MCL coexpression mm9:2742

Phase1 CAGE Peaks

	Short description
Mm9::chr11:96711177..96711211,+	p1@Copz2
Mm9::chr17:34168501..34168579,-	p1@ENSMUST00000168978
Mm9::chr7:135047593..135047639,+	p1@Bckdk

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0047323	[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity	0.0172574371336219
GO:0018106	peptidyl-histidine phosphorylation	0.0271039742192012
GO:0018202	peptidyl-histidine modification	0.0271039742192012
GO:0030126	COPI vesicle coat	0.0271039742192012
GO:0030663	COPI coated vesicle membrane	0.0271039742192012
GO:0004673	protein histidine kinase activity	0.0271039742192012
GO:0030137	COPI-coated vesicle	0.0271039742192012
GO:0016775	phosphotransferase activity, nitrogenous group as acceptor	0.0301790093598672
GO:0006829	zinc ion transport	0.0402078145071049
GO:0030120	vesicle coat	0.0402078145071049
GO:0030662	coated vesicle membrane	0.0402078145071049
GO:0005798	Golgi-associated vesicle	0.0402078145071049

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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