Coexpression cluster:C1603

Full id: C1603_Hepatocyte_colon_duodenum_small_gall_temporal_liver

Phase1 CAGE Peaks

Hg19::chr10:96500094..96500099,+	p@chr10:96500094..96500099 +
Hg19::chr11:72492630..72492635,-	p13@STARD10
Hg19::chr20:3052792..3052806,+	p3@OXT
Hg19::chr6:25754961..25754980,+	p1@SLC17A4
Hg19::chr6:25781321..25781354,+	p@chr6:25781321..25781354 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0031895	V1B vasopressin receptor binding	0.00176610837712359
GO:0031855	oxytocin receptor binding	0.00176610837712359
GO:0050891	body fluid osmoregulation	0.00176610837712359
GO:0005185	neurohypophyseal hormone activity	0.00176610837712359
GO:0031894	V1A vasopressin receptor binding	0.00176610837712359
GO:0031893	vasopressin receptor binding	0.00176610837712359
GO:0005436	sodium:phosphate symporter activity	0.00313951715827406
GO:0018987	osmoregulation	0.00313951715827406
GO:0007567	parturition	0.00313951715827406
GO:0015114	phosphate transmembrane transporter activity	0.00494430280628434
GO:0005184	neuropeptide hormone activity	0.010591971141342
GO:0015296	anion:cation symporter activity	0.011473621593484
GO:0015103	inorganic anion transmembrane transporter activity	0.0192720292833527
GO:0001664	G-protein-coupled receptor binding	0.026200316927439
GO:0015294	solute:cation symporter activity	0.0268009883676938
GO:0050878	regulation of body fluid levels	0.0275458901971794
GO:0006814	sodium ion transport	0.0358555567995223
GO:0008509	anion transmembrane transporter activity	0.0402145638426299
GO:0005179	hormone activity	0.0402145638426299
GO:0015293	symporter activity	0.0425894721577773
GO:0048878	chemical homeostasis	0.0487516949656449
GO:0022414	reproductive process	0.0487516949656449

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
metabolising cell	1.81e-07	12
endopolyploid cell	1.81e-07	12
parenchymal cell	1.81e-07	12
polyploid cell	1.81e-07	12
hepatocyte	1.81e-07	12
endodermal cell	6.85e-07	59

Uber Anatomy

Ontology term	p-value	n
digestive system	7.91e-10	155
digestive tract	7.91e-10	155
primitive gut	7.91e-10	155
endoderm-derived structure	1.65e-09	169
endoderm	1.65e-09	169
presumptive endoderm	1.65e-09	169
adult organism	1.85e-09	115
subdivision of digestive tract	4.81e-09	129
endodermal part of digestive tract	4.81e-09	129
epithelium of foregut-midgut junction	1.36e-08	25
anatomical boundary	1.36e-08	25
hepatobiliary system	1.36e-08	25
foregut-midgut junction	1.36e-08	25
septum transversum	1.36e-08	25
gut epithelium	3.90e-08	54
gastrointestinal system	4.88e-08	35
intestine	8.62e-08	27
liver	1.01e-07	19
digestive gland	1.01e-07	19
liver bud	1.01e-07	19
abdomen element	1.66e-07	55
abdominal segment element	1.66e-07	55
immune organ	1.83e-07	26
digestive tract diverticulum	3.82e-07	23
sac	5.59e-07	26
abdominal segment of trunk	6.48e-07	61
abdomen	6.48e-07	61

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.