1A
3.2e-35FFCP PHASE2:Hg19::chr12:6485243..6485254,-#_cb582b8d04726300ba735214656a4fbap18@SCNN1A
5.96e-34FFCP PHASE2:Hg19::chr6:31023284..31023287,-#_66109a9b1eaf5977fbeed0e193be1aebp@chr6:31023284..31023287, -
5.96e-34FFCP PHASE1:Hg19::chr6:31023284..31023287,-#_66109a9b1eaf5977fbeed0e193be1aebp@chr6:31023284..31023287, -
2.09e-33FFCP PHASE2:Hg19::chr2:113994209..113994222,-#_bea44a0717ed293934c870e63776f676p11@PAX8
2.09e-33FFCP PHASE1:Hg19::chr2:113994209..113994222,-#_bea44a0717ed293934c870e63776f676p11@PAX8
1.41e-32FFCP PHASE1:Hg19::chr14:57960456..57960478,-#_6ea820d651c7ada64da35bfe1d657ff1p2@C14orf105
1.41e-32FFCP PHASE2:Hg19::chr14:57960456..57960478,-#_6ea820d651c7ada64da35bfe1d657ff1p2@C14orf105
2.17e-32FFCP PHASE2:Hg19::chr3:190105935..190105966,+#_9837bdce7a30848ad8441e0c277b3d56p1@CLDN16
2.17e-32FFCP PHASE1:Hg19::chr3:190105935..190105966,+#_9837bdce7a30848ad8441e0c277b3d56p1@CLDN16
3.1e-30FFCP PHASE2:Hg19::chr3:112127710..112127713,-#_761e6f658924ebb8383222732e4ebfdfp@chr3:112127710..112127713, -
3.1e-30FFCP PHASE1:Hg19::chr3:112127710..112127713,-#_761e6f658924ebb8383222732e4ebfdfp@chr3:112127710..112127713, -
4.84e-30FFCP PHASE2:Hg19::chr20:49347516..49347535,-#_029a1b8e18037b0c18c259f0db50a874p@chr20:49347516..49347535, -
4.84e-30FFCP PHASE1:Hg19::chr20:49347516..49347535,-#_029a1b8e18037b0c18c259f0db50a874p@chr20:49347516..49347535, -
6.17e-30FFCP PHASE2:Hg19::chr6:30890348..30890372,+#_41094a97b7ac42864c6d816b6f465a14p5@VARS2
6.17e-30FFCP PHASE1:Hg19::chr6:30890348..30890372,+#_41094a97b7ac42864c6d816b6f465a14p5@VARS2
8.26e-30FFCP PHASE1:Hg19::chr9:133986807..133986821,+#_f0888a2725374dae240091201bcc3ed5p3@AIF1L
8.26e-30FFCP PHASE2:Hg19::chr9:133986807..133986821,+#_f0888a2725374dae240091201bcc3ed5p3@AIF1L
8.74e-30FFCP PHASE2:Hg19::chr3:190106002..190106011,+#_431185e4017a509a9f2f61cf5521a5dcp4@CLDN16
8.74e-30FFCP PHASE1:Hg19::chr3:190106002..190106011,+#_431185e4017a509a9f2f61cf5521a5dcp4@CLDN16
4.28e-29FFCP PHASE1:Hg19::chr7:7606139..7606151,-#_adfabb1338255ccc8ff619f6cafec05dp@chr7:7606139..7606151, -
4.28e-29FFCP PHASE2:Hg19::chr7:7606139..7606151,-#_adfabb1338255ccc8ff619f6cafec05dp@chr7:7606139..7606151, -
5.09e-29FFCP PHASE2:Hg19::chr6:30890599..30890626,+#_2260373560b2727eb669bc7f96ea59bdp4@VARS2
5.09e-29FFCP PHASE1:Hg19::chr6:30890599..30890626,+#_2260373560b2727eb669bc7f96ea59bdp4@VARS2
4.74e-28FFCP PHASE1:Hg19::chr11:117695245..117695263,-#_723efa28220f037013375cc7c2f05367p7@FXYD2
4.74e-28FFCP PHASE2:Hg19::chr11:117695245..117695263,-#_723efa28220f037013375cc7c2f05367p7@FXYD2
2.38e-27FFCP PHASE2:Hg19::chr11:117695233..117695244,-#_375e8bbc1775a16f657e72934f822a5cp11@FXYD2
2.38e-27FFCP PHASE1:Hg19::chr11:117695233..117695244,-#_375e8bbc1775a16f657e72934f822a5cp11@FXYD2
3.11e-27FFCP PHASE2:Hg19::chr10:91043499..91043510,+#_dedd9f3d7d87b073b0a3bab27de6556ep2@ENST00000354541
3.11e-27FFCP PHASE1:Hg19::chr10:91043499..91043510,+#_dedd9f3d7d87b073b0a3bab27de6556ep2@ENST00000354541
5.07e-27FFCP PHASE2:Hg19::chr1:17519128..17519138,+#_6825167a87574e7566b148b5eefe4340p@chr1:17519128..17519138, +
5.07e-27FFCP PHASE1:Hg19::chr1:17519128..17519138,+#_6825167a87574e7566b148b5eefe4340p@chr1:17519128..17519138, +
