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UBERON:0002106

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Name:spleen
Definition:"Organ found in virtually all vertebrate animals with important roles in regard to red blood cells and the immune system.[1] In humans, it is located in the left upper quadrant of the abdomen. It removes old red blood cells and holds a reserve in case of hemorrhagic shock, especially in animals like horses (not in humans), while recycling iron.[2] It synthesizes antibodies in its white pulp and removes, from blood and lymph node circulation, antibody-coated bacteria along with antibody-coated blood cells." [Wikipedia:Spleen]
Xrefs:
links:

AAO:0010395
BTO:0001281
EFO:0000869
EMAPA:18767
EV:0100055
FMA:7196
GAID:1289
galen:Spleen
[1]
MA:0000141
MAT:0000085
MESH:A.15.382.520.604.713
MIAA:0000085
ncithesaurus:Spleen
OpenCyc:Mx4rvVjgw5wpEbGdrcN5Y29ycA
SCTID:181279003
TAO:0000436
VHOG:0000120
XAO:0000328

ZFA:0000436
Comments:This class was created automatically from a combination of ontologies
Alt_id: UBERON:FMA_7196-MA_0000141-MIAA_0000085-XAO_0000328-ZFA_0000436
Subset: organ_slim
uberon_slim
vertebrate_core

Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:UBERON:0000077(mixed endoderm/mesoderm-derived structure),UBERON:0002075(viscus),UBERON:0004177(hemopoietic organ),UBERON:0005057(immune organ),UBERON:0005172(abdomen element)
develops_from:UBERON:0003104(mesenchyme),UBERON:0006293(spleen primordium)
part_of:UBERON:0000916(abdomen),UBERON:0001007(digestive system),UBERON:0002323(body cavity),UBERON:0002390(hematopoietic system),UBERON:0002405(immune system)



Children

is a:FF:10424-106D1 (splenic lymphoma with villous lymphocytes cell line:SLVL)
derives from:FF:0010025 (human spleen - adult sample),FF:0010044 (human spleen - fetal sample),FF:0011306 (mouse spleen- adult sample),FF:0011360 (mouse spleen- embryo E16 sample),FF:0011417 (mouse spleen- neonate N10 sample),FF:0011430 (mouse spleen- neonate N20 sample),FF:0011491 (mouse spleen- neonate N25 sample),FF:0011517 (mouse spleen-, embryo E18 sample)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)

FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology

Human (Homo sapiens)

Mouse (Mus musculus)


Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0002106 (spleen), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
8.98e-131FFCP PHASE2:Hg19::chr21:28820892..28820899,-#_736a17cfbd40f566fd6df9e82ed4ec5ep4@ENST00000420186, p4@uc002ymh.2
8.98e-131FFCP PHASE1:Hg19::chr9:127260615..127260651,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr9:127260615..127260651, -
8.98e-131FFCP PHASE2:Hg19::chr16:84218794..84218800,+#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr16:84218794..84218800, +
8.98e-131FFCP PHASE1:Hg19::chr6:152639579..152639586,-#_736a17cfbd40f566fd6df9e82ed4ec5ep60@SYNE1
8.98e-131FFCP PHASE1:Hg19::chr10:98014943..98014960,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr10:98014943..98014960, -
8.98e-131FFCP PHASE2:Hg19::chr10:98014943..98014960,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr10:98014943..98014960, -
8.98e-131FFCP PHASE1:Hg19::chr14:75904485..75904519,+#_736a17cfbd40f566fd6df9e82ed4ec5ep12@JDP2
8.98e-131FFCP PHASE1:Hg19::chr9:133973310..133973321,+#_736a17cfbd40f566fd6df9e82ed4ec5ep18@AIF1L
8.98e-131FFCP PHASE2:Hg19::chr15:95561320..95561328,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr15:95561320..95561328, -
8.98e-131FFCP PHASE1:Hg19::chr11:56859638..56859643,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr11:56859638..56859643, -
8.98e-131FFCP PHASE1:Hg19::chr9:127269462..127269484,-#_736a17cfbd40f566fd6df9e82ed4ec5ep2@NR5A1
8.98e-131FFCP PHASE1:Hg19::chr8:47834174..47834213,+#_736a17cfbd40f566fd6df9e82ed4ec5ep1@ENST00000524012
8.98e-131FFCP PHASE2:Hg19::chr11:56859638..56859643,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr11:56859638..56859643, -
8.98e-131FFCP PHASE2:Hg19::chr19:32401253..32401271,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr19:32401253..32401271, -
8.98e-131FFCP PHASE2:Hg19::chr8:22424743..22424759,-#_736a17cfbd40f566fd6df9e82ed4ec5ep1@ENST00000517384
8.98e-131FFCP PHASE2:Hg19::chrX:69645652..69645664,+#_736a17cfbd40f566fd6df9e82ed4ec5ep7@GDPD2
8.98e-131FFCP PHASE1:Hg19::chr21:28820954..28820963,-#_736a17cfbd40f566fd6df9e82ed4ec5ep3@ENST00000420186, p3@uc002ymh.2
8.98e-131FFCP PHASE1:Hg19::chr11:1891326..1891337,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr11:1891326..1891337, -
8.98e-131FFCP PHASE2:Hg19::chr11:1891326..1891337,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr11:1891326..1891337, -
8.98e-131FFCP PHASE2:Hg19::chr21:28820911..28820933,-#_736a17cfbd40f566fd6df9e82ed4ec5ep1@ENST00000420186, p1@uc002ymh.2
8.98e-131FFCP PHASE2:Hg19::chr11:925449..925458,+#_736a17cfbd40f566fd6df9e82ed4ec5ep17@AP2A2
8.98e-131FFCP PHASE2:Hg19::chr9:127269434..127269438,-#_736a17cfbd40f566fd6df9e82ed4ec5ep8@NR5A1
8.98e-131FFCP PHASE1:Hg19::chr6:119812455..119812476,-#_736a17cfbd40f566fd6df9e82ed4ec5ep1@uc003pyn.1
8.98e-131FFCP PHASE2:Hg19::chr14:75904485..75904519,+#_736a17cfbd40f566fd6df9e82ed4ec5ep12@JDP2
8.98e-131FFCP PHASE1:Hg19::chr11:56859693..56859701,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr11:56859693..56859701, -
8.98e-131FFCP PHASE1:Hg19::chr7:22259740..22259751,-#_736a17cfbd40f566fd6df9e82ed4ec5ep19@RAPGEF5
8.98e-131FFCP PHASE2:Hg19::chr9:79894790..79894797,+#_736a17cfbd40f566fd6df9e82ed4ec5ep10@VPS13A
8.98e-131FFCP PHASE1:Hg19::chr9:127269488..127269495,-#_736a17cfbd40f566fd6df9e82ed4ec5ep5@NR5A1
8.98e-131FFCP PHASE2:Hg19::chr4:76901930..76901942,+#_736a17cfbd40f566fd6df9e82ed4ec5ep1@ENST00000501239
8.98e-131FFCP PHASE2:Hg19::chr11:56859693..56859701,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr11:56859693..56859701, -
8.98e-131FFCP PHASE2:Hg19::chr8:22436248..22436259,+#_736a17cfbd40f566fd6df9e82ed4ec5ep11@PDLIM2
8.98e-131FFCP PHASE1:Hg19::chr9:124516729..124516752,+#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr9:124516729..124516752, +
8.98e-131FFCP PHASE2:Hg19::chr1:159172187..159172197,-#_736a17cfbd40f566fd6df9e82ed4ec5ep1@uc001ftm.1
