MCL coexpression mm9:1422

Phase1 CAGE Peaks

	Short description
Mm9::chr1:135811366..135811375,-	p@chr1:135811366..135811375 -
Mm9::chr1:135811991..135811998,-	p@chr1:135811991..135811998 -
Mm9::chr1:135817923..135817934,-	p3@Prelp
Mm9::chr1:135817938..135817969,-	p1@Prelp
Mm9::chr1:135817970..135817986,-	p2@Prelp
Mm9::chr8:131209294..131209358,+	p5@Itgb1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0042685	cardioblast cell fate specification	0.00569769352983071
GO:0042684	cardioblast cell fate commitment	0.00569769352983071
GO:0010002	cardioblast differentiation	0.0113947627233114
GO:0045214	sarcomere organization	0.0182211315066188
GO:0031594	neuromuscular junction	0.0182211315066188
GO:0030239	myofibril assembly	0.0182211315066188
GO:0055002	striated muscle cell development	0.0182211315066188
GO:0055001	muscle cell development	0.0182211315066188
GO:0035051	cardiac cell differentiation	0.0182211315066188
GO:0031032	actomyosin structure organization and biogenesis	0.0182211315066188
GO:0048628	myoblast maturation	0.0182211315066188
GO:0048627	myoblast development	0.0182211315066188
GO:0005178	integrin binding	0.0182211315066188
GO:0001708	cell fate specification	0.0182211315066188
GO:0000082	G1/S transition of mitotic cell cycle	0.0182211315066188
GO:0042383	sarcolemma	0.0194242790689466
GO:0051146	striated muscle cell differentiation	0.0194242790689466
GO:0008305	integrin complex	0.0215051615186753
GO:0045445	myoblast differentiation	0.0215705580130174
GO:0051325	interphase	0.0222237577923401
GO:0051329	interphase of mitotic cell cycle	0.0222237577923401
GO:0048513	organ development	0.0242452063641671
GO:0032403	protein complex binding	0.0242452063641671
GO:0019717	synaptosome	0.0246555107125972
GO:0005201	extracellular matrix structural constituent	0.0251050382667859
GO:0042692	muscle cell differentiation	0.0251050382667859
GO:0007160	cell-matrix adhesion	0.0251050382667859
GO:0048741	skeletal muscle fiber development	0.0251050382667859
GO:0048747	muscle fiber development	0.0251050382667859
GO:0031589	cell-substrate adhesion	0.0254036841775843
GO:0043235	receptor complex	0.0255021912101114
GO:0048731	system development	0.0255021912101114
GO:0048469	cell maturation	0.0255021912101114
GO:0045596	negative regulation of cell differentiation	0.0284229123324066
GO:0007229	integrin-mediated signaling pathway	0.0287339879187794
GO:0021700	developmental maturation	0.0287339879187794
GO:0007519	skeletal muscle development	0.0291396984880458
GO:0048856	anatomical structure development	0.0291396984880458
GO:0045165	cell fate commitment	0.0291396984880458
GO:0051093	negative regulation of developmental process	0.0295444077178587
GO:0001701	in utero embryonic development	0.0329521095651926
GO:0014706	striated muscle development	0.0329521095651926
GO:0007275	multicellular organismal development	0.0329521095651926
GO:0045595	regulation of cell differentiation	0.0388340955699746
GO:0030036	actin cytoskeleton organization and biogenesis	0.0388340955699746
GO:0030029	actin filament-based process	0.0400656162891692
GO:0007517	muscle development	0.0400656162891692
GO:0007507	heart development	0.0401718168432316
GO:0008284	positive regulation of cell proliferation	0.0407341498512422
GO:0001501	skeletal development	0.0408222322428206
GO:0032502	developmental process	0.0469809866053202
GO:0043009	chordate embryonic development	0.0469809866053202
GO:0009792	embryonic development ending in birth or egg hatching	0.0469809866053202
GO:0000278	mitotic cell cycle	0.0469809866053202

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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