MCL coexpression mm9:644

Phase1 CAGE Peaks

	Short description
Mm9::chr10:80318068..80318083,+	p2@3110056O03Rik
Mm9::chr11:102217808..102217820,-	p@chr11:102217808..102217820 -
Mm9::chr15:83254210..83254223,-	p@chr15:83254210..83254223 -
Mm9::chr1:75233328..75233336,+	p10@Dnajb2
Mm9::chr4:122959994..122960005,+	p3@LOC100503296 p3@Pabpc4
Mm9::chr6:28374572..28374589,+	p@chr6:28374572..28374589 +
Mm9::chr6:38826531..38826540,-	p9@Hipk2
Mm9::chr6:86055182..86055186,+	p@chr6:86055182..86055186 +
Mm9::chr7:25162358..25162371,+	p@chr7:25162358..25162371 +
Mm9::chr9:121361587..121361593,-	p@chr9:121361587..121361593 -
Mm9::chr9:98197322..98197331,+	p6@Nmnat3

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0008717	D-alanyl-D-alanine endopeptidase activity	0.035451443793266
GO:0016772	transferase activity, transferring phosphorus-containing groups	0.035451443793266
GO:0000309	nicotinamide-nucleotide adenylyltransferase activity	0.035451443793266
GO:0045806	negative regulation of endocytosis	0.035451443793266
GO:0043388	positive regulation of DNA binding	0.035451443793266
GO:0051099	positive regulation of binding	0.035451443793266
GO:0009435	NAD biosynthetic process	0.035451443793266
GO:0019674	NAD metabolic process	0.035451443793266
GO:0042771	DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis	0.035451443793266
GO:0051101	regulation of DNA binding	0.035451443793266
GO:0019363	pyridine nucleotide biosynthetic process	0.035451443793266
GO:0016605	PML body	0.035451443793266
GO:0030330	DNA damage response, signal transduction by p53 class mediator	0.035451443793266
GO:0016740	transferase activity	0.035451443793266
GO:0008630	DNA damage response, signal transduction resulting in induction of apoptosis	0.035451443793266
GO:0042364	water-soluble vitamin biosynthetic process	0.035451443793266
GO:0051051	negative regulation of transport	0.035451443793266
GO:0009110	vitamin biosynthetic process	0.035451443793266
GO:0004190	aspartic-type endopeptidase activity	0.035451443793266
GO:0051098	regulation of binding	0.0374148170020494
GO:0006769	nicotinamide metabolic process	0.0391900315242104
GO:0019362	pyridine nucleotide metabolic process	0.0408027456076468
GO:0007224	smoothened signaling pathway	0.0455185289494597
GO:0008629	induction of apoptosis by intracellular signals	0.0467300915721629
GO:0006733	oxidoreduction coenzyme metabolic process	0.0478437468235302
GO:0030100	regulation of endocytosis	0.048440920128482
GO:0042770	DNA damage response, signal transduction	0.048440920128482

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
abdomen element	2.03e-09	49
abdominal segment element	2.03e-09	49
abdominal segment of trunk	2.03e-09	49
abdomen	2.03e-09	49
spleen	1.48e-08	6
cavity lining	1.48e-08	6
serous membrane	1.48e-08	6
gastrointestinal system mesentery	1.48e-08	6
stomach region	1.48e-08	6
mesentery	1.48e-08	6
gastrointestinal system serosa	1.48e-08	6
mesentery of stomach	1.48e-08	6
gut mesentery	1.48e-08	6
dorsal mesentery	1.48e-08	6
dorsal mesogastrium	1.48e-08	6
peritoneal cavity	1.48e-08	6
spleen primordium	1.48e-08	6

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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