MCL coexpression mm9:3616

Phase1 CAGE Peaks

	Short description
Mm9::chr7:25857276..25857305,-	p6@Grik5
Mm9::chr7:25857306..25857385,-	p2@Grik5
Mm9::chr9:58335890..58335917,+	p1@6030419C18Rik

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0008328	ionotropic glutamate receptor complex	0.014134662795157
GO:0005234	extracellular-glutamate-gated ion channel activity	0.014134662795157
GO:0004970	ionotropic glutamate receptor activity	0.014134662795157
GO:0005231	excitatory extracellular ligand-gated ion channel activity	0.0207308387662302
GO:0008066	glutamate receptor activity	0.0207308387662302
GO:0005230	extracellular ligand-gated ion channel activity	0.0217255002221857
GO:0043235	receptor complex	0.0217255002221857
GO:0015276	ligand-gated ion channel activity	0.0217255002221857
GO:0022834	ligand-gated channel activity	0.0217255002221857
GO:0045211	postsynaptic membrane	0.0256779707445351
GO:0044456	synapse part	0.0259135484577878

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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