MCL coexpression mm9:352

Phase1 CAGE Peaks

	Short description
Mm9::chr11:110829330..110829356,+	p1@Kcnj16
Mm9::chr11:110887986..110887996,+	p@chr11:110887986..110887996 +
Mm9::chr11:110888086..110888097,+	p@chr11:110888086..110888097 +
Mm9::chr11:110888191..110888202,+	p@chr11:110888191..110888202 +
Mm9::chr11:110888212..110888223,+	p@chr11:110888212..110888223 +
Mm9::chr11:110888243..110888264,+	p@chr11:110888243..110888264 +
Mm9::chr11:110888334..110888345,+	p@chr11:110888334..110888345 +
Mm9::chr11:110888559..110888570,+	p@chr11:110888559..110888570 +
Mm9::chr16:95479224..95479251,+	p4@Kcnj15
Mm9::chr16:95479762..95479812,+	p2@Kcnj15
Mm9::chr16:95500135..95500148,+	p@chr16:95500135..95500148 +
Mm9::chr16:95518529..95518548,+	p@chr16:95518529..95518548 +
Mm9::chr16:95519497..95519507,+	p@chr16:95519497..95519507 +
Mm9::chr16:95519570..95519592,+	p@chr16:95519570..95519592 +
Mm9::chr16:95520301..95520322,+	p@chr16:95520301..95520322 +
Mm9::chr16:95520404..95520427,+	p@chr16:95520404..95520427 +
Mm9::chr17:53985259..53985325,-	p2@Sult1c2
Mm9::chr19:47490807..47490818,-	p@chr19:47490807..47490818 -
Mm9::chr2:150445083..150445108,-	p@chr2:150445083..150445108 -
Mm9::chr2:60437965..60437970,-	p@chr2:60437965..60437970 -
Mm9::chr7:47790409..47790412,-	p@chr7:47790409..47790412 -
Mm9::chr7:52814581..52814608,+	p2@Hsd17b14

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005242	inward rectifier potassium channel activity	0.000447372529800722
GO:0005249	voltage-gated potassium channel activity	0.00717172697264855
GO:0030955	potassium ion binding	0.00717172697264855
GO:0022843	voltage-gated cation channel activity	0.00717172697264855
GO:0005267	potassium channel activity	0.00717172697264855
GO:0003987	acetate-CoA ligase activity	0.00744527133803683
GO:0006813	potassium ion transport	0.00744527133803683
GO:0022832	voltage-gated channel activity	0.00744527133803683
GO:0005244	voltage-gated ion channel activity	0.00744527133803683
GO:0031420	alkali metal ion binding	0.00752153119655392
GO:0006085	acetyl-CoA biosynthetic process	0.0114205222894252
GO:0005261	cation channel activity	0.0114205222894252
GO:0016405	CoA-ligase activity	0.0114205222894252
GO:0022836	gated channel activity	0.0114205222894252
GO:0046873	metal ion transmembrane transporter activity	0.0121532063962398
GO:0015672	monovalent inorganic cation transport	0.0121532063962398
GO:0005216	ion channel activity	0.0152915638660538
GO:0016878	acid-thiol ligase activity	0.0152915638660538
GO:0022838	substrate specific channel activity	0.0152915638660538
GO:0022803	passive transmembrane transporter activity	0.0152915638660538
GO:0015267	channel activity	0.0152915638660538
GO:0016208	AMP binding	0.0152915638660538
GO:0030001	metal ion transport	0.0154776894817964
GO:0008324	cation transmembrane transporter activity	0.0196797953300529
GO:0006812	cation transport	0.0196797953300529
GO:0016877	ligase activity, forming carbon-sulfur bonds	0.0198224386536927
GO:0006084	acetyl-CoA metabolic process	0.0281834557475736
GO:0015075	ion transmembrane transporter activity	0.0315087188656955
GO:0008146	sulfotransferase activity	0.0339201572775825
GO:0006811	ion transport	0.0348154338118834
GO:0016782	transferase activity, transferring sulfur-containing groups	0.0348154338118834
GO:0022891	substrate-specific transmembrane transporter activity	0.0348154338118834
GO:0031980	mitochondrial lumen	0.0348154338118834
GO:0005759	mitochondrial matrix	0.0348154338118834
GO:0022857	transmembrane transporter activity	0.0438405471363389

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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