8.98e-131FFCP PHASE2:Hg19::chr9:127260615..127260651,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr9:127260615..127260651, -
8.98e-131FFCP PHASE1:Hg19::chr1:28520450..28520453,-#_736a17cfbd40f566fd6df9e82ed4ec5ep21@PTAFR
8.98e-131FFCP PHASE2:Hg19::chr21:28820941..28820952,-#_736a17cfbd40f566fd6df9e82ed4ec5ep2@ENST00000420186, p2@uc002ymh.2
8.98e-131FFCP PHASE1:Hg19::chr8:22424709..22424716,-#_736a17cfbd40f566fd6df9e82ed4ec5ep2@ENST00000517384
8.98e-131FFCP PHASE2:Hg19::chr17:78171885..78171900,+#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr17:78171885..78171900, +
8.98e-131FFCP PHASE1:Hg19::chr1:157811772..157811796,-#_736a17cfbd40f566fd6df9e82ed4ec5ep7@CD5L
8.98e-131FFCP PHASE1:Hg19::chr11:56859584..56859589,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr11:56859584..56859589, -
8.98e-131FFCP PHASE2:Hg19::chr9:133973310..133973321,+#_736a17cfbd40f566fd6df9e82ed4ec5ep18@AIF1L
8.98e-131FFCP PHASE1:Hg19::chr16:84218794..84218800,+#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr16:84218794..84218800, +
8.98e-131FFCP PHASE2:Hg19::chr11:56859584..56859589,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr11:56859584..56859589, -
8.98e-131FFCP PHASE2:Hg19::chr9:127269462..127269484,-#_736a17cfbd40f566fd6df9e82ed4ec5ep2@NR5A1
8.98e-131FFCP PHASE1:Hg19::chr21:28820892..28820899,-#_736a17cfbd40f566fd6df9e82ed4ec5ep4@ENST00000420186, p4@uc002ymh.2
8.98e-131FFCP PHASE1:Hg19::chr11:925449..925458,+#_736a17cfbd40f566fd6df9e82ed4ec5ep17@AP2A2
8.98e-131FFCP PHASE2:Hg19::chr6:152639579..152639586,-#_736a17cfbd40f566fd6df9e82ed4ec5ep60@SYNE1
8.98e-131FFCP PHASE1:Hg19::chr19:32401253..32401271,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr19:32401253..32401271, -
8.98e-131FFCP PHASE2:Hg19::chr8:47834174..47834213,+#_736a17cfbd40f566fd6df9e82ed4ec5ep1@ENST00000524012
8.98e-131FFCP PHASE2:Hg19::chr21:28820954..28820963,-#_736a17cfbd40f566fd6df9e82ed4ec5ep3@ENST00000420186, p3@uc002ymh.2
8.98e-131FFCP PHASE1:Hg19::chr8:22424743..22424759,-#_736a17cfbd40f566fd6df9e82ed4ec5ep1@ENST00000517384
8.98e-131FFCP PHASE1:Hg19::chrX:69645652..69645664,+#_736a17cfbd40f566fd6df9e82ed4ec5ep7@GDPD2
8.98e-131FFCP PHASE2:Hg19::chr7:22259740..22259751,-#_736a17cfbd40f566fd6df9e82ed4ec5ep19@RAPGEF5
8.98e-131FFCP PHASE1:Hg19::chr11:56859603..56859606,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr11:56859603..56859606, -
8.98e-131FFCP PHASE2:Hg19::chr11:56859603..56859606,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr11:56859603..56859606, -
8.98e-131FFCP PHASE2:Hg19::chr9:127269488..127269495,-#_736a17cfbd40f566fd6df9e82ed4ec5ep5@NR5A1
8.98e-131FFCP PHASE1:Hg19::chr21:28820911..28820933,-#_736a17cfbd40f566fd6df9e82ed4ec5ep1@ENST00000420186, p1@uc002ymh.2
8.98e-131FFCP PHASE1:Hg19::chr17:78171885..78171900,+#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr17:78171885..78171900, +
8.98e-131FFCP PHASE2:Hg19::chr9:124516729..124516752,+#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr9:124516729..124516752, +
8.98e-131FFCP PHASE2:Hg19::chr6:119812455..119812476,-#_736a17cfbd40f566fd6df9e82ed4ec5ep1@uc003pyn.1
8.98e-131FFCP PHASE1:Hg19::chr9:79894790..79894797,+#_736a17cfbd40f566fd6df9e82ed4ec5ep10@VPS13A
8.98e-131FFCP PHASE1:Hg19::chr10:98014908..98014919,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr10:98014908..98014919, -
8.98e-131FFCP PHASE1:Hg19::chr4:76901930..76901942,+#_736a17cfbd40f566fd6df9e82ed4ec5ep1@ENST00000501239
8.98e-131FFCP PHASE2:Hg19::chr10:98014908..98014919,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr10:98014908..98014919, -
8.98e-131FFCP PHASE1:Hg19::chr8:22436248..22436259,+#_736a17cfbd40f566fd6df9e82ed4ec5ep11@PDLIM2
8.98e-131FFCP PHASE1:Hg19::chr1:159172187..159172197,-#_736a17cfbd40f566fd6df9e82ed4ec5ep1@uc001ftm.1
