Coexpression cluster:C161
From FANTOM5_SSTAR
Full id: C161_mesothelioma_Mesothelial_acute_mesenchymal_extraskeletal_renal_placenta
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
No results for this coexpression
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0030036 | actin cytoskeleton organization and biogenesis | 0.0201157464163886 |
GO:0030029 | actin filament-based process | 0.0201157464163886 |
GO:0001666 | response to hypoxia | 0.0201157464163886 |
GO:0014065 | phosphoinositide 3-kinase cascade | 0.0201157464163886 |
GO:0048715 | negative regulation of oligodendrocyte differentiation | 0.0201157464163886 |
GO:0021897 | forebrain astrocyte development | 0.0201157464163886 |
GO:0021896 | forebrain astrocyte differentiation | 0.0201157464163886 |
GO:0048745 | smooth muscle development | 0.0201157464163886 |
GO:0048485 | sympathetic nervous system development | 0.0201157464163886 |
GO:0048713 | regulation of oligodendrocyte differentiation | 0.0201157464163886 |
GO:0022011 | myelination in the peripheral nervous system | 0.0201157464163886 |
GO:0048854 | brain morphogenesis | 0.0201157464163886 |
GO:0032292 | ensheathment of axons in the peripheral nervous system | 0.0201157464163886 |
GO:0048853 | forebrain morphogenesis | 0.0201157464163886 |
GO:0043409 | negative regulation of MAPKKK cascade | 0.0201157464163886 |
GO:0048844 | artery morphogenesis | 0.0201157464163886 |
GO:0014014 | negative regulation of gliogenesis | 0.0201157464163886 |
GO:0045686 | negative regulation of glial cell differentiation | 0.0201157464163886 |
GO:0043535 | regulation of blood vessel endothelial cell migration | 0.0201157464163886 |
GO:0008334 | histone mRNA metabolic process | 0.0201157464163886 |
GO:0019834 | phospholipase A2 inhibitor activity | 0.0201157464163886 |
GO:0008475 | procollagen-lysine 5-dioxygenase activity | 0.0201157464163886 |
GO:0007406 | negative regulation of neuroblast proliferation | 0.0201157464163886 |
GO:0014044 | Schwann cell development | 0.0201157464163886 |
GO:0048483 | autonomic nervous system development | 0.0201157464163886 |
GO:0014037 | Schwann cell differentiation | 0.0201157464163886 |
GO:0021987 | cerebral cortex development | 0.0232400732033849 |
GO:0050890 | cognition | 0.0232400732033849 |
GO:0043534 | blood vessel endothelial cell migration | 0.0232400732033849 |
GO:0014002 | astrocyte development | 0.0232400732033849 |
GO:0008092 | cytoskeletal protein binding | 0.0264037330716217 |
GO:0008486 | diphosphoinositol-polyphosphate diphosphatase activity | 0.0264037330716217 |
GO:0030325 | adrenal gland development | 0.0264037330716217 |
GO:0045124 | regulation of bone resorption | 0.0307290422170373 |
GO:0021543 | pallium development | 0.0307290422170373 |
GO:0045685 | regulation of glial cell differentiation | 0.0307290422170373 |
GO:0014013 | regulation of gliogenesis | 0.0307290422170373 |
GO:0032320 | positive regulation of Ras GTPase activity | 0.0307290422170373 |
GO:0008542 | visual learning | 0.0307290422170373 |
GO:0007010 | cytoskeleton organization and biogenesis | 0.0307290422170373 |
GO:0048708 | astrocyte differentiation | 0.0339818460437372 |
GO:0043525 | positive regulation of neuron apoptosis | 0.0373116614685102 |
GO:0007632 | visual behavior | 0.0375400593471159 |
GO:0001889 | liver development | 0.0375400593471159 |
GO:0030199 | collagen fibril organization | 0.0375400593471159 |
GO:0021510 | spinal cord development | 0.0375400593471159 |
GO:0030867 | rough endoplasmic reticulum membrane | 0.0375400593471159 |
GO:0021537 | telencephalon development | 0.0375400593471159 |
GO:0042308 | negative regulation of protein import into nucleus | 0.0375400593471159 |
GO:0042992 | negative regulation of transcription factor import into nucleus | 0.0375400593471159 |
GO:0048709 | oligodendrocyte differentiation | 0.0375400593471159 |
GO:0050768 | negative regulation of neurogenesis | 0.0376951644035807 |