1.22e-26FFCP PHASE2:Hg19::chr18:77104123..77104150,+#_22cb997ef415e4889579061610892b97p5@ATP9B
1.22e-26FFCP PHASE1:Hg19::chr18:77104123..77104150,+#_22cb997ef415e4889579061610892b97p5@ATP9B
2.01e-25FFCP PHASE2:Hg19::chr7:98453821..98453843,-#_307a9e7f028abc61847ac88863817a7ep@chr7:98453821..98453843, -
2.01e-25FFCP PHASE1:Hg19::chr7:98453821..98453843,-#_307a9e7f028abc61847ac88863817a7ep@chr7:98453821..98453843, -
4.31e-25FFCP PHASE2:Hg19::chr2:167467988..167467993,-#_1c2b70b1f44d53a7657a758a92e4c084p@chr2:167467988..167467993, -
4.31e-25FFCP PHASE1:Hg19::chr2:167467988..167467993,-#_1c2b70b1f44d53a7657a758a92e4c084p@chr2:167467988..167467993, -
4.31e-25FFCP PHASE2:Hg19::chr9:133986740..133986750,+#_1c2b70b1f44d53a7657a758a92e4c084p7@AIF1L
4.31e-25FFCP PHASE1:Hg19::chr9:133986740..133986750,+#_1c2b70b1f44d53a7657a758a92e4c084p7@AIF1L
5.5e-25FFCP PHASE2:Hg19::chr2:189157368..189157381,-#_756cd5ed9cef41a7605328e321f152a5p@chr2:189157368..189157381, -
5.5e-25FFCP PHASE1:Hg19::chr2:189157368..189157381,-#_756cd5ed9cef41a7605328e321f152a5p@chr2:189157368..189157381, -
7.93e-25FFCP PHASE1:Hg19::chr9:119741711..119741743,-#_9089b107a6bd1c18742e01ed095c5698p@chr9:119741711..119741743, -
7.93e-25FFCP PHASE2:Hg19::chr9:119741711..119741743,-#_9089b107a6bd1c18742e01ed095c5698p@chr9:119741711..119741743, -
8.07e-25FFCP PHASE2:Hg19::chr19:51472081..51472088,-#_7c568511d01d5921ecb948cc5bb83246p8@KLK6
8.07e-25FFCP PHASE1:Hg19::chr19:51472081..51472088,-#_7c568511d01d5921ecb948cc5bb83246p8@KLK6
1.21e-24FFCP PHASE2:Hg19::chr7:27219833..27219845,-#_3d5d96ff08727a1ed6ec79b9aee1a83bp7@HOXA10
1.21e-24FFCP PHASE1:Hg19::chr7:27219833..27219845,-#_3d5d96ff08727a1ed6ec79b9aee1a83bp7@HOXA10
1.29e-24FFCP PHASE2:Hg19::chr20:6034241..6034256,-#_d9c2f55dfe3aefae37b65cd0e4ee9701p@chr20:6034241..6034256, -
1.29e-24FFCP PHASE1:Hg19::chr20:6034241..6034256,-#_d9c2f55dfe3aefae37b65cd0e4ee9701p@chr20:6034241..6034256, -
7.91e-24FFCP PHASE1:Hg19::chr11:117695415..117695426,-#_3f03d32d84f28eae7f004f0af351b7ecp3@FXYD2
7.91e-24FFCP PHASE2:Hg19::chr21:41029235..41029269,+#_3f03d32d84f28eae7f004f0af351b7ecp2@B3GALT5
7.91e-24FFCP PHASE1:Hg19::chr21:41029235..41029269,+#_3f03d32d84f28eae7f004f0af351b7ecp2@B3GALT5
7.91e-24FFCP PHASE2:Hg19::chr11:117695415..117695426,-#_3f03d32d84f28eae7f004f0af351b7ecp3@FXYD2
9.99e-24FFCP PHASE1:Hg19::chr18:3456189..3456200,+#_c80dbc7a4937a2c4efd22daa803aa85bp@chr18:3456189..3456200, +
9.99e-24FFCP PHASE2:Hg19::chr10:102505954..102505973,+#_c80dbc7a4937a2c4efd22daa803aa85bp3@PAX2
9.99e-24FFCP PHASE1:Hg19::chr10:102505954..102505973,+#_c80dbc7a4937a2c4efd22daa803aa85bp3@PAX2
9.99e-24FFCP PHASE2:Hg19::chr18:3456189..3456200,+#_c80dbc7a4937a2c4efd22daa803aa85bp@chr18:3456189..3456200, +
3.27e-23FFCP PHASE2:Hg19::chr12:6484832..6484841,+#_27203789cb9aab8bf4b5f1648d0c0297p@chr12:6484832..6484841, +
3.27e-23FFCP PHASE1:Hg19::chr12:6484832..6484841,+#_27203789cb9aab8bf4b5f1648d0c0297p@chr12:6484832..6484841, +
3.29e-23FFCP PHASE2:Hg19::chr3:43532224..43532252,-#_fb05df539063047ce63bb73d661bc0e6p@chr3:43532224..43532252, -
3.29e-23FFCP PHASE1:Hg19::chr3:43532224..43532252,-#_fb05df539063047ce63bb73d661bc0e6p@chr3:43532224..43532252, -

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