MCL coexpression mm9:440

Phase1 CAGE Peaks

	Short description
Mm9::chr10:80962341..80962353,-	p@chr10:80962341..80962353 -
Mm9::chr14:103379325..103379344,+	p@chr14:103379325..103379344 +
Mm9::chr16:91406066..91406089,+	p9@Il10rb
Mm9::chr18:62316324..62316329,-	p@chr18:62316324..62316329 -
Mm9::chr19:32329718..32329755,+	p@chr19:32329718..32329755 +
Mm9::chr1:130602320..130602335,+	p@chr1:130602320..130602335 +
Mm9::chr1:87505064..87505089,+	p@chr1:87505064..87505089 +
Mm9::chr1:89523255..89523265,+	p@chr1:89523255..89523265 +
Mm9::chr1:89749728..89749742,-	p@chr1:89749728..89749742 -
Mm9::chr4:130470264..130470268,+	p@chr4:130470264..130470268 +
Mm9::chr5:108117177..108117198,+	p@chr5:108117177..108117198 +
Mm9::chr5:65883638..65883674,-	p@chr5:65883638..65883674 -
Mm9::chr5:73194336..73194339,+	p@chr5:73194336..73194339 +
Mm9::chr5:99765762..99765773,+	p@chr5:99765762..99765773 +
Mm9::chr7:25230809..25230816,+	p@chr7:25230809..25230816 +
Mm9::chr8:26178393..26178407,-	p@chr8:26178393..26178407 -
Mm9::chr9:107904389..107904396,+	p@chr9:107904389..107904396 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0004920	interleukin-10 receptor activity	0.000986139264778393
GO:0019969	interleukin-10 binding	0.000986139264778393
GO:0004907	interleukin receptor activity	0.0118336711773407
GO:0019965	interleukin binding	0.0118336711773407
GO:0019838	growth factor binding	0.0118336711773407
GO:0007596	blood coagulation	0.0118336711773407
GO:0007599	hemostasis	0.0118336711773407
GO:0004896	hematopoietin/interferon-class (D200-domain) cytokine receptor activity	0.0118336711773407
GO:0050817	coagulation	0.0118336711773407
GO:0019955	cytokine binding	0.0125508633699068
GO:0050878	regulation of body fluid levels	0.0125508633699068
GO:0042060	wound healing	0.0129841669862488
GO:0009611	response to wounding	0.043693555116335

Relative expression of the co-expression cluster over median <br>Analyst:

---

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

---

Cell Type

Ontology term	p-value	n
hematopoietic cell	6.13e-19	32
hematopoietic oligopotent progenitor cell	6.13e-19	32
hematopoietic stem cell	6.13e-19	32
angioblastic mesenchymal cell	6.13e-19	32
hematopoietic multipotent progenitor cell	6.13e-19	32
common myeloid progenitor	1.23e-12	19
connective tissue cell	1.69e-12	46
mesenchymal cell	1.69e-12	46
stem cell	6.07e-12	97
hematopoietic lineage restricted progenitor cell	1.05e-11	25
megakaryocyte progenitor cell	3.07e-11	6
megakaryocyte	3.07e-11	6
motile cell	2.58e-10	54
myeloid cell	9.34e-09	16
somatic stem cell	1.23e-08	91
multi fate stem cell	1.23e-08	91
lymphoid lineage restricted progenitor cell	4.68e-08	12
CD4-positive, alpha-beta T cell	8.64e-08	8
megakaryocyte-erythroid progenitor cell	1.58e-07	9
lymphocyte	2.02e-07	13
common lymphoid progenitor	2.02e-07	13
mature alpha-beta T cell	6.12e-07	9
alpha-beta T cell	6.12e-07	9
immature T cell	6.12e-07	9
mature T cell	6.12e-07	9
immature alpha-beta T cell	6.12e-07	9

Uber Anatomy

Ontology term	p-value	n
connective tissue	1.69e-12	46
musculoskeletal system	3.68e-09	32
bone marrow	9.34e-09	16

Disease

Ontology term	p-value	n
musculoskeletal system cancer	2.41e-13	3
muscle cancer	2.41e-13	3
organ system cancer	6.80e-07	6

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}