GO:0001937 | negative regulation of endothelial cell proliferation | 0.0376951644035807 |
GO:0046823 | negative regulation of nucleocytoplasmic transport | 0.0376951644035807 |
GO:0043542 | endothelial cell migration | 0.0376951644035807 |
GO:0048593 | camera-type eye morphogenesis | 0.0376951644035807 |
GO:0045453 | bone resorption | 0.0376951644035807 |
GO:0051224 | negative regulation of protein transport | 0.0376951644035807 |
GO:0021782 | glial cell development | 0.0376951644035807 |
GO:0001952 | regulation of cell-matrix adhesion | 0.0376951644035807 |
GO:0043408 | regulation of MAPKKK cascade | 0.0427637789090141 |
GO:0007405 | neuroblast proliferation | 0.0454643875921512 |
GO:0001936 | regulation of endothelial cell proliferation | 0.0454643875921512 |
GO:0005791 | rough endoplasmic reticulum | 0.0454643875921512 |
GO:0007612 | learning | 0.0454643875921512 |
GO:0004859 | phospholipase inhibitor activity | 0.0458540850453024 |
GO:0016998 | cell wall catabolic process | 0.0458540850453024 |
GO:0048871 | multicellular organismal homeostasis | 0.0458540850453024 |
GO:0001935 | endothelial cell proliferation | 0.0458540850453024 |
GO:0055102 | lipase inhibitor activity | 0.0458540850453024 |
GO:0030336 | negative regulation of cell migration | 0.0458540850453024 |
GO:0001894 | tissue homeostasis | 0.0458540850453024 |
GO:0010382 | cell wall metabolic process | 0.0469532635158058 |
GO:0007047 | cell wall organization and biogenesis | 0.0469532635158058 |
GO:0042990 | regulation of transcription factor import into nucleus | 0.0469930026170049 |
GO:0042991 | transcription factor import into nucleus | 0.0469930026170049 |
GO:0006400 | tRNA modification | 0.0469930026170049 |
GO:0042306 | regulation of protein import into nucleus | 0.0469930026170049 |
GO:0045229 | external encapsulating structure organization and biogenesis | 0.0469930026170049 |
GO:0031418 | L-ascorbic acid binding | 0.0469930026170049 |
GO:0033157 | regulation of intracellular protein transport | 0.0469930026170049 |
GO:0051271 | negative regulation of cell motility | 0.0469930026170049 |
GO:0000049 | tRNA binding | 0.0469930026170049 |
GO:0007422 | peripheral nervous system development | 0.0469930026170049 |
GO:0043407 | negative regulation of MAP kinase activity | 0.0469930026170049 |
GO:0040013 | negative regulation of locomotion | 0.0469930026170049 |
GO:0046850 | regulation of bone remodeling | 0.0469930026170049 |
GO:0001656 | metanephros development | 0.0469930026170049 |
GO:0001649 | osteoblast differentiation | 0.0469930026170049 |
GO:0043523 | regulation of neuron apoptosis | 0.0469930026170049 |
GO:0032386 | regulation of intracellular transport | 0.0469930026170049 |
GO:0048592 | eye morphogenesis | 0.0469930026170049 |
GO:0051349 | positive regulation of lyase activity | 0.0469930026170049 |
GO:0042552 | myelination | 0.0469930026170049 |
GO:0045762 | positive regulation of adenylate cyclase activity | 0.0469930026170049 |
GO:0031281 | positive regulation of cyclase activity | 0.0469930026170049 |
GO:0006928 | cell motility | 0.0485635400987374 |
GO:0051674 | localization of cell | 0.0485635400987374 |
GO:0051223 | regulation of protein transport | 0.0485635400987374 |
GO:0006383 | transcription from RNA polymerase III promoter | 0.0485635400987374 |
GO:0046822 | regulation of nucleocytoplasmic transport | 0.0493015702913813 |
GO:0010001 | glial cell differentiation | 0.0493015702913813 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>
Ontology term | p-value | n |
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Ontology term | p-value | n |
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Ontology term | p-value | n |
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Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
No analysis results for this cluster
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
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