8.98e-131FFCP PHASE1:Hg19::chr11:56859608..56859619,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr11:56859608..56859619, -
8.98e-131FFCP PHASE1:Hg19::chr9:127269434..127269438,-#_736a17cfbd40f566fd6df9e82ed4ec5ep8@NR5A1
8.98e-131FFCP PHASE2:Hg19::chr1:28520450..28520453,-#_736a17cfbd40f566fd6df9e82ed4ec5ep21@PTAFR
8.98e-131FFCP PHASE2:Hg19::chr11:56859608..56859619,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr11:56859608..56859619, -
8.98e-131FFCP PHASE2:Hg19::chr1:157811772..157811796,-#_736a17cfbd40f566fd6df9e82ed4ec5ep7@CD5L
8.98e-131FFCP PHASE1:Hg19::chr21:28820941..28820952,-#_736a17cfbd40f566fd6df9e82ed4ec5ep2@ENST00000420186, p2@uc002ymh.2
8.98e-131FFCP PHASE1:Hg19::chr15:95561320..95561328,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr15:95561320..95561328, -
8.98e-131FFCP PHASE2:Hg19::chr8:22424709..22424716,-#_736a17cfbd40f566fd6df9e82ed4ec5ep2@ENST00000517384
6.24e-88FFCP PHASE1:Hg19::chr19:32401274..32401289,-#_ad33c80427af15cbdae05963c6c52f28p@chr19:32401274..32401289, -
6.24e-88FFCP PHASE1:Hg19::chr21:40459334..40459341,+#_ad33c80427af15cbdae05963c6c52f28p@chr21:40459334..40459341, +
6.24e-88FFCP PHASE2:Hg19::chr9:127267367..127267383,+#_ad33c80427af15cbdae05963c6c52f28p@chr9:127267367..127267383, +
6.24e-88FFCP PHASE2:Hg19::chr4:146461014..146461025,+#_ad33c80427af15cbdae05963c6c52f28p@chr4:146461014..146461025, +
6.24e-88FFCP PHASE2:Hg19::chr3:130267501..130267516,+#_ad33c80427af15cbdae05963c6c52f28p@chr3:130267501..130267516, +
6.24e-88FFCP PHASE2:Hg19::chr1:21011608..21011618,-#_ad33c80427af15cbdae05963c6c52f28p15@KIF17
6.24e-88FFCP PHASE2:Hg19::chr19:32401274..32401289,-#_ad33c80427af15cbdae05963c6c52f28p@chr19:32401274..32401289, -
6.24e-88FFCP PHASE1:Hg19::chr22:36718586..36718593,-#_ad33c80427af15cbdae05963c6c52f28p@chr22:36718586..36718593, -
6.24e-88FFCP PHASE1:Hg19::chr11:56859722..56859732,-#_ad33c80427af15cbdae05963c6c52f28p@chr11:56859722..56859732, -
6.24e-88FFCP PHASE2:Hg19::chr21:40459334..40459341,+#_ad33c80427af15cbdae05963c6c52f28p@chr21:40459334..40459341, +
6.24e-88FFCP PHASE1:Hg19::chr4:146461014..146461025,+#_ad33c80427af15cbdae05963c6c52f28p@chr4:146461014..146461025, +
6.24e-88FFCP PHASE2:Hg19::chr11:56859722..56859732,-#_ad33c80427af15cbdae05963c6c52f28p@chr11:56859722..56859732, -
6.24e-88FFCP PHASE1:Hg19::chr3:130267501..130267516,+#_ad33c80427af15cbdae05963c6c52f28p@chr3:130267501..130267516, +
6.24e-88FFCP PHASE1:Hg19::chr9:127267367..127267383,+#_ad33c80427af15cbdae05963c6c52f28p@chr9:127267367..127267383, +
6.24e-88FFCP PHASE1:Hg19::chr1:21011608..21011618,-#_ad33c80427af15cbdae05963c6c52f28p15@KIF17
6.24e-88FFCP PHASE2:Hg19::chr22:36718586..36718593,-#_ad33c80427af15cbdae05963c6c52f28p@chr22:36718586..36718593, -
9.74e-88FFCP PHASE1:Hg19::chr7:151070957..151070988,+#_9d693fbafe05dbaa637fb69ee44aa626p@chr7:151070957..151070988, +
9.74e-88FFCP PHASE1:Hg19::chr2:128321491..128321509,+#_9d693fbafe05dbaa637fb69ee44aa626p@chr2:128321491..128321509, +
9.74e-88FFCP PHASE2:Hg19::chr16:70680361..70680370,+#_9d693fbafe05dbaa637fb69ee44aa626p6@IL34
9.74e-88FFCP PHASE1:Hg19::chr12:72481040..72481051,+#_9d693fbafe05dbaa637fb69ee44aa626p19@TRHDE
9.74e-88FFCP PHASE1:Hg19::chr14:24168655..24168686,+#_9d693fbafe05dbaa637fb69ee44aa626p@chr14:24168655..24168686, +
9.74e-88FFCP PHASE1:Hg19::chr2:1508349..1508357,+#_9d693fbafe05dbaa637fb69ee44aa626p@chr2:1508349..1508357, +
9.74e-88FFCP PHASE2:Hg19::chr12:72481040..72481051,+#_9d693fbafe05dbaa637fb69ee44aa626p19@TRHDE
9.74e-88FFCP PHASE1:Hg19::chr16:70680361..70680370,+#_9d693fbafe05dbaa637fb69ee44aa626p6@IL34
9.74e-88FFCP PHASE2:Hg19::chr2:128321491..128321509,+#_9d693fbafe05dbaa637fb69ee44aa626p@chr2:128321491..128321509, +
9.74e-88FFCP PHASE2:Hg19::chr14:24168655..24168686,+#_9d693fbafe05dbaa637fb69ee44aa626p@chr14:24168655..24168686, +

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