Coexpression cluster:C218
From FANTOM5_SSTAR
Full id: C218_tonsil_lymph_CD19_spleen_colon_appendix_salivary
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| p.value | FDR | nGenes | nPathway | Name |
|---|---|---|---|---|
| 2.72719518243547e-17 | 8.63157275240828e-15 | 17 | 511 | Signaling in Immune system (Reactome):REACT_6900 |
| 4.06974933269274e-28 | 2.57615132759451e-25 | 14 | 48 | {FCGR2B,50} (Static Module):NA |
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0003823 | antigen binding | 4.21115196817957e-05 |
| GO:0006955 | immune response | 5.67426408314668e-05 |
| GO:0002376 | immune system process | 6.98965686274625e-05 |
| GO:0019815 | B cell receptor complex | 0.00536865337511534 |
| GO:0019814 | immunoglobulin complex | 0.00536865337511534 |
| GO:0005771 | multivesicular body | 0.00596490702026829 |
| GO:0050853 | B cell receptor signaling pathway | 0.0140557926159866 |
| GO:0001772 | immunological synapse | 0.0178836616630865 |
| GO:0042100 | B cell proliferation | 0.0178836616630865 |
| GO:0050851 | antigen receptor-mediated signaling pathway | 0.0196590009575182 |
| GO:0030183 | B cell differentiation | 0.0196590009575182 |
| GO:0002429 | immune response-activating cell surface receptor signaling pathway | 0.0196590009575182 |
| GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 0.0196590009575182 |
| GO:0002757 | immune response-activating signal transduction | 0.0196590009575182 |
| GO:0002764 | immune response-regulating signal transduction | 0.0196590009575182 |
| GO:0045121 | lipid raft | 0.023659252672592 |
| GO:0009897 | external side of plasma membrane | 0.023659252672592 |
| GO:0005770 | late endosome | 0.023659252672592 |
| GO:0032943 | mononuclear cell proliferation | 0.023659252672592 |
| GO:0046651 | lymphocyte proliferation | 0.023659252672592 |
| GO:0042113 | B cell activation | 0.0259246100408165 |
| GO:0030098 | lymphocyte differentiation | 0.0259598057034707 |
| GO:0002253 | activation of immune response | 0.0275385060338675 |
| GO:0050778 | positive regulation of immune response | 0.0306676533211757 |
| GO:0002684 | positive regulation of immune system process | 0.0306676533211757 |
| GO:0002521 | leukocyte differentiation | 0.0308542166241833 |
| GO:0050776 | regulation of immune response | 0.0318196556640933 |
| GO:0002682 | regulation of immune system process | 0.0318196556640933 |
| GO:0051240 | positive regulation of multicellular organismal process | 0.0322514226524992 |
| GO:0043235 | receptor complex | 0.0326537506581756 |
| GO:0009986 | cell surface | 0.0424455817755085 |
| GO:0046649 | lymphocyte activation | 0.043050663867282 |
| GO:0030097 | hemopoiesis | 0.0433505808108114 |
| GO:0048534 | hemopoietic or lymphoid organ development | 0.0448795842241041 |
| GO:0045321 | leukocyte activation | 0.0448795842241041 |
| GO:0002520 | immune system development | 0.0448795842241041 |
| GO:0005768 | endosome | 0.0462833074571253 |
| GO:0001775 | cell activation | 0.0487668118354535 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| B cell | 3.14e-23 | 14 |
| lymphocyte of B lineage | 2.13e-12 | 24 |
| pro-B cell | 2.13e-12 | 24 |
| single nucleate cell | 7.79e-08 | 3 |
| mononuclear cell | 7.79e-08 | 3 |
| Ontology term | p-value | n |
|---|---|---|
| adult organism | 1.38e-51 | 114 |
| blood | 3.85e-22 | 15 |
| haemolymphatic fluid | 3.85e-22 | 15 |
| organism substance | 3.85e-22 | 15 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
{{{tfbs_overrepresentation_jaspar}}} |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)
| TF | #promoters | Enrichment | p-value | q-value |
|---|---|---|---|---|
| POU2F2#5452 | 18 | 2.41044460352008 | 0.000297931662909141 | 0.00307771364417089 |
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
