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Coexpression cluster:C595

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Full id: C595_teratocarcinoma_HES3GFP_H9_testicular_Wilms_hepatoblastoma_neuroblastoma



Phase1 CAGE Peaks

Hg19::chr12:75760714..75760729,+p1@GLIPR1L1
Hg19::chr15:75052999..75053003,-p@chr15:75052999..75053003
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Hg19::chr18:11261018..11261023,-p@chr18:11261018..11261023
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Hg19::chr1:63220075..63220077,+p@chr1:63220075..63220077
+
Hg19::chr22:35029651..35029657,-p@chr22:35029651..35029657
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Hg19::chr22:35029659..35029670,-p@chr22:35029659..35029670
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Hg19::chr6:10417399..10417415,-p32@TFAP2A
Hg19::chr6:10417454..10417460,-p40@TFAP2A
Hg19::chr6:3222149..3222154,+p@chr6:3222149..3222154
+
Hg19::chr8:70963473..70963506,-p@chr8:70963473..70963506
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Hg19::chrX:136648643..136648711,+p2@ZIC3
Hg19::chrX:136648735..136648747,+p9@ZIC3
Hg19::chrX:136648753..136648767,+p5@ZIC3
Hg19::chrX:136648768..136648781,+p6@ZIC3
Hg19::chrX:136648807..136648822,+p8@ZIC3


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0009855determination of bilateral symmetry0.0312453970958568
GO:0009799determination of symmetry0.0312453970958568
GO:0007368determination of left/right symmetry0.0312453970958568
GO:0003705RNA polymerase II transcription factor activity, enhancer binding0.0351417582722758



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Disease
Ontology termp-valuen
cancer3.43e-35235
disease of cellular proliferation1.40e-34239
cell type cancer4.83e-28143
carcinoma3.72e-19106
organ system cancer4.26e-12137
germ cell and embryonal cancer9.69e-1022
germ cell cancer9.69e-1022


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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